The University of Jordan. Accreditation & Quality Assurance Center. COURSE Syllabus

Transcription

1 The University of Jordan Accreditation & Quality Assurance Center COURSE Syllabus

2 1 Course title Principles of Genetics and molecular biology 2 Course number Credit hours (theory, practical) 3 Contact hours (theory, practical) 3 (theory) 4 Prerequisites/corequisites General Biochemistry 5 Program title 6 Program code 7 Awarding institution The University of Jordan 8 Faculty Medicine 9 Department Physiology and Biochemistry 10 Level of course 2 nd year 11 Year of study and semester (s) Second semester of every year 12 Qualification 13 Other department (s) involved in teaching the course 14 Language of Instruction English 15 Date of production/revision October 11, Course Coordinator: Office numbers, office hours, phone numbers, and addresses should be listed. TBD at Faculty of Medicine 17. Other instructors: Office numbers, office hours, phone numbers, and addresses should be listed. TBD at Faculty of Medicine 18. Course Description: As stated in the approved study plan. This is a three-credit hour course mandatory for second-year medical students. The course is designed to introduce medical students to the basics of cell and molecular biology and medical genetics. The basics include the study of cell structure and function, the genetic material, DNA and RNA, with regards to chemical structure, replication, transcription, translation, in addition to the study of basic molecular biology tools and techniques. The course also introduces students to the main principles of medical genetics in relation to various genetic disorders 1

3 19. Course aims and outcomes: A- Aims: The overall objective is to: 1) cell organization and function of the different components and abnormalities, 2) learn the basic processes of the central dogma of molecular biology including DNA replication, RNA transcription, and protein translation. 2) become familiar with basic molecular biology techniques involved in recombinant DNA technology, and 3) learn the genetic basis and the principles of disease inheritance. B- Intended Learning Outcomes (ILOs): Upon successful completion of this course students will be able to A1- Recognize the different cell models. A2- Learn the molecular components of cells. A3- Understand the structure of plasma membranes of eukaryotic cells. A4- Know the different types of membrane proteins. A5- Recognize the role of membrane proteins in transport. A6- Understand the molecular mechanism of cystic fibrosis. A7- Understand the structure and role of the endoplasmic reticulum in protein synthesis and sorting. A8- Understand the role of the endoplasmic reticulum in lipid synthesis. A9- Understand the structure and roles of the Golgi apparatus in the synthesis of cellular molecules. A10- Understand the mechanism of vesicular transport. A11- Understand the structure and role of lysosomes and endosomes. A12- Understand the mechanism of endocytosis. A13- Recognize lysosomal storage diseases. A14- Understand the structure of the mitochondria. A15- Discuss mitochondrial diseases. A16- Understand the structure and function of peroxisomes. A17- Understand the structure of the nucleus and the nuclear membrane. A18- Know the nuclear lamina diseases. A19- Understand the structure and organization of the actin cytoskeleton. A20- Understand the role of actin and myosin in cell movement and muscle contraction. A21- Understand the structure and organization of microtubules and their role in vesicular transport. A22- Understand the structure and role of intermediate filaments. A23- Know the association of keratin dysfunction in skin diseases. A24- Recall the different components of the extracellular matrix. A25- Recall the steps involving the synthesis of collagen proteins. A26- Recall diseases related to collagen synthesis. A27- Understand the mechanisms of cell-matrix and cell-cell interaction. A28- Recall the different modes of cell signaling with emphasis on cell surface receptors and their intracellular signaling molecules and their cellular effects. A29- Understand the phases and molecular control of the cell cycle. A30- Understand the molecular regulation of cell death. A31- Understand the types and properties of cancer cells. 2

4 A32- Recognize the basic features of DNA/RNA structures. A33- Learn the main steps and reactions involved in DNA replication. A34- Learn the main steps and reactions involved in RNA transcription. A35- Learn the main steps and reactions involved in protein translation. A36- Understand the various mechanisms and stages involved in regulation of gene expression. A37- Differentiate between the main types of DNA damage and the different mechanisms involved in DNA repair. A38- Understand the function and regulation of cancer related genes including oncogenes, tumor suppressors, and regulators of apoptosis. A39- Learn with basic molecular biology techniques involved in recombinant DNA technology. A40- Learn the concept of stem cells and their uses in therapy. A41- Recognize the main features of chromosome structure. A42- Differentiate between the main patterns of inheritance. A43- Understand the basic principles of multifactorial inheritance. A44- Recognize the main types of chromosomal aberrations. A45- Understand the basic principles of chromosomal disorders. A46- Focus on biochemical genetics and disorders of metabolism. A47- Know the basics of pharmacogenetics and Pharmacogenomics. 20. Topic Outline and Schedule: Topic Introduction into cellular molecules, model systems of cell biology, and eukaryotic cell organelles Biomembranes and membrane proteins and their role in plasma membrane transport Protein sorting and transport, and endoplasmic reticulum The Golgi apparatus and vesicular transport Lysosome, endocytosis, endocytosis, and lysosomal storage diseases Mitochondria and peroxisomes The nucleus Week Instructor Achieved ILOs Evaluation Methods 1 TBD A1-2 Mid 1 TBD A3-6 Mid 1 TBD A7-8 Mid 2 TBD A9-10 Mid 2 TBD A11-13 Mid 2 TBD A14-16 Mid 3 TBD A17-18 Mid Reference 1 (pp ) and Ch.2 (43-57) 2 (pp ) Ch. 13 ( ) 10 ( ) 10 ( ) 10 ( ) Ch. 13 ( ) 10 ( , ) 9 ( ) 3

5 The actin cytoskeleton and cell movement Microtubules and intermediate filaments The extracellular matrix Cell signaling The cell cycle Cell proliferation, differentiation, and death Cancer: a cellular perspective 3 TBD A19-20 Mid 3 TBD A21-23 Mid 4 TBD A24-27 Mid 4 TBD A28 Mid 4 TBD A29 Mid 5 TBD A30 Mid 5 TBD A31 Mid 12 ( ) 12 ( ) 14 ( ) 15 ( ) 16 ( ) 17 ( ) 18 ( ) Nucleic acid structure 5 TBD A32 Mid Marks, Ch. 12 DNA replication 6 TBD A33 Marks, Ch. 13 RNA transcription 6 TBD A34 Marks, Ch. 14 Protein synthesis 6 TBD A35 Marks, Ch. 15 Regulation of gene expression 7 TBD A36 Marks, Ch. 16 DNA repair 9 TBD A37 Marks, Ch. 13 Cancer: a Molecular perspective 9-10 TBD A38 Marks, Ch. 18 Recombinant DNA technology TBD A39 Marks, Ch. 17 Extracurricular Cell renewal and stem cells 11 TBD A40 material Structure & function of chromosomes 11 TBD A41 Emrey's, Ch. 3 Autosomal dominant & recessive 12 TBD A42 inheritance Emrey's, Ch. 7 Sex linked & mitochondrial 13 TBD A42 inheritance Emrey's, Ch. 7 Multifactorial inheritance & common 13 TBD A43 disease Emrey's, Ch. 9 Chromosomal aberrations 12 TBD A44 Emrey's, Ch. 3 Chromosomal disorders TBD A45 Emrey's, Ch. 18 Biochemical genetics: disorders of Emrey's, Ch. 14 TBD A46 metabolism 11 Pharmacogenetics/Pharmacogenomics 15 TBD A47 Emrey's, Ch. 4

6 Teaching Methods and Assignments: Development of ILOs is promoted through the following teaching and learning methods: Lectures 22. Evaluation Methods and Course Requirements: Opportunities to demonstrate achievement of the ILOs are provided through the following assessment methods and requirements: 23. Course Policies: A- Attendance policies: B- Absences from s and handing in assignments on time: C- Health and safety procedures: D- Honesty policy regarding cheating, plagiarism, misbehavior: E- Grading policy: 5

7 F- Available university services that support achievement in the course: Books at library and online services 24. Required equipment: None 25. References: A- Required book (s), assigned reading and audio-visuals: 1. The Cell: A Molecular Approach, Geoffrey M. Cooper and Robert E. Hausmann, 6th edition, Sinauer Associates, Mark's Basic Medical Biochemistry, Smith, Marks and Lieberman, Lippincott, Williams and Wilkins, Emrey's Elements of Medical Genetics, Muller & Young, Churchil Livingstone, 13th edition, B- Recommended books, materials, and media: 1. Molecular Biology, Robert F. Weaver, 2 nd edition, McGraw Hill Genes VII, Benjamin Lewin, edition 1, Oxford Univ. Press, Medical Genetics, Jorde, Carey, Bamshad, White, Mosby. 4 th edition, Mosby, Additional information: 6

8 Name of Course Coordinator: Signature: Date: Head of curriculum committee/department: Signature: Head of Department: Signature: Head of curriculum committee/faculty: Signature: Dean: Signature: Copy to: Head of Department Assistant Dean for Quality Assurance Course File 7