3 S. Heidelberg ESBL Extended spectrum lactamase

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1 Vol. 25 No. 123 almonella Heidelberg 1 almonella enterica serovar Heidelberg 1 3. Heidelberg EBL Extended spectrum lactamase CTX M 2 EBL. Heidelberg almonella enterica serovar Heidelberg 1 3. Heidelberg EBL Extended spectrum lactamase CTX M 2 EBL. Heidelberg A 7 21 B A 7 22 A Key words almonella HeidelbergEBL CTX M

2 ,800 mm mm mm 3 CP 6.83 mg dl BUN 9.4 mg dl Cr 0.36 mg dl Na 135 meq l K 3.8 meq l Cl 99 meq l $ 1 HPF 5 9 HPF almonella serogroup O4 CTX M 2 EBL almonella Heidelberg 1 X 4 2 CTX M 2 EBL almonella Heidelberg ABPC PPC CEZ CCL CFPN P CTM CTX CP CAZ CPDX CTX CMZ FMOX MC GM AMK MNO LVFX PM C MEPM FOM T AZT BT ABPC BT CPZ CVA AMPC TAZ PPC MC kg0.16 D 39.5 CP X gasless 1 almonella serogroup O4 192 DP MC192 2 O4 r 1,2. Heidelberg CTX M 2 EBL CTX M 2 2 O157 FOM Fosfomycin calcium 80 mg kg CP FOM

3 Vol. 25 No Heidelberg 1,2 3,4 10. Heidelberg almonella serogroup O almonella serogroup O4. Typhimurium. aintpaul 2. Heidelberg Heidelberg CMY AmpC EBL 7. Enteritidis 8. Newport 9. Heidelberg EBL 10. Heidelberg , ,15 FOM EBL FOM 16,17

4 Han J, et al Comparison of almonella enterica serovar Heidelberg isolates from human patients with those from animal and food sources. J Clin Microbiol , The National Microbiology Laboratory NML and Centre for Food borne, Environmental and Zoonotic nfectious Diseases CFEZD, Public Health Agency of Canada and Provincial Public Health Microbiology Laboratories National Enteric urveillance Program NEP ANNUAL UMMAY 2010 ncluding erotype and Phage Type Tables for 2010, NEP and NML, lnm.gc.ca NEP PNME assets pdf NEP_ 2010_Annual_eport_ENG.pdf 3 Hennessy TW, et al Egg consumption is the principal risk factor for sporadic almonella serotype Heidelberg infections a case control study in FoodNet sites. Clin nfect Dis 38 uppl , Dutil L, et al Ceftiofur resistance in almonella enterica erovar Heidelberg from chicken meat and humans, Canada. Emerg nfect Dis , http: niid ja iasr 510 surveillance iasr graphs 2331 iasrgbak2.html 6 almonella Heidelberg Zhao, et al beta Lactam resistance in salmonella strains isolated from retail meats in the United tates by the National Antimicrobial esistance Monitoring ystem between 2002 and Appl Environ Microbiol , zumiya H, et al dentification of CTX M 14 Lactamase in a almonella enterica erovar Enteritidis solate from Japan. Antimicrob Agents Chemother , almonella Newport Book Currie A, et al Frozen chicken nuggets and strips and eggs are leading risk factors for almonella Heidelberg infections in Canada. Epidemiol nfect , Crump JA, et al Antimicrobial resistance among invasive nontyphoidal almonella enterica isolates in the United tates National Antimicrobial esistance Monitoring ystem, 1996 to Antimicrob Agents Chemother , Burt C, et al Fatal myocarditis secondary to almonella septicemia in a young adult. J Emerg Med , Zhao, et al Antimicrobial resistance in almonella enterica serovar Heidelberg isolates from retail meats, including poultry, from 2002 to Appl Environ Microbiol , Arshad MM, et al Epidemiologic attributes of invasive non typhoidal almonella infections in Michigan, nt J nfect Dis , chinohe N, et al Effects of fosfomycin on higa toxin producing Escherichia coli quantification of copy numbers of higa toxin encoding genes and their expression levels using real time PC. J Med Microbiol ,

5 Vol. 25 No. 127 First report of extended spectrumlactamase producing almonella enterica serovar Heidelberg isolates in Japan Masahiro UENO Department of Pediatrics, Hasuda sshinkai Hospital almonella enterica serovar Heidelberg is among the most frequently isolated serovars both in clinical cases of salmonellosis and from retail meats and food animals in North America. Meanwhile, over recent years in Japan,. Heidelberg has been isolated in only several cases per year. n addition, there have been no clinical reports so far of extended spectrumlactamase EBLproducing. Heidelberg isolates in Japan. This clinical case report presents a pediatric patient with acute gastroenteritis caused by CTX M 2 EBL producing. Heidelberg for the first time in Japan. ince the almonella species is generally of high pathogenicity, courses of treatment in some instances need to consider possible resistance of this strain to multiple antimicrobial agents. More attention should be paid to the selection of antimicrobial agents for treatment and to progress additional resistance for antimicrobial agents among almonella species