Radiotracers for Early Diagnosis - ReSearching for a Better Life!

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Marshall William Quinn
5 years ago
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1 Radiotracers for Early Diagnosis - ReSearching for a Better Life!

2 CONTACT INFORMATION: Horia Hulubei National Institute of Physics and Nuclear Engineering - IFIN- HH 30 Reactorului Street Bucharest-Magurele, ROMANIA secretar@nipne.ro Radioisotopes and Radiation Metrology Department Radiopharmaceuticals Research Centre Tel.: (+4) Fax.: (+4) dana.niculae@nipne.ro

radioisotopes (short lived) via cyclotron. The medical radionuclides are especially envisaged.

3 Radiopharmaceuticals Research Program Production of PET Radioisotopes Production of SPECT Radioisotopes via cyclotron Production and post-processing of positron/gamma/beta emitters radioisotopes (short lived) via cyclotron. The medical radionuclides are especially envisaged. PET: F-18, C-11, N-13, O-15, I-124 for imaging; Cu-64 for imaging and therapy SPECT: Tc-99m, I-123 for imaging

Radiopharmaceuticals Research Program Developing of new radiopharmaceuticals for molecular imaging GMP Production of radiopharmaceuticals for clinical

Molecules with specific biological activity and preferential tumor uptake, involved in pathological mechanisms, such as antibodies, peptides and hormones

4 Radiopharmaceuticals Research Program Developing of new radiopharmaceuticals for molecular imaging GMP Production of radiopharmaceuticals for clinical testing Potential radiopharmaceuticals for imaging and targeted therapy of cancer are preclinically evaluated. Molecules with specific biological activity and preferential tumor uptake, involved in pathological mechanisms, such as antibodies, peptides and hormones were radiolabelled with gamma/positrons/ beta emitters. At the GMP production site the successful agents will be prepared according to pharmacological safety requirements for human use and clinically tested.

Radiopharmaceuticals Research Program Pharmacological development using

is expected to play an increasingly important role in drug discovery and

Positron Emission Tomography (PET), as a non-invasive imaging technique

its interaction with drug molecules and changes over time and upon

5 Radiopharmaceuticals Research Program Pharmacological development using C-11 and PET imaging Developing hybrid imaging technology Molecular imaging is expected to play an increasingly important role in drug discovery and development. Positron Emission Tomography (PET), as a non-invasive imaging technique that provides quantitative information about a drug target s distribution, its interaction with drug molecules and changes over time and upon therapeutic intervention, has been increasingly recognized as a powerful imaging modality that provides a specific and sensitive biomarker for drug development.

Nuclear Physics Applications at cyclotron Research Program Applications of cyclotron and linear accelerator

corrosion studies; Neutron activator for nanostructure activation for brachytherapy; Neutron activation of

transfer to hot-cells; Beam optics research/development; Positron source in line with the cyclotron for

6 Nuclear Physics Applications at cyclotron Research Program Applications of cyclotron and linear accelerator Industrial applications of cyclotron TLA/UTLA (Thin Layer Activation/ Ultrathin Layer Activation) for wear corrosion studies; Neutron activator for nanostructure activation for brachytherapy; Neutron activation of nanoparticles for industry; Irradiation system of high currents for Tc-99m production with rabbit for automatic transfer to hot-cells; Beam optics research/development; Positron source in line with the cyclotron for accelerating slow positrons (advanced stage build-up); Irradiation for electronic device testing; Experimental physics, dosimetry, etc

7 Positron emitting medical radioisotopes Radiopharmaceuticals Fluorine-18 T 1/2 = 110 min 18 F-FDG Iodine-124 T 1/2 = 4.2 d 18 F-DOPA Technetium-99m T 1/2 = 6.1 h 18 F-FLT Nitrogen-13 T 1/2 = 9.9 min 18 F-FES Carbon-11 T 1/2 = 20.3 min Na 18 F Oxygen-15 T 1/2 = 2 min 124 I-MIBG Copper-64 T 1/2 =12.7 h 68 Ga-DOTA-TOC Iodine-123 T 1/2 =13.2 h 68 Ga-RGD....

Equipments Cyclotron TR-19 Cyclotron- fully automated and

14-19MeV; External Ion Source (H - ) and Extraction System;

position alignment; Gaseous, solid and liquid targets; Solid

8 Equipments Cyclotron TR-19 Cyclotron- fully automated and computer controlled; Variable Energy: extraction energy 14-19MeV; External Ion Source (H - ) and Extraction System; Automated Target Changer with precise real-time target position alignment; Gaseous, solid and liquid targets; Solid targets processing system; Experimental hall with additional beam lines.

Equipments Radiochemistry Automated synthesis units (Fastlab GE,

Automated robotic dispenser for radiopharmaceuticals;

spectrometry); Analytical equipment: chromatography HPLC, GC FID,

flow hoods for aseptic manipulations, incubator, autoclave, bubble

10 Equipments Radiochemistry Automated synthesis units (Fastlab GE, Synthra); Hot Cells for radiochemistry (Comecer); A-class Automated robotic dispenser for radiopharmaceuticals; Radiochemistry lab (radiochemistry hoods, calibrators, gamma spectrometry); Analytical equipment: chromatography HPLC, GC FID, TLC with radiodetection); Micro (radiobiology) laboratory (laminar flow hoods for aseptic manipulations, incubator, autoclave, bubble point tester, particle counter, endotox); Micro PET (pre-clinical studies on small animals).

PLANUL NAŢIONAL DE CERCETARE, DEZVOLTARE ŞI INOVARE, PNII Programul CAPACITĂȚI 2010-2013 Dezvoltarea infrastructurii pentru

12 PLANUL NAŢIONAL DE CERCETARE, DEZVOLTARE ŞI INOVARE, PNII Programul CAPACITĂȚI Dezvoltarea infrastructurii pentru cercetari de frontiera in fizica nucleara si domenii conexe 7PM/1/2008 /

Best MeV. Best , 25 MeV

Best MeV. Best , 25 MeV Best 15 15 MeV 400 µa Best 25 20, 25 MeV 400 µa Best 28u/35 20, 28 35 15 MeV 400 1000 µa Best 70 70 35 MeV 700 µa 2014 Best Cyclotron Systems Best Cyclotron Systems 8765 Ash St., Unit 7, Vancouver, BC