Curriculum Vitae. Personal Information. Education

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1 Curriculum Vitae Dr. Balakrishna Dulla Doctoral Research Fellow Institute of Organic Chemistry University of Regensburg D Regensburg, Germany Personal Information Date of birth: July 31, 1985 Nationality: Indian Marital status: Unmarried Education Ph.D. in Organic & Medicinal Chemistry, / University of Regensburg (Regensburg, Germany, In collaboration with DR. Reddy s Institute of Life Sciences, University of Hyderabad, INDIA)) Advisors: Prof. Dr. Oliver Reiser Prof. Dr. Javed Iqbal Ph.D. thesis title: Synthesis & pharmacological characterization of novel N & O containing Heterocyclic compounds as Potential Therapeutic agents. Grade: Magna cum laude Research trainee, / Dr. Reddy s Institute of Life Sciences, University of Hyderabad, INDIA Chemistry faculty, / System Degree & Junior Collage, Srikakulam, Andhra University, INDIA M.Sc. in Organic Chemistry, / Andhra University (Andhra Pradesh, India) Grade: Distinction B.Sc. in Chemistry, / Sri. G.C.S.R Collage (Rajam, Andhra Pradesh) Andhra University (Andhra Pradesh, India) Grade: Silver Medal (Secure 2 nd Place)

2 Research Experience University of Hyderabad, /30-04/2010 Dr. Reddy s Institute of Life Sciences; Research trainee with Prof. Dr. Javed Iqbal (Former Director of Dr. Reddy s Institute of Life Sciences) Designed and completed total synthesis (16 steps) of fragment of Roseophilin Investigated on design, synthesis and evaluation of 3-guanidine aryl oxazole as a novel class of LSD1 inhibitors with anti-proliferative activity in vitro and in vivo. Design and synthesis of novel Indanone Indoles with anti cancer activity. Developed unique novel methodology for synthesis of benzoxazole, Benzoimidazole University of Regensburg, / Institute of Organic Chemistry, (INDIGO student): Advisor: Prof. Dr. Oliver Reiser Worked extensively on design, synthesis and pharmacological evaluation of dehydroshikimic acid analogues as anti-tuberculosis agents BASF Ludwigshafen, Germany, /30-11/2010 Internship as INDIGO student: Advisor: Dr. Benoit Blank I was responsible for Organic Synthesis in the field of renewable resources University of Hyderabad, / Dr. Reddy s Institute of Life Sciences; Junior Research Fellow with Prof. Dr. Javed Iqbal (Former Director of Dr. Reddy s Institute of Life Sciences) Investigated on synthesis of novel drug-like scaffolds by diastereoselective intra- molecular Aza-Diels-Alder cyclization based on α-amino acid and vanillin precursors. Regioselective Intramolecular 1,3-dipolar Cycloadditions of Isovanillin derived Nitrones: Transformation into Oxazepine Containing Tricyclic Scaffolds. University of Hyderabad, / Dr. Reddy s Institute of Life Sciences; Senior Research Fellow with Dr. Marina S. Rajadurai Investigating fluorescent saccharide sensors as potential tool for the diagnosis of carbohydrate metabolism disorders & Organic Nano-Vesicular Cargoes for Sustained Drug Delivery Teaching Experience Chemistry faculty, / and / Trained students for GATE-CY, CSIR-NET, IIT-JEE, MEDICAL, HYDERABAD CENTRAL UNIVERSITY, INDIA VIRAT A Division of Viratian Educational Services Pvt. Ltd., 16-01/2014-Present IIT-JEE, MEDICAL Entrance Coaching Centre: Head of the Chemistry Dept. Sambalpur Odisha, Training students for GATE, CSIR-NET, IIT-JEE, MEDICAL entrance exams in Chemistry subject Supervised two undergraduate and two master students during their research projects at the University of Hyderabad, University of Regensburg, Germany

3 Research area/ interest Skills Total synthesis: Design of novel strategies for natural products, hybrids of natural products Organo catalysis: Design of novel Organo catalysts with stereo specific applications Photo chemistry & Nano chemistry: Applications of Organo catalysts in total synthesis using Photochemistry Strong background and extensive experience with the analytical techniques; NMR, HPLC, IR, LCMS, Elemental analysis and Cyclic voltammeter. Hands on experience on various purification techniques: Column chromatography, TLC, GC. Well versed in handling the air/moisture sensitive reagents and Organ metallic reactions. Fluorescence spectrometer (Perkin Elmer, Cary Eclipse, Edinburgh Instruments), UV spectrophotometer (JASCO, C a r y ). Software Publishing: MS Office (Word, PowerPoint, and Excel) Endnote Adobe Illustrator Adobe Photoshop. Scientific: HyperChem Chemdraw profit Origin Messtrack, SciFinder, Software related to abovementioned instruments Scholarships and Awards Senior Research fellowship of Department of Science & Technology, India-2013 Junior Research fellowship of Department of Science & Technology, India Fellowship of the Council of Scientific and Industrial Research (CSIR) (for Ph.D. in India) Have qualified Graduate Aptitude Test in Engineering (GATE) (for Ph.D. in India) Secured 4.0 points in Summer semester 2010, Organic chemistry Modern Synthetic Methods (6. sem) (53162, 4 st.) at University of Regensburg, Germany. INDIGO Graduate Program Fellowship by the Indian-German Graduate School (INDIGO) for "Advanced Organic Synthesis for a Sustainable Future (Regensburg, Germany 2010). Gold Medal: Master of Sciences with % in Organic Chemistry, Rajah R.S.R.K. Ranga Rao P.G College, Andhra University, India. Silver Medal: Bachelor of Sciences with % in Chemistry, Sri. G. C. S. R Degree College, Andhra University, India. Discussion Leader in 3 rd INDIGO Ph.D. Research Conference and Intensive Course "Sustainable chemistry", conducted by IIT Madras, Chennai, India, February 12-16, 2012.

4 Research Publications 1. Balakrishna Dulla, Baojie Wan, Scott G. Franzblau, Ravikumar Kapavarapu, Oliver Reiser*, Javed Iqbal*, Manojit Pal* Construction and functionalization of fused pyridine ring leading to novel compounds as potential antitubercular agents Bioorg. Med. Chem. Lett., 2012, 12, doi: /j.bmcl Epub 2012 Jun Javed Iqbal*, Neelima Tangellamudi*, Balakrishna Dulla, Sridhar Balasubramanian Novel synthesis of 2H-benzo[b][1,4]oxazines from 2,5 dihydroxy benzaldehyde and Aminoacid precursors Org. Lett. 2012, 14, doi: /ol Epub 2012 Jan D. R. Gorja, K. Shiva Kumar, B. Dulla, K. Mukkanti and M. Pal Pd/C-mediated Alkynylation of Indazoles: Synthesis and Pharmacological Evalution of Mono & Dialkynyl-substituted Indazoles J. Heterocyclic Chemistry, 2012, 51, doi: /jhet Balakrishna Dulla, Vandana Rathore, Girdhar Singh Deora, Krishna Tulasi, Kiranam Chetti, Oliver Reiser*, Javed Iqbal*, Manojit Pal* Synthesis and Pharmacological evolution of novel 3- guanidine phenyl oxazoles as LSD1 protein inhibitors for the potential treatment of Cancer Org. Biomol. Chem. 2013, 11, doi: /c3ob40217g 5. Rambabu Dandela, Balakrishna Dulla, P. Radha Krishna, M. V. Basaveswara Rao, Manojit Pal a, * Amberlyst-15 Catalyzed synthesis of 2-substituted 1,3-benzazoles in water under ultrasound Synthetic Communications. 2013, 00, 000. doi: / Balakrishna Dulla, S. Vijayavardhini, D. Rambabu, V. Radha, M. Basaveswara Rao, Manojit Pal* Catalyst / surfactant free chemoselective acylation of amines in water Current Green Chemistry 2013, 1, doi: / Balakrishna Dulla, E. Sailaja b, Upendar Reddy. Ch, Madhu Aeluri, Arunasree M. Kalle, Manojit Pal* Synthesis of indole based novel small molecules and their in vitro anti-proliferative effects on various cancer cell lines. Tetrahedron Lett. 2014, 55, doi: /j.tetlet Balakrishna Dulla, Sunder Kumar Kolli, Upendar Reddy CH, Giridhar Singh Deora, R. Ramesh Raju, c, * Manojit Pal a, * Pd/C-mediated arylation followed by I 2 -catalyzed hydration strategy: Preparation of functionalized novel indanone derivatives Synthetic Communications. 2014, 44, 10.

5 9. Balakrishna Dulla, Neelima D. Tangellamudi*, Sridhar Balasubramanian, Swapna Yellanki, Raghavender Medishetti, Pushkar Kulkarni,* Javed Iqbal,* Oliver Reiser,* and Manojit Pal* Isovanillin derived N-(un)substituted hydroxylamines possessing an o-allylic group: valuable precursors to bioactive N-heterocycles Org. Biomol. Chem. 2014, 12, doi: /C3OB42460J (SELECTED FOR COVER PAGE ARTICLE) 10. Upendar Reddy CH, E. Sailaja, Balakrishna Dulla, Arunasree M. Kalle, S. Bhavani, D. Rambabu, M. V. Basaveswara Rao,* Manojit Pal* Synthesis and in vitro anti-proliferative effects of 3-(hetero)aryl substituted 3-[(prop-2-ynyloxy) (thiophen-2-yl)methyl]pyridine derivatives on various cancer cell lines. Bioorg. Med. Chem. Lett., 2014, 24, doi: /j.bmcl Epub 2014 Jan Ajay Kumar Botcha, Balakrishna Dulla, E. Ramanjaneya Reddy, Keerthana Sarma Chennubhotla, Pushkar Kulkarni* Rajadurai Chandrasekar* and Marina S. Rajadurai* Synthesis, Self-assembly, Controlling Vesicles Fusion and Terfenadine Loading/Release Studies Journal of Nanotechnology, 2014, Volume 2014, Article ID , Gangadhar C, Balakrishna Dulla, Sivakumat Kota, Manojit Pal* "A simple access to N-(un)substituted isoquinolin-1(2h)-ones: unusual formation of regioisomeric isoquinolin-1(4h)-ones" Chem. Commun., 2014, 50, doi: /c4cc01580k. Patents 1. M. P al, B. Dulla, U. Reddy CH, M. Auleri, J. Iqbal* Novel compounds for cancer treatments Indian patent filed in Feb-2011, ApplicationNumber: 228/CHE/2011. Oral Presentations & Conferences 1. Poster presentation at International Conference on Chemical Biology (ICCB-2014) held at Indian Institute of Chemical Technology, Hyderabad, India, on February, Balakrishna Dulla, Synthesis of dehydroshikimic acid analogues as novel anti-tuberculosis scaffolds 2nd INDIGO Conference conducted in Donaustauf near Regensburg / Germany, October 3-6, Balakrishna Dulla, Novel synthesis of 2H-benzo[b][1,4]oxazines from 2,5-dihydroxy benzaldehyde and Aminoacid precursors 3rd INDIGO Conference conducted by IIT Madras, Chennai, India, February 12-16, th INDIGO Conference conducted in University of Regensburg / Germany, October 6-10, 2013.

6 5. Catalyst Dr. Reddy Chemistry Conclave (International year of Chemistry), December 16-17, The Summer School Medicinal Chemistry GRK 760, Regensburg, Germany, week guest lecturers of Prof. Dr. Ian Fleming at Dr. Reddy s Institute of Life Sciences, Hyderabad, India. (Held during December-2010, 2011, 2012). References Prof. Dr. Oliver Reiser Institute of Organic Chemistry University of Regensburg Universitätsstr. 31, Room: CH D Regensburg, Germany Oliver.Reiser@chemie.uniregensburg.de Phone Prof. Dr Javed Iqbal Former Director Dr. Reddy s Institute of Life Sciences Hyderabad Central University Gachibowli, Hyderabad Andhrapradesh , India prof.javediqbal@gmail.com Phone: Prof. Dr. Manojit Pal Head Organic and Medicinal Chemistry Dr. Reddy s Institute of Life Sciences (An associated Institute of University of Hyderabad) Gachibowli, Hyderabad Andhrapradesh , India manojitp@drils.org Phone: