Yale Chemistry 800 MHz Supercooled Magnet. Nuclear Magnetic Resonance
|
|
- Hubert Lewis
- 6 years ago
- Views:
Transcription
1 Yale Chemistry 800 Mz Supercooled Magnet Nuclear Magnetic Resonance
2 B o Atomic nuclei in The absence of a magnetic field Atomic nuclei in the presence of a magnetic field α spin - with the field β spin - opposed to the field
3 The Precessing Nucleus resonance o α spin resonance β spin no resonance no resonance R f
4 The Precessing Nucleus Again The Continuous Wave Spectrometer The Fourier Transform Spectrometer
5 Observable Nuclei Odd At. Wt.; s = ±1/2 Nuclei C 6 15 N 7 19 F 9 31 P 15. Abundance (%) Odd At. No.; s = ±1 Nuclei N 7 Unobserved Nuclei 12 C 6 16 O 8 32 S 16
6 ΔE = hν ΔE = γh/2π(b o ) h = Planck s constant:1.58x10-37 kcalsec γ = Gyromagnetic ratio: sensitivity of nucleus to the magnetic field. 1 = 2.67x10 4 rad sec -1 gauss -1 Thus: ν = γ/2π(b o ) For a proton, if B o = 14,092 gauss (1.41 tesla, 1.41 T), ν = 60x10 6 cycles/sec = 60 Mz and ΔE N = Nhν = cal/mole
7 R f Field vs. Magnetic Field for a Proton E 60 Mz 100 Mz ΔE = γh/2π(b o ) 500 Mz 1.41 T 2.35 T T B o
8 R f Field /Magnetic Field for Some Nuclei Nuclei R f (Mz) B o (T) γ/2π (Mz/T) 1 13 C 2 19 F 31 P
9 Fortunately, all protons are not created equal! 60 Mz 60,000,000 z at 1.41 T 60,000,600 z downfield deshielded 60 z } upfield shielded 240 z Me 4 Si δ scale (ppm) at 500 Mz } 500 z δ = (ν obs - ν TMS )/ν inst(mz) = ( )/60 = 4.00 chemical shift
10 Where Nuclei Resonate at 11.74T 12 ppm 2 RCO 2 12 ppm 1 (TMS) ~380 ppm 31 P ( 3 PO 4 ) ~220 ppm ppm 19 F (CFCl 3 ) C 4 13 C PX 3 CP 2 -SO 2 F -CF 2 -CF R 2 C=O Mz
11 Chemical Shifts of Protons
12 The Effect of Electronegativity on Proton Chemical Shifts TMS CCl 3 C 2 Cl 2 C 3 Cl C 4 δ=7.26 δ=5.30 δ=3.05 δ= δ TMS CBr 3 δ=6.83 C 2 Br 2 δ=4.95 C 3 Br δ= δ
13 Chemical Shifts and Integrals δ 4.0 δ 2.2 area = 3 TMS area = δ homotopic protons: chemically and magnetically equivalent 3 C Cl C C 2 Cl enantiotopic protons: chemically and magnetically equivalent Cl
14 Spin-Spin Splitting anticipated spectrum δ = 1.2 area = 9 TMS δ = 6.4 area = 1 δ = 4.4 area = δ Br Br C 3 Br C C C C 3 C 3
15 Spin-Spin Splitting observed spectrum δ = 1.2 area = 9 TMS δ = 6.4 area = 1 δ = 4.4 area = 1 β α α β δ J coupling constant = 1.5 z Br Br C Br C C 3 C C 3 C 3 J is a constant and independent of field
16 Spin-Spin Splitting δ = 6.4 J = 1.5 z δ = 4.4 J = 1.5 z β α α ν local β ν local ν observed ν observed δ ν applied ν applied Br Br C 3 This spectrum is not recorded at ~6 Mz! δ and J are not to scale. Br C C C C 3 C 3
17 Multiplicity of Spin-Spin Splitting for s = ±1/2 multiplicity (m) = 2Σs + 1 # equiv. neighbors spin (1/2) multiplicity pattern (a + b) n symbol singlet (s) 1 1/2 2 1:1 doublet (d) 2 2/2 = 1 3 1:2:1 triplet (t) 3 3/2 4 1:3:3:1 quartet (q) 4 4/2 = 1 5 1:4:6:4:1 quintet (qt)
18 1 NMR of Ethyl Bromide (90 Mz) C 3 C 2 Br for spins ααβ αββ αβα βαβ ααα βαα ββα βββ for spins αβ αα βα ββ δ = 3.43 area = 2 90 z/46 pixels = 3J/12 pixels : J= 7.83 z δ = 1.68 area = 3
19 1 NMR of Isopropanol (90 Mz) (C 3 ) 2 CO 1 septuplet; no coupling to O 6, d, J = 7.5 z ( )x90/6 = 7.5 z 1, s δ4.25 δ3.80
20 Proton Exchange of Isopropanol (90 Mz) (C 3 ) 2 CO + D 2 O (C 3 ) 2 COD
21 Diastereotopic Protons: 2-Bromobutane Br homotopic sets of protons pro-r Diastereotopic protons R pro-s
22 Diastereotopic Protons: 2-Bromobutane at 90Mz Br δ1.03 (3, t) δ1.70 (3, d) δ1.82 (1, m) δ1.84 (1, m) δ4.09 (1, m (sextet?))
23 1 NMR of Propionaldehyde: 300 Mz O δ1.13 (3, t, J = 7.3 z) δ9.79 (1, t, J = 1.4 z) Is this pattern at δ2.46 a pentuplet given that there are two different values for J? No!
24 1 NMR of Propionaldehyde: 300 Mz δ2.46 O 7.3 z 7.3 z 7.3 z 1.4 z 7.3 z 7.3 z quartet of doublets δ9.79 (1, t, J = 1.4 z) δ1.13 (3, t, J = 7.3 z)
25 1 NMR of Ethyl Vinyl Ether: 300 Mz J = 14.4 z J 3, t, J = 7.0 z = 1.9 z O J = 6.9 z δ3.96 (1, dd, J = 6.9, 1.9 z) δ4.17 (1, dd, J = 14.4, 1.9 z) 2, q, J = 7.0 z δ6.46 (1, dd, J = 14.4, 6.9 z)
26 ABX Coupling in Ethyl Vinyl Ether δ O δ δ3.96 (1, dd, J = 6.9, 1.9 z) δ4.17 (1, dd, J = 14.4, 1.9 z) δ3.96 δ6.46 (1, dd, J = 14.4, 6.9 z) Another example
27 Dependence of J on the Dihedral Angle The Karplus Equation
28 1 NMR (400 Mz): cis-4-t-butylcyclohexanol O e e a e triplet of triplets a e e δ e δ4.03, J( J( a ) a = ) = z z J( J( e ) e = ) = z z 11.4 z 400 z
29 1 NMR (400 Mz): trans-4-t-butylcyclohexanol a e O a e triplet of triplets a a a δ3.51, J( a ) = 11.1 z J( e ) = 4.3 z z
30 W X Y Z Peak Shape as a Function of Δδ vs. J Δδ >> J Δδ J δ Δδ ~= J δ Δδ = δ
31 Magnetic Anisotropy Downfield shift for aromatic protons (δ ) B o
32 Magnetic Anisotropy R C C Upfield shift for alkyne protons (δ ) B o
33 13 C Nuclear Magnetic Resonance 13 C Chemical Shifts
34 Where s Waldo?
35 One carbon in 3 molecules of squalene is 13 C What are the odds that two 13 C are bonded to one another? ~10,000 to 1
36 13 C NMR Spectrum of Ethyl Bromide at 62.8 Mz J C = 126 z J C = 151 z C 1 J C = 3 z C 2 Br J C = 5 z TMS J C = 118 z Si ppm (δ)
37 13 C NMR Spectrum of Ethyl Bromide at 62.8 Mz Off resonance decoupling of the 1 region removes small C- coupling. J C = 126 z J C = 151 z C 1 J C = 3 z Broadband decoupling removes all C- coupling. C 2 Br J C = 5 z TMS J C = 118 z Si ppm (δ)
38 13 C Spectrum of Methyl Salicylate (Broadband Decoupled)
39 13 C Spectrum of Methyl p-ydroxybenzoate (Broadband Decoupled)
40 The 13 C Spectrum of Camphor O
41 F. E. Ziegler, 2004 The End
To Do s. Answer Keys are available in CHB204H
To Do s Read Chapters 2, 3 & 4. Complete the end-of-chapter problems, 2-1, 2-2, 2-3 and 2-4 Complete the end-of-chapter problems, 3-1, 3-3, 3-4, 3-6 and 3-7 Complete the end-of-chapter problems, 4-1, 4-2,
More informationTo Do s. Answer Keys are available in CHB204H
To Do s Read Chapters 2, 3 & 4. Complete the end-of-chapter problems, 2-1, 2-2, 2-3 and 2-4 Complete the end-of-chapter problems, 3-1, 3-3, 3-4, 3-6 and 3-7 Complete the end-of-chapter problems, 4-1, 4-2,
More informationCHEM 322 Laboratory Methods in Organic Chemistry. Introduction to NMR Spectroscopy
EM 322 Laboratory Methods in Organic hemistry Introduction to NMR Spectroscopy What structural information does NMR spectroscopy provide? 1) hemical shift (δ) data reveals the molecular (functional group)
More information4) protons experience a net magnetic field strength that is smaller than the applied magnetic field.
1) Which of the following CANNOT be probed by an spectrometer? See sect 16.1 Chapter 16: 1 A) nucleus with odd number of protons & odd number of neutrons B) nucleus with odd number of protons &even number
More informationQuímica Orgânica I. Nuclear Magnetic Resonance Spectroscopy (I) Ciências Farmacêuticas Bioquímica Química AFB QO I 2007/08 1 AFB QO I 2007/08 2
Química Orgânica I Ciências Farmacêuticas Bioquímica Química AFB QO I 2007/08 1 Nuclear Magnetic Resonance Spectroscopy (I) AFB QO I 2007/08 2 1 Adaptado de: Organic Chemistry, 6th Edition; L. G. Wade,
More informationChapter 9. Nuclear Magnetic Resonance. Ch. 9-1
Chapter 9 Nuclear Magnetic Resonance Ch. 9-1 1. Introduction Classic methods for organic structure determination Boiling point Refractive index Solubility tests Functional group tests Derivative preparation
More informationCHEM Chapter 13. Nuclear Magnetic Spectroscopy (Homework) W
CHEM 2423. Chapter 13. Nuclear Magnetic Spectroscopy (Homework) W Short Answer 1. For a nucleus to exhibit the nuclear magnetic resonance phenomenon, it must be magnetic. Magnetic nuclei include: a. all
More informationChapter 13: Molecular Spectroscopy
Chapter 13: Molecular Spectroscopy Electromagnetic Radiation E = hν h = Planck s Constant (6.63 x 10-34 J. s) ν = frequency (s -1 ) c = νλ λ = wavelength (nm) Energy is proportional to frequency Spectrum
More informationNMR = Nuclear Magnetic Resonance
NMR = Nuclear Magnetic Resonance NMR spectroscopy is the most powerful technique available to organic chemists for determining molecular structures. Looks at nuclei with odd mass numbers or odd number
More informationNuclear spin and the splitting of energy levels in a magnetic field
Nuclear spin and the splitting of energy levels in a magnetic field Top 3 list for 13 C NMR Interpretation 1. Symmetry 2. Chemical Shifts 3. Multiplicity 13 C NMR of C 3 O 1 NMR of C 3 O 13 C NMR of C
More informationChapter 14. Nuclear Magnetic Resonance Spectroscopy
Organic Chemistry, Second Edition Janice Gorzynski Smith University of Hawai i Chapter 14 Nuclear Magnetic Resonance Spectroscopy Prepared by Rabi Ann Musah State University of New York at Albany Copyright
More information4) protons experience a net magnetic field strength that is smaller than the applied magnetic field.
1) Which of the following CANNOT be probed by an spectrometer? See sect 16.1 Chapter 16: 1 A) nucleus with odd number of protons & odd number of neutrons B) nucleus with odd number of protons &even number
More informationChapter 13 Nuclear Magnetic Resonance Spectroscopy
Organic Chemistry, 6 th Edition L. G. Wade, Jr. Chapter 13 Nuclear Magnetic Resonance Spectroscopy Jo Blackburn Richland College, Dallas, TX Dallas County Community College District 2006, Prentice Hall
More informationChapter 15 Lecture Outline
Organic Chemistry, First Edition Janice Gorzynski Smith University of Hawaii Chapter 5 Lecture Outline Introduction to NMR Two common types of NMR spectroscopy are used to characterize organic structure:
More informationNuclear Magnetic Resonance Spectroscopy: Tools for Structure Determination
Nuclear Magnetic Resonance Spectroscopy: Tools for Structure Determination Chung-Ming Sun Department of Applied Chemistry National Chiao Tung University Hualien 300, Taiwan Introduction NMR (Nuclear Magnetic
More informationNMR Nuclear Magnetic Resonance Spectroscopy p. 83. a hydrogen nucleus (a proton) has a charge, spread over the surface
NMR Nuclear Magnetic Resonance Spectroscopy p. 83 a hydrogen nucleus (a proton) has a charge, spread over the surface a spinning charge produces a magnetic moment (a vector = direction + magnitude) along
More information4) protons experience a net magnetic field strength that is smaller than the applied magnetic field.
1) Which of the following CANNOT be probed by an NMR spectrometer? See sect 15.1 Chapter 15: 1 A) nucleus with odd number of protons & odd number of neutrons B) nucleus with odd number of protons &even
More informationNuclear Magnetic Resonance (NMR)
Nuclear Magnetic Resonance (NMR) E E increases with increasing magnetic field strength Boltzmann distribution at thermal equilibrium: N (m=-1/2) /N (m=+1/2) = e ( E/kT) with E = γ(h/2π)b o NMR Physical
More informationChapter 13 Structure t Determination: Nuclear Magnetic Resonance Spectroscopy
John E. McMurry www.cengage.com/chemistry/mcmurry Chapter 13 Structure t Determination: ti Nuclear Magnetic Resonance Spectroscopy Revisions by Dr. Daniel Holmes MSU Paul D. Adams University of Arkansas
More informationChapter 16 Nuclear Magnetic Resonance Spectroscopy
hapter 16 Nuclear Magnetic Resonance Spectroscopy The Spinning Proton A spinning proton generates a magnetic field, resembling that of a small bar magnet. An odd number of protons in the nucleus creates
More informationJanuary 30, 2018 Chemistry 328N
Lecture 4 Some More nmr January 30, 2018 Tricks for solving unknowns Review. Empirical formula is lowest common denominator ratio of atomic composition From Homework: unknown has an empirical formula of
More informationThe Use of NMR Spectroscopy
Spektroskopi Molekul Organik (SMO): Nuclear Magnetic Resonance (NMR) Spectroscopy All is adopted from McMurry s Organic Chemistry The Use of NMR Spectroscopy Used to determine relative location of atoms
More informationNuclear Magnetic Resonance Spectroscopy
13 Nuclear Magnetic Resonance Spectroscopy Solutions to In-Text Problems 13.1 (b) Apply Eq. 13.2b with = 360 MHz. chemical shift in Hz = δ = (4.40)(360) = 1584 Hz 13.2 (b) Follow the same procedure used
More informationOAT Organic Chemistry - Problem Drill 19: NMR Spectroscopy and Mass Spectrometry
OAT Organic Chemistry - Problem Drill 19: NMR Spectroscopy and Mass Spectrometry Question No. 1 of 10 Question 1. Which statement concerning NMR spectroscopy is incorrect? Question #01 (A) Only nuclei
More informationChapter 13: Nuclear Magnetic Resonance (NMR) Spectroscopy direct observation of the H s and C s of a molecules
hapter 13: Nuclear Magnetic Resonance (NMR) Spectroscopy direct observation of the s and s of a molecules Nuclei are positively charged and spin on an axis; they create a tiny magnetic field + + Not all
More informationNuclear Spin States. NMR Phenomenon. NMR Instrumentation. NMR Active Nuclei. Nuclear Magnetic Resonance
Nuclear Magnetic Resonance NMR Phenomenon µ A spinning charged particle generates a magnetic field. A nucleus with a spin angular momentum will generate a magnetic moment (!). E Nuclear Spin States aligned
More information4) protons experience a net magnetic field strength that is smaller than the applied magnetic field.
1) Which of the following CANNOT be probed by an spectrometer? See sect 15.1 Chapter 15: 1 A) nucleus with odd number of protons & odd number of neutrons B) nucleus with odd number of protons &even number
More informationStructure Determination: Nuclear Magnetic Resonance Spectroscopy
Structure Determination: Nuclear Magnetic Resonance Spectroscopy Why This Chapter? NMR is the most valuable spectroscopic technique used for structure determination More advanced NMR techniques are used
More informationTuesday, January 13, NMR Spectroscopy
NMR Spectroscopy NMR Phenomenon Nuclear Magnetic Resonance µ A spinning charged particle generates a magnetic field. A nucleus with a spin angular momentum will generate a magnetic moment (μ). If these
More information1. neopentyl benzene. 4 of 6
I. 1 H NMR spectroscopy A. Theory 1. The protons and neutrons in atomic nuclei spin, as does the nucleus itself 2. The circulation of nuclear charge can generate a nuclear magnetic moment, u, along the
More informationNuclear Magnetic Resonance Spectroscopy
Nuclear Magnetic Resonance Spectroscopy Features: Used to identify products of reactions Also gives information about chemical environment, connectivity and bonding of nuclei Requirements: Pure or mostly
More informationNMR Spectroscopy. Chapter 19
NMR Spectroscopy Chapter 19 Nuclear Magnetic Resonance spectroscopy is a powerful analytical technique used to characterize organic molecules by identifying carbon-hydrogen frameworks within molecules.
More informationTo Do s. Read Chapter 3. Complete the end-of-chapter problems, 3-1, 3-3, 3-4, 3-6 and 3-7. Answer Keys are available in CHB204H
Read Chapter 3. To Do s Complete the end-of-chapter problems, 3-1, 3-3, 3-4, 3-6 and 3-7 Answer Keys are available in CB204 NMR Chemical Shifts Further Discussion A set of spectral data is reported when
More information1,1,2-Tribromoethane. Spin-Spin Coupling
NMR Spin oupling Spin-Spin oupling Spectra usually much more complicated than a series of single lines, one for each type of hydrogen. Peaks are often split into a number of smaller peaks, sometimes with
More informationExperiment 11: NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Experiment 11: NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY Purpose: This is an exercise to introduce the use of nuclear magnetic resonance spectroscopy, in conjunction with infrared spectroscopy, to determine
More informationNUCLEAR MAGNETIC RESONANCE AND INTRODUCTION TO MASS SPECTROMETRY
NUCLEAR MAGNETIC RESONANCE AND INTRODUCTION TO MASS SPECTROMETRY A STUDENT SHOULD BE ABLE TO: 1. Identify and explain the processes involved in proton ( 1 H) and carbon-13 ( 13 C) nuclear magnetic resonance
More informationORGANIC - CLUTCH CH ANALYTICAL TECHNIQUES: IR, NMR, MASS SPECT
!! www.clutchprep.com CONCEPT: PURPOSE OF ANALYTICAL TECHNIQUES Classical Methods (Wet Chemistry): Chemists needed to run dozens of chemical reactions to determine the type of molecules in a compound.
More informationInstrumental Chemical Analysis
L15 Page1 Instrumental Chemical Analysis Nuclear Magnetic Resonance Dr. Ahmad Najjar Philadelphia University Faculty of Pharmacy Department of Pharmaceutical Sciences 1 st semester, 2017/2018 Nuclear Magnetic
More informationORGANIC - CLUTCH CH ANALYTICAL TECHNIQUES: IR, NMR, MASS SPECT
!! www.clutchprep.com CONCEPT: PURPOSE OF ANALYTICAL TECHNIQUES Classical Methods (Wet Chemistry): Chemists needed to run dozens of chemical reactions to determine the type of molecules in a compound.
More informationORGANIC - BROWN 8E CH NUCLEAR MAGNETIC RESONANCE.
!! www.clutchprep.com CONCEPT: 1 H NUCLEAR MAGNETIC RESONANCE- GENERAL FEATURES 1 H (Proton) NMR is a powerful instrumental method that identifies protons in slightly different electronic environments
More information16.1 Introduction to NMR Spectroscopy. Spectroscopy. Spectroscopy. Spectroscopy. Spectroscopy. Spectroscopy 4/11/2013
What is spectroscopy? NUCLEAR MAGNETIC RESONANCE (NMR) spectroscopy may be the most powerful method of gaining structural information about organic compounds. NMR involves an interaction between electromagnetic
More informationHow NMR Works Section II
How NMR Works ----- Section II by Shaoxiong Wu 02-20-2010 In the section I we have evaluated one spin system by using an one spin Hamiltonian act on a EigenFunction and then get the EigenValue, i.e. the
More information13.24: Mass Spectrometry: molecular weight of the sample
hapter 13: Spectroscopy Methods of structure determination Nuclear Magnetic Resonances (NMR) Spectroscopy (Sections 13.3-13.19) Infrared (IR) Spectroscopy (Sections 13.20-13.22) Ultraviolet-visible (UV-Vis)
More informationNuclear Magnetic Resonance H-NMR Part 1 Introduction to NMR, Instrumentation, Sample Prep, Chemical Shift. Dr. Sapna Gupta
Nuclear Magnetic Resonance H-NMR Part 1 Introduction to NMR, Instrumentation, Sample Prep, Chemical Shift Dr. Sapna Gupta Introduction NMR is the most powerful tool available for organic structure determination.
More informationIntroduction to NMR spectroscopy
Introduction to NMR spectroscopy Nuclei of isotopes which possess an odd number of protons, an odd number of neutrons, or both, have a nuclear spin quantum number, I, such that, I = 1/2n, where n is an
More informationLecture Notes Chem 51A S. King
Lecture Notes hem 51A S. King hapter 14 Nuclear Magnetic Resonance Spectroscopy Nuclear Magnetic Resonance (NMR) spectroscopy uses energy in the radiowave portion of the electromagnetic spectrum. The nuclei
More informationChapter 7. Nuclear Magnetic Resonance Spectroscopy
Chapter 7 Nuclear Magnetic Resonance Spectroscopy I. Introduction 1924, W. Pauli proposed that certain atomic nuclei have spin and magnetic moment and exposure to magnetic field would lead to energy level
More information16.1 Introduction to NMR. Spectroscopy
16.1 Introduction to NMR What is spectroscopy? Spectroscopy NUCLEAR MAGNETIC RESNANCE (NMR) spectroscopy may be the most powerful method of gaining structural information about organic compounds. NMR involves
More informationChapter 13 Spectroscopy
hapter 13 Spectroscopy Infrared spectroscopy Ultraviolet-Visible spectroscopy Nuclear magnetic resonance spectroscopy Mass Spectrometry 13.1 Principles of Molecular Spectroscopy: Electromagnetic Radiation
More informationExperiment 2 - NMR Spectroscopy
Experiment 2 - NMR Spectroscopy OBJECTIVE to understand the important role of nuclear magnetic resonance spectroscopy in the study of the structures of organic compounds to develop an understanding of
More informationCHEM311 FALL 2005 Practice Exam #3
EM311 FALL 2005 Practice Exam #3 Instructions: This is a multiple choice / short answer practice exam. For the multiple-choice questions, there may be more than one correct answer. If so, then circle as
More informationCHEM 242 NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY CHAP 14B ASSIGN
CHEM 242 NUCLEAR MAGNETIC RESNANCE SPECTRSCPY CHAP 14B ASSIGN 1. A proton NMR spectrum is observed to contain following the pattern below; what do you conclude? A. This must be a quartet that is part of
More informationNuclear Magnetic Resonance Parameters
Nuclear Magnetic Resonance Parameters P. K. Madhu Department of Chemical Sciences Tata Institute of Fundamental Research omi Bhabha Road Colaba Mumbai 400 005, India NMR: What are the Potentials? Understanding
More informationAn Introduction to NMR Spectroscopy. The types of information accessible via high resolution NMR include:
1 of 40 An Introduction to NMR Spectroscopy 1 NMR 13C NMR The types of information accessible via high resolution NMR include: 1. Functional group analysis (chemical shifts) 2. Bonding connectivity and
More informationBackground: In this chapter we will discuss the interaction of molecules with a magnetic field.
Chapter 4 NMR Background: In this chapter we will discuss the interaction of molecules with a magnetic field. * Nuclear Spin Angular Momenta - recall electrons & spin -- our spin functions are and which
More informationProton NMR. Four Questions
Proton NMR Four Questions How many signals? Equivalence Where on spectrum? Chemical Shift How big? Integration Shape? Splitting (coupling) 1 Proton NMR Shifts Basic Correlation Chart How many 1 H signals?
More informationMagnetic Nuclei other than 1 H
Magnetic Nuclei other than 1 H 2 H (Deuterium): I = 1 H,D-Exchange might be used to simplify 1 H-NMR spectra since H-D couplings are generally small; - - - -O- - - -D 2 -O- triplet of triplets slightly
More informationChapter 18: NMR Spectroscopy
The most important tool of the chemist for the determination of molecular structure is Nuclear Magnetic Resonance Spectroscopy, or NMR spectroscopy. NMR spectra are acquired on a special instrument called
More informationWilliam H. Brown & Christopher S. Foote
Requests for permission to make copies of any part of the work should be mailed to:permissions Department, Harcourt Brace & Company, 6277 Sea Harbor Drive, Orlando, Florida 32887-6777 William H. Brown
More informationNMR spectra of some simple molecules. Effect of spinning: averaging field inhomogeneity (nmr1.pdf pg 2)
NMR spectra of some simple molecules Effect of spinning: averaging field inhomogeneity (nmr1.pdf pg 2) N S H 0 H o Because the protons have a magnetic field associated with them, the field changes as across
More information3.15 Nuclear Magnetic Resonance Spectroscopy, NMR
3.15 Nuclear Magnetic Resonance Spectroscopy, NMR What is Nuclear Magnetic Resonance - NMR Developed by chemists and physicists together it works by the interaction of magnetic properties of certain nuclei
More informationCHEM311 FALL 2005 Practice Exam #3
CHEM311 FALL 2005 Practice Exam #3 Instructions: This is a multiple choice / short answer practice exam. For the multiple-choice questions, there may be more than one correct answer. If so, then circle
More information- 1/2. = kb o = hνν + 1/2. B o increasing magnetic field strength. degenerate at B o = 0
NMR EXPERIMENT When magnetically active nuclei are placed into an external magnetic field, the magnetic fields align themselves with the external field into two orientations. During the experiment, electromagnetic
More informationPrinciples of Molecular Spectroscopy: Electromagnetic Radiation and Molecular structure. Nuclear Magnetic Resonance (NMR)
Principles of Molecular Spectroscopy: Electromagnetic Radiation and Molecular structure Nuclear Magnetic Resonance (NMR) !E = h" Electromagnetic radiation is absorbed when the energy of photon corresponds
More informationChapter 9. Nuclear Magnetic Resonance and Mass Spectrometry. 1. Introduction. 2. Nuclear Magnetic Resonance (NMR) Spectroscopy
hapter 9 Nuclear Magnetic Resonance and Mass Spectrometry reated by Professor William Tam & Dr. Phillis hang 1. Introduction Spectroscopy the study of the interaction of light with matter Spectroscopy
More informationThe resonance frequency of the H b protons is dependent upon the orientation of the H a protons with respect to the external magnetic field:
Spin-Spin Splitting in Alkanes The signal arising from a proton or set of protons is split into (N+1) lines by the presence of N adjacent nuclei Example 1: Bromoethane The resonance frequency of the H
More informationNuclear Magnetic Resonance (NMR) Spectroscopy Introduction:
Nuclear Magnetic Resonance (NMR) Spectroscopy Introduction: Nuclear magnetic resonance spectroscopy (NMR) is the most powerful tool available for organic structure determination. Like IR spectroscopy,
More informationNMR Spectroscopy. for 1 st B.Tech INTRODUCTION Lecture -1 Indian Institute of Technology, Dhanbad
NMR Spectroscopy for 1 st B.Tech Lecture -1 Indian Institute of Technology, Dhanbad by Dr. R P John & Dr. C. Halder INTRODUCTION Nucleus of any atom has protons and neutrons Both Proton and Neutron has
More informationNuclear Magnetic Resonance Spectroscopy Chem 4010/5326: Organic Spectroscopic Analysis Andrew Harned
Nuclear Magnetic Resonance Spectroscopy Chem 4010/5326: Organic Spectroscopic Analysis 2015 Andrew Harned NMR Spectroscopy NMR Spectroscopy All nuclei have a nuclear spin quantum number (I) I = 0, 1/2,
More informationMOLECULAR SPECTROSCOPY AND PHOTOCHEMISTRY
20 CHAPTER MOLECULAR SPECTROSCOPY AND PHOTOCHEMISTRY 20.1 Introduction to Molecular Spectroscopy 20.2 Experimental Methods in Molecular Spectroscopy 20.3 Rotational and Vibrational Spectroscopy 20.4 Nuclear
More informationSpectroscopy in Organic Chemistry. Types of Spectroscopy in Organic
Spectroscopy in Organic Chemistry Spectroscopy Spectrum dealing with light, or more specifically, radiation Scope to see Organic Spectroscopy therefore deals with examining how organic molecules interact
More informationNUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
NMR Spectroscopy 1 NULEAR MAGNETI RESONANE SPETROSOPY Involves interaction of materials with the low-energy radiowave region of the electromagnetic spectrum Origin of Spectra Theory All nuclei possess
More informationC h a p t e r S i x t e e n: Nuclear Magnetic Resonance Spectroscopy. An 1 H NMR FID of ethanol
0.2 0.4 0.6 0.8 1.0 1.2 1.4 1.6 1.8 2.0 2.2 2.4 2.6 2.8 3.0 3.2 3.4 3.6 C h a p t e r S i x t e e n: Nuclear Magnetic Resonance Spectroscopy An 1 NMR FID of ethanol Note: Problems with italicized numbers
More informationObjective 4. Determine (characterize) the structure of a compound using IR, NMR, MS.
Objective 4. Determine (characterize) the structure of a compound using IR, NMR, MS. Skills: Draw structure IR: match bond type to IR peak NMR: ID number of non-equivalent H s, relate peak splitting to
More informationIndirect Coupling. aka: J-coupling, indirect spin-spin coupling, indirect dipole-dipole coupling, mutual coupling, scalar coupling (liquids only)
Indirect Coupling aka: J-coupling, indirect spin-spin coupling, indirect dipole-dipole coupling, mutual coupling, scalar coupling (liquids only) First, two comments about direct coupling Nuclear spins
More informationNMRis the most valuable spectroscopic technique for organic chemists because it maps the carbon-hydrogen framework of a molecule.
Chapter 13: Nuclear magnetic resonance spectroscopy NMRis the most valuable spectroscopic technique for organic chemists because it maps the carbon-hydrogen framework of a molecule. 13.2 The nature of
More informationChapter 16 Nuclear Magnetic Resonance Spectroscopy
Chapter 16 Nuclear Magnetic Resonance Spectroscopy Review of Concepts Fill in the blanks below. To verify that your answers are correct, look in your textbook at the end of Chapter 16. Each of the sentences
More informationModule 13: Chemical Shift and Its Measurement
Subject Chemistry Paper No and Title Module No and Title Module Tag Paper 12: Organic Spectroscopy CHE_P12_M13_e-Text TABLE OF CONTENTS 1. Learning Outcomes 2. Introduction 3. Shielding and deshielding
More informationCH Exam #4 (Take Home) Date Due: 11/25,26/2013
CH2710 - Exam #4 (Take Home) Date Due: 11/25,26/2013 Section I - Multiple Choice - Choose the BEST answer from the choices given and place the letter of you choice in the space provided. 1. Energy absorbed
More informationAnswers to Assignment #5
Answers to Assignment #5 A. 9 8 l 2 5 DBE (benzene + 1 DBE) ( 9 2(9)+2-9 8+1+1 = 10 ˆ 5 DBE) nmr pattern of two doublets of equal integration at δ7.4 and 7.9 ppm means the group (the δ7.9 shift) IR band
More informationNMR SPECTROSCOPY DR. M. KANJIA. Copyright reserved NMRS. Application to reproduce to Dr M Kanjia
NMR SPECTROSCOPY DR. M. KANJIA Copyright reserved NMRS Application to reproduce to Dr M Kanjia 13 C NMR Spectra of Butan-2-ol CH 3 CHOH CH 2 CH 3 135 DEPT 13 C NMR CH 3 CHOH CH 2 CH 3 D = Doublet T = Triplet
More informationChem 325 NMR Intro. The Electromagnetic Spectrum. Physical properties, chemical properties, formulas Shedding real light on molecular structure:
Physical properties, chemical properties, formulas Shedding real light on molecular structure: Wavelength Frequency ν Wavelength λ Frequency ν Velocity c = 2.998 10 8 m s -1 The Electromagnetic Spectrum
More informationChapter 14 Spectroscopy
hapter 14 Spectroscopy There are four major analytical techniques used for identifying the structure of organic molecules 1. Nuclear Magnetic Resonance or NMR is the single most important technique for
More informationE35 SPECTROSCOPIC TECHNIQUES IN ORGANIC CHEMISTRY
E35 SPECTRSCPIC TECNIQUES IN RGANIC CEMISTRY Introductory Comments. These notes are designed to introduce you to the basic spectroscopic techniques which are used for the determination of the structure
More informationPAPER No. 12: ORGANIC SPECTROSCOPY. Module 19: NMR Spectroscopy of N, P and F-atoms
Subject Chemistry Paper No and Title Module No and Title Module Tag Paper 12: Organic Spectroscopy CHE_P12_M19_e-Text TABLE OF CONTENTS 1. Learning Outcomes 2. 15 N NMR spectroscopy 3. 19 F NMR spectroscopy
More informationOther problems to work: 3-Chloropentane (diastereotopic H s), 1- chloropentane.
Let s look at some specific examples. Dichloroacetaldehyde, l 2 HHO, has two inequivalent toms, H1 and H2. We expect to see two resonances, one at around δ 10.5 ppm and one around δ 5.5 ppm. (The H2 resonance
More informationClickers. a. I watched all 5 videos b. The dog ate my iphone
Clickers a. I watched all 5 videos b. The dog ate my iphone 40% 33% 33% 40% 59% 67% of you: Watch youtube! PRBLEMS: Complete end of chapter 13 problems 1 10 from Lab Manual Answers 1 NMR Protons (nucleus
More informationCHEMISTRY 213 XMAS 04 1 ANSWER ON THE GREEN COMPUTER ANSWER SHEET PROVIDED USING A PENCIL CHOICES MAY BE USED MORE THAN ONCE
CHEMISTRY 213 XMAS 04 1 ANSWER ON THE GREEN COMPUTER ANSWER SHEET PROVIDED USING A PENCIL CHOICES MAY BE USED MORE THAN ONCE Using the molecules: A: CH 3 CH CHCO 2 CH 3 B: CH 3 CO 2 CH CHCH 3 C: CH 3 CH
More informationNMR Spin-Spin Coupling. Further Discussion
NMR Spin-Spin oupling Further Discussion Signs and Mechanisms Most important mechanism is Fermi contact mechanism (see below). J can be either positive or negative. Signs of J usually DO NOT affect the
More informationC NMR Spectroscopy
13.14 13 C NMR Spectroscopy 1 H and 13 C NMR compared: both give us information about the number of chemically nonequivalent nuclei (nonequivalent hydrogens or nonequivalent carbons) both give us information
More informationSpin-Spin Coupling. H b1 H 3 C C Br. Review: 1 H- 1 H Coupling
Review: 1-1 Coupling b1 3 C C Br b2 multiplicity: n + 1 rule can determine peak intensities by considering nuclear spin probabilities on adjacent hydrogens or use Pascal's triangle Coupling Constants (J)
More informationCHEMISTRY Organic Chemistry Laboratory II Spring 2019 Lab #5: NMR Spectroscopy
Team Members: Unknown # CHEMISTRY 244 - Organic Chemistry Laboratory II Spring 2019 Lab #5: NMR Spectroscopy Purpose: You will learn how to predict the NMR data for organic molecules, organize this data
More informationIR, MS, UV, NMR SPECTROSCOPY
CHEMISTRY 318 IR, MS, UV, NMR SPECTROSCOPY PROBLEM SET All Sections CHEMISTRY 318 IR, MS, UV, NMR SPECTROSCOPY PROBLEM SET General Instructions for the 318 Spectroscopy Problem Set Consult the Lab Manual,
More informationUsing NMR and IR Spectroscopy to Determine Structures Dr. Carl Hoeger, UCSD
Using NMR and IR Spectroscopy to Determine Structures Dr. Carl Hoeger, UCSD The following guidelines should be helpful in assigning a structure from NMR (both PMR and CMR) and IR data. At the end of this
More informationAnalysis of NMR Spectra Part 2
Analysis of NMR Spectra Part 2-1- Analysis of NMR Spectra Part 2 "Things should be made as simple as possible, but not any simpler." Albert Einstein 1.1 Review of Basic NMR Concepts NMR analysis is a complex
More informationθ-1) B z dθ = 0 r 3 θ=0
207 NMR Spectroscopy and rganic Structure Determination Scott Virgil California Institute of Technology SPIN-SPIN CUPLING IN NMR SPECTRSCPY Interaction of Nuclear Spins in NMR Spectroscopy A. Dipolar Coupling
More informationChapter 13 Nuclear Magnetic Resonance Spectroscopy
William. Brown Christopher S. Foote Brent L. Iverson Eric Anslyn http://academic.cengage.com/chemistry/brown Chapter 13 Nuclear Magnetic Resonance Spectroscopy William. Brown Beloit College Two Nobel Prizes
More informationHWeb27 ( ; )
HWeb27 (9.1-9.2; 9.12-9.18) 28.1. Which of the following cannot be determined about a compound by mass spectrometry? [a]. boiling point [b]. molecular formula [c]. presence of heavy isotopes (e.g., 2 H,
More informationUnderstanding NMR Spectroscopy James Keeler
Understanding NMR Spectroscopy James Keeler University of Cambridge, Department of Chemistry c James Keeler, 00 What this course is about This course is aimed at those who are already familiar with using
More informationNuclear magnetic resonance spectroscopy
nuclear spin transitions O Nuclear magnetic resonance spectroscopy 1 H, 13 C, 2-dimensional which transitions? wavelength and intensity; ppm what happens if we change the environment of the nucleus? substituent
More information