PANEL DISCUSSION. Radionuclides and Health A promising future! OCTOBER 14-16, 2014 PARIS LE BOURGET FRANCE
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1 PANEL DISCUSSION Radionuclides and Health A promising future! Hosted by Richard Zimmermann, Chrysalium Consulting Discussion coordinated by François Sarkozy, President of FSNB Health & Care Speakers: Remigiusz Barańczyk - Nuclear Fuel Market Observatory Sector (European Commission) Patrick Bourdet - President and CEO of Areva Med Kevin Charlton - Head of Nuclear Development for the OECD Nuclear Energy Agency Kristoff Muylle Bordet Institute, Brussels, President of the Belgium Nuclear Medicine Society Guy Turquet de Beauregard - IBA Molecular, President of AIPES Avec la participation de OCTOBER 14-16, 2014 PARIS LE BOURGET FRANCE 1
2 An Introduction to Nuclear Technologies for Healthcare Richard Zimmermann Le Bourget - October 16, 2014 MEDraysintell
3 Medical Imaging Morphological Analysis Functional Analysis Molecular Imaging MRI X rays Scintigraphy Ultrasound Radiotherapy Hadrontherapy 3
4 What is the size of a cell? 4
5 Principle of Molecular Targeting Pathology Receptor Ligand / Vector Radio-isotopes Imaging ex. Labeling with Technetium (Gamma emitter) Linker + chelator 5
6 Nuclear Imaging - Cardiology 6
7 Nuclear Imaging: Cardiology 7
8 Fluorodeoxyglucose - FDG - small organic molecule behaving like glucose - accumulating in tumors and metastases - labeled with 18 F (half-life 108 min) 8
9 Breast Cancer Lymphoma 9
10 10
11 11
12 Imaging of Amyloid Plaques ( 18 F-AV45) Control Alzheimer s disease 12
13 Neuronal Degenerative Diseases Healthy Control Lewy Body Alzheimer s Fronto -temporal Degeneration Disease Degeneration 11 C PIB Rowe
14 Radionuclide manufacturing tools Reactor Tool to generate the bulk radionuclide or precursor e.g. 177 Lu, 99 Mo, 131 I Cyclotron Tool to generate bulk short-lived radionuclides e.g. 18 F, 111 In, 123 I, 67 Ga, 201 Tl Generator Tool to generate on-site very short lived radionuclides e. g. 99m Tc, 188 Re, 82 Rb, 68 Ga 14
15 Radiopharmaceuticals manufacturing tools Synthesis automates: The radionuclide is transfored in radiopharmaceutical Hot cells Tool containing the automates clean room Class C or B Final product: showing syringe protection and lead containers 15
16 Different types of radioactivity Alpha (α): 2 protons + 2 neutrons: Therapy 7400x weight of electron Gamma: (γ-ray) SPECT imaging Beta minus: e - = high energy electron: Therapy Auger electron: e - = low energy electron: Therapy Beta plus: positron = antielectron (e + ) e - + e + -> 2γ : PET imaging 16
17 Principe of Molecular Targeting Pathology Receptor Ligand / Vector Radio-isotopes Therapy ex. Labeling with Lutetium (Beta emitter) Linker + chelator 17
18 Nuclear Imaging - Oncology Use of isotopes in form of simple salts imaging and therapy Example: iodine Application: thyroïd imaging Iode 123 ( emitter, t ½ 13.2 h ) : Diagnostic and follow up Iode 131 ( - emitter, t ½ 8.02 d) : Diagnostic and therapy 18
19 Metabolic Radiotherapy Pancreatic Neuroendocrine Liver Metastase five years post treatment with Somatostatin peptide analogue labelled with 90 Y (three cycles) and 177 Lu (one single treatment) Prof. R. Baum - Bad Berka
20 213 Bi vs. 177 Lu-DOTATOC (2012 SNM image of the year) 213 Bi: half-life 45min (11GBq = 300mCi) 20
21 Thanks for your attention MEDraysintell Thanks to Prof. Peter Ell, Prof. Bengt Langstrom, Philips Healthcare, IBA, AZE 21
22 PANEL DISCUSSION Radionuclides and Health A promising future! Hosted by Richard Zimmermann, Chrysalium Consulting Discussion coordinated by François Sarkozy, President of FSNB Health & Care Speakers: Remigiusz Barańczyk - Nuclear Fuel Market Observatory Sector (European Commission) Patrick Bourdet - President and CEO of Areva Med Kevin Charlton - Head of Nuclear Development for the OECD Nuclear Energy Agency Kristoff Muylle Bordet Institute, Brussels, President of the Belgium Nuclear Medicine Society Guy Turquet de Beauregard - IBA Molecular, President of AIPES Avec la participation de OCTOBER 14-16, 2014 PARIS LE BOURGET FRANCE 22
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