The Conferience Experience
|
|
|
- Joel Mills
- 5 years ago
- Views:
Transcription
1 The Conferience Experience Modern Synthetic Methods & Chiral USA (11 13 July, Philadelphia) 234 th ACS National Meeting & Exposition (19 23 August, Boston) Aman Desai A Group Meeting Presentation 7 th Sep. 2007
2 What, Why & How many? Modern Synthetic Methods & Chiral USA Reaction to reality (11 13 July, Boston) What? What? Why? A three day conference and exhibition. Entire focus on asymmetric methodology/synthesis, at the academic as well as the industrial level. Provide a forum where industry and academia can meet to discuss new synthetic methodology & chiral chemistry. Why did I attend? How many? In 3 days, I could get to know the latest in chiral chemistry at the academic as well as the industrial level. Got an awesome discount! 13 academic talks 11 industrial talks ~ 10 exhibiting companies 1 poster (mine!)
3 Who? From academia: Steven Nolan (ICIQ, Spain) Barry Trost (Stanford) Xumu Zhang (SUNY, Rutgers) Michael Krische (U. Texas) Mathew Gaunt (U. Cambridge, UK) Erick Carreira (ETH-Zurich) Dean Toste (U. Cal. Berkeley) John Montgomery (U. Michigan) Vadim Soloshonok (U. klohoma) Clark Landis (U. Wisconsin) Patrick Walsh (U. Penn.) Marisa Kozlowski (U. Penn.) Kevin Burgess (TAMU) From industry: Scott May (Eli Lilly) Johan Wennerberg (DuPont) Kevin Campos (Merck) Ian Lennon (Dowpharma) Fred Hancock (Johnson Matthey Catalysis) Michel Guillaume (Johnson & Johnson) Michael Schwarm (Degussa) Xudong Wei (Boehringer) Surendra Singh (Sepracor) Brian Freer (Chiral Technologies) Benoit Pugin (Solvias)
4 Who? From industry: Scott May (Eli Lilly) Johan Wennerberg (DuPont) Kevin Campos (Merck) Ian Lennon (Dowpharma) Fred Hancock (Johnson Matthey Catalysis) Michel Guillaume (Johnson & Johnson) Michael Schwarm (Degussa) Xudong Wei (Boehringer) Surendra Singh (Sepracor) Brian Freer (Chiral Technologies) Benoit Pugin (Solvias) Asymmetric hydrogenation Lewis acid catalyzed Michael reactions Asymmetric hydrogenation Asymmetric hydrogenation Asymmetric hydrogenation Chiral pool Biocatalysis lefin metathesis Asymmetric hydrogenation Chiral chromatography Asymmetric hydrogenation Asymmetric hydrogenation by and large the only asymmetric synthesis methodology really explored in industry till now!
5 Industrial chiral chemistry is in its infancy. Asymmetric synthesis is and will remain a hot field for a long time. A lot of unexplored territory. A world of potential. So Yeah Aziridinations! Go VAPL/VANL! Rock on Carbene Complexes!
6 Who? From academia: Steven Nolan (ICIQ, Spain) Barry Trost (Stanford) Xumu Zhang (SUNY, Rutgers) Michael Krische (U. Texas) Mathew Gaunt (U. Cambridge, UK) Erick Carreira (ETH-Zurich) Dean Toste (U. Cal. Berkeley) John Montgomery (U. Michigan) Vadim Soloshonok (U. klohoma) Clark Landis (U. Wisconsin) Patrick Walsh (U. Penn.) Marisa Kozlowski (U. Penn.) Kevin Burgess (TAMU) From industry: Scott May (Eli Lilly) Johan Wennerberg (DuPont) Kevin Campos (Merck) Ian Lennon (Dowpharma) Fred Hancock (Johnson Matthey Catalysis) Michel Guillaume (Johnson & Johnson) Michael Schwarm (Degussa) Xudong Wei (Boehringer) Surendra Singh (Sepracor) Brian Freer (Chiral Technologies) Benoit Pugin (Solvias)
7 Who? From academia: Steven Nolan (ICIQ, Spain) Barry Trost (Stanford) Xumu Zhang (SUNY, Rutgers) Michael Krische (U. Texas) Mathew Gaunt (U. Cambridge, UK) Erick Carreira (ETH-Zurich) Dean Toste (U. Cal. Berkeley) John Montgomery (U. Michigan) Vadim Soloshonok (U. klohoma) Clark Landis (U. Wisconsin) Patrick Walsh (U. Penn.) Marisa Kozlowski (U. Penn.) Kevin Burgess (TAMU) From industry: Scott May (Eli Lilly) Johan Wennerberg (DuPont) Kevin Campos (Merck) Ian Lennon (Dowpharma) Fred Hancock (Johnson Matthey Catalysis) Michel Guillaume (Johnson & Johnson) Michael Schwarm (Degussa) Xudong Wei (Boehringer) Surendra Singh (Sepracor) Brian Freer (Chiral Technologies) Benoit Pugin (Solvias)
8 Who? From academia: Steven Nolan (ICIQ, Spain) Barry Trost (Stanford) Xumu Zhang (SUNY, Rutgers) Michael Krische (U. Texas) Mathew Gaunt (U. Cambridge, UK) Erick Carreira (ETH-Zurich) Dean Toste (U. Cal. Berkeley) John Montgomery (U. Michigan) Vadim Soloshonok (U. klohoma) Clark Landis (U. Wisconsin) Patrick Walsh (U. Penn.) Marisa Kozlowski (U. Penn.) Kevin Burgess (TAMU) From industry: Scott May (Eli Lilly) Johan Wennerberg (DuPont) Kevin Campos (Merck) Ian Lennon (Dowpharma) Fred Hancock (Johnson Matthey Catalysis) Michel Guillaume (Johnson & Johnson) Michael Schwarm (Degussa) Xudong Wei (Boehringer) Surendra Singh (Sepracor) Brian Freer (Chiral Technologies) Benoit Pugin (Solvias)
9 Michael Krische Formation of C-C bonds via Catalytic Hydrogenation Awarded the Dowpharma prize for Creativity in Chiral Chemistry Can Hydrogenation Intermediates be intercepted and rerouted to products of C-C coupling?
10 Michael Krische Formation of C-C bonds via Catalytic Hydrogenation H 2 Mediated Synthesis of α-hydroxy Esters: JACS 2006, 718. R + Et LnRh + LnRh R H H Et R H LnRh R R H Et R RhLn H Et H R H Et LnRh H R H Et R R LnRh H H H Et R H 2
11 Michael Krische Formation of C-C bonds via Catalytic Hydrogenation Alkyne-Imine H 2 -Coupling: JACS 2007, ASAP Acetylene Couplings: JACS 2006, Unactivated Alkynes Intramolecular Coupling: JACS 2006, Enantioselective Reductive Aldol Coupling
12 Who? From academia: Steven Nolan (ICIQ, Spain) Barry Trost (Stanford) Xumu Zhang (SUNY, Rutgers) Michael Krische (U. Texas) Mathew Gaunt (U. Cambridge, UK) Erick Carreira (ETH-Zurich) Dean Toste (U. Cal. Berkeley) John Montgomery (U. Michigan) Vadim Soloshonok (U. klohoma) Clark Landis (U. Wisconsin) Patrick Walsh (U. Penn.) Marisa Kozlowski (U. Penn.) Kevin Burgess (TAMU) From industry: Scott May (Eli Lilly) Johan Wennerberg (DuPont) Kevin Campos (Merck) Ian Lennon (Dowpharma) Fred Hancock (Johnson Matthey Catalysis) Michel Guillaume (Johnson & Johnson) Michael Schwarm (Degussa) Xudong Wei (Boehringer) Surendra Singh (Sepracor) Brian Freer (Chiral Technologies) Benoit Pugin (Solvias)
13 Brian Freer Chiral Chromatography Discussions with process chemists show a consistent message chromatography is considered to be: Last resort Temporary Solution Inelegant Difficult to use Conference Presentations often include: Benefit is no chromatography Removed expensive chromatography step But, several months to develop a 3 stage asymmetric route using metal catalysis (higher variable and fixed costs) to give 50% yield. Chiral chromatography would have give an overall enantiomer yield of 45%
14 Brian Freer Chiral Chromatography To date 6 drugs are produced at multi-tonne scale. DAICEL (Japan): SMB multi-tonne production of a chiral drug. UCB (Belgium): Chiral SMB multi-tonne production of 2 drugs. Honeywell/SAFC (Ireland): Chiral SMB system > 10 MTA Productivity vs. Scale 50 mm column (diameter) for 12 kg enantiomer/week Upto 800 mm column for 2020 kg enantiomer/week. Success rate = 75% Guaranteed yield = 90% (per enantiomer)
15 Who? From academia: Steven Nolan (ICIQ, Spain) Barry Trost (Stanford) Xumu Zhang (SUNY, Rutgers) Michael Krische (U. Texas) Mathew Gaunt (U. Cambridge, UK) Erick Carreira (ETH-Zurich) Dean Toste (U. Cal. Berkeley) John Montgomery (U. Michigan) Vadim Soloshonok (U. klohoma) Clark Landis (U. Wisconsin) Patrick Walsh (U. Penn.) Marisa Kozlowski (U. Penn.) Kevin Burgess (TAMU) From industry: Scott May (Eli Lilly) Johan Wennerberg (DuPont) Kevin Campos (Merck) Ian Lennon (Dowpharma) Fred Hancock (Johnson Matthey Catalysis) Michel Guillaume (Johnson & Johnson) Michael Schwarm (Degussa) Xudong Wei (Boehringer) Surendra Singh (Sepracor) Brian Freer (Chiral Technologies) Benoit Pugin (Solvias)
16 Benoit Pugin New Ligands for Asymmetric Catalytic Hydrogenation New Ferrocenyl Diphosphine Ligands in the Solvias Pipeline
17 Benoit Pugin New Ligands for Asymmetric Catalytic Hydrgenation Monophos (DSM) - TN > ee 90% - currently used in production! De Vries et al., Chem. Eur. J. 2006, 12, 4722.
18 0Who? From academia: Steven Nolan (ICIQ, Spain) Barry Trost (Stanford) Xumu Zhang (SUNY, Rutgers) Michael Krische (U. Texas) Mathew Gaunt (U. Cambridge, UK) Erick Carreira (ETH-Zurich) Dean Toste (U. Cal. Berkeley) John Montgomery (U. Michigan) Vadim Soloshonok (U. klohoma) Clark Landis (U. Wisconsin) Patrick Walsh (U. Penn.) Marisa Kozlowski (U. Penn.) Kevin Burgess (TAMU) From industry: Scott May (Eli Lilly) Johan Wennerberg (DuPont) Kevin Campos (Merck) Ian Lennon (Dowpharma) Fred Hancock (Johnson Matthey Catalysis) Michel Guillaume (Johnson & Johnson) Michael Schwarm (Degussa) Xudong Wei (Boehringer) Surendra Singh (Sepracor) Brian Freer (Chiral Technologies) Benoit Pugin (Solvias)
19 Xumu Zhang - Innovative Phosphines for Regioselective and Enantioselective Hydroformylation Yan, Y.; Zhang, X. J. Am. Chem. Soc. 2006, 128, 7198.
20 A New Future Project Maybe? asymmetric allylic substitution asymmetric hydroboration Easy synthesis Fast screening
21 What, Why & How many? 234 th ACS National Meeting (19-23 August, Boston) What? What? A five day conference and exhibition. The biggest chemistry meeting in America, and probably in the world. Why did I attend? How many? To learn about the latest research in my field, and others. To get new ideas. To revel in the atmosphere that is created by the presence of thousands of graduate students/professors/chemists under a single roof! total registrants students. 324 exhibitors papers presented. 844 half-day oral sessions. 97 poster sessions.
22 Who? George Whitesides (Harvard) Scott Denmark (UIUC) Masakatsu Shibasaki (U. Tokyo) Elias J. Corey (Harvard) Hisashi Yamamoto (U. Chicago) David Macmillan (Princeton U.) Scott Schaus (Boston U.) Samuel Danishefsky (Columbia) Kevin Campos (Merck) Yoshinori Yamamoto (Tohoku U., Japan) Amir Hoveyda (Boston College) Vladimir Birman (Washington U.) Phil Baran (Scripps) Amos Smith (U. Penn.) Dale Boger (Scripps) Gregory Fu (MIT) John Hartwig (UIUC) Michael Krische (U. Texas) Student Speakers Student Posters Exposition
23 Who? George Whitesides (Harvard) Scott Denmark (UIUC) Masakatsu Shibasaki (U. Tokyo) Elias J. Corey (Harvard) Hisashi Yamamoto (U. Chicago) David Macmillan (Princeton U.) Scott Schaus (Boston U.) Samuel Danishefsky (Columbia) Kevin Campos (Merck) Yoshinori Yamamoto (Tohoku U., Japan) Amir Hoveyda (Boston College) Vladimir Birman (Washington U.) Phil Baran (Scripps) Amos Smith (U. Penn.) Dale Boger (Scripps) Gregory Fu (MIT) John Hartwig (UIUC) Michael Krische (U. Texas) Student Speakers Student Posters Exposition
24 Who? George Whitesides (Harvard) Scott Denmark (UIUC) Masakatsu Shibasaki (U. Tokyo) Elias J. Corey (Harvard) Hisashi Yamamoto (U. Chicago) David Macmillan (Princeton U.) Scott Schaus (Boston U.) Samuel Danishefsky (Columbia) Kevin Campos (Merck) Yoshinori Yamamoto (Tohoku U., Japan) Amir Hoveyda (Boston College) Vladimir Birman (Washington U.) Phil Baran (Scripps) Amos Smith (U. Penn.) Dale Boger (Scripps) Gregory Fu (MIT) John Hartwig (UIUC) Michael Krische (U. Texas) Student Speakers Student Posters Exposition
25 Scott Denmark - Lewis Base Activation of Lewis Acids CN R R LDA, TBSCl THF TBS N C R R chiral Bronsted acid N PG KF NaHC 3 PG HN CN R R R' H * P H VAPL/VANL P * N S CF 3 H Scott Denmark, Unpublished results.
26 Who? George Whitesides (Harvard) Scott Denmark (UIUC) Masakatsu Shibasaki (U. Tokyo) Elias J. Corey (Harvard) Hisashi Yamamoto (U. Chicago) David Macmillan (Princeton U.) Scott Schaus (Boston U.) Samuel Danishefsky (Columbia) Kevin Campos (Merck) Yoshinori Yamamoto (Tohoku U., Japan) Amir Hoveyda (Boston College) Vladimir Birman (Washington U.) Phil Baran (Scripps) Amos Smith (U. Penn.) Dale Boger (Scripps) Gregory Fu (MIT) John Hartwig (UIUC) Michael Krische (U. Texas) Student Speakers Student Posters Exposition
27 Hisashi Yamamoto - Design of Super Bronsted Acids
28 Hisashi Yamamoto - Even More Acidic Systems?
29 Who? George Whitesides (Harvard) Scott Denmark (UIUC) Masakatsu Shibasaki (U. Tokyo) Elias J. Corey (Harvard) Hisashi Yamamoto (U. Chicago) David Macmillan (Princeton U.) Scott Schaus (Boston U.) Samuel Danishefsky (Columbia) Kevin Campos (Merck) Yoshinori Yamamoto (Tohoku U., Japan) Amir Hoveyda (Boston College) Vladimir Birman (Washington U.) Phil Baran (Scripps) Amos Smith (U. Penn.) Dale Boger (Scripps) Gregory Fu (MIT) John Hartwig (UIUC) Michael Krische (U. Texas) Student Speakers Student Posters Exposition
30 The Schaus Group - Asymmetric Boration with Chiral Diols First General Catalytic Asymmetric Petathesis Reaction
31 The Schaus Group - Asymmetric Boration with Chiral Diols First General Catalytic Asymmetric Petathesis Reaction R' R H B R' R'' NH R'' + H Et NR'' 2 H C 2 Et R' H R' R B + B R' * H R'H * + H R'H R' B H R'' 2 N C 2 Et * H R' H B R R NR'' 2 Et * H
32 The Schaus Group - Asymmetric Boration with Chiral Diols
33 Who? George Whitesides (Harvard) Scott Denmark (UIUC) Masakatsu Shibasaki (U. Tokyo) Elias J. Corey (Harvard) Hisashi Yamamoto (U. Chicago) David Macmillan (Princeton U.) Scott Schaus (Boston U.) Samuel Danishefsky (Columbia) Kevin Campos (Merck) Yoshinori Yamamoto (Tohoku U., Japan) Amir Hoveyda (Boston College) Vladimir Birman (Washington U.) Phil Baran (Scripps) Amos Smith (U. Penn.) Dale Boger (Scripps) Gregory Fu (MIT) John Hartwig (UIUC) Michael Krische (U. Texas) Student Speakers Student Posters Exposition
34 The Cordova Group - Proline Catalysis (6 posters!)
35 The Take-Home Message It is good to go to conferences because Expand your knowledge of chemistry in your field. Get lots of new ideas/dreams (getting them to work is your problem). Networking. Meet new people. See new places. A lot of fun!
36 All Work And No Play Makes Jack A Dull Boy Philadelphia
37 All Work And No Play Makes Jack A Dull Boy Boston = ACS + Blue Man Show + Restaurants + Bars - Parents + Friends
Hydrogen-Mediated C-C Bond Formation
EPFL - ISIC - LSPN Hydrogen-Mediated C-C Bond Formation History and selected examples The Research of Prof. Michael Krische (University of Texas at Austin) LSPN Group Seminar Mathias Mamboury Table of
Catalytic Oxidation Metal and Non-Metal Systems 26 Hisashi YAMAMOTO (Molecular Catalyst Research Center, Chubu University, Japan)
Program MONDAY, JULY 6, 2015 15:00 17:00 Registration 17:10 17:20 Opening Remarks: Keiji MARUOKA 17:20 18:05 Plenary Lecture 1 Chair: Yasuyuki KITA Asymmetric counteranion directed catalysis (ACDC): a
Direct Catalytic Aldol Reactions
Direct Catalytic Aldol eactions Shibasakiʼs and Trostʼs contributions toward the development of catalytic enolate reactions. Li Li Ln Li ʻThe time has come,ʼ the Walrus said, ʻTo talk of many things: f
The Career of Tristan H. Lambert
The Career of Tristan H. Lambert Jian Rong( 荣健 ) Hu Group Meeting Apr 11, 2016 Tristan H. Lambert: Biographical Notes Professional experience 2011-present: Associate Professor, Columbia University 2006-2011:
Stereodivergent Catalysis. Aragorn Laverny SED Group Meeting July
Stereodivergent Catalysis Aragorn Laverny SED Group Meeting July 31 2018 1 Stereodivergent Catalysis In the context of asymmetric synthesis, a stereodivergent process is one that allows access to any given
A Highly Efficient Organocatalyst for Direct Aldol Reactions of Ketones and Aldehydes
A ighly Efficient rganocatalyst for Direct Aldol Reactions of Ketones and Aldehydes Zhuo Tang, Zhi-ua Yang, Xiao-ua Chen, Lin-Feng Cun, Ai-Qiao Mi, Yao-Zhong Jiang, and Liu-Zhu Gong Contribution from the
Palladium-Catalyzed Oxygenation of Unactivated sp 3 C-H Bonds
Palladium-Catalyzed xygenation of Unactivated sp 3 C- Bonds Pd(Ac) 2 5 mol% PhI(Ac) 2 1.1 eq. Pd 2 Ac Desai, L. P.; ull, K. L.; Sanford *, M. S. University of Michigan J. Am. Chem. Soc. 2004, 126, ASAP
Solvias (R)-MeO-BIPHEP Ligand Kit
metals inorganics organometallics catalysts ligands custom synthesis cgm facilities nanomaterials Catalog # 96-3655 Solvias ()- and (S)-Me BIE Ligand Kits for asymmetric hydrogenation and other catalytic
NIH Postdoctoral Scholar Adviser: Professor Barry M. Trost. The University of Michigan, Ann Arbor, MI
Kami L. Hull Current Position Assistant Professor Department of Chemistry University of Illinois at Urbana Champaign Office: (217) 300-0196 600 S. Mathews e-mail: kamihull@illinois.edu Champaign, IL 61821
Axalta s Distinguished Lecture Series at University of Pennsylvania Features Professor Omar Yaghi s Presentation on Metal-organic Frameworks
Axalta s Distinguished Lecture Series at University of Pennsylvania Features Professor Omar Yaghi s Presentation on Metal-organic Frameworks Leading researcher speaks on constructing new chemical structures
Science of Synthesis. Full-text resource for methods in synthetic organic chemistry. Best methods. Best results. Request a free trial:
www.thieme-connect.com Science of Synthesis Full-text resource for methods in synthetic organic chemistry Best methods. Best results. Request a free trial: www.thieme.com/sos Science of Synthesis Science
Regioselective Reductive Cross-Coupling Reaction
Lit. Seminar. 2010. 6.16 Shinsuke Mouri (D3) Regioselective Reductive Cross-Coupling Reaction Glenn C. Micalizio obtained a Ph.D. at the University of Michigan in 2001 under the supervision of Professor
Chapter 14. Principles of Catalysis
Organometallics Study Meeting 2011/08/28 Kimura Chapter 14. Principles of Catalysis 14. 1. General Principles 14.1.1. Definition of a Catalyst 14.1.2. Energetics of Catalysis 14.1.3. Reaction Coordinate
Communicating Research to the General Public
Communicating Research to the General Public At the March 5, 2010 UW-Madison Chemistry Department Colloquium, Prof. Bassam Z. Shakhashiri, the director of the Wisconsin Initiative for Science Literacy
BOSS XVI. Programme. Sunday July 8, :30 Registration. 17:00 Opening
Sunday July 8, 2018 14:30 Registration 17:00 Opening Session Chairs: Prof. Paul KNOCHEL (LUDWIG MAXIMILIANS UNIVERSITY, Munich, Germany) Prof. Gwilherm EVANO (ULB, Brussels, Belgium) Prof. Guido VERNIEST
Chiral Quest Technology for Asymmetric Hydrogenation Applications and Gaps
Chiral Quest Technology for Asymmetric Hydrogenation Applications and Gaps Dr Ian C. Lennon Senior Vice President, Global Business Development Chiral Quest Corp., Cambridge, UK ilennon@chiralquest.com
Abstract Process Economics Program Report 232 CHIRAL INTERMEDIATES (March 2001)
Abstract Process Economics Program Report 232 CHIRAL INTERMEDIATES (March 2001) Chiral chemicals are a unique class of compounds that, although chemically identical, exist as mirror images of each other
Stereoselective Organic Synthesis
Stereoselective rganic Synthesis Prabhat Arya Professor and Leader, Chemical Biology Program Dean, Academic Affairs, Institute of Life Sciences (An Associate Institute of University of yderabad Supported
Career Review of Dean Toste I. 2015/9/9 Zhi Ren
Career Review of Dean Toste I 2015/9/9 Zhi Ren Introduction F. Dean Toste, now in UC Berkeley Career: Full Professor since 2009-now Associate Professor 2006-2009 Assistant Professor 2002-2006 Faculty Scientist
Chem 253 Problem Set 7 Due: Friday, December 3, 2004
Chem 253 roblem Set 7 ue: Friday, ecember 3, 2004 Name TF. Starting with the provided starting material, provide a concise synthesis of. You may use any other reagents for your synthesis. It can be assumed
Science of Synthesis. Full-text resource for methods in synthetic organic chemistry. Best methods. Best results. Request a free trial:
www.thieme-connect.com Science of Synthesis Full-text resource for methods in synthetic organic chemistry Best methods. Best results. Request a free trial: www.thieme.com/sos Science of Synthesis Science
Non-Enzymatic Enantioselective Polyene Cyclizations. Adam Hill Chem 535 May, 2 nd 2013
Non-Enzymatic Enantioselective Polyene Cyclizations Adam Hill Chem 535 May, 2 nd 2013 Enantioselective Polyene Cyclization (?) General Method to Rapidly Build Molecular Complexity (+) Exquisite Stereo-
Chiral Ionic Liquids (CILs) in Asymmetric Synthesis: The story so far.
Chiral Ionic Liquids (CILs) in Asymmetric Synthesis: The story so far. Literature Presentation Aman Desai 06.16.06 1. Angew. Chem. Int. Ed. 2006, 45, 3689 2. Angew. Chem. Int. Ed. 2006, 45, 3093 3. Tetrahedron:
Iron Catalysis in Organic Synthesis Multitasking Champion. Current literature Andrey Kuzovlev
Iron Catalysis in Organic Synthesis Multitasking Champion Current literature Andrey Kuzovlev 02.03.2017 Introduction Readily available, cheap, relatively nontoxic, 1.300 ppm residual iron is acceptable
Planar-Chiral Phosphine-Olefin Ligands Exploiting a (Cyclopentadienyl)manganese(I) Scaffold to Achieve High Robustness and High Enantioselectivity
Planar-Chiral Phosphine-Olefin Ligands Exploiting a (Cyclopentadienyl)manganese(I) Scaffold to Achieve High Robustness and High Enantioselectivity Reporter: Cong Liu Checker: Hong-Qiang Shen Date: 2017/02/27
Catalytic Asymmetric Total Syntheses of Quinine and Quinidine
Catalytic Asymmetric Total Syntheses of Quinine and Quinidine 8 7 9 2 1 3 4 6 5 7 9 8 2 1 3 4 6 5 Quinine Zhensheng Ding Quinidine January 22 2004 Chinese ew Year Day 1. Jacobsen, E.,. J. Am. Chem. Soc.
Chiral Bronsted Acids as Catalysts
Chiral Bronsted Acids as Catalysts Short Literature Seminar 6/3/08 Dustin aup BIL Derived osphoric Acids - First reported in 1992 as a ligand by irrung and coworkers. 4 h 2 irrung Tet. Lett. 1992, 33,
Asymmetric Synthesis of Medium-Sized Rings by Intramolecular Au(I)-Catalyzed Cyclopropanation
Asymmetric Synthesis of Medium-Sized ings by Intramolecular Au(I)-Catalyzed Cyclopropanation 1 2 Iain D. G. Watson, Stefanie itter, and F. Dean Toste JACS, ASAP, 1/22/2009 DI: 10.1021/ja8085005 2.5 mol%
Science of Synthesis Full-text resource for methods in synthetic organic chemistry Best methods. Best results.
www.thieme-connect.com Full-text resource for methods in synthetic organic chemistry Best methods. Best results. The log-in to MySoS enables you to save personal settings, search queries and manually revised
Journal Club Presentation by Remond Moningka 04/17/2006
β-alkyl-α-allylation of Michael Acceptors through the Palladium-Catalyzed Three-Component Coupling between Allylic Substrate, Trialkylboranes, and Activated lefins Yoshinori Yamamoto, et al. J. rg. Chem.
Recent Developments in Alkynylation
--New approaches to introduce an alkynyl group Reporter: Zhao-feng Wang Supervisor: Yong Huang 2013-03-27 Contents 1. Introduction of Acetylene Chemistry 2. Nucleophilic alkynylation : Classic text book
BOSS XV. Programme. Sunday July 10, :30 Registration. 17:00 Opening
Sunday July 10, 2016 14:30 Registration 17:00 Opening Prof. Bert U.W. MAES (UNIVERSITY OF ANTWERP, Antwerp, Belgium) 17:10 L01 - Perspectives in Chemistry: From Supramolecular Chemistry to Adaptive Chemistry
ChiralIonic Liquids. An Adolescent Technology. Jeremy Henle 1/24/12
ChiralIonic Liquids An Adolescent Technology Jeremy Henle 1/24/12 Strategies in Asymmetric Synthesis Chiral Induction Starting Materials Chiral Catalysts Chiral Solvents Enantioenriched Chiral Auxillaries
II. Special Topics IIA. Enolate Chemistry & the Aldol Reaction
P. Wipf - Chem 2320 1 3/20/2006 II. Special Topics IIA. Enolate Chemistry & the Aldol Reaction Boger Notes: p. 147-206 (Chapter VIII) Carey/Sundberg: B p. 57-95 (Chapter B 2.1) Problem of the Day: Wang,
NIH Postdoctoral Scholar Adviser: Professor Barry M. Trost. The University of Michigan, Ann Arbor, MI
Kami L. Hull Current Position Assistant Professor Department of Chemistry University of Illinois at Urbana Champaign Office: (217) 300-0196 600 S. Mathews e-mail: kamihull@illinois.edu Champaign, IL 61821
Enantioselective Borylations. David Kornfilt Denmark Group Meeting Sept. 14 th 2010
Enantioselective Borylations David Kornfilt Denmark Group Meeting Sept. 14 th 2010 30.000-foot View Enantioenriched Organoboranes What to do with them Crudden C. M. et. al., Eur. J. Org. Chem. 2003, 46
Total synthesis of Spongistatin
Literature Semminar 1. Introduction: Total synthesis of Spongistatin Chen Zhihua (M2) Isolation: Pettit et al. J. rg. Chem. 1993, 58, 1302. Kitagawa et al. Tetrahedron Lett. 1993, 34, 1993. Fusetani et
Bifunctional Asymmetric Catalysts: Design and Applications. Junqi Li CHEM Sep 2010
Bifunctional Asymmetric Catalysts: Design and Applications Junqi Li CHEM 535 27 Sep 2010 Enzyme Catalysis vs Small-Molecule Catalysis Bronsted acid Lewis acid Lewis acid Bronsted base Activation of both
Short Literature Presentation 10/4/2010 Erika A. Crane
Copper-Catalyzed Enantioselective Synthesis of trans-1- Alkyl-2-substituted Cyclopropanes via Tandem Conjugate Additions-Intramolecular Enolate Trapping artog, T. D.; Rudolph, A.; Macia B.; Minnaard, A.
PhD research with Prof. Lutz H. Gade at the Univ. of Strasbourg. Postdoc in 2003 with Andreas Pfaltz (Basel Switzerland)
idium-catalyzed Asymmetric Isomerization of rimary Allylic Alcohols Mantilli, L., Gerard, D., Torche, S., Besnard, C., Mazet * C. Angew. Chem. Int. Ed., 2009, 48, 1-6 1,n-Glycols as Dialdehyde Equivalents
Asymmetric Hydrogenation: A Sustainable Technology for Pharmaceutical Manufacture
Asymmetric Hydrogenation: A Sustainable Technology for Pharmaceutical Manufacture Presentation for the RSC Symposium 2016: Survival in the Speciality Chemicals Industry 1 st June 2016 Dr Ian C. Lennon
Nucleophilic Heterocyclic Carbene Catalysis. Nathan Werner Denmark Group Meeting September 22 th, 2009
Nucleophilic Heterocyclic Carbene Catalysis Nathan Werner Denmark Group Meeting September 22 th, 2009 Thiamine Thiamine Vitamin B 1 The first water-soluble vitamin described Is naturally synthesized by
The Vinylogous Aldol Reaction
The Vinylogous Aldol Reaction Reporter: Sixuan Meng Supervisor: Prof. Huang 2013-09-09 Zanardi, F. et al. Chem. Rev. 2000, 100, 1929 Zanardi, F. et al.. Chem. Rev. 2011, 111, 3076 Introduction 2 3 Regiochemical
Domino Reactions in Total Synthesis! Reporter: Tianhe Yang! Supervisors: Prof. Yang! Prof. Chen! Prof. Tang!
1! Domino Reactions in Total Synthesis! Reporter: Tianhe Yang! Supervisors: Prof. Yang! Prof. Chen! Prof. Tang! 2! utline! 1. Brief Introduction! 2. ucleophilic Dominoes! 3. Electrophilc Dominoes! 4. Radical
Recent applications of chiral binaphtholderived phosphoric acid in catalytic asymmetric reactions
Recent applications of chiral binaphtholderived phosphoric acid in catalytic asymmetric reactions 1. Seayad, J.; Seayad, A. M.; List, B. J. Am. Chem. Soc. 2006, ASAP. 2. Storer, R. L.; Carrera, D. E.;
Catalytic Enantioselective Diels-Alder Reactions Chwee T.S 1 and Wong M.W 2
Catalytic Enantioselective Diels-Alder Reactions Chwee T.S 1 and Wong M.W 2 Department of Chemistry,Faculty of Science, National University of Singapore 10 Kent Ridge Road, Singapore 117546 Abstract Theoretical
Lecture 6: Transition-Metal Catalysed C-C Bond Formation
Lecture 6: Transition-Metal Catalysed C-C Bond Formation (a) Asymmetric allylic substitution 1 u - d u (b) Asymmetric eck reaction 2 3 Ar- d (0) Ar 2 3 (c) Asymmetric olefin metathesis alladium π-allyl
Chiral Brønsted Acid Catalysis
Chiral Brønsted Acid Catalysis Aryl Aryl Aryl Aryl S CF 3 2 P Fe CF 3 CF 3 2 Jack Liu ov. 16, 2004 CF 3 Introduction Chiral Brønsted acid catalysis in nature: enzymes and peptides Chiral Brønsted acid
Homogeneous Catalysis - B. List
omogeneous Catalysis - B. List 2.2.2 Research Area "rganocatalytic Asymmetric α-alkylation of Aldehydes" (B. List) Involved:. Vignola, A. Majeed Seayad bjective: α-alkylations of carbonyl compounds are
Microscopy, topological states of matter, graphene and low dimensional materials, solid state realizations of quantum information processing.
Monica T. Allen CONTACT INFORMATION RESEARCH INTERESTS 476 Lomita Mall, Stanford University E-mail: mtallen@stanford.edu Stanford, CA 94305-4045 Web: http://web.stanford.edu/ mtallen Microscopy, topological
Suggested solutions for Chapter 41
s for Chapter 41 41 PBLEM 1 Explain how this synthesis of amino acids, starting with natural proline, works. Explain the stereoselectivity of each step after the first. C 2 C 2 3 CF 3 C 2 2 Pd 2 C 2 +
2003 National Name Exchange Annual Report
2003 National Name Exchange Annual Report Executive Summary 28 th annual meeting Hilton, University of Florida Conference Center April 16, 2004 Hosted by the University of Florida http://www.grad.washington.edu/nameexch/national/
Morita Baylis Hillman Reaction. Aaron C. Smith 11/10/04
Morita Baylis Hillman Reaction Aaron C. Smith 11/10/04 Outline 1. Background 2. Development of Asymmetric Variants 3. Aza-Baylis Hillman Reaction 4. Applications of Baylis Hillman Adducts Outline 1. Background
Phosphine-Catalyzed Formation of Carbon-Sulfur Bonds: Catalytic Asymmetric Synthesis of gamma-thioesters
Phosphine-Catalyzed Formation of Carbon-Sulfur Bonds: Catalytic Asymmetric Synthesis of gamma-thioesters The MIT Faculty has made this article openly available. Please share how this access benefits you.
Visions In Chemistry Symposium - sanofi-aventis and NJ-ACS. [ registration directions history schedule ]
![Visions In Chemistry Symposium - sanofi-aventis and NJ-ACS. [ registration directions history schedule ]](/thumbs/78/77908523.jpg "Visions In Chemistry Symposium - sanofi-aventis and NJ-ACS. [ registration directions history schedule ]")
[ registration directions history schedule ] i s p r o u d t o p r e s e n t t h e 2 0 0 8 V ISIONS I N CHEMISTRY S Y M P O S I U M o n T h u r s d a y, M a y 1 5, 2 0 0 8 a t t h e R a r i t a n V a l
Sept 2012 Ph.D., organic chemistry UC Irvine Prof. Elizabeth R. Jarvo, advisor
BUCK L. H. TAYLOR Department of Chemistry Carleton College 1 North College St. Northfield, MN 55057 btaylor@carleton.edu http://bucktaylor.weebly.com/ Education Sept 2012 Ph.D., organic chemistry UC Irvine
Chiral Catalyst II. Palladium Catalysed Allylic Displacement ( -allyl complexes) 1. L n Pd(0) 2. Nuc
Chiral Catalyst II ast lecture we looked at asymmetric catalysis for oxidation and reduction Many other organic transformations, this has led to much investigation Today we will look at some others...
A Stereoselective Synthesis of (+)-Gonyautoxin 3
A Stereoselective Synthesis of (+)-Gonyautoxin 3 Mulcahy, J. V.; Du Bois, J. J. Am. Chem. Soc. 2008, 130, 12630-12631 Total Synthesis of (+)-Lithospermic Acid by Asymmetric Intramolecular Alkylation via
Pavel Kočovský Outline of Research
Pavel Kočovský Outline of Research Credo: For those who seek to discover new reactions, the most insightful lessons come from trying to trace important reactivity principles back to their origins. (K.
Rhodium Catalyzed Alkyl C-H Insertion Reactions
Rhodium Catalyzed Alkyl C-H Insertion Reactions Rh Rh Jeff Kallemeyn 5/17/05 1. Cyclopropanation The Versatile and Reactive Rhodium Carbene R + Et Rh 2 (Ac) 4 R C 2 Et N 2 2. [2,3] sigmatropic rearrangement
The Story of Hyperforin Exploring Path to Concise Synthesis
Exploring Path to Concise Synthesis Presenter: Advisor: Prof. Dong The University of Texas at Austin If a man keeps cherishing his old knowledge, so as continually to be acquiring new, he may be a teacher
H Organometallic Catalysis in Industry
H Organometallic Catalysis in Industry Some terminology: Catalytic cycles: a circular path meant to show productive reactions, in order, that lead from the catalytically active species and its reaction
Chemistry 335 Supplemental Slides: Interlude 1. Reduction: addition of hydrogen to the substrate. Oxidation: addition of oxygen to the substrate
Interlude 1: Oxidations, Reductions & Other Functional Group Interconversions (FGI) 1. Definition of Oxidation and Reduction For practical purposes in organic chemistry, oxidation and reduction are defined
Rhodium Catalyzed Hydroacylation
Literature Report Changbin Yu 2012-12-04 检查 : 蔡先锋 Rhodium Catalyzed ydroacylation Vy M. Dong* Education h.d. California Institute of Technology, 2004 M.S. University of California at Berkeley, 2000 BS
Short Access to (+)-Lupinine and (+)-Epiquinamide via Double Hydroformylation
Short Access to (+)-Lupinine and (+)-Epiquinamide via Double Hydroformylation Kai Gao Checker: Changbin Yu Mann, A.* et al rg. Lett. 2009, ASAP Strategy for the formation of quinolizidine alkaloids R H
Thieme Chemistry E-Books
www.thieme-connect.com/chemistry-ebooks Thieme Chemistry E-Books SERIES Science of Synthesis Houben-Weyl MONOGRAPHS Protecting Groups Spectroscopic Methods Synthetic Methods of Organometallic and Inorganic
Additions to Metal-Alkene and -Alkyne Complexes
Additions to tal-alkene and -Alkyne Complexes ecal that alkenes, alkynes and other π-systems can be excellent ligands for transition metals. As a consequence of this binding, the nature of the π-system
Oxidative Enolate Coupling in Total Synthesis
Literature Seminar 2010.6.2 Oxidative Enolate Coupling in Total Synthesis Shi-Liang, Shi Appointment April, 2009 Member, Skaggs Institute for Chemical Biology June, 2008 Professor of Chemistry July, 2006
Lewis Base Activation of Lewis Acids: Development of a Lewis Base Catalyzed Selenolactonization
Lewis Base Activation of Lewis Acids: Development of a Lewis Base Catalyzed Selenolactonization Denmark, S.E. and Collins, W.R. rg. Lett. 2007, 9, 3801-3804. C 2 H + Se Lewis Base CH 2 Cl 2 Se Presented
Berkeley Emerging Research Scholars (BERS): Laboratory Research Experience Program. June 26 - August 04, 2017
Berkeley Emerging Research Scholars (BERS): Laboratory Research Experience Program June 26 - August 04, 2017 About the Program Through Dean Douglas S. Clark and the College of Chemistry, Professor Omar
Metal-catalyzed asymmetric hetero-diels-alder reactions of unactivated dienes with glyoxylates
Pure & Appl. Chern., Vol. 70, No. 5, pp. 11 17-1 122, 1998. Printed in Great Britain. (0 1998 IUPAC Metal-catalyzed asymmetric hetero-diels-alder reactions of unactivated dienes with glyoxylates Mogens
AQUEOUS ORGANOMETALLIC CATALYSIS
AQUEOUS ORGANOMETALLIC CATALYSIS Catalysis by Metal Complexes Volume 23 Editors: B. R. James, The University of British Columbia, Vancouver, Canada P. W. N. M. van Leeuwen, University of Amsterdam, The
I. Introduction. Peng Zhao. Liu lab
Asymmetric Total Synthesis of Mycoleptodiscin A Shupeng Zhou, Hao Chen, Yijie Luo, Wenhao Zhang and Ang Li Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai
Iridium-Catalyzed Hydrogenation with Chiral P,N Ligands
Iridium-Catalyzed Hydrogenation with Chiral P, Ligands 贾佳 utline Brief Introduction Hydrogenation of C=C Bonds Hydrogenation of C= Bonds Hydrogenation of C= Bonds Conclusion Brief Introduction First example
David W.C. MacMillan: Career-in-Review. Yan Xu Dong Group Meeting Jan. 2, 2014
David W.C. MacMillan: Career-in-Review Yan Xu Dong Group Meeting Jan. 2, 2014 David W.C. MacMillan: A Brief Introduction Career 1968 Born in Bellshill, Scotland. 1987-1991 Undergraduate degree in chemistry
Ionic Liquids (IL s): An Ionic Liquid-Supported Ruthenium Carbene Complexes for RCM in Ionic Liquids
Ionic Liquids (IL s): An Ionic Liquid-Supported Ruthenium Carbene Complexes for RCM in Ionic Liquids J. Am. Chem. Soc. 2003, 125, 9248-49 Angew. Chem. Int. Ed. 2003, 42, 3395-3398 Literature presentation
Stereoselective reactions of enolates
1 Stereoselective reactions of enolates Chiral auxiliaries are frequently used to allow diastereoselective enolate reactions Possibly the most extensively studied are the Evan s oxazolidinones These are
Asymmetric Carbon-Carbon Bond Formation gamma to a Carbonyl Group: Phosphine-Catalyzed Addition of Nitromethane to Allenes
Asymmetric Carbon-Carbon Bond Formation gamma to a Carbonyl Group: Phosphine-Catalyzed Addition of Nitromethane to Allenes The MIT Faculty has made this article openly available. Please share how this
Asymmetric Synthesis of α-substituted Allyl Boranes and Their Application in the Synthesis of Iso-agatharesinol
Asymmetric Synthesis of αsubstituted Allyl oranes and Their Application in the Synthesis of Isoagatharesinol Yuang Yu Fang and Varinder K. Aggarwal University of ristol, UK Angew. Chem. Int. Ed. 2007,
Stereocontrolled organocatalytic synthesis of prostaglandin PGF 2 in seven steps
Stereocontrolled organocatalytic synthesis of prostaglandin PGF 2 in seven steps Graeme Coulthard, William Erb, Varinder K. Aggarwal Nature. August 15, 2012. DI: 10.1038/nature11411 N C 2 then [Bn 2 N
Research in our group encompasses the following 4 areas in Synthetic Organic Chemistry.
Research in our group encompasses the following 4 areas in Synthetic Organic Chemistry. 1] Development of Asymmetric Catalysis 2] Total Synthesis of Natural products 3] Development of Novel Protecting-Group-Free
Indiana University Office Phone: Assistant Professor, Indiana University, Bloomington, IN
M. KEVIN BROWN Indiana University Office Phone: 812-856-9114 Department of Chemistry e-mail: brownmkb@indiana.edu 800 E. Kirkwood Ave. Bloomington, IN APPOINTMENTS Associate Professor, 2017-present Indiana
ACS Green Chemistry Institute. ACS Green Chemistry Institute
American Chemical Society Advancing Green Chemistry Innovation in the Pharmaceutical Industry: The ACS GCI Pharmaceutical Roundtable s Research Grant Program Julie B. Manley Guiding Green LLC Contracted
Silica-Supported Cationic Gold(I) Complexes as Heterogeneous Catalysts for Regio- and Enantioselective Lactonization Reactions
Silica-Supported Cationic Gold(I) Complexes as Heterogeneous Catalysts for Regio- and Enantioselective Lactonization Reactions Xing-Zhong Shu, Son C. Nguyen,Ying He, Fadekemi Oba, Qiao Zhang, Christian
Palladium-Catalyzed Asymmetric Benzylic Alkylation Reactions
Palladium-Catalyzed Asymmetric Benzylic Alkylation Reactions Reporter: Hong-Qiang Shen Checker: Cong Liu Date: 2016/07/12 Masahiro Miura et al. Angew. Chem. Int. Ed. 2016, 55, 6973. Masahiro Miura Osaka
Xuefeng Jiang Professor Education Academic Career Awards International Invited Lecture USA Germany Shanghai Taiwan Singapore)
Xuefeng Jiang( 姜雪峰 ) Professor East China Normal University, 200062, Shanghai, China Tel: +86-21-52133654 E-mail: xfjiang@chem.ecnu.edu.cn Web: http://faculty.ecnu.edu.cn/s/641/main.jspy Education 1999-2003
Heterogeneous chiral catalysis on surfaces, in nanopores and with emulsions
Prof. Can Li's Laboratory Heterogeneous chiral catalysis on surfaces, in nanopores and with emulsions Chiral catalysis is of great industrial interest for the production of enantiomerically pure compounds.
Functionalization of C(sp 3 ) H Bonds Using a Transient Directing Group
Literature eport Functionalization of C(sp 3 ) Bonds Using a Transient Directing Group eporter: Mu-Wang Chen Checker: Yue Ji Date: 2016-04-05 Yu, J.-Q. et al. Science 2016, 351, 252-256. Scripps esearch
The School of Science and Engineering
The School of Science and Engineering Chemistry Office: 2015 Percival Stern Hall Phone: (504) 865-5573 Fax: (504) 865-5596 Website: http://chem.tulane.edu Professors Larry D. Byers, Ph.D., Princeton Mark
C h a p t e r 1. Enantioselective LUMO-Lowering Organocatalysis. The presentation of the Nobel Prize in 2001 to William S. Knowles, Ryoji Noyori,
1 C h a p t e r 1 Enantioselective LUM-Lowering rganocatalysis. I. Introduction. The presentation of the obel Prize in 2001 to William S. Knowles, Ryoji oyori, and K. Barry Sharpless recognized the influence
Science of Synthesis Workbench Editions Best methods. Best results. New topic: Biocatalysis in Organic Synthesis
www.thieme-chemistry.com Science of Synthesis Workbench Editions Best methods. Best results. New topic: Biocatalysis in Organic Synthesis Science of Synthesis Workbench Editions Multicomponent Reactions
Rising Novel Organic Synthesis
Literature report Rising Novel Organic Synthesis Methods Based on the Cleavage of N-N and N-O Bonds Reporter: Zhang-Pei Chen Checker : Mu-Wang Chen Date: 04/03/2014 Kürti, L. et al. Kürti, L. et al. Science
Literature Report IX. Cho, S. H. et al. Org. Lett. 2016, 18, Cho, S. H. et al. Angew. Chem. Int. Ed. 2017, 56,
Literature Report IX ynthesis of β-aminoboronates by Copper(I)- Catalyzed Addition of Diborylalkanes to Imines Reporter Checker Date : hubo Hu : Xiaoyong Zhai : 2017-9-1818 Cho,. H. et al. rg. Lett. 2016,
Heterogenized Homogeneous Catalysts for Fine Chemicals Production: Materials and Processes
Platinum Metals Rev., 2011, 55, (3), 180 185 Heterogenized Homogeneous Catalysts for Fine Chemicals Production: Materials and Processes Edited by Pierluigi Barbaro and Francesca Liguori (Istituto di Chimica
Hydroboration. Carreira: Chapter 7
ydroboration Carreira: Chapter 7 ydroboration of alkenes/alkynes is one of the most versatile reactions available. Most commonly, the resulting alkyl borane intermediates are not isolated, but are used
Controlled Polymerizations
Wednesday Meeting Controlled Polymerizations 10/15/2014 Ki-Young Yoon Organometallics : A Friend of Total Synthesis Total Synthesis Organometallics e.g. Barry Trost Organometallics : A Friend of Polymer
N-Heterocyclic Carbene Catalysis via Azolium Dienolates: An Efficient Strategy for Enantioselective Remote Functionalizations
Angew. Chem. Int. Ed. 2017, 10.1002. 1 N-Heterocyclic Carbene Catalysis via Azolium Dienolates: An Efficient Strategy for Enantioselective Remote Functionalizations Reporter: En Li Supervisor: Prof. Yong
CHEM 4725/8725 Organometallic Chemistry. Spring 2016
Lecture Time and Location: CHEM 4725/8725 Organometallic Chemistry Spring 2016 11:15 am - 12:30 pm Tuesdays and Thursdays 111 Smith Hall Instructor: Prof. Ian A. Tonks 568A Kolthoff Hall Phone: 612.624.4705
Multicatalyst Promoted Asymmetric Tandem Reactions
Literature presentation Kishor Mohanan Multicatalyst Promoted Asymmetric Tandem Reactions Features of Tandem Catalysis Reduces the yield losses associated with the purification of intermediates, Save time,
The Synthesis of Molecules Containing Quaternary Stereogenic Centers via the Intramolecular Asymmetric Heck Reaction
The Synthesis of Molecules Containing Quaternary Stereogenic Centers via the Intramolecular Asymmetric Heck Reaction Reported by Eric P. Gillis April 19, 2007 INTRODUCTION The enantioselective synthesis