Curriculum Vitae. Name: Dr. Kamaldeep Paul (PhD, Department of Chemistry, Guru Nanak Dev University, Amritsar; Postdoc, Yonsei University, S.
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1 Curriculum Vitae Name: Dr. Kamaldeep Paul (PhD, Department of Chemistry, Guru Nanak Dev University, Amritsar; Postdoc, Yonsei University, S. Korea) Present Position: Assistant Professor, School of Chemistry and Biochemistry, Thapar University, Patiala Area of Specialization: Synthetic Organic Chemistry, Medicinal Chemistry Area of Research: Our research group is involved in design and multistep synthesis of various hybrid molecules of biological active heterocyclic moieties and their appendages which are identified as a new class of cancer chemotherapeutic agents with significant therapeutic efficacy against solid tumors. These nitrogen-containing hybrid heterocyclic compounds are characterized by various spectroscopic techniques viz. NMR (1D and 2D NMR), Mass, IR, CHN analysis, Single X-ray crystal etc. These compounds are evaluated in vitro as multidrug resistance (MDR) modulators (anticancer), kinase inhibitors (anticancer), antimalarial and antituberculosis activity and studies the structure activity relationships (SAR) to find out most potent drugs. Sponsored Projects (Last five years) S. No. Title of Project Project Cost (Lacs) 1. Hybrids of Substituted Benzimidazole and Quinazoline /purine/pyrazolo pyrimidine analogous as Antituberculosis and Antimalarial activity. 2. Coupling of Substituted Quinazoline /Xanthine and Purine/Pyrimidine/ Benzimidazole : A Novel Scaffold for Kinase Inhibitors 3. Heterocyclic Substituted Quinazoline and Pyrazolo[3,4-d]pyrimidine Derivatives: Novel Scaffold for Aurora Kinase Inhibitors 4. Novel Scaffolds of P-glycoprotein Modulators to Overcome Multidrug Resistance in Cancer cells Funding Agency Scheme 7.0 CSIR Drug Discovery UGC Major Research Project Duration CSIR EMR DST Fast Track
2 5. Encapsulation of Multidrug Resistance (MDR) Modulators and Anticancer Drugs on Carbon Nanotubes for Tumor-Targeted Drug Delivery 1.0 Thapar University Seed Money Professional recognition, awards, fellowships received Postdoctoral Fellow: BK21 fellowship, Department of Chemistry and Medicinal Chemistry, Yonsei University, Wonju, South Korea (March, 2008-Feb, 2009). Junior Research Fellow: CSIR ( ). Prof. Harjit Singh fellowship for the promotion of research in chemical sciences (2001) UGC/ NET qualified (June, 2001 & December, 2001) (Chemical Science, Academic Experience Degree and Spacialization University/Institute Year of Completion Marks and Division Supervisor Name Ph D (Organic and Medicinal M Sc (Applied Department of Chemistry, Guru Nanak Dev University, Amritsar, India Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, India 2006 Prof. Palwinder Singh % (First) Prof. Sumanjit Kaur Research Experience S. No. Position Instituion/organizati on/country Department/Division and Faculty/School Start Date End Date 1. Assistant Professor 2. Research Scientist 3. BK 21- Postdoc Research Fellow Thapar University, Patiala, India Ranbaxy Research Laboratory, Gurgaon, India Yonsei University, South Korea. School of Chemistry and Biochemistry Research & Development (CRD) School of Chemistry and Medicinal Chemistry 2010 Till date
3 4. Research Scientist Jubilant Chemsys Ltd., Noida, India Contract Research Organizations (CRO) Research Guidance (Last Five Years) S.No Title of Thesis Level Year Supervisor Completed /Ongoing 1. Synthesis and in vitro evaluation of PhD -- Supervisor Ongoing heterocyclic core moieties as multidrug resistance modulators 2. Design and synthesis of benzimidazole PhD -- Supervisor Ongoing core moieties and structure activity relationship studies based on in vitro evaluation as anticancer drugs 3. Registered (URB pending) PhD -- Supervisor Ongoing 4. Registered (URB pending) PhD -- Supervisor Ongoing 5. Registered (URB pending) PhD -- Supervisor Ongoing 6. Synthesis and In vitro Evaluation of Coumarin - Benzimidazole Hybrids as Anticancer Agents 7. Rhodamine based chemosensor for copper and iron 8. Regioselcetive nitration/amination of N- allylated benzimdazole derivatives MSc 2012 Supervisor Completed MSc 2011 Supervisor Completed MSc 2011 Supervisor Completed Selected Research Publications S.No. Title of Paper Author(s) Journal Vol Page Publ. Year Impact Factor 1. FRET-based Luxami, Organic & DOI: ratiometric detection V. Verma, Biomolecular /c2o of Hg 2+ and biothiols M., Rani, Chemistry b25794g. using napthalimiderhodamine dyads R, Paul, K, Kumar, S (Royal Society of 2. Cross-coupling reaction of β-β- Difluoro-a- Choi, J.H., Paul, K, jung, Bull. Korean Soc.(Korean
4 phenylvinylstannane with Alkenyl Iodides: Novel Approach to 2- Phenyl-1,1-Difluoro- 1,3-Butadienes. 3. Synthesis of 2-Fluoro- 3-phenylthio-1,3- butadiene and 2- Trifluoromethyl-3- phenythio-1,3- butadiene and their reactivity. 4. Anti-cancer activities of 5-acyl-6-[2- hydroxy/benzy loxy-3- (amino)- propylamino]-1,3- dialkyl-1h-pyrimidin- 2,4-diones. 5. Studies of interaction between uracil-based hybrid molecules and P-glycoprotein-Search for multidrug resistance modulators. 6. Synthesis of pyrazole based hybrid molecules: Search for potent multidrug resistance modulators 7. A practical approach for spiro- and 5- monoalkylated barbituric acids 8. Synthesis of 5-acyl-6- [2-hydroxy-3-(amino)- propylamino]-1,3- dialkyl-1hpyrimidine-2,4-diones Y.H., I.H., Hwang, J.H., Choi, J.H., I.H. Singh, P. Holzer, W. Singh, P. Holzer, W. Chemical Society) Organic Letters (American Chemical Society), J. Het. (Wiley Sciences) Org. Biomol., (Royal Society of
5 9. Synthesis of Piperlonguminine. Conferences and Workshops Chung, B.Y., I.H., Paul, K., Woo, L., Bang, S.S. Patent 2009 Filed S.No. Conference/Workshop Place Month/Year 1. Latest Development in the Emerging Green Technology Based on the Application of Microwave Energy to Material Processing 2. National Conference on recent advances in chemical & environmental sciences 3. 4 th NIPER (RBL)-CDRI symposium on Medicinal and Pharmaceutical Chemistry 4. The 101 st National Meeting of the Korean Chemical Society 5. A National Symposium on New Challenges of Chemistry 6. A National School on New Dimension to NMR: From Molecules to Human Behavior 7. IUPAC International Conference on Biodiversity and Natural Products: Chemistry and Medical Applications 8. National Workshop on Curriculum Development in Natural Products at Postgraduate Level PTU, Jalandhar Aug , 2012 Modi College, Patiala March 3, 2012 CDRI, Lucknow Feb, 23-25, 2012 Kintex, (South April, 21-23, Korea) 2008 Guru Nanak Dev March 20-21, University, Amritsar 2006 NEHU, Shilong, May 23-June 3, Meghalaya New Delhi. January 26-31, 2004, NIPER, S.A.S. Nagar, Punjab. 9. National Bioorganic Symposium 7 Guru Nanak Dev University, Amritsar. 10. National Conference on Recent Advances Guru Nanak Dev in Thermodynamics of Chemical and University, Amritsar. Biological Systems November 25-27, 2003 November 9-10, 2001 May 7-9, 2001
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