Formulation and Ocular Bioavailability of Certain Drugs from Ophthalmic Preparations
|
|
- Marianna Hensley
- 6 years ago
- Views:
Transcription
1 Formulation and Ocular Bioavailability of Certain Drugs from Ophthalmic Preparations Thesis presented by Ghada Saad Ahmed El-Moursy B. Pharm. Mansoura University (2007) Submitted in Partial Fulfillment for the Master Degree in Pharmaceutical Sciences (Pharmaceutics) Under the Supervision of Prof. Dr. Abd El-Gawad H. Abd El-Gawad Professor of Pharmaceutics Faculty of Pharmacy, Mansoura University Prof. Dr. Osama Abd EL-Azeem Soliman Professor of Pharmaceutics Faculty of Pharmacy, Mansoura University - 1 -
2 The complicated anatomical structure of the eye and precorneal factors are the main factors that may hinder the absorption of drugs from eye surface and so decrease their bioavailability. Precorneal factors include blinking, tear formation, tear turn over, and flow through nasolacrimal duct. Numerous strategies were developed to increase the bioavailability of ophthalmic drugs by prolonging the contact time between the preparations containing drug and the corneal/conjunctival epithelium. These strategies are including viscosity enhancers, penetration enhancers, nanoparticles, usage of mucoadhesive polymers, and other controlled systems, like ocuserts. The main objective of this thesis, is to formulate certain ophthalmic preparations including eye gels, ocuserts, microemulsions and in-situ gelling systems using different polymers. In-vitro release characteristics and accelerated stability study of the prepared formulations were of prime interest in this investigation. Also, in-vivo study of the selected formulae was performed to examine the ocular bioavailability of the investigated drugs in the eye tissues. In this thesis, two drugs were selected; the first drug was desloratadine (antihistaminic agent) and the second one was gatifloxacin (antibacterial agent). To fulfill these goals, this thesis includes the following two parts: Part I: Formulation and Evaluation of Desloratadine Ophthalmic Preparations. Part II: Formulation and Evaluation of Gatifloxacin Ophthalmic Preparations. Part I Formulation and Evaluation of Desloratadine Ophthalmic Preparations This part consists of four chapters and deals with formulation, evaluations of the ophthalmic formulations containing desloratadine. In addition, accelerated stability of desloratadine from different ophthalmic formulae and the effect of the drug on the decongesion time of inflamed rabbits eyes were studied. Furthermore, the ocular bioavailability of the drug was investigated
3 Chapter 1 Formulation and In-vitro Evaluation of Desloratadine Ophthalmic Preparations The work in this chapter involved the formulation of desloratadine in different ophthalmic preparations including eye gels, microemulsions, and ocuserts using different polymers such as; hydroxypropyl methylcellulose, methylcellulose, sodium carboxymethyl cellulose, and sodium alginate. The characterizations of the prepared formulae were performed through the determination of drug content, ph, viscosity, and transmission electron microscopy (TEM) for microemulsions. Furthermore, in-vitro release through cellophane membrane in phosphate buffer of ph 7.4 at 37 o C was investigated. Then, the kinetic analysis of the release data was done. From the obtained results it was clear that: 1) The prepared ophthalmic preparations showed that the drug content was complied with pharmacopial limits, ph values tolerated by the eye, and acceptable viscosity limits. 2) Regarding the percentage of the drug release from different formulations, it was found that, the drug release is affected by the polymer types and dosage forms. 3) The nature of polymers utilized affected drug release in the following order: HPMC > Sod. CMC > MC. 4) Ocuserts exhibited a significantly higher release of desloratadine with the corresponding gels of the same polymers due to the difference in their viscosities upon exposure to the release conditions, as the higher the viscosity the slower drug release rate. 5) Microemulsions of desloratadine were successfully prepared employing isopropyl myristate as oil phase, tween 80 as surfactant, and propylene glycol as cosurfactant in different ratios, which was suggested depending on pseudoternary phase diagram. 6) The drug from microemulsions released slowly as it was located in the internal oil phase. 7) Images of microemulsions by transmission electron microscopy showed that all the prepared microemulsions have distinct shapes which are perfectly spherical with solid dense surfactant and co-surfactant cores surrounded by evenly distributed thin coat that may be comprised of oils
4 8) Regarding the results of the release kinetic analysis: the drug release mechanism from the different ophthalmic formulations was a combination of two mechanisms Higuchi model followed by first-order model, in which one is more predominant than the other. Chapter 2 Stability Study of Desloratadine in Ophthalmic Preparations The purpose of work in this chapter was, to study the effect of different storage temperatures on the physical and chemical stability of desloratadine in ophthalmic formulations. The stability study was carried out on the formulations prepared in chapter 1. The tested formulations were stored at different temperatures (30 o C, 35 o C, and 40 o C) for six months. The tested formulations were evaluated initially and at specified time intervals (1, 2, 3, 4, 5 and 6 months) for their physical characteristics, ph, viscosity, in-vitro release and drug content. The obtained results revealed that: 1) The decomposition rate of desloratadine followed first-order degradation kinetics. 2) The prepared formulations exhibited the highest physical and chemical stability up to six months of storage at 30 C, 35 C and 40 C except formulae containing MC polymer showed the least stable formulations. 3) The stability of the tested formulae could be arranged in the following order; ocuserts > eye gels > microemulsions. 4) The nature of polymers utilized affected drug stability in the following order: HPMC > Sod. CMC > MC. 5) The most stable formula for ocusert was HPMC & Sod. Alg formula (25.77 months), for eye gel was HPMC formula (24.33 months) and for microemulsion was Sod. CMC formula (23.45 months) at 25 o C. 6) The most stable formulae were selected for further study of the effect of desloratadine ophthalmic formulations on the treatment of allergic conjunctivitis
5 Chapter 3 Effect of Desloratadine Ophthalmic Formulations on the Treatment of Allergic Conjunctivitis The purpose of work in this chapter was to study the effect of the selected ophthalmic formulations containing desloratadine on the inflamed rabbits eyes after instillation of histamine solution and determine the average of decongestion time. These formulae were selected on the basis of in-vitro drug release and stability data. The selected formulae were HPMC eye gel, HPMC/Sod. Alg ocusert and Sod. CMC microemulsions, in addition to the control formula, drug suspended in water (0.05% w/v). The obtained results can be summarized as follow: 1) Desloratadine, as antihistaminic drug, could treat the histamine induced ocular surface redness in the rabbits eyes successfully. 2) The average currance times of the inflamed rabbits eyes treated with the tested formulations which containing 0.05% of desloratadine are markedly influenced by the formulation type (eye gels, ocuserts or microemulsions). 3) The tested formulae regarding to their effect on the currancy time can be arranged in the following order; microemulsions > ocuserts > eye gels. Chapter 4 Ocular Bioavailability of Desloratadine from Different Ophthalmic Preparations in Rabbits Eyes This chapter deals with the study of the effect of polymers and dosage form on the uptake of desloratadine by eye tissues and aqueous humor of rabbits, at different time intervals after application of the selected ophthalmic preparations. The selected formulae were HPMC eye gel, HPMC/Sod. Alg ocusert and Sod. CMC microemulsions, in addition to the control formula, drug suspended in water (0.05% w/v). Then, the drug concentration in each tissue was determined by high performance liquid chromatography (HPLC) assay. From the obtained results it was clear that: 1) The peak time for maximum drug concentration (T max ) from tested formulations in eye tissues and aqueous humor after application on rabbits eyes was 2 hrs for all tested formulations. While, T max for control preparation was 1 hr
6 2) All selected formulations provided the higher C max of the drug in cornea followed by conjunctiva, iris-ciliary body then aqueous humor. 3) The ocular bioavailability of the drug in all eye tissues and aqueous humor from the tested formulations, was found to be in the following order; microemulsion > ocusert > eye gel > control. Part II Formulation and Evaluation of Gatifloxacin Ophthalmic Preparations This part consists of two chapters and deals with the formulation, in-vitro and in-vivo evaluation of ophthalmic formulations containing gatifloxacin. Chapter 1 Formulation and In-vitro Evaluation of Gatifloxacin from Different Ophthalmic Preparations The work in this chapter involved the formulation of gatifloxacin in different ophthalmic preparations including in-situ gelling systems, microemulsions, and ocuserts using different polymers. The physical characteristics of the prepared formulae were performed through the determination of drug content, ph, viscosity, and transmission electron microscopy (TEM) for microemulsions. Furthermore, in-vitro release through cellophane membrane in phosphate buffer of ph 7.4 at 37 o C was investigated. Then, the kinetic analysis of release data was done. The obtained results can be summarized as follow: 1) The prepared ophthalmic preparations showed drug content that complied with pharmacopeial limits, ph values tolerated by the eye, and acceptable viscosity limits. 2) Regarding the percentage of the drug release from different formulations, it was found that, the drug release is varied with the polymer types and dosage forms. 3) According to the result of in-situ gelling systems: a) The combined solutions which were free flowing liquid at the room temperature would convert to gels after administration, which could ensure suitable gel strength and prevent rapid drainage from the eye and so improve the bioavailability of the drug. b) The in-situ gelling systems produced sustained drug release over 12 hrs
7 4) Regarding to the release data, the tested formulations were arranged in the following order; in-situ gelling systems > ocuserts > microemulsions. 5) Regarding to the results of the release kinetic analysis: the drug release mechanism from the different ophthalmic formulations was a combination of two mechanisms Higuchi model followed by first-order model, in which one is more predominant than the other. Chapter 2 Ocular Bioavailability of Gatifloxacin from Different Preparations in Rabbits Eyes Ophthalmic This chapter deals with the study of the effect of polymer type and dosage form on the uptake of gatifloxacin by eye tissues and aqueous humor of rabbits, at different time intervals after application of the selected ophthalmic preparations. The selected formulae were sodium alginate & carbopol 940 in-situ gelling system, polyvinyl alcohol & carbopol 940 ocusert and sodium carboxymethyl cellulose microemulsion, in addition to the control formula, Tymer drops (0.3% w/v). The drug concentration in each tissue was determined by high performance liquid chromatography (HPLC) assay. From the obtained results it was clear that: 1) The peak time for maximum drug concentration (T max ) from tested formulations in eye tissues and aqueous humor after application on rabbits eyes was 2 hrs for all tested formulations. 2) All selected formulations provided the higher C max of the drug in conjunctiva followed by cornea, iris-ciliary body then aqueous humor. 3) The ocular bioavailability of the drug in all eye tissues and aqueous humor from the tested formulations, was found to be in the following order; in-situ gelling systems > microemulsions > ocuserts > control
Potential Use of Cyclodextrins for the Improvement of Ocular Bioavailability of Meloxicam
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-issn:2278-38, p-issn:2319-7676. Volume 12, Issue 5 Ver. I (Sep. Oct. 217), PP 79-96 www.iosrjournals.org Potential Use of Cyclodextrins for
More informationKing Saud University College of Pharmacy Department of Pharmaceutics. Biopharmaceutics PHT 414. Laboratory Assignments 2010 G 1431 H
King Saud University College of Pharmacy Department of Pharmaceutics Biopharmaceutics PHT 414 Laboratory Assignments 20 G 1431 H Department of Pharmaceutics Biopharmaceutics PHT -414 Laboratory Assignments
More informationAnalysis of Some Drugs Affecting the Respiratory System
Analysis of Some Drugs Affecting the Respiratory System A Thesis Presented By Nehal Fayek Farid Faragallah B. Pharm. Sci. (1996) M.Sc. in Analytical Chemistry (2003) For The Degree of Doctor of Philosophy
More information8. FORMULATION OF LANSOPRAZOLE NANOPARTICLES
8. FORMULATION OF LANSOPRAZOLE NANOPARTICLES FORMULATION OF LANSOPRAZOLE NANOPARTICLES Preparation of capsule of modified solubility to protect the drug from degradation To protect the drug from degradation
More informationMethyl Cellulose Based Sustained Release Thermosensitive in situ Fast Gelling Ocular Delivery of Ketorolac Tromethamine
Asian Journal of Chemistry Vol. 22, No. 3 (2010), 2147-2154 Methyl Cellulose Based Sustained Release Thermosensitive in situ Fast Gelling Ocular Delivery of Ketorolac Tromethamine MANAS BHOWMIK*, SANCHITA
More informationIsotonic and Buffer Solutions
Isotonic and Buffer Solutions It is generally accepted that for ophthalmic and parenteral administration, isotonic solutions are better tolerated by the patient than those at the extremes of hypo- and
More informationPharmaceutics I صيدالنيات 1. Unit 6
Pharmaceutics I صيدالنيات 1 Unit 6 1 Rheology of suspensions Rheology, the study of flow, addresses the viscosity characteristics of powders, fluids, and semisolids. Materials are divided into two general
More informationMethocel E4M: Preparation and Properties as a Vehicle for the Ocular Drug Delivery of Vancomycin
166 Chiang Mai J. Sci. 2014; 41(1) Chiang Mai J. Sci. 2014; 41(1) : 166-173 http://epg.science.cmu.ac.th/ejournal/ Contributed Paper Methocel E4M: Preparation and Properties as a Vehicle for the Ocular
More informationResearch Article. Jafar Akbari 1,2*, Reza Enayatifard 1, Majid Saeedi 1,2 and Massoud Saghafi 1. Abstract. Trop J Pharm Res, October 2011;10(5): 535
Tropical Journal of Pharmaceutical Research October 2011; 10 (5): 535-541 Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved. Research Article
More informationSolution containing non volatile substance
University of Sulaimani Pharmacy College 3 rd level Pharmaceutical Compounding Solution containing non volatile substance Dr. Hiba Hani q Objectives Ø Simple solution definition Ø Types of solution Ø Rate
More information295 J App Pharm 03(03): (2011) Nayak et al., 2011 COMPARATIVE STABILITY STUDY OF METRONIDAZOLE IN AQUEOUS AND NON AQUEOUS VEHICLE
295 J App Pharm 03(03): 295-300 (2011) Nayak et al., 2011 Research Article COMPARATIVE STABILITY STUDY OF METRONIDAZOLE IN AQUEOUS AND NON AQUEOUS VEHICLE Satish Nayak, D. C. Goupale*, Atul Dubey and Vipin
More informationBulletin of Pharmaceutical Sciences Assiut University
Bull. Pharm. Sci., Assiut University, Vol. 35, Part 2, 212, pp. 181-197. Bulletin of Pharmaceutical Sciences Assiut University FORMULATION AND EVALUATION OF SOME SELECTED TIMOLOL MALEATE OPHTHALMIC PREPARATIONS
More informationIndian Journal of Research in Pharmacy and Biotechnology
Formulation and evaluation of enteric coated sustained release matrix tablets of Duloxetine hydrochloride A.Bharathi*, P.Rama Chandra rao, V.Aswini priya, N.Anusha Department of Pharmaceutical Sciences,
More informationFormulation and Evaluation of Release-Retardant Matrix Tablets of Diclofenac Sodium
FABAD J. Pharm. Sci., 31, 119-16, 006 RESEARCH ARTICLE Formulation and Evaluation of Release-Retardant Matrix Tablets of Diclofenac Sodium Sunita DAHIYA*, Formulation and Evaluation of Release-Retardant
More informationKetorolac tromethamine (KT)[1] is
RESEARCH ARTICLE Derivative and Simultaneous Equation Methods for the Determination of Fluorometholone and Ketorolac in Ophthalmic Preparations Chandaka Prasanna Kumar*, Bulusu Ravi Teja, Bhupathiraju
More informationNovel Formulation Development and Evaluation of Nanoparticles Based in Situ Gelling System for The Ophthalmic Delivery of Ciprofloxacin Hydrochloride
Available online on www.ijddt.com International Journal of Drug Delivery Technology 2015; 5(4); 126-131 Research Article ISSN: 0975-4415 Novel Formulation Development and Evaluation of Nanoparticles Based
More informationNorfloxacin Loaded ph Triggered Nanoparticulate in-situ Gel for Extraocular Bacterial Infections: Optimization, Ocular Irritancy and Corneal Toxicity
Iranian Journal of Pharmaceutical Research (2016), 15 (1): 3-22 Received: February 2014 Accepted: September 2014 Copyright 2016 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and
More informationFormulation development and evaluation of glyburide beads for controlled release
Available online at wwwscholarsresearchlibrarycom Scholars Research Library Der Pharmacia Lettre, 213, 5 (3):17-177 (http://scholarsresearchlibrarycom/archivehtml) ISSN 975-571 USA CODEN: DPLEB4 Formulation
More informationSolid Dispersion Incorporated Microcapsules: Predictive Tools for Improve the Half Life and Dissolution Rate of Pioglitazone Hydrochloride
American Journal of Biomedical Research 2013, Vol. 1, No. 3, 57-70 Available online at http://pubs.sciepub.com/ajbr/1/3/3 Science and Education Publishing DOI:10.12691/ajbr-1-3-3 Solid Dispersion Incorporated
More informationJournal of Chemical and Pharmaceutical Research
Available on line www.jocpr.com Journal of Chemical and Pharmaceutical Research ISSN No: 0975-7384 CODEN(USA): JCPRC5 J. Chem. Pharm. Res., 2011, 3(2):66-79 Evaluation of two in situ gelling systems for
More informationOverview. Lecture 5 Colloidal Dispersions
Physical Pharmacy Lecture 5 Colloidal Dispersions Assistant Lecturer in Pharmaceutics Overview Dispersed Systems Classification Colloidal Systems Properties of Colloids Optical Properties Kinetic Properties
More informationINTERNATIONAL RESEARCH JOURNAL OF PHARMACY
INTERNATIONAL RESEARCH JOURNAL OF PHARMACY www.irjponline.com ISSN 2230 8407 Research Article NOSE TO BRAIN DELIVERY OF ZIPRASIDONE MICROEMULSION: DESIGEN AND CHARACTERIZATION Amarjitsing Premsinh Rajput*,
More informationCHAPTER 7 SUMMARY AND CONCLUSIONS. constitutes the objective of many a research project in the field of pharmaceutical
CHAPTER 7 SUMMARY AND CONCLUSIONS Taste masking and development of palatable dosage forms of bitter drugs constitutes the objective of many a research project in the field of pharmaceutical technology.
More informationFormulation and Evaluation of Timolol Maleate Gel Containing Stimuli Sensitive Polymers
Formulation and Evaluation of Timolol Maleate Gel Containing Stimuli Sensitive Polymers N. Roshan* 1, M. Rahul 2 1 Shri Jagdishprasad Jhabarmal Tibrewala University, Dist-Jhunjhunu, Raj, India 2 Dr.Vedprakash
More informationMohammad.Zuber. et al. / International Journal of Biopharmaceutics. 2012; 3(1): International Journal of Biopharmaceutics
44 e- ISSN 0976-1047 Print ISSN 2229-7499 International Journal of Biopharmaceutics Journal homepage: www.ijbonline.com IJB THE EFFECT OF VARIOUS SURFACTANTS ON RELEASE BEHAVIOR OF LIDOCAINE HCL FROM ETHYLCELLULOSE
More information3 rd Food Emulsions Short Course November 13 th & 14 th, 2008 University of Massachusetts. David Julian McClements University of Massachusetts
3 rd Food Emulsions Short Course November 13 th & 14 th, 2008 University of Massachusetts David Julian McClements University of Massachusetts Program Objectives Review Basic Principles of Emulsion Science
More informationPhase Behaviour of Microemulsion Systems Containing Tween-80 and Brij-35 as Surfactant
Received on 20/04/2012; Revised on 29/04/2012; Accepted on 09/06/2012 Phase Behaviour of Microemulsion Systems Containing Tween-80 and Brij-35 as Surfactant Chetan Singh Chauhan *, Navneet singh Chouhan,
More informationDesign and In Vitro Characterization of Dexlansoprazole Controlled Release Tablets
ORIGINAL ARTICLE Design and In Vitro Characterization of Dexlansoprazole Controlled Release Tablets Y. Naveen Kumar 1, J. Sreekanth 2, P. Vijay Chander Reddy 3 1 Drugs Control Administration, Hyderabad,
More informationCDER Risk Assessment to Evaluate Potential Risks from the Use of Nanomaterials in Drug Products
CDER Risk Assessment to Evaluate Potential Risks from the Use of Nanomaterials in Drug Products Celia N. Cruz, Ph.D. CDER Nanotechnology Working Group Office of Pharmaceutical Science 1 Disclaimer The
More informationEFFECT OF HYDROXYPROPYL-β-CYCLODEXTRIN ON THE SOLUBILITY, STABILITY AND IN-VITRO RELEASE OF CIPROFLOXACIN FOR OCULAR DRUG DELIVERY
Acta Poloniae Pharmaceutica ñ Drug Research, Vol. 69 No. 4 pp. 719ñ724, 2012 ISSN 0001-6837 Polish Pharmaceutical Society EFFECT OF HYDROXYPROPYL-β-CYCLODEXTRIN ON THE SOLUBILITY, STABILITY AND IN-VITRO
More informationDesign, Formulation and Evaluation of Transdermal Ketoprfen Gel. Cairo, Egypt. North Sinai, Egypt
Design, Formulation and Evaluation of Transdermal Ketoprfen Gel Ahmed M. Samy 1, Mamdouh M. Ghorab 2, Shadeed G. Shadeed 2 and Eman A. Mazyed 3 1 Department of Pharmaceutics and Industrial Pharmacy, Faculty
More informationInternational Journal of Advanced Chemical Science and Applications (IJACSA)
Water-sorption behavior of some commonly used pharmaceutical excipients: Microcrystalline cellulose (MCC), Hydroxypropyl methylcellulose (HPMC) and Croscarmellose Sodium 1 A Ravikiran, 2 M Arthanareeswari,
More informationEUROPEAN PATENT APPLICATION
@ Publication number: 0136 1 0 0 A2 EUROPEAN PATENT APPLICATION Application number: 84305891.8 Int. CI.*: A 61 K 31/70, A 61 K 47/00 @ Date of filing : 29.08.84 ( ) Priority: 02.09.83 US 528976 @ Applicant:
More informationPhysicochemical Characterization of Acyclovir Topical Semisolid Dosage Forms Towards TCS Validation Flavian Ștefan Rădulescu, Dalia Simona Miron
Physicochemical Characterization of Acyclovir Topical Semisolid Dosage Forms Towards TCS Validation Flavian Ștefan Rădulescu, Dalia Simona Miron University of Medicine and Pharmacy Carol Davila, Bucharest,
More informationFormulation and evaluation of matrix tablets of Famotidine using hydrophilic polymer
Available online at www.scholarsresearchlibrary.com Scholars Research Library Archives of Applied Science Research, 2010, 2 (3):212-220 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-508X
More informationCronicon PHARMACEUTICAL SCIENCE. Research Article The Impact of the Polymer Content on the Kinetics of Propranolol HCl from Buccal Adhesive Tablets
Cronicon OPEN ACCESS Majid Saeedi 1 * and Katayoun Morteza-Semnani 2 1 Department of Pharmaceutics, Mazandaran University of Medical Science, Iran 2 Department of Medicinal Chemistry, Mazandaran University
More informationANALYTICAL STUDY FOR TADALAFIL (Cialis ) AND EQUIVALENT COMPOUNDS
ANALYTICAL STUDY FOR TADALAFIL (Cialis ) AND EQUIVALENT COMPOUNDS Thesis Presented for the Partial Fulfillment of Master Degree in Pharmaceutical Sciences "Analytical Chemistry" By Moataz Abdalla Yehia
More informationI International Bureau
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization I International Bureau (10) International Publication Number (43) International
More informationDevelopment of 5% Abamectin EW formulation
Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2014, 6(6):28-32 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Development of 5% Abamectin EW formulation Baohua
More informationPractical Pharmaceutical Technology I USP Dissolution Method for PARACETAMOL 500 mg Tablets Section No. 6 Group D
University of Jordan Faculty of Pharmacy Practical Pharmaceutical Technology I USP Dissolution Method for PARACETAMOL 500 mg Tablets Section No. 6 Group D USP Dissolution Method for PARACETAMOL 500 mg
More informationINTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND BIO-SCIENCE
INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND BIO-SCIENCE DEVELOPMENT OF VALIDATED UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF BETAXOLOL HYDROCHLORIDE IN BULK AND PHARMACEUTICAL DOSAGE FORM SIDHARTH
More informationDEVELOPMENT AND VALIDATION OF A HPLC METHOD FOR IN-VIVO STUDY OF DICLOFENAC POTASSIUM
IJPSR (2013), Vol. 4, Issue 2 (Research Article) Received on 28 September, 2012; received in revised form, 24 November, 2012; accepted, 23 January, 2013 DEVELOPMENT AND VALIDATION OF A HPLC METHOD FOR
More informationNANOPARTICLES FORMULATION USING COUNTER ION INDUCED GELIFICATION TECHNIQUE: IN VITRO CHLORAMPHENICOL RELEASE
International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 3, Issue 3, 2011 Research Article NANOPARTICLES FORMULATION USING COUNTER ION INDUCED GELIFICATION TECHNIQUE: IN VITRO
More informationFACULTY OF PHARMACY. M. Pharmacy I Semester (Suppl.) Examination, November 2015 (Common To All) Subject: Pharmaceutical Analytical Techniques
M. Pharmacy I Semester (Suppl.) Examination, November 2015 (Common To All) Subject: Pharmaceutical Analytical Techniques Code No. 6001 / S Note: Answer any Five questions. All questions carry equal marks.
More informationEffect of Alkaline Excipients on The Release Profile of Gliclazide Extended Release Tablets
Effect of Alkaline Excipients on The Release Profile of Gliclazide Extended Release Tablets Monika Srivastav 1, B Prabhakar 1, Ashok Omray 2 1 School of Pharmacy & Technology Management, NMIMS University,
More informationINFLUENCE OF POLYMERS ON SUPERSATURATION OF IBUPROFEN SODIUM IN VITRO AND IN VIVO: A MECHANISTIC EVALUATION JENNA LESCHEK TEREBETSKI
INFLUENCE OF POLYMERS ON SUPERSATURATION OF IBUPROFEN SODIUM IN VITRO AND IN VIVO: A MECHANISTIC EVALUATION By JENNA LESCHEK TEREBETSKI A Dissertation submitted to the Graduate School-New Brunswick Rutgers,
More informationDEVELOPMENT OF MUCOADHESIVE BIOPOLYMERS FOR FOOD FORMULATION
DEVELOPMENT OF MUCOADHESIVE BIOPOLYMERS FOR FOOD FORMULATION By MOHD FAIZAL ALI A thesis submitted to The University of Birmingham for the degree of DOCTOR OF PHILOSOPHY School of Chemical Engineering
More informationJournal of Controlled Release
Journal of Controlled Release 136 (2009) 88 98 Contents lists available at ScienceDirect Journal of Controlled Release journal homepage: www.elsevier.com/locate/jconrel Review Thixotropic property in pharmaceutical
More informationInternational Journal of Chemistry and Pharmaceutical Sciences. International Journal of Chemistry and Pharmaceutical Sciences
D. Nirmala Kumari et al, IJCPS, 2015, 3(5): 1678 1683 ISSN: 2321-3132 International Journal of Chemistry and Pharmaceutical Sciences Journal Home Page: www.pharmaresearchlibrary.com/ijcps Research Article
More informationDevelopment of a mucoadhesive nanoparticulate drug delivery system for a targeted drug release in the bladder
Development of a mucoadhesive nanoparticulate drug delivery system for a targeted drug release in the bladder Jan Barthelmes Department of harmaceutical Technology Content 1. Introduction 2. Methods &
More informationFormulation & Evaluation of Mucoadhesive Drug Delivery System of Nifedipine
Formulation & Evaluation of Mucoadhesive Drug Delivery System of Nifedipine Vipul*, Ashish Singh Research and Development Department, Phyto Ingredients Biopharma Pvt. Ltd., Yamunanagar, Haryana, India
More informationIAJPS 2016, 3 (6), Naresh N S and Pratyusha A ISSN Available online at:
CODEN (USA): IAJPBB ISSN: 2349-7750 INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES Available online at: http://www.iajps.com Research Article FORMULATION DESIGN AND EVALUATION OF SAXAGLIPTIN SUSTAINED
More informationpharmaceutics ISSN
Pharmaceutics 2010, 2, 199 208; doi:10.3390/pharmaceutics2020199 Article OPEN ACCESS pharmaceutics ISSN 1999-4923 www.mdpi.com/journal/pharmaceutics Asymmetric Membrane Capsules for Extended Delivery of
More informationPreparation and Characterization of Gatifloxacin Encapsulated Chitosan Nanoparticles for Ocular Drug Delivery
Preparation and Characterization of Gatifloxacin Encapsulated Chitosan Nanoparticles for Ocular Drug Delivery Sharulata Ravisankar 1, Nibedita Dey 2, Arul Prakash Francis 2, Pandian K 3, T. Devasena 1*
More informationScholars Research Library. Innovation on Development and Evaluation of Gastric Oral Floating Capsules Containing Captopril
Available online at www.scholarsresearchlibrary.com Der Pharmacia Lettre, 2011, 3(3): 103-109 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4 Innovation on Development
More informationMouth Disintegrating Tablets of Taste-Masked Ondansetron HCl
Asian Journal of Chemistry Vol. 19, No. 5 (2007), 3455-3460 Mouth Disintegrating Tablets of Taste-Masked Ondansetron HCl V.K. CHATAP, D.K. SHARMA*, ANIL MIDDHA, R.D. GUPTA, VIPIN SAINI, MAHENDRA SHIRADKAR
More informationINTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND BIO-SCIENCE
INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND BIO-SCIENCE TO STUDY THE ANALYSIS OF SOLID ORAL DOSAGE FORMS INCLUDING THE DIFFERENT MODERN ANALYTICAL TECHNIQUES PATEL PRIYANKA P., SANGHADIYA DIVYANG
More informationInfluence of different grades and concentrations of hydroxypropyl methyl cellulose on the release of metformin hydrochloride
World Journal of Pharmaceutical Sciences ISSN (Print): 2321-3310; ISSN (Online): 2321-3086 Published by Atom and Cell Publishers All Rights Reserved Available online at: http://www.wjpsonline.org/ Original
More informationDevelopment of therapeutically applicable S-nitrosoglutathione formulation
Development of therapeutically applicable S-nitrosoglutathione formulation Ph.D. Thesis Istvan Hornyak Semmelweis University Doctoral School of Basic Medicine Supervisor: Official Reviewers: Zsombor Lacza,
More informationFormulation & Evaluation of Floatable Insitu Gel for Stomach-specific Drug Delivery of Ofloxacin
American Journal of Advanced Drug Delivery www.ajadd.co.uk Original Article Formulation & Evaluation of Floatable Insitu Gel for Stomach-specific Drug Delivery of Ofloxacin SANKET CHANIYARA *1, DRON MODI
More informationPHARMACEUTICAL BULLETINS
PHARMACEUTICAL BULLETINS TABLE OF CONTENTS BULLETIN 1 BULLETIN 2 BULLETIN 3 POLYMERS FOR PHARMACEUTICAL APPLICATIONS Introduction Product Descriptions Typical Properties of Lubrizol s Pharmaceutical Polymers
More informationApplied physical pharmacy 10. Rheology
Applied physical pharmacy 10. Rheology Sungkyunkwan University, School of Pharmacy Physical Pharmacy Lab Gyoung Won Kim CONTENTS Introduction Newtonian system Non - Newtonian system Thixotropy Viscoelasticity
More informationWork plan & Methodology: HPLC Method Development
Work plan & Methodology: HPLC Method Development The HPLC analytical Method developed on the basis of it s chemical structure, Therapeutic category, Molecular weight formula, pka value of molecule, nature,
More informationGuar gum is derived from the seeds of Cyamopsis tetragonolobus. Guar has certain drawbacks such as uncontrolled rate of
RESEARCH ARTICLE Compatibility testing and rheological characterization in development of novel in situ guar gum-based ophthalmic dosage form NG Nanjundaswamy, Fatima Sanjeri Dasankoppa 1 Department of
More informationThe University of Jordan
The University of Jordan Faculty: Pharmacy Department: Pharmaceutics and Pharmaceutical Technology Program: BSc. of Pharmacy Academic Year/ Semester: 2013/2014/ 1 st semester Course Name (Course Number):
More informationPreparation And Characterization Of Simvastatin Nanosuspension By Homogenization Method
International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol.5, No.1, pp 193-197, Jan-Mar 2013 Preparation And Characterization Of Simvastatin Nanosuspension By Homogenization Method
More informationAnalysis of Case II drug transport with radial and axial release from cylinders
International Journal of Pharmaceutics 254 (23) 183 188 Analysis of Case II drug transport with radial and axial release from cylinders Kosmas Kosmidis a, Eleni Rinaki b, Panos Argyrakis a, Panos Macheras
More informationCYCLOSERINE Final text for addition to The International Pharmacopoeia. (November 2008) CYCLOSERINUM CYCLOSERINE
December 2008 CYCLOSERINE Final text for addition to The International Pharmacopoeia (November 2008) This monograph was adopted at the Forty-third WHO Expert Committee on Specifications for Pharmaceutical
More informationCustom ingredients, inc CustoPoly. Conditioning, Emulsifying, Stabilizing, Suspending, Thickening and Gelling
CustoPoly Conditioning, Emulsifying, Stabilizing, Suspending, Thickening and Gelling CustoPoly E series- Emulsion Polymers CustoPoly E series are versatile, liquid polymers for thickening and emulsifying
More informationOPTIMIZATION OF FREEZE DRYING CONDITION OF PREDNISOLONEACETATE SOLID LIPID NANPARTICLES USING BOX-BEHNKEN DESIGN
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article OPTIMIZATION OF FREEZE DRYING CONDITION OF PREDNISOLONEACETATE SOLID LIPID NANPARTICLES USING
More informationPharmaceutics I. Unit 6 Rheology of suspensions
Pharmaceutics I اينالديصيدلينيات 1 Unit 6 Rheology of suspensions 1 Rheology, the science of the flow or deformation of matter (liquid or soft solid) under the effect of an applied force. It addresses
More informationDESIGN OF SOME TOPICAL DELIVERY SYSTEMS WITH LIDOCAINE BASED ON COLLAGEN FOR WOUND TREATMENT
DESIGN OF SOME TOPICAL DELIVERY SYSTEMS WITH LIDOCAINE BASED ON COLLAGEN FOR WOUND TREATMENT MIHAELA VIOLETA GHICA 1, MADALINA GEORGIANA ALBU 2, LACRAMIOARA POPA 1 1 Physical-Chemistry and Colloids Department,
More informationSTABILITY INDICATING RP HPLC METHOD FOR ANALYSIS OF DORZOLAMIDE HCl IN THE BULK DRUG AND IT S PHARMACEUTICAL DOSAGE FORM
International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 3, Issue 3, 2011 Research Article STABILITY INDICATING RP HPLC METHOD FOR ANALYSIS OF DORZOLAMIDE HCl IN THE BULK DRUG
More informationDISSOLUTION PROFILLING OF NIMESULIDE SOLID DISPERSIONS WITH POLYETHYLENE GLYCOL, TALC AND THEIR COMBINATIONS AS DISPERSION CARRIERS
International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol.2, No.1, pp 480-484, Jan-Mar 2010 DISSOLUTION PROFILLING OF NIMESULIDE SOLID DISPERSIONS WITH POLYETHYLENE GLYCOL, TALC
More informationThe microparticle system has become an indispensable part of the controlled drug delivery fields for the past few decades since it can
Microencapsulation Microencapsulation is a process or technique by which thin coatings can be applied reproducibly to small particles of solids, droplets of liquids, or dispersions, thus, forming microcapsules.
More informationAnion Analysis of Ophthalmic Irrigation Solutions with the Shimadzu Prominence IC System Craig Young, PhD, Sr. Tech Support Specialist
High Performance Liquid Chromatography SSI HPLC 5 Anion Analysis of Ophthalmic Irrigation Solutions with the Shimadzu Prominence IC System Craig Young, PhD, Sr. Tech Support Specialist Introduction Ophthalmic
More informationInternational Journal of Pharma and Bio Sciences V1(2)2010
P. S.GOUDANAVAR *, R.S.BAGALI, CHANDRASHEKHARA.S AND S. M.PATIL K.L.E s College of Pharmacy, Nipani, Karnataka, India * Corresponding Author p.goudanavar@rediffmail.com ABSTRACT Sustained release oral
More informationImportance Of Accelerated Stability Study
Importance Of Accelerated Stability Study Accelerated stability testing All medicinal products decompose with time. Paradoxically, when this decomposition is being assessed the skilled formulator becomes
More informationCHAPTER - 3 ANALYTICAL PROFILE. 3.1 Estimation of Drug in Pharmaceutical Formulation Estimation of Drugs
CHAPTER - 3 ANALYTICAL PROFILE 3.1 Estimation of Drug in Pharmaceutical Formulation 3.1.1 Estimation of Drugs ANALYTICAL PROFILE 84 3.1 ESTIMATION OF DRUG IN PHARMACEUTICAL FORMULATION. Agrawal A et al
More informationEvaluation of Dissolution Behavior of Paracetamol Suspensions
Evaluation of Dissolution Behavior of Paracetamol Suspensions Md. Golam Azam 1 and Syed Shabbir Haider 2 1 Department of Pharmacy, Northern University Bangladesh, 3/18, Iqbal Road, Mohammadpur, Dhaka-1207,
More informationASAP: Accelerated Stability Assessment Program. Improved Protocol and Data Analysis for Accelerated Shelf-Life Estimation of Solid.
ASAP: Accelerated Stability Assessment Program Improved Protocol and Data Analysis for Accelerated Shelf-Life Estimation of Solid Dosage Forms Kenneth C. Waterman Research Fellow, Pfizer Inc A more rapid
More informationMr.N.Srikar M.Pharm.,(Ph.D) KRISHNA TEJA PHARMACY COLLEGE
. Mr.N.Srikar M.Pharm.,(Ph.D) KRISHNA TEJA PHARMACY COLLEGE CONTENTS Introduction Definition Importance Newton's laws Types of flow Viscosity Measurements of viscosity Pharmaceutical applications 2 INTRODUCTION
More informationJournal of Chemical and Pharmaceutical Research, 2017, 9(6): Research Article
Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2017, 9(6):113-119 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Analysis of Particle Size Distribution of Some Powders
More informationParticle Size and Shape Analysis in PHARMACEUTICAL INDUSTRY.
Particle Size and Shape Analysis in PHARMACEUTICAL INDUSTRY Generalities Many analytical methods exist for the characterization of products manufactured in the pharmaceutical industry. Measuring the size
More informationGFC Analysis of Water-Soluble Polymers with TSKgel PW-type Columns. Contents
No.035 GFC Analysis of Water-Soluble Polymers with TSKgel PW-type Columns Contents Page 1. Introduction 2. Separation ranges for each grade of TSKgel PW-type column 3. GFC apparatus for water-soluble systems
More informationTWO VISIBLE SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF NEPAFENAC IN OPHTHALMIC SUSPENSION
Int. J. Chem. Sci.: 8(4), 2010, 2358-2362 TWO VISIBLE SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF NEPAFENAC IN OPHTHALMIC SUSPENSION Ch. HARI PRASAD *, B. ANUPAMA, V. JAGATHI, P. BASKARA RAO and G.
More informationResearch Article DESIGN AND EVALUATION OF SUSTAINED RELEASE FORMULATIONS OF THEOPHYLLINE USING NATURAL POLYMERS
International Journal of Research and Development in Pharmacy and Life Sciences Available online at http//www.ijrdpl.com October - November, 2013, Vol. 2, No.6, pp 721-725 ISSN: 2278-0238 Research Article
More informationDevelopment and Validation of Stability Indicating RP-HPLC Method for the Determination of Anagrelide HCl in Pharmaceutical Formulation
ISSN 0976 3333 Available Online at www.ijpba.info International Journal of Pharmaceutical & Biological Archives 2013; 4(2): 342-346 ORIGINAL RESEARCH ARTICLE Development and Validation of Stability Indicating
More informationPhysical Pharmacy. Chemical Kinetics and Stability
Physical Pharmacy Chemical Kinetics and Stability Chemical Kinetics and Stability The purpose of stability testing is to provide evidence on how the quality of a drug substance or drug product varies with
More informationFormulation and in vitro evaluation of candesartan liquid solid compacts to enhance drug solubility
IJPAR Vol.5 Issue 1 Jan- Mar -2016 Journal Home page: ISSN:2320-2831 Research article Open Access Formulation and in vitro evaluation of candesartan liquid solid compacts to enhance drug solubility Sai
More informationGFC separation of water-soluble polymers with TSKgel PW-type columns (2) using the PWXL series. Contents
No.038 GFC separation of water-soluble polymers with TSKgel PW-type columns (2) using the PWXL series Contents Page 1. Introduction 2. Calibration curves, theoretical plate numbers and separation range
More informationChapter 7 FORMULATION AND CHARACTERIZATION OF PULSINCAP
161 Chapter 7 FORMULATION AND CHARACTERIZATION OF PULSINCAP 162 Chapter 7 FORMULATION AND CHARACTERIZATION OF PULSINCAP S.No. Name of the Sub-Title Page No. 7.1. Optimization of formulations of Pulsincap
More informationColloidal dosage Forms Dr. rer. nat. Rebaz H. Ali
University of Sulaimani School of Pharmacy Dept. of Pharmaceutics Third level - Second semester Colloidal dosage Forms Dr. rer. nat. Rebaz H. Ali Outlines Disperse systems Introduction Lyophilic Lyophobic
More informationINTERNATIONAL RESEARCH JOURNAL OF PHARMACY ISSN Research Article
INTERNATIONAL RESEARCH JOURNAL OF PHARMACY www.irjponline.com ISSN 2230 8407 Research Article MUCOADHESIVE MICROBEADS OF METFORMIN HCL: A PROMISING SUSTAINED DRUG DELIVERY SYSTEM B. Samyuktha Rani 1 *,
More informationSupplementary Information. Core-Shell Silver/Polymeric Nanoparticles-Based Combinatorial Therapy against Breast Cancer In-vitro
Supplementary Information Core-Shell Silver/Polymeric Nanoparticles-Based Combinatorial Therapy against Breast Cancer In-vitro Nancy M. El-Baz 1,2, Laila Ziko 1,3, Rania Siam 1,3, Wael Mamdouh 1,2 * 1
More informationVANDERBILTMinerals. Published Articles, Papers and Presentations
Distributed in the Interest of Product Development VANDERBILTMinerals Published Articles, Papers and Presentations Vanderbilt Minerals, LLC, 33 Winfield Street, P.O. Box 5150, Norwalk, CT 06856-5150 Telephone:
More informationIn Situ Gelation-Induced Death of Cancer Cells Based on Proteinosomes
Supporting information for In Situ Gelation-Induced Death of Cancer Cells Based on Proteinosomes Yuting Zhou, Jianmin Song, Lei Wang*, Xuting Xue, Xiaoman Liu, Hui Xie*, and Xin Huang* MIIT Key Laboratory
More informationFormulation and evaluation of suspensions: Mefenamic acid prodrugs
REPORT Formulation and evaluation of suspensions: Mefenamic acid prodrugs Kamal Shah 1*, Sushant K. Shrivastava 2 and Pradeep Mishra 1 1 Institute of Pharmaceutical Research, GLA University, Mathura, UP,
More informationOpportunities for Regulatory Relief via In Vitro Dissolution. James E. Polli June 10, 2015
Opportunities for Regulatory Relief via In Vitro Dissolution James E. Polli jpolli@rx.umaryland.edu June 10, 2015 Topics Current issues with in vitro dissolution IVIVC, IVIVR, and biopharmaceutic risk
More informationPharma Ingredients & Services. Lutrol L and Lutrol F-Grades. Technical Information. Poloxamers for Pharmaceutical Use
Technical Information April 2010 Supersedes issue dated February 2010 Lutrol L and Lutrol F-Grades 03_100102e-03/Page 1 of 8 = Registered trademark of BASF group Poloxamers Ph. Eur., Poloxamer USP/NF Poloxamers
More information