Amman Samer Hasan Ahmad Hussein-Al-Ali, PhD, Chemistry (nanosciences, drug delivery,

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1 Amman Samer Hasan Ahmad Hussein-Al-Ali, PhD, Chemistry (nanosciences, drug delivery, PERSONAL PARTICULARS Date of Birth : 21 October 1972 Place of Birth : Kuwait Sex : Male Martial Status : Married Nationality : Jordanian advance materials) Occupation : *Assistant Professor at Isra University, Faculty of Pharmacy (2014) until now *Postdoctoral Research Fellow, Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia (2013) Address : Amman- Jordan EDUCATION: Ph.D. University Putra Malaysia, Serdang, Selangor, Malaysia (2012). Major: Nanosciences Minor: Chemistry, advance materials Grade: 3.732/4 (A-) Title of Thesis: Preparation of Ellagic acid, Hippuric acid, Perindopril Erbumine and Cetirizine nanocomposites for drug delivery M.Sc. Mysore University, Mysore, India (2002). Major: Inorganic Chemistry Grade: 69.3% (First class) B.Sc. Sana a University, Sana a, Yemen (1997). Major: Chemistry Minor: Biology Grade: 3.32/5 (Very good with honour) PROFESSIONAL EXPERIENCES 1

2 Post doctoral Fellow Research, Laboratory of Molecular Biomedicine, Institute of Bioscience; University Putra Malaysia; from February 2013 until February Demonstrator at Inorganic Chemistry Lab. Faculty of Science, University Putra Malaysia; from December 2010 to May Chemistry teacher in the Al-Rayan secondary private school, Madenah Al-Monurah, Saudi Arabia, from September 2002 to September 2008 Demonstrator at Inorganic Chemistry Lab. Faculty of Science, Jordan University; from January 2002 to May Chemistry teacher in the Al-Etihad secondary private school, Amman, Jordan, from September 1997 to September 2000 RECENT PUBLISHED RESEARCH PAPERS 1. Mohd Zobir Hussein, Samer Hasan Hussein Al Ali, Zulkarnain Zainal, Muhammad Nazrul Hakim. Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent. International Journal of Nanomedicine. 2011;6: Samer Hasan Hussein Al Ali, Mothanna Al-Qubaisi, Mohd Zobir Hussein, Zulkarnain Zainal, Muhammad Nazrul Hakim. Preparation of hippurate-zinc Layered Hydroxide Nanohybrid and Its Synergistic effect with Tamoxifen on the HepG2 Cell Lines. International Journal of Nanomedicine. 2011;6: Samer Hasan Hussein Al Ali, Mothanna Al-Qubaisi, Mohd Zobir Hussein, Maznah Ismail, Zulkarnain Zainal, Muhammad Nazrul Hakim. Controlled release and angiotensin-converting enzyme inhibition properties of an antihypertensive drug based on a perindopril erbumine-layered double hydroxide nanocomposite. International Journal of Nanomedicine. 2012;7: Samer Hasan Hussein Al Ali, Mothanna Al-Qubaisi, Mohd Zobir Hussein, Zulkarnain Zainal, Muhammad Nazrul Hakim. Controlled-release formulation of antihistamine based on cetirizine zinc-layered hydroxide nanocomposites and its effect on histamine release from basophilic leukemia (RBL-2H3) cells. International Journal of Nanomedicine. 2012;7: Samer Hasan Hussein Al Ali, Mothanna Al-Qubaisi, Mohd Zobir Hussein, Zulkarnain 2

3 Zainal, Muhammad Nazrul Hakim. Comparative study of Mg/Al- and Zn/Al-layered double hydroxide-perindopril erbumine nanocomposites for inhibition of angiotensinconverting enzyme. International Journal of Nanomedicine. 2012;7: Samer Hasan Hussein Al Ali, Mothanna Al-Qubaisi, Mohd Zobir Hussein, Mazah Ismail, Zulkarnain Zainal, Muhammad Nazrul Hakim. In vitro inhibition of histamine release behavior of cetirizine intercalated into Zn/Al- and Mg/Al-layered double hydroxides. International Journal of Molecular Science.2012;13: Bullo Saifullah, Mohd Zobir Hussein, Samer Hasan Hussein Al Ali. Controlledrelease approaches towards the chemotherapy of tuberculosis. International Journal of Nanomedicine. 2012;7: Samer Hasan Hussein Al Ali, Mothanna Al-Qubaisi, Mohd Zobir Hussein, Maznah Ismail, Saifullah Bullo. Hippuric acid nanocomposite enhances doxorubicin and oxaliplatin-induced cytotoxicity in MDA-MB231, MCF-7 and Caco2 cell lines. Drug Design, Development and Therapy, 2013; 7: Samer Hasan Hussein Al Ali, Mothanna Al-Qubaisi, Mohamed El Zowalaty, Mohd Zobir Hussein and Maznah Ismail. Antimicrobial Activity of Hippurate Nanocomposite and Its Cytotoxicity Effect in Combination with Cytarabine against HL-60. Journal of nanomaterials. 2013; Aminu Umar Kura, Samer Hasan Hussein Al Ali, Mohd Zobir Hussein, Sharida Fakurazi, Palanisamy Arulselvan, Development of a controlled-release anti-parkinson nanodelivery system using levodopa as the active agent. International Journal of Nanomedicine. 2013: Bullo Saifullah, Mohd Zobir Hussein, Samer Hasan Hussein-Al-Ali, Palanisamy Arulselvan, Sharida Fakurazi Sustained Release Formulation of an Anti-Tuberculosis Drug Based on Para-amino Salicylic Acid-Zinc Layered Hydroxide Nanpcomposite Chemistry Central Journal. : 2013, 7: Farahnaz Barahuie, Mohd Zobir Hussein, Samer Hasan Hussein-Al-Ali, Palanisamy Arulselvan, Sharida Fakurazi and Zulkarnain Zainal Preparation and controlled release studies of protocatechuic acid-magnesium/aluminium-layered double hydroxide nanocomposite International Journal of Nanomedicine. 2013;8: Mothanna Sadiq Al-Qubaisi, Abdullah Rasedee, Moayad Husein Flaifel, Sahrim Hj 3

4 Ahmad, Samer Hussein-Al-Ali, Mohd Zobir Hussein, Eltayeb E.M. Eid, Zulkarnain Zainal, Mohd Saeed, Muna Ilowefah, Sharida Fakurazi, Norhaszalina Mohd Isa, Mohamed El Zowalaty Cytotoxicity of nickel zinc ferrite nanoparticles on cancer cells of epithelial origin International Journal of Nanomedicine. 2013;8: Samer Hasan Hussein Al Ali, Mothanna Al-Qubaisi, Mohamed El Zowalaty, Maznah Ismail, and Mohd Zobir Hussein Cytotoxicity and antimicrobial activity studies of an ellagic acid-zinc layered hydroxide intercalation compound Science of Advanced Materials. 2013, 5, Shafiu Abdullahi Kamba, Maznah Ismail, Samer Hasan Hussein Al Ali, Tengku Azmi Tengku Ibrahim, Zuki Abu Bakar Zakaria Invitro Delivery and Control release of Doxorubicin for targeting Osteosarcoma bone Cancer Molecules 2013, 18, Mothanna Sadiq Al-Qubaisi, Abdullah Rasedee, Moayad Husein Flaifel, Sahrim Hj Ahmad, Samer Hussein-Al-Ali, Mohd Zobir Hussein, Zulkarnain Zainal, Fatah H Alhassan, Yun Taufiq Yap, Ismail Adam Arabab, Bandar A Al-Asbahi Mohamed El Zowalaty, Thomas J Webster Induction of apoptosis in cancer cells by NiZn ferrite nanoparticles through mitochondrial cytochrome C release International Journal of Nanomedicine. 2013: Bullo Saifullah, Mohd Zobir Hussein, Samer Hasan Hussein-Al-Ali, Palanisamy Arulselvan, Sharida Fakurazi Antituberculosis nanodelivery system with controlledrelease properties based on para-amino salicylate zinc aluminum-layered doublehydroxide nanocomposites Drug Design, Development and Therapy, 2013: Samer Hasan Hussein-Al-Ali, Mohamed El Zowalaty, Mohd Zobir Hussein, Maznah Ismail, and Thomas J. Webster Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic International Journal of Nanomedicine, 2014: Samer Hasan Hussein-Al-Ali, Mohamed E. El Zowalaty, Mohd Zobir Hussein, Maznah Ismail, Dena Dorniani, and Thomas J. Webster Novel kojic acid-polymerbased magnetic nanocomposites for medical applications International Journal of nanomedicine. 2014: Samer Hasan Hussein-Al-Ali1, Palanisamy Arulselvan, Mohd Zobir Hussein, Sharida 4

5 Fakurazi, Maznah Ismail, Dena Dorniani, Mohammad Ezzat El Zowalaty Synthesis, characterization, controlled release and cytotoxic effect studies of anthranilic acid loaded chitosan and polyethylene glycol-magnetic nanoparticles on murine macrophage RAW cells Nano. 2014; 9, Samer Hasan Hussein-Al-Ali, Palanisamy Arulselvan, Sharida Fakurazi, Mohd Zobir Hussein,, and Dena Dorniani Arginine-chitosan and arginine-polyethylene glycol conjugated superparamagnetic nanoparticles preparation with cytotoxicity and controlled release studies. Journal of biomaterials applications, 2014, 29: Dena Dorniani, Aminu Umar Kura, Samer Hasan Hussein-Al Ali, Mohd Zobir Hussein, Sharida Fakurazi, Abdul Halim Shaari and, Zalina Ahmad In Vitro Sustained Release Study of Gallic acid Coated with Magnetite-PEG and Magnetite-PVA for Drug Delivery The Scientific World Journal, Volume 2014, Article ID , 11 pages 23. Aminu Umar Kura, Samer Hasan Hussein-Al-Ali, Mohd Zobir Hussein, Sharida Fakurazi Preparation of Tween 80- Zn/Al-Levodopa-Layered Double Hydroxides for Drug Delivery System, The Scientific World Journal. Volume 2014 (2014), Article ID , 10 pages 24. Samer Hasan Hussein-Al-Ali, Mohamed E. El Zowalaty, Aminu Umar Kura, Banjamin Geilidi, Sharida Fakurazi, Thomas J. Webster, Mohd Zobir Hussein Antimicrobial Activity and Controlled Release Studies of a Novel Nystatin Conjugated Iron Oxide Nanocomposite, BioMed Research International, Volume 2014 (2014), Article ID , 13 pages 25. Samer Hasan Hussein-Al-Ali, Mohamed E. El Zowalaty, Mohd Zobir Hussein, Banjamin Geilidi and Thomas J. Webster, Synthesis, Characterization and Antimicrobial Activity of Ampicillin conjugated magnetic nanobiotic for medical applications, International Journal of Nanomedicine, Volume 2014:9(1) Pages Dena Dorniani, Aminu Umar Kura, Samer Hasan Hussein-Al Ali, Mohd Zobir Hussein, Sharida Fakurazi, Abdul Halim Shaari and, Zalina Ahmad Release Behavior and Toxicity Profiles towards Leukemia (WEHI-3B) Cell Lines of 6-Mercaptopurine- PEG-Coated Magnetite Nanoparticles Delivery System The Scientific World Journal, 2014 (2014), Article ID , 11 pages 27. Aminu Umar Kura, Nooraini Mohd Ain, Mohd Zobir Hussein, Sharida Fakurazi, Samer 5

6 Hasan Hussein-Al-Ali Toxicity and Metabolism of Layered Double Hydroxide Intercalated with Levodopa in a Parkinsons Disease Model International Journal of Molecular Sciences. 2014, 15(4): Ethar Y. Salih, Zulkifly Abbas, Samer Hasan Hussein Al Ali, and Mohd Zobir Hussein Dielectric Behavior of Zn/Al-NO 3 (LDHs) Filled with Polyvinyl Chloride Nanocomposite at Low Microwave Frequencies. Volume 2014 (2014), Article ID , 6 pages 29. Samer Hasan Hussein-Al-Ali, Palanisamy Arulselvan, Sharida Fakurazi, Mohd Zobir Hussein. The In vitro Therapeutic Activity of Betulinic Acid on Breast Cancer Cells (MCF-7) and normal fibroblast cell (3T3), Journal Material Science, (2014) 49: Mohamed Ezzat El Zowalaty, Samer Hassan Hussein Al Ali, Mohamed I Husseiny, Benjamin M Geilich, Thomas J Webster, Mohd Zobir Hussein. " The ability of streptomycin-loaded chitosan-coated magnetic nanocomposites to possess antimicrobial and antituberculosis activities" International Journal of Nanomedicine, Volume 2015:10 Pages Samer Hasan Hussein-Al-Ali, Sepideh Keshan Balavandy, Zurina Zainal Abidin, Aminu Umar Kura, Sharida Fakurazi, Mohd Zobir Hussein, and Mohammed Fawaz Silwadi. " The In vitro Therapeutic Activity of Ellagic acid-alginate-silver Nanoparticles on Breast Cancer Cells (MCF-7) and normal fibroblast cell (3T3)". Science of Advanced Materials, (2015), under typesetting 32. Nor Suzariana Samuri, Samer Hasan Hussein-Al-Ali, Aminu Kura, Mohd Zobir Hussein, Sharida Fakurazi, Abdul Halim Shaari." Synthesis and characterization of magnetic chitosan-l-dopa nanocomposite". Current Nanoscience, (2015), Under Review 33. Samer Hasan Hussein-Al-Ali, Mothanna Al-Qubaisi, Abdullah Rasedee, and Mohd Zobir Hussein Cytotoxicity Study of an Ellagic Acid-Zinc Layered Hydroxide nanocomposite Journal of Nanoscience and Nanotechnology, (2015), under review 34. Samer Hasan Hussein-Al-Ali, Palanisamy Arulselvan, Mohd Zobir Hussein, Sharida Fakurazi Enhance efficiency of kojic acid as skin anticancer drug through polymersmagnetic nanoparticles OncoTargets and Therapy, (2015) under review A CADEMIC ACTIVITIES 6

7 Reviewer at International Journal of Nanomedicine. ACADEMIC AWARDS Gold Medal at University Putra Malaysia in Invention and Research Exhibition for project titled: (Preparation of hippurate-zinc layered hydroxide nanohybrid and its synergistic effect with tamoxifen on HepG2 cell lines).2012 Silver Medal at University Putra Malaysia in Invention and Research Exhibition for project titled: (Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent, University Putra Malaysia, Malaysia).2012 RECENT CONFERENCES 1. Samer Hasan Hussein Al Ali, Mothanna Al-Qubaisi, Mohd Zobir Hussein, Zulkarnain Zainal and Muhammad Nazrul Hakim. Controlled release and angiotensin-converting enzyme inhibitor properties of an antihypertensive drug based on a perindopril erbumine-layered double hydroxide nanocomposite. International conference on Nanotechnology (ICONT 2012) University Malaysia Pahang, Malaysia. 2. Samer Hasan Hussein Al Ali, Mohd Zobir Hussein. Controlled-release formulation of antihistamine based on cetirizine zinc-layered hydroxide nanocomposites and its effect on histamine release from basophilic leukemia (RBL-2H3) cells. Fundamental Science Congress (FSC 2012), University Putra Malaysia, Malaysia 3. Mohd Zobir Hussein, Samer Hasan Hussein Al Ali, Zulkarnain Zainal, Muhammad Nazrul Hakim. Synthesis of antiproliferative nanohybrid using ellagic acid as the active agent. Regional fundamental science congress 2011; University Putra Malaysia. 4. Mohd Zobir Hussein, Samer Hasan Hussein Al Ali. Synthesis and characterization of (zinc - Layered Hydroxide-hippurate) nanohybrid by direct reaction of zinc oxide under aqueous environment. The international conference for nanomaterials synthesis and characterization (INSC 2011) 2011; Seri Kembangan,, Selangor, Malaysia 5. Mohd Zobir Hussein, Samer Hasan Hussein Al Ali, Zulkarnain Zainal. Synthesis and characterization of (zinc -Layered-Hippurate) nanohybrid by simple direct reaction of zinc oxide with hippurate aqueous solution.2 nd seminar on catalysis science and technology (2 nd CAST) organized by Centre of excellence for catalysis science and technology- Faculty of science, 2010 University Putra Malaysia. RECENT WORKSHOPS 7

8 1. Workshop on Animal Cell Culture, Organized by the Institute of Bioscience (IBS, Universiti Putra Malaysia 2. Workshop on Advanced Materials and Nanotechnology (WAMN), "Synthesis, Characterization and Application of Carbon Nanotubes", Organized by the Institute of Advanced Technology (ITMA), Faculty of Engineering and Faculty of Science, 2011, Universiti Putra Malaysia. 3. Workshop on nanomaterials synthesis and characterization, the international conference for nanomaterials synthesis and characterization (INSC 2011), 2011 Seri Kembangan, Selangor, Malaysia. 4. Workshop on advanced materials and nanotechnology (WAMN 2010), organized by Institute of advanced technology (ITMA), 2010, University Putra Malaysia. CURRENT RESEARCH INTEREST AND FUTURE WORKS I began my Ph.D. project at the Chemistry Department, Faculty of Science-University Putra Malaysia. The goal of my project was development of novel nanocarriers to prolongation time release of antihistamine and anti hypertension drugs. In addition to decrease the side effect of anticancer drugs. For this purpose, I applied the final products on the different cancer cells using MTT assays. I began my postdoctoral work at Institute of Biosciences, University Putra Malaysia. The goal was to develop a novel silver nanoparticles and graphene oxide nanolayers against cancer cells. My future work will focus on two parts, development biosensors using nanotechnology as well as development nanomaterials for using in solar cells. REFEREES Prof. Dr. Mohd Zobir Hussein Prof. Dr. Zulkarnain Zainal mzobir@upm.edu.my zulkar@putra.upm.edu.my Prof. Dr. Muhammad Nazrul Hakim nazrul.hakim@gmail.com 8

Dr. Moayad Husein Alhaj Mahmoud Flaifel

Dr. Moayad Husein Alhaj Mahmoud Flaifel Assistant Professor Personal Data Nationality Jordanian Date of Birth 21/June/1979 Department Physics Official IAU Email mhflaifel@uod.edu.sa Language Proficiency