Radiotracers for Early Diagnosis - ReSearching for a Better Life!
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1 Radiotracers for Early Diagnosis - ReSearching for a Better Life!
2 CONTACT INFORMATION: Horia Hulubei National Institute of Physics and Nuclear Engineering - IFIN- HH 30 Reactorului Street Bucharest-Magurele, ROMANIA secretar@nipne.ro Radioisotopes and Radiation Metrology Department Radiopharmaceuticals Research Centre Tel.: (+4) Fax.: (+4) dana.niculae@nipne.ro
3 Radiopharmaceuticals Research Program Production of PET Radioisotopes Production of SPECT Radioisotopes via cyclotron Production and post-processing of positron/gamma/beta emitters radioisotopes (short lived) via cyclotron. The medical radionuclides are especially envisaged. PET: F-18, C-11, N-13, O-15, I-124 for imaging; Cu-64 for imaging and therapy SPECT: Tc-99m, I-123 for imaging
4 Radiopharmaceuticals Research Program Developing of new radiopharmaceuticals for molecular imaging GMP Production of radiopharmaceuticals for clinical testing Potential radiopharmaceuticals for imaging and targeted therapy of cancer are preclinically evaluated. Molecules with specific biological activity and preferential tumor uptake, involved in pathological mechanisms, such as antibodies, peptides and hormones were radiolabelled with gamma/positrons/ beta emitters. At the GMP production site the successful agents will be prepared according to pharmacological safety requirements for human use and clinically tested.
5 Radiopharmaceuticals Research Program Pharmacological development using C-11 and PET imaging Developing hybrid imaging technology Molecular imaging is expected to play an increasingly important role in drug discovery and development. Positron Emission Tomography (PET), as a non-invasive imaging technique that provides quantitative information about a drug target s distribution, its interaction with drug molecules and changes over time and upon therapeutic intervention, has been increasingly recognized as a powerful imaging modality that provides a specific and sensitive biomarker for drug development.
6 Nuclear Physics Applications at cyclotron Research Program Applications of cyclotron and linear accelerator Industrial applications of cyclotron TLA/UTLA (Thin Layer Activation/ Ultrathin Layer Activation) for wear corrosion studies; Neutron activator for nanostructure activation for brachytherapy; Neutron activation of nanoparticles for industry; Irradiation system of high currents for Tc-99m production with rabbit for automatic transfer to hot-cells; Beam optics research/development; Positron source in line with the cyclotron for accelerating slow positrons (advanced stage build-up); Irradiation for electronic device testing; Experimental physics, dosimetry, etc
7 Positron emitting medical radioisotopes Radiopharmaceuticals Fluorine-18 T 1/2 = 110 min 18 F-FDG Iodine-124 T 1/2 = 4.2 d 18 F-DOPA Technetium-99m T 1/2 = 6.1 h 18 F-FLT Nitrogen-13 T 1/2 = 9.9 min 18 F-FES Carbon-11 T 1/2 = 20.3 min Na 18 F Oxygen-15 T 1/2 = 2 min 124 I-MIBG Copper-64 T 1/2 =12.7 h 68 Ga-DOTA-TOC Iodine-123 T 1/2 =13.2 h 68 Ga-RGD....
8 Equipments Cyclotron TR-19 Cyclotron- fully automated and computer controlled; Variable Energy: extraction energy 14-19MeV; External Ion Source (H - ) and Extraction System; Automated Target Changer with precise real-time target position alignment; Gaseous, solid and liquid targets; Solid targets processing system; Experimental hall with additional beam lines.
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10 Equipments Radiochemistry Automated synthesis units (Fastlab GE, Synthra); Hot Cells for radiochemistry (Comecer); A-class Automated robotic dispenser for radiopharmaceuticals; Radiochemistry lab (radiochemistry hoods, calibrators, gamma spectrometry); Analytical equipment: chromatography HPLC, GC FID, TLC with radiodetection); Micro (radiobiology) laboratory (laminar flow hoods for aseptic manipulations, incubator, autoclave, bubble point tester, particle counter, endotox); Micro PET (pre-clinical studies on small animals).
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12 PLANUL NAŢIONAL DE CERCETARE, DEZVOLTARE ŞI INOVARE, PNII Programul CAPACITĂȚI Dezvoltarea infrastructurii pentru cercetari de frontiera in fizica nucleara si domenii conexe 7PM/1/2008 /
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