Supplemental Table 48. Studies reporting the prevalence of rheumatoid arthritis in multiple sclerosis

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1 Supplemental Table 48. Studies reporting the prevalence of rheumatoid in multiple sclerosis Study Region/ Source/ Diagnostic Diagnostic Crude Overall Age- Crude Standardized Quality (Year) Sub-Region Population Day/Period Criteria: MS/ Criteria: Standardized Score Established By Overall / Established By Males Females Males Females Baker 11 Australia/ Patients at NR NR NR NR NR 1/8 (1972) Melbourne the Royal diagnosed: / Melbourne criteria NR Case records and 2/326 = 0.61% Hospital positive serological tests (RF) Barcello United States/ Dataset NR Mailed NR NR NR NR NR 4/9 s 3 California consisting of diagnosed/string questionnaire, (2006) 176 ently ascertained telephone ~2% (index families, and clinically interview cases), ~2% each family characterized (overall cases) with at least multiple 1 index case sclerosis of multiple Raw numbers sclerosis not provided 176 index cases and 386 overall MS cases

2 De England/ Patients at Medical records NR NR NR NR NR 3/8 Keyser 16 London the National diagnosed: Poser (1988) Hospital for 5/828 = 0.60% Nervous Diseases with clinically or laboratory supported definite MS Deretzi Greece/North Neurology Jan 200-Jan NR NR NR NR NR 6/9 19 (2010) department/ 2009 diagnosed: : RRMS McDonald /981 = 0.31% patients administered questionnaire, confirmed by hospitalization records and medical reports Eaton 21 Denmark Hospitalized Administrative NR NR NR NR NR 4/8 (2007) MS data codes population ICD8 ICD-8 43/9,961 = % ICD10 ICD-10 G35 M05 Edwards England/ Outpatient NR MS clinic NR NR NR NR NR 2/8

3 22 (2004) Henders on 27 (2000) Horton 29 (2010) Kang 30 (2010) Nottingham MS clinic database : Registry/Clinical Database/Chart Review Australia/ Royal Initially Queensland Brisbane identified from : Hospital medical records Mailed Department ICD 340, questionnaire of 205/later Neurology/ confirmed Admitted neurologist patients diagnosis (Poser) Canada/ Participants Oct 2008-Oct MacDonald The Self- Manitoba recruited ; diagnosed Administered United States/ from 2 by neurologist at Comorbidity Ohio different MS MS clinic Questionnaire clinics (validated questionnaire). Validated by medical records data. Taiwan NHIRD 2007 ICD-9-CM code ICD-9-CM population, age 15 at least one years hospitalization or two ambulatory claims 2/658 = 0.30% NR NR NR NR NR 4/9 4/117 = 3.42% 2/404= 0.50% NR NR NR NR NR 5/8 by medical records 8/404= 1.98% by questionnaire 29/898 = 3.23% NR NR NR NR NR 4/8

4 Langer- United States/ KPNC Diagnostic codes NR NR NR NR NR 6/8 Gould 33 Northern population December entered by, Juvenile (2010) California 2005 neurologists and rheumatoid 44/5,296 = GPs, MS- : 0.83% specific At least two Juvenile medications, administrative data rheumatoid MRI codes by a (codes/criteria specialist/ KPNC 2/5,296 = not specified) (codes not 0.02% specified) Before MS diagnosis: 2/924 = 0.22% Laroni 34 Italy/ Multiple NR Poser NR NR NR NR NR 5/9 (2006) Veneto Sclerosis : Centre of Medical chart 2/245 = 0.82% Veneto review/interviews/ Region Self Report Marrie 37 United States NARCOMS October 2006 Self-report Online/Mailed NR NR 5/9 a (2008) Registry Survey population 318/8,748 = Marrie 68 (volunteers) 3.64% b (2011) At MS Onset: 55/8,713 =

5 0.63% At MS Diagnosis: 102/8,713 = 1.17% Marrie % ( % 3.0% (2011) 3.4) (1.9- (2.5, 3.4) 4.3) Midgard Norway/ Identified Jan 1, Bauer 3/155 = 1.94% NR NR NR NR NR 6/9 43 Hordaland through two Dec 31, 1986 (1996) County population- Interviews based completed by incidence neurologists studies Ramago Canada 19 MS From Poser and/or NR 30/1, /3,733 = NR NR 5/9 palan 53 Clinics in not specified Macdonald 2005 : = 2.31% 3.29% (2007) Canada Medical chart 153/5031 = review/ 3.04% Standardized administered questionnaires Seyfert 5 Germany/ All patients NR (18 month - NR NR NR NR NR 5/8 (1990) Berlin admitted to follow-up) diagnosed: Poser administered hospital for questionnaire/ 1/101 = 0.99% MS Confirmed by

6 Tremlett 63 (2002) Wynn 65 (1990) Wales United States/ Minnesota Diagnosis of MS recorded after 1993 and registered in database Mayo Clinic clinical records/191 clinically definite cases living in Rochester for at least one year Administrative data codes/ GPMD (code not specified) diagnosed: Poser biological tests and medical records review : Administrative data code Rheumatic diseases: Clinical chart review 5/320 = 1.56% Rheumatic diseases (rheumatoid & ankylosing spondylitis) 1/ 2,905 person years = 0.34% NR NR NR NR NR 6/8 NR NR NR NR NR 5/8 NR: Not Reported, NHIRD: National Health Insurance Research Database, KPNC: Kaiser Permanente Northern California, NARCOMS: North American Research Committee on Multiple Sclerosis. a- Self-reported diagnoses of MS previously validated in random sample of study population against medical records and physician report; b reported in another manuscript using the same study population.

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