Director, Amity Institute of Click Chemistry Research and Studies (AICCRS)

Transcription

1 NAME DESIGNATION ID DR. MONALISA MUKHERJEE Associate Professor, Amity Institute of Biotechnology (AIB) Director, Amity Institute of Click Chemistry Research and Studies (AICCRS) CONTACT NUMBER RESEARCH INTERESTS Research in Biomimetics and Nanostructured Materials Laboratory (AIB) focuses on diverse background like chemical biology, catalysis, material science and drug delivery. We aim towards the development of functional molecules of use to humankind with various approaches, among which the biomimetics or bio-inspired is one of the most significant route. We are also trying to introduce artificial molecules (designed based on an understanding of in vivo reactions) into living cells to examine the chemical reactions within living organisms. Presently the goal of our research is a three pronged approach: 1. Development of novel nanostructures materials, which have application in bio-imaging, sensing, catalysis, and various other applications. 2. Synthesis and characterization of hydrogels and their composites for delivering drugs because they can be molded into specific shapes and designed to release their payload. 3. Development of model systems as chemical paradigms for mimicking reactions of cytochrome P450 and NO synthase to reveal the nature of unseen intermediates in the reaction mechanism. In Molecular Science and Engineering Laboratory (AICCRS) we conduct research at the intersection of chemical, electrical, and biological engineering as well as materials, biological, and physical sciences. The major aim lies in exploring innovative technologies in nanoscale manipulation and design at a molecular scale which has the potential for societal impact in areas such as energy, health care, and the environment. EDUCATIONAL QUALIFICATIONS: Name of College / University Degree Year Center for Bio-Medical Engineering, Indian Institute of Technology, Delhi, INDIA University of North Bengal, West Bengal Ph. D awarded on the thesis titled Studies on Heme Proteins mimetic materials - In the area of Bio-inorganic chemistry. M.Sc. in Chemistry - specialization in Organic Chemistry University of North Bengal, West Bengal B.Sc. (Honours) in Chemistry

2 Title of Ph.D. thesis: Studies on Heme Proteins mimetic materials EXPERIENCE (in chronological order) Designation Type of post held (/ research) Name of the Institute Research research Indian Association for the Cultivation Assistant of Science, Jadavpur, INDIA Year (From To) March december 1999 Project Associate research Center for Bio-Medical Engineering, Indian Institute of Technology, Delhi, INDIA December February 2008 Lecturer (Probation) April March 2009 Senior Lecturer (Permanent position) Assistant Professor (Permanent position) Associate Professor(Perm anent position No. of Ph.D. students supervised Awarded: 0 Ongoing: 3 April 2009-August 2010 September April 2015 May till date 1. The prime reactive intermediate in the iron(iii) porphyrin complex catalyzed oxidation reactions by ter-butyl Hydroperoxide, Wadhwani, P.; Mukherjee, M.; Bandyopadhyay, D.; J. Am. Chem. Soc., 2001, 123, [ Impact Factor ] PUBLICATIONS (mention total no. here) 2. Biomimetic oxidation of L-arginine with hydrogen peroxide catalyzed by the resin-supported iron (III) porphyrin, Mukherjee, M.; Ray, A. R.; J. Mol. cat A: Chemical., 2007, 266, [Impact Factor 3.7 ] 3. Nitric oxide synthase-like activity of ion exchange resins modified with iron(iii) porphyrins in the oxidation of L-arginine by H 2O 2: Mechanistic insights, Mukherjee, M.; Ray, A. R.; Catalysis Communications., 2007, 8, [ Impact Factor 3.7 ]

3 4. L-arginine oxidation with Hydrogen peroxide catalyzed by synthetic heme-thiolate complex relevant to Nitric oxide synthase, Mukherjee, M.; IJSER., 2013, 4 : [ Impact Factor ] 5. HER2 protein biomarker based sensor systems for the breast cancer diagnosis Chandra, P.; Suman.P.; Mukherjee, M.; J Mol Biomark Diagn., 2013, [Impact factor 2.1 ]. 6. Prospects and advancement in c-reactive protein detection Airon, H.; Suman.P.; Mukherjee, M.; Chandra, P.; World J MethMethodol., 2014 March 26; 4(1): Prospecting novel heme-thiolate SR complex as a biomimetic model for nitric oxide synthase(nos) Suhag, D.; Mukherjee, M. ISBN: , Full Conference Proceedings Paper , International Conference on Recent Trends in Materials and Devices (ICRTMD-2013). Oct 30-31st. AUUP, Noida. 8. N-doped carbon nanosheets with antibacterial activity: Mechanistic insight Chakraborty, A.; Patni, P.; Suhag, D.; Saini, G.; Singh, A.; Chakrabarti, S.; Mukherjee, M.; RSC Advances., Royal society of Chemistry 2015, 5, [ Impact Factor ] 9. Hydrothermal synthesis of nitrogen doped graphene nanosheets from carbon nanosheets with enhanced electrocatalytic Properties, Suhag, D.; Saini, G.; Singh, A.; Chakrabarti, S.; Mukherjee, M.; RSC Adv., Royal society of Chemistry, 2015, 5, [ Impact Factor ] 10. Physically cross-linked ph-responsive hydrogels with tunable formulations for controlled drug delivery, Suhag, D.; Bhatia, R.; Das, S.; Shakeel, A.; Ghosh, A. ; Singh.; Chakrabarti, S.; Mukherjee, M.; RSC Adv., Royal society of Chemistry. 2015, 5, [Impact Factor - 3.9] 11. Polymer Nanocomposites using Click Chemistry: A Novel Material for Hydrogen Peroxide Sensor, Majumder, P.; Rattan, S; Mukherjee, M.; RSC Adv., Royal society of Chemistry. 2015, 5, [Impact Factor - 3.9]

4 12. The Role of Substrate in the correct diagnosis of the reactive intermediates in the Iron (III) porphyrin complex catalyzed oxidation reactions by Hydroperoxides, Suhag, D.; Chakrabarti, S.; Mukherjee, M.; manuscript sent for publication J. Inorg. Biochem.2015 [Impact Factor 3.5] 13. Nitrogen-doped carbon nanosheets as efficient metalfree catalyst for the regiospecific oxidation of palladium-carbon bonds, communicated to ACS catalysis [ Impact factor- 7.6] 1. Process for preparation of Iron (III) porphyrin catalyst immobilized on Dowex resin and its application thereof in biomimetic oxidation, Mukherjee, M.; Indian Patent Appl. (2011) No. 813/DEL/ Regiospecific oxidation of C-M bond of organometallic compound with hydrogen peroxide using chiral iron(iii) salen complexes as catalyst, Mukherjee, M.; Srivastava, A. K.; Indian patent Appl. (2011) No. 1098/DEL/ Graphene based chemical sensor for the detection of toxic heavy metal complexes in drinking water, Chakraborti, S.; Mukherjee. M.; Moses, E. J.; Indian patent Appl. (2012) 1030/DEL/2012. PATENTS (total no.) 4. Efficient organic photovoltaic devices based on photoactive graphene and semiconductor nanoparticles,, Chakraborti, S.; Sinha. O.P.; Moses, E. J.; Mukherjee, M.; Indian patent Appl. ( 2012) 1029/DEL/ Development of novel nanocomposites as chemical sensor using functionalized graphite nanoparticles, and grafted polymers through chemical ligation, Rattan, S.; Mukherjee. M; Moses, E. J.; Indian patent Appl. ( 2012) 806/DEL/ The alkali metal tertiary butoxide promoted, thiazolium salt, catalysed synthesis of electron deficient amides, Moses, E. J.; Burnley V. J.; Carbon, G.; Indian patent Appl. (2012) 3453/DEL/2012.

5 7. Hydrogels for transdermal drug delivery and a method to manufacture the same, Suhag, D.; Bhatia, R.; Das, S.; Shakeel, A.; Ghosh, A. ; Singh.; Chakrabarti, S.; Mukherjee, M.; Indian patent Appl. (2015) 1388/DEL/2015. RESEARCH PROJECTS Completed: 01 Ongoing: 1 Details: Development of Nitric Oxide synthase mimetic material and its application as biosensor. (DST) SR/FT/CS-006/2010 Sustainable synthesis of graphene quantum dots: Application for in-vivo bio-imaging and diagnosis. ( With Nottingham university, applied for EPSRC center for doctoral training in sustainable Chemistry) 1. Invited talk in Energy, materials and nanotechnology ( EMN) Hong Kong Meeting, taking place at Hong Kong from December 9 to 12, Invited talk in Recent Trends in Nano-Bio interface on 18th December 2015, JNU, New Delhi. 3. Invited talk in Asian Network for Natural and Unnatural Materials 4 (ANNUM 4 SINGAPORE 2016) Prelude May 20, 2015, IIT Delhi. AWARDS & HONOURS/ DISTINCTIONS 4. Invited talk in International Conference on Advancement in Materials, Health and Safety Towards Sustainable Energy and Environment, (MHS-2014) organized by IJAA and AERB, 7-8 Aug, 2014, Chennai. 5. Invited talk in UK-India Research Partnerships Forum Organized by Nottingham University, British council and Manipal University in India Habitat center New Delhi from 26-27th June Received Distinguished Visiting Scientist Award for the year 2011 from University of Nottingham, United Kingdom. 7. Received DST fast track Project on Development of NO-synthase mimetic materials and its application as biosensor. Amount of grant Rs.19,80,000/-(March 2010)

6 8. Foreign Travel grant from Department of Science and technology and Indian National Science Academy for presenting research paper at the 8th World Biomaterials Congress, Amsterdam, 28 May - 1 June Best poster presentation award in XVI Conference of Society for Biomaterials and Artificial Organs, New Delhi, INDIA, February 24-26, Excellent oral presentation certificate received in International Symposium on Advanced Materials and Processing (ISAMAP 2K4), held at I.I.T Kharagpur, INDIA, December Senior Research Fellowship from C.S.I.R, Human Resource Development group in Qualified Graduate Aptitude Test in Engineering (GATE 92. 5percentile) in 1998, Subject-Chemistry. 13. National Scholarship award under Govt. of India scheme Scholarship from Ministry of Human Resource & Development (MHRD) for pursuing Ph. D in IIT Delhi MEMBERSHIP with Professional/ Academic bodies Reviewer of many science journals: Nanoscale, Royal society advances, ACS Applied Materials and Interface, Bulletin of Materials Science, Journal of Molecular Catalysis A. Chemical Life Membership Chemical research Society of India. Annual Membership American Chemical society (ACS), USA. Annual Membership Royal Society of Chemistry (RSC) UK.