Course Specification Medicinal Chemistry-1
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1 Quality Assurance Unit Faculty of Pharmacy-Assiut University Course Specification Medicinal Chemistry-1 Programme(s) on which the course is given: B. Sc. (Pharmaceutical science) Major or Minor element of programme: Major Department offering the programme: Faculty of Pharmacy Department offering the course: Medicinal Chemistry Academic year / Level: 2012/2013, Third year (1 st Semester) Date of specification approval: Basic Information Title: Medicinal Chemistry-1 Code: PHC Level: Third year (1 st Semester) Dept.: Medicinal Chemistry Lecture: 2 h /week Tutorial/ Practical: 3 h /week Total: 5 h /week 2- Aims of Course 1. Provide the basic knowledge of medicinal chemistry, through identification of the chemistry of different drug classes including analgesics and anti-inflammatory, diagnostic agents gastrointestinal drugs, antihistaminics, drug metabolism, drug design and physicochemical parameters. 2. Acquire the knowledge about drug synthesis, analysis, mechanism of action and SAR. 3. Provide the basics of the concept of drug design and prodrug approaches as well as physicochemical parameters affecting drug action, absorption and bioavailability. 3- Intended Learning Outcomes of Course(ILOs) i
2 a- Knowledge and Understanding: a2-explain the basic physicochemical properties of drugs including electronic, lipophilic, steric parameters in relation to synthetic, biotechnology and radiolabled products. a6- Describe the appropriate knowledge concerning chemistry of medicinal gents, their synthesis, isolation, identification by spectral techniques as well as structural activity relationship (SAR) and drug design. a11- Mention the activity and toxic profile of various drugs deduced from structure, and biotransformation processes. b- Intellectual Skills: b3- Predict the methods of synthesis and properties of medicinal agents and their relation to molecular structure. b4- Apply spectral data for identification of raw materials as well as pharmaceutical compounds. b7- Integrate information and propose approaches for monitoring and design of medicinal agents of different sources. b11- Select and assess appropriate methods of extraction, isolation, purification, identification of medicines from synthetic origin. c- Professional and practical Skills: c7- Handle properly chemicals in the lab and be aware of the rules of good laboratory practice(glp). c9- Synthesize, isolate and identify drug molecules. c11- Conduct research studies and analyze results. d- General and Transferable Skills: d9- Work effectively in a team and present results in written and oral forms. d12- Manage the time effectively in laboratory and home work. d13- Demonstrate critical thinking, problem solving and decision making abilities. ii
3 Course Contents A. Theoretical Contents Topic Total units Lecture (2hr) Tutorial / Practical (3 h) Introduction Physicochemical properties of drug molecules Analgesics and antiinflammatory Gastrointestinal drugs Antihistaminics Prostaglandins Diagnostic agents Drug design drug metabolism Total B. Practical Contents No. Subject 1 Introduction to Computer-Aided Drug Design 2 Chem Draw and Chem3D Basics 3 MOE Tour & Protein Data Bank 4 Molecular Modelling, Basic Functions & Operations 5 Lipinski's Rule of Five 6 Molecular Docking 7 Drug design and Drug metabolism tutorials iii
4 4- Teaching and Learning Methods 4.1- Lectures Practical training (Laboratory). 4.3-Tutorials and class activity. 5- Teaching and learning methods for disables Not applicable 6- Student Assessment a- Student Assessment methods 6.1-Written exam to assess ILOs: a2,a6, a11, 6.2- Oral exam to assess ILOs: a2,a6, a11,,, d9, d12 and d Practical exam to assess ILOs: 2,a6, a11,,, d9, d12 and d Tutorial classes to assess ILOs: 2,a6, a11,,, d9, d12 and d13 b- Student Assessment Schedule No. Assessment Week 1. Practical exam every week 2. Mid-Term exam 10 th 3. Final written exam 16 th 4. Oral exam 16 th c- Weighting of Assessments No. Exam. Mark % 1. Mid-Term Examination Final-Term Examination Oral Examination Practical Examination Semester Work Other types of assessment - - Total % iv
5 7- List of References a-course Notes: 1- Medicinal Chemistry- 1 PHC-415 (2012) 2- Practical Medicinal Chemistry-1 PHC-415 (2012) b- Essential Books (Text Books): 1. Graham Patrick An Introduction to Medicinal Chemistry 4 th edition (2009) Oxford University press, Oxford, UK. 2. William O. Foye Principle of Medicinal Chemistry, 6 th edition (2008), Lipincott Williams & Wilkins, London. 3. Wilson and Gisvolds Textbook of Organic, Medicinal and Pharmaceutical Chemistry 10 th edition (1998), Lippencott Raven Publishers, Philadelphia, New York. c- (Recommended books): 1. Povl Krogsgaard - Larsen Textbook of Drug Design and Discovery 4 th edition (2010), CRC Press, Raton, Fl, USA. 2. Donald Cairns Essentials of Pharmaceutical Chemistry 3 rd edition, (2008) Pharmaceutical press, London. 3. M. E. Wolff Burger s Medicinal Chemistry and Drug Discovery 5 th edition (1997), Wiley-interscience Publication, New York. 4. A. Gennaro (Editor), Remington s pharmaceutical Sciences, 21 th edition (2006), Lippincott Williams & Wilkins, Maryland, USA. 5. J.L.Mc.Guire Pharmaceuticals, Classes, Therapeutic agents, Areas of Application, 2000, Wiley-VCH Verlag GmbH, Weinheim. 6. Egyptian Pharmacopoeia (1984) 7. United State Pharmacopoeia (2007) 8. British Pharmacopoeia (2009) 9. European Pharmacopoeia Vol. 2 (2008) v
6 d- (Periodicals, Web Sites. etc) h p://depts.washington.edu/medchem/420temp.html rww/ mcm408/sylabus.pdf layla/medchem/amcl.htm h p:// 8- Facilities Required for Teaching and Learning Computers and software. Course Coordinator: Prof. Dr Hamdy M. Abdel-Rahman Head of Department: Prof. Dr Atef Abdel-Monem Program Director Date: / 11 /2012 vi
7 University:. Assiut Course Title Medicinal chemistry-1 Faculty: Pharmacy Course Code PHC 415 Department: Medicinal Chemistry Matrix of the Intended Learning Outcomes (ILOs) of the Course Topi c Introduction +PGs, Drug design and drug metabolism (Tutorial)* Drug design and drug metabolism (Tutorial) Drug design and drug metabolism Physicochemical properties Analgesics NSAIDs NSAIDs GIT + NSAIDs Week 1 st 2 nd 3 rd 4 th 5 th 6 th 7 th 8 th 9 th Knowledge and Understanding a6 a6 Intellectual Skills b4, b11 Professional and Practical Skills c7, c11 General and Transferable Skills viii
8 Midterm Exam antihistaminics GIT GIT Diagnostic agents 10 th 11 th 12 th 13 th 14 th Course Coordinator: Prof. Dr Hamdy M. Abdel-Rahman Head of Department: Prof. Dr Atef Abdel-Monem Date: 18/ 10 /2012 ix
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