Syllabus of Organic Chemistry

Transcription

1 Assistant Professor Examination-2017 Syllabus of Organic Chemistry Organic Chemistry: 1. lupac nomenclature of organic molecules Including regio- and stereoisomers. 2. Stereochemistry: Concept of isomerism, types of isomerism, optical isomerism, elements of symmetry, molecular chirality, enantionmers, stereogenic centre, optical activity, properties of enantiomers, chiral and achiral molecules with two stereogenic centres, diastereomers, threo and erythro diasteromers, meso compounds, resolution of enantiomers, inversion, retention and racemisation; relative and absolute configuration, sequence rule, D & L and R & S systems of nomenclature; geometrical isomerism- determination of configuration of geometric isomers; E & Z system of nomenclature, configurational and conformational isomerism in acyclic and cyclic compounds; stereogenicity, stereoselectivity, enantioselectivity, diastereoselectivity and asymmetric induction; determination of enantiomeric and diastereomeric excess; optical activity in the absence of chiral carbon [biphenyls, allenes and spiranes}. 3. Nature ofhonding in organic molecules: Delocalized chemical bonding - conjugation, resonance, hyperconjugation, bonding in fullerenes, tautomerism; aromaticity in benzenoid and non-benzoid compounds, Huckel's rule, energy level of TT-molecular orbitals, annulenes, anti-aromaticity.

2 4. Organic reactive intermediates: Generation, stability and reactivity of carbocations, carbanions, free radicals, carbenes, benzynes and nitrenes. 5. Reaction mechanism: Type of mechanisms, types of reactions, organic reaction mechanisms involving addition, elimination and substitution reactions with electrophilic, nucleophilic or radical species; determination of reaction pathways. 6. Common named reactions and rearrangements - applications in organic synthesis. 7. Preparations, typical reactions, structures, and uses of following classes of compounds: Alkanes, cycloalkanes, alkenes, alkyl and aryl halides, alcohols phenols and ethers, aldehydes and ketones, carboxylic acids and their derivatives, organic compounds containing nitrogen: cyanides and isocyanides, nitro compounds, amines and diazonium salts. 8. Concepts in organic synthesis: Retrosynthesis, disconnection, synthons, linear and convergent synthesis, umpolung of reactivity and protecting groups; functional. group interconversion including oxidations and reductions. 9. Pericyclic reactions: electrocyclisation, cycloaddition, sigmatropic rearrangements and other related concerted reactions, principles and applications of photochemical reactions in organic chemistry. 10. Heterocyclic compounds: Synthesis and reactivity of common heterocyclic compounds containing one or two heteroatoms [0, N, S}.

3 11. Chemistry of natural products: Carbohydrates, proteins and peptides, fatty acids, nucleic acids, terpenes, steroids and alkaloids, biogenesis of terpenoids and alkaloids. 12. Organic photochemistry: Excited states of organic molecules, photochemistry of alkenes and carbonyl compounds, Norrish type 1 and type II reactions, Paterno- Buchi reaction. Barton reaction, photo-fries rearrangement. 13. Spectroscopy: Structure determination of organic compounds by IR, UV-Vis, NMR and Mass spectroscopic techniques. 14. Polymer Chemistry: Classification of polymers, polymerization; condensation, addition/radical chain-ionic and co-ordination and copolymerization, polymerization conditions and polymer reactions, molecular weights and their determinations.

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