Nuclear medicine and Radiation technologies

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1 ЗАКРЫТОЕ АКЦИОНЕРНОЕ ОБЩЕСТВО «РУСАТОМ ОВЕРСИЗ» Nuclear medicine and Radiation technologies Istanbul

2 State Corporation «ROSATOM» world leader in nuclear energy

Uranium production Uranium enrichment Nuclear fuel production Equipment

3 State Corporation ROSATOM Nuclear medicine C omposite materials Nuclear energy Science Nuclear and radiation security Nuclear power icebreakers Uranium production Uranium enrichment Nuclear fuel production Equipment production NPP design and Construction Energy production Maintenance and repairs 3

4 RUSATOM OVERSEAS

5 RUSATOM OVERSEAS Nuclear power icebreakers Nuclear and radiation security Technologies and fundamental science Energy production Nuclear weapon RUSATOM OVERSEAS is State Corporation ROSATOM company, devoted for overseas business development in the fields of: Nuclear Power Generation; Nuclear Medicine; Radiation Technologies. Nuclear Medicine Centers of Irradiation 5

6 RUSATOM OVERSEAS marketing offices Czech Republic Ukraine Slovak Republic Hungary Singapore SAR 6

7 Radionuclide diagnostics

8 Radionuclide diagnostics Radionuclide diagnostics Cyclotron complex manufacturing by NIIEFA Module of synthesis manufacturing by NIITFA Target station manufacturing by NIIEFA Department of Positron emission tomography Department of Gammatomography SPECT/CT EFATOM manufacturing by NIIEFA PET/CT manufacturing by NIIEFA 8

Single-photon emission computed tomograph «EFATOM» (SPECT/CT) Tomograph is aimed for medical diagnostic

characteristics similar to the current level of foreign technology.

9 Single-photon emission computed tomograph «EFATOM» (SPECT/CT) Tomograph is aimed for medical diagnostic tests of human viscera with imaging technique of pharmaceuticals distribution radiolabeled with gamma-emitting radiopharmaceuticals. In 2008 the EFATOM successfully tested in Hospital 83 FMBA in Moscow, showing its compliance with the characteristics similar to the current level of foreign technology. NIIEFA has the registration certificate FCR 2009/05499, that confirm the permission to manufacture, sale the EFATOM tomograph. To date more than 9,500 diagnostic workup was hold. overall view EFATOM under clinical investigation 9

Compact cyclotrons CC-12 a special-purpose

production of radiopharmaceuticals for PET

10 Compact cyclotrons CC-12 a special-purpose cyclotron for producing 12 MeV proton beams The cyclotron is intended for producing ultra short - lived radionuclide's for production of radiopharmaceuticals for PET Under construction in one of Central European countries 10

The cyclotron is intended to effectively produce both ultra shortlived and short-lived radionuclide's.

11 Compact cyclotrons СС18/9М a cyclotron for producing proton beams with an energy variable from 12 up to 18 MeV and deuteron beams with an energy variable from 6 up to 9MeV. The cyclotron is intended to effectively produce both ultra shortlived and short-lived radionuclide's. CC18/9 Installed in: National PET-Center of University of Turku, Turku, Finland; Russian Research Center for Radiology and Surgical Technologies, Saint Petersburg, Russia CC-18/9M Under construction in NIITFA? Moscow, Russia. 11

In addition to routine production of commonly used radionuclide's, the cyclotron allows research to be

12 12 Compact cyclotrons МСС-30/15 a cyclotron for producing proton beams with an energy variable from 18 up to 30 MeV and deuteron beams with an energy variable from 9 up to 15 MeV. In addition to routine production of commonly used radionuclide's, the cyclotron allows research to be carried out aimed at producing new promising radiopharmaceuticals MCC-30/15 Installed in: PET-Center of University of Yuvaskula, Yuvaskula, Finland;

13 Proton therapy

controlled penetration depth is up to 30 cm 2.

the tumor Healthy tissues behind the tumor are not exposed to radiation 3.

4. Effective radiotherapy for treatment of children with minimal side effects

14 Why proton therapy? 1. Highly-accurate type of radiotherapy The maximum dose treats the tumor precisely The controlled penetration depth is up to 30 cm 2. Minimal damage to healthy tissues Minimal dose exposure of healthy tissues before the tumor Healthy tissues behind the tumor are not exposed to radiation 3. Maximum curative effect Increase in life expectancy Lower chance of secondary tumors 4. Effective radiotherapy for treatment of children with minimal side effects Minimal exposure of healthy tissues before the tumor Side effects are 8 times lower than other radiotherapies Conclusion: Proton therapy is an effective and advanced therapy able to save numerous lives. 14

Costs of construction and equipment 40-45 M$ depending on selected configuration. 3.

15 Concept Compact and inexpensive solution* that will make proton therapy affordable to patients. Concept of the Proton therapy center is a result of scientific work in Russia since Center s moderate size will reduce initial investments. 2. Costs of construction and equipment M$ depending on selected configuration. 3. Modern methods will allow for gradual increase of the Center s admission capacity. 4. Exceptional oncological treatment. 5. Treatment of all disease locations at lower than the world average prices (due to customer flow and engineering compactness of the solution). 15

16 Irradiation center

17 Irradiation center package solution for radiation technological treatment of the goods Irradiation Center - The affiliated companies of

We offer a package solution for planning, production and sales of radiation technological equipment and provide services in ionirradiation

Main services: Sterilization of medical devices Irradiation treatment of food disinsection of agricultural goods Modification of materials

17 17 Irradiation center package solution for radiation technological treatment of the goods Irradiation Center - The affiliated companies of ROSATOM have gained profound experience in the irradiation management. We offer a package solution for planning, production and sales of radiation technological equipment and provide services in ionirradiation of different products. Main services: Sterilization of medical devices Irradiation treatment of food disinsection of agricultural goods Modification of materials Polymer crosslinking Reinforcement of tires components. Radiation treatment can be effected by 3 types of irradiation: gamma (with radioactive isotopes): braking radiation (X-ray): electron beam (β-irradiation). Irradiation causes the ionization process in the products tissue that leads to modification of the atomic structure

18 Irradiation center package solution for radiation technological treatment of the goods Equipment of the irradiation center: Particle accelerators and radionuclide sources of gammairradiation are

18 18 Irradiation center package solution for radiation technological treatment of the goods Equipment of the irradiation center: Particle accelerators and radionuclide sources of gammairradiation are used as generators in the Irradiation center. Particle accelerators Linear accelerator generating electron beams with scanner is placed in the shielding block. Main characteristics of the accelerators: Electron energy from 0,2 to 10 MeV Electron beam power kwt Benefits: High productivity, user-friendly system of the process control. Parameter A convertor unit transforming electron beam into braking radiation (energy up to 5 MeV) may be used in order to achieve high penetrating power of radiation. Gamma-facility In a gamma-facility a closed radionuclide source with Co-60 is used for ionizing irradiation. Main parameters: Initial activity of the source 350±10% KCu (12,95*1015 Bq); Maximal capacity of the radiator 1000 KCu; Benefits: high penetrating power of the γ-irradiation, irradiation dose flexibility, irradiation process autonomy. Medical devices sterilization Food irradiation Disinsectio n of crops Polymers modification Electrons energy 5-10 Up to Electron beam power, kwt Absorbed dose (max. - 10)

19 Business development solutions

Business development solutions RUSATOM OVERSEAS provides RUSATOM OVERSEAS involvement options Technologies solutions Engineering solutions BOO

20 Business development solutions RUSATOM OVERSEAS provides RUSATOM OVERSEAS involvement options Technologies solutions Engineering solutions BOO Build-Own-Operate (co-investment possible) Construction solutions EPC Engineering-Procurement- Construction Financial solutions Procurement solutions Equipment supplier 20

21 21

22 Contacts Ovchinnikov Anton, project manager +7 (495) (5221) 22

State Atomic Energy Corporation Rosatom Russian Radiation Technologies: opportunities to success

State Atomic Energy Corporation Rosatom Russian Radiation Technologies: opportunities to success M.Batkov, Director Radiation Technologies Program 15.04.2013 Rosatom is the largest hi-tech manufacturer