DR. MOHAMMAD ABID. Visiting Asstt. Professor (UGC-RAMAN Fellow) Eppley Institute for Research in Cancer & Allied Diseases,
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1 DR. MOHAMMAD ABID Visiting Asstt. Professor (UGC-RAMAN Fellow) Eppley Institute for Research in Cancer & Allied Diseases, University of Nebraska Medical Center (UNMC), Omaha, USA Assistant Professor Department of Bio-Sciences Faculty of Natural Sciences JMI, New Delhi, India Tel: extn: 74302; Mobile: (India), (USA) (Office) (alternate) Guest Editor: Special Issue on Challenges and Opportunities in Anticandidal Drug Discovery & Development to be published in Letters in Drug Design and Discovery (Bentham Publications) date of publication: July 2017 Field of Specialization: Structure based drug design and medicinal Chemistry Research interests My research group is involved in multidisciplinary research projects in the areas of synthetic organic, bioorganic and medicinal chemistry. Of particular interest, we are investigating: Computer-aided design and subsequent synthesis of small molecule inhibitors Synthesis and biological studies of bioactive natural scaffolds and their derivatives Structure-based Design of enzyme Inhibitors for antimicrobial targets Development of new synthetic methodologies Post-doctoral Research Experience: July 2016-present Visiting Assistant Professor at Eppley Institute for Research in Cancer & Allied Diseases, University of Nebraska Medical Center, Omaha, NE , USA Sept Jan Aug Dec Post-doctoral Fellow at Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR-8601, University Paris Descartes, Paris, France with Prof. Isabelle ARTAUD. Research Associate, Organic Chemistry, IIT Kanpur, India Post-doctoral Teaching Experience: 09 Dec present Assistant Professor, Department of Bio-Sciences, Faculty of
2 Natural Sciences, Jamia Millia Islamia, New Delhi-25. Jan Dec 2010 Assistant Professor, Department of Chemistry, Government P. G. Graduate College, Musafirkhana, Dist. Sultanpur, UP, India. April 2008-Aug 2008 Lecturer in Chemistry, Department of Chemical Engineering and Polymer Technology, Jubail Industrial College, Jubail, KSA. Jan 2006-March 2008 Lecturer in Chemistry, Department of Chemistry, B. N. Degree College, Shahabad, Dist. Hardoi, UP INDIA. Education: Ph.D. (Organic Chemistry), Department of Chemistry, JMI, New Delhi India Thesis title: Synthesis Characterization & Evaluation of Biological Activity of Some Heterocyclic Compounds with Prof. Amir Azam M.Sc. Organic Chemistry, A.M.U., Aligarh India with first class in Dissertation: 1,3-Dipolar Cycloaddition Reactions B.Sc. (Hons.) Chemistry, A.M.U., Aligarh India with first class in Professional recognition, awards, fellowships received: RAMAN Postdoctoral Fellowship awarded by the University Grant Commission, Govt. of India to work at Eppley Institute for Research in Cancer & Allied Diseases, UNMC, Omaha, NE , USA for one Year (July 2016-July 2017). Travel grant from SERB, DST, Govt. of India and JMI, New Delhi to present a paper in 15 th Tetrahedron Symposium-Asia Edition Conference during Oct held in SINGAPORE. Indian Academy of Sciences-Summer Research Fellowship for a period of 02 months with Prof. S. Chandrasekaran, Department of Organic Chemistry, IISc Bangalore during May 2011-July Postdoctoral Fellowship (PDF) for a period of 18 months with Prof. Isabelle ARTAUD, UMR-8601 at University Paris Descartes, Paris, FRANCE during Sept to Jan Research Associateship (RA) for 5 months under a DST Project at Department of Organic Chemistry, IIT Kanpur during Aug to Dec Senior Research Fellowship (SRF) under a CSIR Project for one year with Prof. Amir Azam, Department of Chemistry, JMI New Delhi during Oct to July Junior Research Fellowship (JRF) under a CSIR Project for two years with Prof. Amir Azam, Department of Chemistry, JMI New Delhi during Sept 2002 to Sept GATE conducted by IISc Bangalore with percentile (2002). CSIR-NET (National Eligibility Test for Lectureship) in Dec Post Graduate Merit scholarship for two years ( ) awarded by Department of Chemistry, AMU.
3 Projects undertaken: S.No. Name of Project Funding Agency Duration Amount sanctioned Status 1. Design & synthesis of novel peptidomimetic antibacterial agents (PI) 2. Synthesis and Pharmacodynamic studies in the efficacy of new diketo acid and triazole based antifungal agents (PI) 3. Designing and structurefunction characterization of antithrombin specific nonheparin coagulation modulators with ability to inhibit thrombosis in vivo (Co-PI) Science & Engineering Research Board (SERB), DST, Govt of India University Grant Commission (UGC), Govt of India Science & Engineering Research Board (SERB), DST, Govt of India Lacs Completed Lacs Completed lacs On-going Administrative Responsibilities July May 2016 Aug 2015-July 2016 Aug 2015-July 2016 Student Advisor, Bioscience Subject Association, Department of Biosciences, Jamia Millia Islamia. Warden, Hall of Residence (Boys), Campus B Sports In charge, Hall of Residence (Boys), Campus B Courses taught at Undergraduate and Postgraduate levels: Under graduate: General, Organic and Biophysical Chemistry. Postgraduate: Organic chemistry & Biomolecules Ph.D. course work: Research Methodology (spectroscopy) Curriculum Development: Actively involved in designing and development of B.Sc. Biosciences syllabi and course content.
4 Students guided for Ph.D.: S. N o. Name of Student Ph.D. Title Date of Registratio n Date of completion Role as 1. Mohammad Irfan Antifungal evaluation and molecular docking studies of new azole derivatives against Candida spp Submitted Supervisor 2. Babita Aneja Synthesis, biological activity and SAR studies of some novel heterocyclic compounds Ongoing C0- Supervisor 3. Bhumika Kumar Characterization of Metacaspase-3 (MCA-3) as a New Potential Drug Target for Malaria Ongoing Supervisor 4. Farheen Shamsi Synthesis In Vitro assessment and docking studies of novel Ongoing Supervisor sulfonamide based anticancer organic scaffolds and their molecular analysis 5. Mir Mohammad Masood Synthesis, biological evaluation and docking studies of some novel heterocyclic compounds Ongoing Cosupervisor 6 Phool Hasan Synthesis and Characterization of N,O Dec 2014 Ongoing Cosupervisor
5 and S containing heterocyclic compounds and evaluation of their antimicrobial potentiality Orientation Program/Refresher Course attended: 100 th four-week Orientation Programme, organized by UGC-Academic Staff College, JMI, New Delhi from 09 th April to 05 th May, rd three-week Refresher Course in Basic Sciences organised by UGC-ASC, JMI from 09 th May to 30 May Affiliation/membership to scientific societies: Member of the American Chemical Society (Membership No ) Member of the Royal Society of Chemistry London (Membership No ) Member of the Asian Council of Science Editors (Membership No ) Society of Biological Chemists India (Life Member LM 3156). Chemical Research Society of India (Life member LM 1410). Former Member-Indian Chemical Society (2004). Former Member -American Chemical Society (2009) IUPAC Sponsored Affiliate Member ( ). Saudi Arabian International Chemical Sciences, Chapter of the American Chemical Society since Projects guided at Postgraduate Level: Abuzar Irfan: Mithy Tatak: Nishant Kumar: Anamika Sharma: Zeenat Khatoon: Nasreen Afsar: Md. Mukuibur Rahman: Nabeela Mofazzal: Waseem Chauhan: Masidur Rahman: Ms. Shagufa: Ms. Anam (B.Tech. Biotech Amity University): Mohd. Yunus: Sneha Singh:
6 Patents Filed: Triazole-amino acid based hybrid as potential inhibitor for Candida infection. TEMP/E- 1/5630/2016-DEL filed on to Intellectual Property, India. Triazole-amino acid based hybrids as potential antifungal drug for Candida infection. TEMP/E-1/7697/2016-DEL filed on to Intellectual Property, India. A method to reduce in vivo thrombus formation and platelet aggregation using Quercetin 3, 3, 4, 5, 7-O- pentasulfate, as a potential antithrombotic and antiplatelet agent. E- 1/31677/2016-DEL, Filed on 24/09/2016 A process for the synthesis of N-substituted 4-quinolone derivatives via LiHMDSinduced in situ cycloconensation. TEMP/E-1/2647/2017- DEL filed on to Intellectual Property, India. Publications: Total Citations: 801, h index: 14, i10 Index: 14 (Google scholar) Mohammad Irfan, Shadab Alam, Nikhat Manzoor, Mohammad Abid*. Effect of quinoline based 1, 2, 3-triazole and its structural analogues on growth and virulence attributes of Candida albicans. PLOS ONE 2017 (accepted). (IF: 3.05) 2. Mir Mohammad Masood, Phool Hasan, Shams Tabrez, Md. Bilal Ahmad, Umesh Yadava, Constantin G. Daniliuc, Yogesh A. Sonawane, Amir Azam, Abdur Rub, Mohammad Abid*. Anti-leishmanial and cytotoxic activities of amino acid-triazole hybrids: Synthesis, biological evaluation, molecular docking and in silico physicochemical properties, Bioorg. Med. Chem. Lett. 27 (2017) (IF: 2.486) 3. M. Yusuf, Amanpreet Kaur, Mohammad Abid. Synthesis, antimicrobial studies and docking simulations of new bis(4,5-dihydropyrazole) derivatives. Journal of Heterocyclic Chemistry 2017 (March 2017). (IF: 0.685) 4. Phool Hasan, Babita Aneja, Mir M. Masood, Md. Belal Ahmad, Umesh Yadava, Constantin G. Daniliuc and Mohammad Abid*. Efficient synthesis of novel N- substituted 2-carboxy-4-quinolones via lithium bis(trimethylsilyl)amide (LiHMDS)- induced in situ cyclocondensation reaction. RSC Advances 2017, 7, (IF: 3.289) 5. Mohammad Abid*, Yogesh A. Sonawane, Jacob I. Contreras, Sandeep Rana and Amarnath Natarajan. Recent Advances in Cancer Drug Development: Targeting Induced Myeloid Cell Leukemia-1 (Mcl-1) Differentiation protein. (Invited Review) Current Medicinal Chemistry (IF: 2.9) 6. Mohammad Abid. An overview of Phosphatidylinositol 3-kinase (PI3K) inhibitors for cancer therapeutics. (Invited Review), Current Bioactive Compounds Mohammad Abid, Farheen Shamsi and Amir Azam. Ruthenium Complexes: An emerging ground to the development of metallopharmaceuticals for cancer therapy. Mini Reviews in Medicinal Chemistry 2016, (Invited review article published in Special issue on anticancer Ru complexes). (IF: 2.84)
7 Babita Aneja, Bhumika Kumar, Mohamad Aman Jairajpuri, Mohammad Abid*. Structure guided drug-discovery approach towards identification of Plasmodium Inhibitors. RSC Advances (Invited review article) 2016, 6, (IF: 3.289) 3. Shadab Alam, Phool Hasan, Babita Aneja, Mohammad Abid*. POCl3 mediated Staudinger reaction of imines with ketenes: Synthesis of monocyclic β-lactam and 1,3- oxazinone derivatives. Rasayan Journal of Chemistry, POCl3 Mediated Staudinger reaction of imines with ketenes: Synthesis of monocyclic β- lactam and 1,3-oxazinone derivatives. Shadab Alam, Phool Hasan, Babita Aneja, Md Belal Ahmad, Mohammad Abid*. RASAYAN Journal of Chemistry. 2016/5 5. Mohammad Irfan, Shabana I. Khan, and Mohammad Abid*. Biological potential and in silico ADME prediction of 1,2,3-triazoles derived from naturally bioactive alcohols. Anti-Infective Agents 2016 (accepted). 6. Shadab Alam, Phool Hasan, Babita Aneja, Umesh Yadava, Constantin G. Daniliuc, Mohammad Abid*. Synthesis and crystal structure analysis of monocyclic β-lactam derivatives. Structural Chemistry and Crystallographic Communications 2016 (Accepted). 7. Aneja, Babita; Irfan, Mohammad; Kapil, Charu; Jairajpuri, Mohamad Aman; Maguire, Ronan; Kavanagh, Kevin; Rizvi, M Moshahid A; Manzoor, Nikhat; Azam, Amir; Mohammad Abid*. Effect of novel triazole amino acid hybrids on growth and virulence of Candida species: in vitro and in vivo studies. Organic & Biomolecular Chemistry 2016, 14, 45, (IF: 3.559) 8. Experimental and Molecular Docking Investigation on DNA Interaction of N-Substituted Phthalimides: Antibacterial, Antioxidant and Hemolytic Activities. Pattan Sirajuddin Nayab, Mohammad Irfan, Mohammad Abid, Rahisuddin. Luminescence A Journal of Biological and Chemical Luminescence. 2016, July 6. (IF: 1.452) 1. Babita Aneja, Mohammad Irfan, Md. Imtaiyaz Hassan, Prakash Amresh, Umesh Yadava, Constantin G. Daniliuc, Amir Azam, Mohammad Abid*. Monocyclic beta- lactam and unexpected oxazinone formation: synthesis, crystal structure, docking studies and antibacterial evaluation. Journal of Enzyme Inhibition & Medicinal Chemistry 2015 (May, 2015), (IF: 3.428). 2. Mir Mohammad Masood, Vijay K. Pillalamarri, Mohammad Irfan, Babita Aneja, Mohamad Aman Jairajpuri, Md. Zafaryab, M. Moshahid A. Rizvi, Umesh Yadava, Anthony Addlagatta, Mohammad Abid*. Diketo acids and their amino acid/dipeptidic analogues as promising scaffolds for the development of bacterial methionine aminopeptidase inhibitors. RSC Advances 2015, 5, (IF: 3.289). 3. Qudsia Rashid, Mohammad Abid, Neha Gupta, Tarun Tyagi, Mohd Zahid Ashraf, Mohamad Aman Jairajpuri. BioMed Research International. Volume 2015 (2015), Article ID , 11 pages. (IF: 2.7). 4. Mohammad Irfan, Babita Aneja, Umesh Yadava, Shabana I. Khan, Nikhat Manzoor,
8 Constantin G. Daniliuc, Mohammad Abid*. Synthesis, QSAR and anticandidal evaluation of 1,2,3-triazoles derived from naturally bioactive scaffolds. European Journal of Medicinal Chemistry, 93, 2015, (IF: 3.902). 4. Mohammad Irfan, Mohammad Abid*. Three-dimensional structure modeling of lanosterol 14-α demethylase of Candida albicans and docking studies with new triazole derivatives. Chemical Informatics. 2015, 1, 1, Evaluation of DNA Binding, Radicals Scavenging and Antimicrobial Studies of Newly Synthesized N-Substituted Naphthalimides: Spectroscopic and Molecular Docking Investigations. Pattan Sirajuddin Nayab, Madhusudana Pulganti, Suresh Kumar Chitta, Mohammad Abid, Rahisuddin. JOURNAL OF FLUORESCENCE. 2015/10. (IF: 1.601) Mohammad Irfan, Mohsin Khan, Nikhat Manzoor, Mohammad Abid*. Synthesis of N- 2-aryl-substituted-1,2,3-triazole Derivatives as Novel Inhibitors of Entamoeba histolytica. Open Journal of Organic Chemistry 2014 Vol 2 No Qudsia Rashid, Mohammad Abid, Mohammad Aman Jairajpuri. Elucidating the specificity of non-heparin-based conformational activators of antithrombin for factor Xa inhibition J. Nat. Sci. Biol. Med 2014, Vol 5, Issue 1, Qudsia Rashid, Poonam Singh, Mohammad Abid, Mohammad Aman Jairajpuri. Limitations of conventional anticoagulant therapy and the promises of non-heparin based conformational activators of antithrombin J. Thromb. Thrombolysis , 2, (IF: 2.039) Mohammad Abid, Abdul Roouf Bhat, Fareeda Athar, Amir Azam. Synthesis, spectral studies and antiamoebic activity of new 1-N-substituted thiocarbamoyl-3-phenyl-2- pyrazolines. European Journal of Medicinal Chemistry, 44, 1, 2009, (IF: 3.902) Kakul Husain, Mohammad Abid, Amir Azam. Novel Pd(II) complexes of 1-Nsubstituted 3-phenyl-2-pyrazoline derivatives and evaluation of antiamoebic activity. European Journal of Medicinal Chemistry, 43, 2, 2008, (IF: 3.902). 2. Mohammad Abid, Subhash M. Agarwal, Amir Azam. Synthesis and antiamoebic activity of metronidazole thiosemicarbazone analogues. European Journal of Medicinal Chemistry, 43, 9, 2008, (IF: 3.902) Asha Budakoti, Mohammad Abid, Amir Azam. Syntheses, characterization and in vitro antiamoebic activity of new Pd(II) complexes with 1-N-substituted thiocarbamoyl-3,5- diphenyl-2-pyrazoline derivatives European Journal of Medicinal Chemistry, 42, 4, 2007, (IF: 3.902) 2. Kakul Husain, Mohammad Abid, Amir Azam. Synthesis, characterization and antiamoebic activity of new indole-3-carboxaldehyde thiosemicarbazones and their Pd(II) complexes European Journal of Medicinal Chemistry, 42, 10, 2007, (IF: 3.902) 2006
9 1. Asha Budakoti, Mohammad Abid, Amir Azam. Synthesis and antiamoebic activity of new 1-N-substituted thiocarbamoyl-3,5-diphenyl-2-pyrazoline derivatives and their Pd(II) complexes. European Journal of Medicinal Chemistry, 41, 1, 2006, (IF: 3.902) 2. Mannar R. Maurya, Amit Kumar, Mohammad Abid, Amir Azam. Dioxovanadium(V) and l-oxo bis[oxovanadium(v)] complexes containing thiosemicarbazone based ONS donor set and their antiamoebic activity Inorganica Chimica Acta, 359, 8, 2006, (IF: 2.322) 3. Mohammad Abid, Amir Azam. Synthesis, characterization and antiamoebic activity of 1- (thiazolo[4,5-b]quinoxaline-2-yl)-3-phenyl-2-pyrazoline derivatives Bioorganic & Medicinal Chemistry Letters, 16, 10, 2006, (IF: 2.486) 4. Maurya MR, Agarwal S, Mohammad Abid, Azam A, Bader C, Ebel M, Rehder D. Synthesis, characterisation, reactivity and in vitro antiamoebic activity of hydrazone based oxovanadium(iv), oxovanadium(v) and mu-bis(oxo)bis{oxovanadium(v)} complexes. Dalton Transactions , 7, (IF: 4.177) Mohammad Abid and Amir Azam. Synthesis and antiamoebic activities of 1-Nsubstituted cyclised pyrazoline analogues of thiosemicarbazones. Bioorganic & Medicinal Chemistry, 13, 6, 2005, (IF: 2.923) 2. Mohammad Abid and Amir Azam. 1-N-Substituted Thiocarbamoyl-3-Phenyl-2- Pyrazolines: Synthesis and In Vitro Antiamoebic Activities European Journal of Medicinal Chemistry, 40, 9, 2005, (IF: 3.902) 3. Mohammad Abid, Kakul Husain, Amir Azam. Synthesis and antiamoebic activity of new oxime ether derivatives containing 2-acetylpyridine/2-acetylfuran Bioorganic & Medicinal Chemistry Letters, 15, 19, 2005, (IF: 2.486) 4. Athar F, Husain K, Mohammad Abid, Agarwal SM, Coles SJ, Hursthouse MB, Maurya MR, Azam A. Synthesis and Anti-Amoebic Activity of Gold(I), Ruthenium(II), and Copper(II) Complexes of Metronidazole. Chemistry Biodiversity , 10, (IF: 1.444) Conference/ Workshop organised Organised Extension lecture series on Recent Advances in Biosciences under the edges of Biosciences Subject Association in March, Organized Extension lecture series on Recent Advances in Biosciences under Biosciences Subject Association in March, Treasurer in UGC-SAP sponsored National Seminar on Metal Toxicity and Oxidative Stress Organised by Department of Biosciences, JMI, New Delhi (September 23-24, 2014). Member of Local organizing Committee in National Conference on Interdisciplinary Approaches in Chemical Sciences (IACS-2015), at CIRBSc, Jamia Millia Islamia, New Delhi (December 16, 2015). Paper presentation in various Conferences/Workshop Attended:
10 International Conference on Recent Advances in Biomedical and Therapeutic Sciences organized by Bundelkhand University, Jhansi (UP) India (Jan , 2004). 41 st Annual Convention of Chemists hosted by Department of Chemistry, University of Delhi, (Dec , 2004). Workshop on Analytical techniques and Instrumentation conducted by Shaheed Raj Guru College of applied Sciences, University of Delhi (26 Dec Jan 2004). International Conference on Chemistry Frontiers and Challenges organized by Department of Chemistry, A. M. U. India (March 05-06, 2011). National Conference on New Vistas in Chemistry held on March 2-3, 2012 organized by the department of Chemistry, A.M.U. Aligarh. Workshop on Bioinformatics Infrastructure & Frontiers (BIF 12) held on March 13-14, 2012 at the Department of Computer Science, JMI, New Delhi. IV Bioinformatics Conference cum Hands-on Training on Application of Bioinformatics in Drug Discovery and Development October, 2012 Organized by Bioinformatics Infrastructure Facility, Jamia Hamdard, Hamdard Nagar, New Delhi. Seventy-eighth Annual Meeting of the Indian Academy of Sciences held at Wadia Institute of Himalayan Geology, Dehradun from 1 to 4 November, International Interdisciplinary Science Conference on Protein folding and diseases organized by Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India (December 8-10, 2012). Lecture workshop on Trans-disciplinary areas of research and teaching by Shanti Swaroop Bhatnagar Awardees February 01-02, 2013 jointly organized by Deen Dayal Upadhyaya College, University of Delhi and IEEE EDS Delhi Chapter, New Delhi. International Conference on Chemistry Frontiers and Challenges organized by Department of Chemistry, A. M. U. India (March 02-03, 2013). 17 th National Seminar on Physics and Technology of Sensors organized by Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India (March 11-13, 2013). National Conference on Recent Trends in Protein Structural Biology organized by Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India (December 16-18, 2013). 6 th National Seminar on New Paradigm in Chemical Sciences-2014 organized by Department of Chemistry, Punjabi University, Patiala, India (February 13, 2014). UGC-SAP sponsored National Seminar on Metal Toxicity and Oxidative Stress Organised by Department of Biosciences, JMI, New Delhi (September 23-24, 2014). National Symposium on Biophysics & Golden Jubilee Meeting of the Indian Biophysical Society organized by Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India (February 14-17, 2015). Mohammad Abid*. Effect of novel triazole-amino acid hybrids on growth and virulence factors of Candida species: In vitro and in vivo anticandidal evaluation.
11 18th CRSI National Symposium in Chemistry. Punjab University, Chandigarh, (5-7 February, 2016). Mohammad Abid*. Diketo acids and their hybrid bioisoster derivatives as potential bacterial biofilm and Methionine Aminopeptidase (MetAP) inhibitors. ACS National Meeting, San Francisco, USA during April 2-6, Invited Talk Mohammad Abid*. Novel triazole-amino acid hybrids and their effect on growth and virulence factors of Candida species: In vitro and in vivo anticandidal evaluation. National Conference on Interdisciplinary Approaches in Chemical Sciences IACS 2015, Centre for Interdisciplinary Research in Basic Sciences, JMI, New Delhi, 16 th December, International Visit: 3 S.No. Purpose of Visit Duration Country visited 1. UGC RAMAN Postdoc Fellow at July 2016-July USA Eppley Institute of Research in Cancer & Allied Diseases, UNMC, USA To present a paper in 15 th Tetrahedron Symposium-Asia Edition conference hosted by Elsevier, UK Oct SINGAPORE 3. Postdoctoral fellowship (PDF) Sept Paris, Jan.2010 FRANCE 4. Lecturer at Jubail Industrial College, April 2008 to Saudi Arabia Kingdom of Saudi Arabia August 2008 Mohammad Abid
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