Chapter 13: Molecular Spectroscopy
|
|
- Clara Louisa Sherman
- 6 years ago
- Views:
Transcription
1 Chapter 13: Molecular Spectroscopy Electromagnetic Radiation E = hν h = Planck s Constant (6.63 x J. s) ν = frequency (s -1 ) c = νλ λ = wavelength (nm) Energy is proportional to frequency Spectrum Wavelength (nm) Frequency (s - 1 )
2
3 Energy is quantized E E2 ΔE = E 2 E 1 = hν Molecules absorb electromagnetic radiation at the energy difference between 2 states. Nuclear Magnetic Resonance (NMR) = nuclear spin states (radio) Infrared = vibrational states UV-Vis = electronic states E1
4 The nuclei that are most useful to organic chemists are: 1 and 13 C both have spin = ±1/2 1 is 99% at natural abundance 13 C is 1.1% at natural abundance
5 Nuclear Spin + + Nuclei ( 1 or 13 C), generate a magnetic field. The magnetic field generated by a nucleus of spin +1/2 is opposite in direction from that generated by a nucleus of spin 1/2.
6 The distribution of nuclear spins is random in the absence of an external magnetic field
7 An external magnetic field causes nuclear magnetic moments to align parallel and antiparallel to applied field
8 There is a slight excess of nuclear magnetic moments aligned parallel to the applied field
9 NMR Spectroscopy 1 Nuclei have intrinsic spin. Overall spin = spin quantum number. Only certain isotopes can be studied by NMR. (For example, 1 = ½ and 13 C = ½) but ( 12 C) cannot. In the absence of a magnelc field, spin states are degenerate. Therefore, NMR is performed in the presence of a large magnelc field.
10
11 NMR Spectroscopy 2 EnergeLc difference between nuclear spin states is very small. Large magnets are used ( Τesla). OUen referred to by 1 frequency ( Mz). Different isotopes have different resonance frequencies. Can look at different isotopes separately (for example, 1 and 13C). See Figure 13.5 (for modern NMR spectrometer) PracLcal ConsideraLons: mg of compound is needed Compound most be dissolved in solvent (deuterated). CDCl3 is the most common.
12 Important relationships in NMR The frequency of absorbed electromagnetic radiation is proportional to the energy difference between two nuclear spin states which is proportional to Units z kj/mol (kcal/mol) the applied magnetic field tesla (T)
13 Important relationships in NMR The frequency of absorbed electromagnetic radiation is different for different elements, and for different isotopes of the same element. For a field strength of 4.7 T: 1 absorbs radiation having a frequency of 200 Mz (200 x 10 6 s -1 ) 13 C absorbs radiation having a frequency of 50.4 Mz (50.4 x 10 6 s -1 )
14 Important relationships in NMR The frequency of absorbed electromagnetic radiation for a particular nucleus (such as 1 ) depends on its molecular environment. This is why NMR is such a useful tool for structure determination.
15 Shielding An external magnetic field affects the motion of the electrons in a molecule, inducing a magnetic field within the molecule. The direction of the induced magnetic field is opposite to that of the applied field. C 0
16 Shielding and Chemical ShiU Bo = external magnelc field B = induced magnelc field generated by electrons
17 Shielding The induced field shields the nuclei (in this case, C and ) from the applied field. A stronger external field is needed in order for energy difference between spin states to match energy of rf radiation. C 0
18 Chemical Shift Chemical shift is a measure of the degree to which a nucleus in a molecule is shielded. Protons in different environments are shielded to greater or lesser degrees; they have different chemical shifts. C 0
19 Chemical Shift Chemical shifts (δ) are measured relative to the protons in tetramethylsilane (TMS) as a standard. 3 C C 3 Si C 3 C 3 δ (ppm) = position of signal - position of TMS peak spectrometer frequency x 10 6
20 Downfield Decreased shielding Upfield Increased shielding (C 3 ) 4 Si (TMS) Chemical shift (δ, ppm) measured relative to TMS
21 Chemical Shift Example: The signal for the proton in chloroform (CCl 3 ) appears 1452 z downfield from TMS at a spectrometer frequency of 200 Mz. δ = position of signal - position of TMS peak spectrometer frequency x 10 6 δ = 1452 z - 0 z 200 x 10 6 x x 10 6 δ = 7.26
22 δ 7.26 ppm Cl C Cl Cl Chemical shift (δ, ppm)
23 Effects of Molecular Structure on 1 Chemical Shifts protons in different environments experience different degrees of shielding and have different chemical shifts
24 Electronegative substituents decrease the shielding of methyl groups least shielded most shielded C 3 F" C 3 OC 3" (C 3 ) 3 N" C 3 C 3 " (C 3 ) 4 Si" δ 4.3 δ 3.2 δ 2.2 δ 0.9 δ 0.0
25 Electronegative substituents decrease shielding δ 0.9 δ 1.3 δ C C 2 C 3 δ 4.3 δ 2.0 δ 1.0 O 2 N C 2 C 2 C 3
26 Effect is cumulative CCl 3 δ 7.3 C 2 Cl 2 δ 5.3 C 3 Cl δ 3.1
27 Protons attached to sp 2 hybridized carbon are less shielded than those attached to sp 3 hybridized carbon C C C 3 C 3 δ 7.3 δ 5.3 δ 0.9
28
29
30 But protons attached to sp hybridized carbon are more shielded than those attached to sp 2 hybridized carbon δ 5.3 C C δ 2.4 C C C 2 OC 3
31
32 Protons attached to benzylic and allylic carbons are somewhat less shielded than usual 3 C C 3 δ 1.5 δ 0.8 δ 0.9 δ 1.3 δ 0.9 δ 1.2 δ C C 2 3 C C 2 C 3
33 Proton attached to C=O of aldehyde is very deshielded C δ 2.4 O 3 C C C δ 9.7 C 3 δ 1.1
34 Type of proton Chemical shift (δ), ppm Type of proton Chemical shift (δ), ppm C NR C Cl C C C Br Ar O C O C 9-10
35 Type of proton Chemical shift (δ), ppm NR 1-3 OR O OAr O C
36 Information contained in an NMR spectrum includes: 1. number of signals 2. their intensity (as measured by area under peak) 3. splitting pattern (multiplicity)
37 Number of Signals protons that have different chemical shifts are chemically nonequivalent exist in different molecular environment
38 N CC 2 OC 3 OC 3 NCC 2 O Chemical shift (δ, ppm)
39 Chemically equivalent protons are in identical environments have same chemical shift replacement test: replacement by some arbitrary "test group" generates same compoun 3 CC 2 C 3 chemically equivalent
40 Chemically equivalent protons Replacing protons at C-1 and C-3 gives same compound (1-chloropropane) C-1 and C-3 protons are chemically equivalent and have the same chemical shift ClC 2 C 2 C 3 C 3 C 2 C 2 Cl 3 CC 2 C 3 chemically equivalent
41 Diastereotopic protons replacement by some arbitrary test group generates diastereomers diastereotopic protons can have different chemical shifts Br δ 5.3 ppm C C 3 C δ 5.5 ppm
42 13.6 Interpreting Proton NMR Spectra
43 13.7 Spin-Spin Splitting in NMR Spectroscopy not all peaks are singlets signals can be split by coupling of nuclear spins
44 Figure (page 536) Cl 2 CC 3 4 lines; quartet 2 lines; doublet C C Chemical shift (δ, ppm)
Chapter 13 Spectroscopy
hapter 13 Spectroscopy Infrared spectroscopy Ultraviolet-Visible spectroscopy Nuclear magnetic resonance spectroscopy Mass Spectrometry 13.1 Principles of Molecular Spectroscopy: Electromagnetic Radiation
More informationPrinciples of Molecular Spectroscopy: Electromagnetic Radiation and Molecular structure. Nuclear Magnetic Resonance (NMR)
Principles of Molecular Spectroscopy: Electromagnetic Radiation and Molecular structure Nuclear Magnetic Resonance (NMR) !E = h" Electromagnetic radiation is absorbed when the energy of photon corresponds
More information4) protons experience a net magnetic field strength that is smaller than the applied magnetic field.
1) Which of the following CANNOT be probed by an NMR spectrometer? See sect 15.1 Chapter 15: 1 A) nucleus with odd number of protons & odd number of neutrons B) nucleus with odd number of protons &even
More informationNuclear Magnetic Resonance (NMR)
Nuclear Magnetic Resonance (NMR) E E increases with increasing magnetic field strength Boltzmann distribution at thermal equilibrium: N (m=-1/2) /N (m=+1/2) = e ( E/kT) with E = γ(h/2π)b o NMR Physical
More informationNMR Spectroscopy. for 1 st B.Tech INTRODUCTION Lecture -1 Indian Institute of Technology, Dhanbad
NMR Spectroscopy for 1 st B.Tech Lecture -1 Indian Institute of Technology, Dhanbad by Dr. R P John & Dr. C. Halder INTRODUCTION Nucleus of any atom has protons and neutrons Both Proton and Neutron has
More informationChapter 14. Nuclear Magnetic Resonance Spectroscopy
Organic Chemistry, Second Edition Janice Gorzynski Smith University of Hawai i Chapter 14 Nuclear Magnetic Resonance Spectroscopy Prepared by Rabi Ann Musah State University of New York at Albany Copyright
More informationWilliam H. Brown & Christopher S. Foote
Requests for permission to make copies of any part of the work should be mailed to:permissions Department, Harcourt Brace & Company, 6277 Sea Harbor Drive, Orlando, Florida 32887-6777 William H. Brown
More information4) protons experience a net magnetic field strength that is smaller than the applied magnetic field.
1) Which of the following CANNOT be probed by an spectrometer? See sect 16.1 Chapter 16: 1 A) nucleus with odd number of protons & odd number of neutrons B) nucleus with odd number of protons &even number
More informationChapter 15 Lecture Outline
Organic Chemistry, First Edition Janice Gorzynski Smith University of Hawaii Chapter 5 Lecture Outline Introduction to NMR Two common types of NMR spectroscopy are used to characterize organic structure:
More informationNuclear Magnetic Resonance (NMR) Spectroscopy Introduction:
Nuclear Magnetic Resonance (NMR) Spectroscopy Introduction: Nuclear magnetic resonance spectroscopy (NMR) is the most powerful tool available for organic structure determination. Like IR spectroscopy,
More informationQuímica Orgânica I. Nuclear Magnetic Resonance Spectroscopy (I) Ciências Farmacêuticas Bioquímica Química AFB QO I 2007/08 1 AFB QO I 2007/08 2
Química Orgânica I Ciências Farmacêuticas Bioquímica Química AFB QO I 2007/08 1 Nuclear Magnetic Resonance Spectroscopy (I) AFB QO I 2007/08 2 1 Adaptado de: Organic Chemistry, 6th Edition; L. G. Wade,
More informationNuclear magnetic resonance spectroscopy
nuclear spin transitions O Nuclear magnetic resonance spectroscopy 1 H, 13 C, 2-dimensional which transitions? wavelength and intensity; ppm what happens if we change the environment of the nucleus? substituent
More informationLecture Notes Chem 51A S. King
Lecture Notes hem 51A S. King hapter 14 Nuclear Magnetic Resonance Spectroscopy Nuclear Magnetic Resonance (NMR) spectroscopy uses energy in the radiowave portion of the electromagnetic spectrum. The nuclei
More informationNMR = Nuclear Magnetic Resonance
NMR = Nuclear Magnetic Resonance NMR spectroscopy is the most powerful technique available to organic chemists for determining molecular structures. Looks at nuclei with odd mass numbers or odd number
More information7a. Structure Elucidation: IR and 13 C-NMR Spectroscopies (text , , 12.10)
2009, Department of Chemistry, The University of Western Ontario 7a.1 7a. Structure Elucidation: IR and 13 C-NMR Spectroscopies (text 11.1 11.5, 12.1 12.5, 12.10) A. Electromagnetic Radiation Energy is
More informationChapter 9. Nuclear Magnetic Resonance. Ch. 9-1
Chapter 9 Nuclear Magnetic Resonance Ch. 9-1 1. Introduction Classic methods for organic structure determination Boiling point Refractive index Solubility tests Functional group tests Derivative preparation
More informationThe Use of NMR Spectroscopy
Spektroskopi Molekul Organik (SMO): Nuclear Magnetic Resonance (NMR) Spectroscopy All is adopted from McMurry s Organic Chemistry The Use of NMR Spectroscopy Used to determine relative location of atoms
More information4) protons experience a net magnetic field strength that is smaller than the applied magnetic field.
1) Which of the following CANNOT be probed by an spectrometer? See sect 16.1 Chapter 16: 1 A) nucleus with odd number of protons & odd number of neutrons B) nucleus with odd number of protons &even number
More informationNMRis the most valuable spectroscopic technique for organic chemists because it maps the carbon-hydrogen framework of a molecule.
Chapter 13: Nuclear magnetic resonance spectroscopy NMRis the most valuable spectroscopic technique for organic chemists because it maps the carbon-hydrogen framework of a molecule. 13.2 The nature of
More informationChapter 16 Nuclear Magnetic Resonance Spectroscopy
hapter 16 Nuclear Magnetic Resonance Spectroscopy The Spinning Proton A spinning proton generates a magnetic field, resembling that of a small bar magnet. An odd number of protons in the nucleus creates
More information4) protons experience a net magnetic field strength that is smaller than the applied magnetic field.
1) Which of the following CANNOT be probed by an spectrometer? See sect 15.1 Chapter 15: 1 A) nucleus with odd number of protons & odd number of neutrons B) nucleus with odd number of protons &even number
More informationStructure Determination: Nuclear Magnetic Resonance Spectroscopy
Structure Determination: Nuclear Magnetic Resonance Spectroscopy Why This Chapter? NMR is the most valuable spectroscopic technique used for structure determination More advanced NMR techniques are used
More information1. neopentyl benzene. 4 of 6
I. 1 H NMR spectroscopy A. Theory 1. The protons and neutrons in atomic nuclei spin, as does the nucleus itself 2. The circulation of nuclear charge can generate a nuclear magnetic moment, u, along the
More informationNUCLEAR MAGNETIC RESONANCE AND INTRODUCTION TO MASS SPECTROMETRY
NUCLEAR MAGNETIC RESONANCE AND INTRODUCTION TO MASS SPECTROMETRY A STUDENT SHOULD BE ABLE TO: 1. Identify and explain the processes involved in proton ( 1 H) and carbon-13 ( 13 C) nuclear magnetic resonance
More informationNMR Nuclear Magnetic Resonance Spectroscopy p. 83. a hydrogen nucleus (a proton) has a charge, spread over the surface
NMR Nuclear Magnetic Resonance Spectroscopy p. 83 a hydrogen nucleus (a proton) has a charge, spread over the surface a spinning charge produces a magnetic moment (a vector = direction + magnitude) along
More informationChem 325 NMR Intro. The Electromagnetic Spectrum. Physical properties, chemical properties, formulas Shedding real light on molecular structure:
Physical properties, chemical properties, formulas Shedding real light on molecular structure: Wavelength Frequency ν Wavelength λ Frequency ν Velocity c = 2.998 10 8 m s -1 The Electromagnetic Spectrum
More informationExperiment 2 - NMR Spectroscopy
Experiment 2 - NMR Spectroscopy OBJECTIVE to understand the important role of nuclear magnetic resonance spectroscopy in the study of the structures of organic compounds to develop an understanding of
More informationC h a p t e r S i x t e e n: Nuclear Magnetic Resonance Spectroscopy. An 1 H NMR FID of ethanol
0.2 0.4 0.6 0.8 1.0 1.2 1.4 1.6 1.8 2.0 2.2 2.4 2.6 2.8 3.0 3.2 3.4 3.6 C h a p t e r S i x t e e n: Nuclear Magnetic Resonance Spectroscopy An 1 NMR FID of ethanol Note: Problems with italicized numbers
More informationChapter 14 Spectroscopy
hapter 14 Spectroscopy There are four major analytical techniques used for identifying the structure of organic molecules 1. Nuclear Magnetic Resonance or NMR is the single most important technique for
More information16.1 Introduction to NMR. Spectroscopy
16.1 Introduction to NMR What is spectroscopy? Spectroscopy NUCLEAR MAGNETIC RESNANCE (NMR) spectroscopy may be the most powerful method of gaining structural information about organic compounds. NMR involves
More informationChapter 13 Structure t Determination: Nuclear Magnetic Resonance Spectroscopy
John E. McMurry www.cengage.com/chemistry/mcmurry Chapter 13 Structure t Determination: ti Nuclear Magnetic Resonance Spectroscopy Revisions by Dr. Daniel Holmes MSU Paul D. Adams University of Arkansas
More informationNuclear Magnetic Resonance H-NMR Part 1 Introduction to NMR, Instrumentation, Sample Prep, Chemical Shift. Dr. Sapna Gupta
Nuclear Magnetic Resonance H-NMR Part 1 Introduction to NMR, Instrumentation, Sample Prep, Chemical Shift Dr. Sapna Gupta Introduction NMR is the most powerful tool available for organic structure determination.
More information16.1 Introduction to NMR Spectroscopy. Spectroscopy. Spectroscopy. Spectroscopy. Spectroscopy. Spectroscopy 4/11/2013
What is spectroscopy? NUCLEAR MAGNETIC RESONANCE (NMR) spectroscopy may be the most powerful method of gaining structural information about organic compounds. NMR involves an interaction between electromagnetic
More informationNuclear spin and the splitting of energy levels in a magnetic field
Nuclear spin and the splitting of energy levels in a magnetic field Top 3 list for 13 C NMR Interpretation 1. Symmetry 2. Chemical Shifts 3. Multiplicity 13 C NMR of C 3 O 1 NMR of C 3 O 13 C NMR of C
More information- 1/2. = kb o = hνν + 1/2. B o increasing magnetic field strength. degenerate at B o = 0
NMR EXPERIMENT When magnetically active nuclei are placed into an external magnetic field, the magnetic fields align themselves with the external field into two orientations. During the experiment, electromagnetic
More informationNMR Spectroscopy. Chapter 19
NMR Spectroscopy Chapter 19 Nuclear Magnetic Resonance spectroscopy is a powerful analytical technique used to characterize organic molecules by identifying carbon-hydrogen frameworks within molecules.
More informationE35 SPECTROSCOPIC TECHNIQUES IN ORGANIC CHEMISTRY
E35 SPECTRSCPIC TECNIQUES IN RGANIC CEMISTRY Introductory Comments. These notes are designed to introduce you to the basic spectroscopic techniques which are used for the determination of the structure
More informationLecture 2 nmr Spectroscopy
Lecture 2 nmr Spectroscopy Pages 427 430 and Chapter 13 Molecular Spectroscopy Molecular spectroscopy: the study of the frequencies of electromagnetic radiation that are absorbed or emitted by substances
More information11. Proton NMR (text , 12.11, 12.12)
2009, Department of Chemistry, The University of Western Ontario 11.1 11. Proton NMR (text 12.6 12.9, 12.11, 12.12) A. Proton Signals Like 13 C, 1 H atoms have spins of ±½, and when they are placed in
More informationNuclear Spin States. NMR Phenomenon. NMR Instrumentation. NMR Active Nuclei. Nuclear Magnetic Resonance
Nuclear Magnetic Resonance NMR Phenomenon µ A spinning charged particle generates a magnetic field. A nucleus with a spin angular momentum will generate a magnetic moment (!). E Nuclear Spin States aligned
More informationChapter 13: Nuclear Magnetic Resonance (NMR) Spectroscopy direct observation of the H s and C s of a molecules
hapter 13: Nuclear Magnetic Resonance (NMR) Spectroscopy direct observation of the s and s of a molecules Nuclei are positively charged and spin on an axis; they create a tiny magnetic field + + Not all
More informationCHEM Chapter 13. Nuclear Magnetic Spectroscopy (Homework) W
CHEM 2423. Chapter 13. Nuclear Magnetic Spectroscopy (Homework) W Short Answer 1. For a nucleus to exhibit the nuclear magnetic resonance phenomenon, it must be magnetic. Magnetic nuclei include: a. all
More informationNuclear Magnetic Resonance Spectroscopy (NMR)
OCR Chemistry A 432 Spectroscopy (NMR) What is it? An instrumental method that gives very detailed structural information about molecules. It can tell us - how many of certain types of atom a molecule
More informationChapter 7. Nuclear Magnetic Resonance Spectroscopy
Chapter 7 Nuclear Magnetic Resonance Spectroscopy I. Introduction 1924, W. Pauli proposed that certain atomic nuclei have spin and magnetic moment and exposure to magnetic field would lead to energy level
More informationYale Chemistry 800 MHz Supercooled Magnet. Nuclear Magnetic Resonance
Yale Chemistry 800 Mz Supercooled Magnet Nuclear Magnetic Resonance B o Atomic nuclei in The absence of a magnetic field Atomic nuclei in the presence of a magnetic field α spin - with the field β spin
More information3.15 Nuclear Magnetic Resonance Spectroscopy, NMR
3.15 Nuclear Magnetic Resonance Spectroscopy, NMR What is Nuclear Magnetic Resonance - NMR Developed by chemists and physicists together it works by the interaction of magnetic properties of certain nuclei
More informationNUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
NMR Spectroscopy 1 NULEAR MAGNETI RESONANE SPETROSOPY Involves interaction of materials with the low-energy radiowave region of the electromagnetic spectrum Origin of Spectra Theory All nuclei possess
More informationORGANIC - EGE 5E CH NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
!! www.clutchprep.com CONCEPT: PURPOSE OF ANALYTICAL TECHNIQUES Classical Methods (Wet Chemistry): Chemists needed to run dozens of chemical reactions to determine the type of molecules in a compound.
More informationTo Do s. Answer Keys are available in CHB204H
To Do s Read Chapters 2, 3 & 4. Complete the end-of-chapter problems, 2-1, 2-2, 2-3 and 2-4 Complete the end-of-chapter problems, 3-1, 3-3, 3-4, 3-6 and 3-7 Complete the end-of-chapter problems, 4-1, 4-2,
More informationNuclear Magnetic Resonance
Nuclear Magnetic Resonance PRINCIPLES OF NMR SPECTROSCOPY Contents Principles of nuclear magnetic resonance The nmr spectrometer Basic principles in nmr application NMR tools used to obtain information
More informationNuclear Magnetic Resonance Spectroscopy: Tools for Structure Determination
Nuclear Magnetic Resonance Spectroscopy: Tools for Structure Determination Chung-Ming Sun Department of Applied Chemistry National Chiao Tung University Hualien 300, Taiwan Introduction NMR (Nuclear Magnetic
More informationSpectroscopy. Empirical Formula: Chemical Formula: Index of Hydrogen Deficiency (IHD)
Spectroscopy Empirical Formula: Chemical Formula: Index of Hydrogen Deficiency (IHD) A)From a structure: B)From a molecular formula, C c H h N n O o X x, Formula for saturated hydrocarbons: Subtract the
More informationC NMR Spectroscopy
13.14 13 C NMR Spectroscopy 1 H and 13 C NMR compared: both give us information about the number of chemically nonequivalent nuclei (nonequivalent hydrogens or nonequivalent carbons) both give us information
More informationTo Do s. Answer Keys are available in CHB204H
To Do s Read Chapters 2, 3 & 4. Complete the end-of-chapter problems, 2-1, 2-2, 2-3 and 2-4 Complete the end-of-chapter problems, 3-1, 3-3, 3-4, 3-6 and 3-7 Complete the end-of-chapter problems, 4-1, 4-2,
More informationTuesday, January 13, NMR Spectroscopy
NMR Spectroscopy NMR Phenomenon Nuclear Magnetic Resonance µ A spinning charged particle generates a magnetic field. A nucleus with a spin angular momentum will generate a magnetic moment (μ). If these
More informationExperiment 11: NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Experiment 11: NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY Purpose: This is an exercise to introduce the use of nuclear magnetic resonance spectroscopy, in conjunction with infrared spectroscopy, to determine
More informationSECOND YEAR ORGANIC CHEMISTRY - REVISION COURSE Lecture 2 MOLECULAR STRUCTURE 2: SPECTROSCOPIC ANALYSIS
Prof Ben Davis SECOND YEAR ORGANIC CEMISTRY - REVISION COURSE Lecture 2 MOLECULAR STRUCTURE 2: SPECTROSCOPIC ANALYSIS Books: Williams and Fleming, " Spectroscopic Methods in Organic Chemistry", arwood
More information13.24: Mass Spectrometry: molecular weight of the sample
hapter 13: Spectroscopy Methods of structure determination Nuclear Magnetic Resonances (NMR) Spectroscopy (Sections 13.3-13.19) Infrared (IR) Spectroscopy (Sections 13.20-13.22) Ultraviolet-visible (UV-Vis)
More informationChapter 13 Nuclear Magnetic Resonance Spectroscopy
Organic Chemistry, 6 th Edition L. G. Wade, Jr. Chapter 13 Nuclear Magnetic Resonance Spectroscopy Jo Blackburn Richland College, Dallas, TX Dallas County Community College District 2006, Prentice Hall
More informationNuclear Magnetic Resonance Spectroscopy
Nuclear Magnetic Resonance Spectroscopy Features: Used to identify products of reactions Also gives information about chemical environment, connectivity and bonding of nuclei Requirements: Pure or mostly
More informationChapter 13. R.F.----µ-wave----I.R. (Heat)------Visible------U.V X-Ray------γ-Ray SPECTROSCOPY. Definition: Types to Be Covered:
hamras Glendale ommunity ollege rganic hemistry 105 Exam 4 Materials hapter 13 SPETRSPY Definition: Types to Be overed: A) Infrared Spectroscopy (IR) B) Nuclear Magnetic Resonance Spectroscopy (NMR) )
More informationJanuary 30, 2018 Chemistry 328N
Lecture 4 Some More nmr January 30, 2018 Tricks for solving unknowns Review. Empirical formula is lowest common denominator ratio of atomic composition From Homework: unknown has an empirical formula of
More informationChapter 13 Nuclear Magnetic Resonance Spectroscopy
William. Brown Christopher S. Foote Brent L. Iverson Eric Anslyn http://academic.cengage.com/chemistry/brown Chapter 13 Nuclear Magnetic Resonance Spectroscopy William. Brown Beloit College Two Nobel Prizes
More informationMOLECULAR SPECTROSCOPY AND PHOTOCHEMISTRY
20 CHAPTER MOLECULAR SPECTROSCOPY AND PHOTOCHEMISTRY 20.1 Introduction to Molecular Spectroscopy 20.2 Experimental Methods in Molecular Spectroscopy 20.3 Rotational and Vibrational Spectroscopy 20.4 Nuclear
More informationNuclear Magnetic Resonance Spectroscopy
Chapter 5 Nuclear Magnetic Resonance Spectroscopy http://www.yteach.co.uk/page.php/resources/view_all?id=nuclear_magnetic _resonance_nmr_spectroscopy_spin_spectrometer_spectrum_proton_t_pag e_5&from=search
More informationAn Introduction to NMR Spectroscopy. The types of information accessible via high resolution NMR include:
1 of 40 An Introduction to NMR Spectroscopy 1 NMR 13C NMR The types of information accessible via high resolution NMR include: 1. Functional group analysis (chemical shifts) 2. Bonding connectivity and
More informationChapter 18: NMR Spectroscopy
The most important tool of the chemist for the determination of molecular structure is Nuclear Magnetic Resonance Spectroscopy, or NMR spectroscopy. NMR spectra are acquired on a special instrument called
More informationModule 13: Chemical Shift and Its Measurement
Subject Chemistry Paper No and Title Module No and Title Module Tag Paper 12: Organic Spectroscopy CHE_P12_M13_e-Text TABLE OF CONTENTS 1. Learning Outcomes 2. Introduction 3. Shielding and deshielding
More informationIntroduction to NMR spectroscopy
Introduction to NMR spectroscopy Nuclei of isotopes which possess an odd number of protons, an odd number of neutrons, or both, have a nuclear spin quantum number, I, such that, I = 1/2n, where n is an
More informationObjective 4. Determine (characterize) the structure of a compound using IR, NMR, MS.
Objective 4. Determine (characterize) the structure of a compound using IR, NMR, MS. Skills: Draw structure IR: match bond type to IR peak NMR: ID number of non-equivalent H s, relate peak splitting to
More informationInstrumental Chemical Analysis
L15 Page1 Instrumental Chemical Analysis Nuclear Magnetic Resonance Dr. Ahmad Najjar Philadelphia University Faculty of Pharmacy Department of Pharmaceutical Sciences 1 st semester, 2017/2018 Nuclear Magnetic
More informationProton NMR. Four Questions
Proton NMR Four Questions How many signals? Equivalence Where on spectrum? Chemical Shift How big? Integration Shape? Splitting (coupling) 1 Proton NMR Shifts Basic Correlation Chart How many 1 H signals?
More informationORGANIC - CLUTCH CH ANALYTICAL TECHNIQUES: IR, NMR, MASS SPECT
!! www.clutchprep.com CONCEPT: PURPOSE OF ANALYTICAL TECHNIQUES Classical Methods (Wet Chemistry): Chemists needed to run dozens of chemical reactions to determine the type of molecules in a compound.
More informationCHEM 322 Laboratory Methods in Organic Chemistry. Introduction to NMR Spectroscopy
EM 322 Laboratory Methods in Organic hemistry Introduction to NMR Spectroscopy What structural information does NMR spectroscopy provide? 1) hemical shift (δ) data reveals the molecular (functional group)
More informationORGANIC - CLUTCH CH ANALYTICAL TECHNIQUES: IR, NMR, MASS SPECT
!! www.clutchprep.com CONCEPT: PURPOSE OF ANALYTICAL TECHNIQUES Classical Methods (Wet Chemistry): Chemists needed to run dozens of chemical reactions to determine the type of molecules in a compound.
More informationNuclear Magnetic Resonance Spectroscopy Chem 4010/5326: Organic Spectroscopic Analysis Andrew Harned
Nuclear Magnetic Resonance Spectroscopy Chem 4010/5326: Organic Spectroscopic Analysis 2015 Andrew Harned NMR Spectroscopy NMR Spectroscopy All nuclei have a nuclear spin quantum number (I) I = 0, 1/2,
More informationOAT Organic Chemistry - Problem Drill 19: NMR Spectroscopy and Mass Spectrometry
OAT Organic Chemistry - Problem Drill 19: NMR Spectroscopy and Mass Spectrometry Question No. 1 of 10 Question 1. Which statement concerning NMR spectroscopy is incorrect? Question #01 (A) Only nuclei
More informationTo Do s. Read Chapter 3. Complete the end-of-chapter problems, 3-1, 3-3, 3-4, 3-6 and 3-7. Answer Keys are available in CHB204H
Read Chapter 3. To Do s Complete the end-of-chapter problems, 3-1, 3-3, 3-4, 3-6 and 3-7 Answer Keys are available in CB204 NMR Chemical Shifts Further Discussion A set of spectral data is reported when
More information22 and Applications of 13 C NMR
Subject Chemistry Paper No and Title Module No and Title Module Tag 12 and rganic Spectroscopy 22 and Applications of 13 C NMR CHE_P12_M22 TABLE F CNTENTS 1. Learning utcomes 2. Introduction 3. Structural
More informationSpectroscopy in Organic Chemistry. Types of Spectroscopy in Organic
Spectroscopy in Organic Chemistry Spectroscopy Spectrum dealing with light, or more specifically, radiation Scope to see Organic Spectroscopy therefore deals with examining how organic molecules interact
More informationi e l d f Energy (E) = Direction visible ultraviolet X-ray gamma infrared
rganic Structure Determination Analytical hemistry Instrument-based methods for determination of structure of organic molecules 1) Infrared Spectroscopy - yields functional groups 2) NMR Spectroscopy -
More information12-June-2016 Chemsheets A Page 1
www.chemsheets.co.uk 12-June-2016 Chemsheets A2 1070 Page 1 SECTION 1 1 H NMR Why compounds absorb radiowaves (background information beyond specifications) NMR (nuclear magnetic resonance) is a very powerful
More informationHWeb27 ( ; )
HWeb27 (9.1-9.2; 9.12-9.18) 28.1. Which of the following cannot be determined about a compound by mass spectrometry? [a]. boiling point [b]. molecular formula [c]. presence of heavy isotopes (e.g., 2 H,
More informationIn a solution, there are thousands of atoms generating magnetic fields, all in random directions.
Nuclear Magnetic Resonance Spectroscopy: Purpose: onnectivity, Map of - framework Process: In nuclear magnetic resonance spectroscopy, we are studying nuclei. onsider this circle to represent a nucleus
More informationCH Exam #4 (Take Home) Date Due: 11/25,26/2013
CH2710 - Exam #4 (Take Home) Date Due: 11/25,26/2013 Section I - Multiple Choice - Choose the BEST answer from the choices given and place the letter of you choice in the space provided. 1. Energy absorbed
More informationDETECTION OF UNPAIRED ELECTRONS
DETECTION OF UNPAIRED ELECTRONS There are experimental methods for the detection of unpaired electrons. One of the hallmarks of unpaired electrons in materials is interaction with a magnetic field. That
More informationBackground: In this chapter we will discuss the interaction of molecules with a magnetic field.
Chapter 4 NMR Background: In this chapter we will discuss the interaction of molecules with a magnetic field. * Nuclear Spin Angular Momenta - recall electrons & spin -- our spin functions are and which
More informationCHEM311 FALL 2005 Practice Exam #3
EM311 FALL 2005 Practice Exam #3 Instructions: This is a multiple choice / short answer practice exam. For the multiple-choice questions, there may be more than one correct answer. If so, then circle as
More informationChapter 9. Nuclear Magnetic Resonance and Mass Spectrometry. 1. Introduction. 2. Nuclear Magnetic Resonance (NMR) Spectroscopy
hapter 9 Nuclear Magnetic Resonance and Mass Spectrometry reated by Professor William Tam & Dr. Phillis hang 1. Introduction Spectroscopy the study of the interaction of light with matter Spectroscopy
More informationORGANIC - BROWN 8E CH NUCLEAR MAGNETIC RESONANCE.
!! www.clutchprep.com CONCEPT: 1 H NUCLEAR MAGNETIC RESONANCE- GENERAL FEATURES 1 H (Proton) NMR is a powerful instrumental method that identifies protons in slightly different electronic environments
More informationThe rest of topic 11 INTRODUCTION TO ORGANIC SPECTROSCOPY
The rest of topic 11 INTRODUCTION TO ORGANIC SPECTROSCOPY 1. Mass spectrometry: SPECTROSCOPIC TECHNIQUES - A technique capable of identifying the presence of various mass segments of organic molecules.
More informationNuclear magnetic resonance spectroscopy II. 13 C NMR. Reading: Pavia Chapter , 6.7, 6.11, 6.13
Nuclear magnetic resonance spectroscopy II. 13 NMR Reading: Pavia hapter 6.1-6.5, 6.7, 6.11, 6.13 1. General - more/better/additional structural information for larger compounds -problems: a) isotopes
More informationNuclear Magnetic Resonance Spectroscopy
Nuclear Magnetic Resonance Spectroscopy Structural Elucidation Nuclear magnetic resonance spectroscopy is the name given to the technique which exploits the magnetic properties of nuclei and measures their
More informationAnalysis of NMR Spectra Part 2
Analysis of NMR Spectra Part 2-1- Analysis of NMR Spectra Part 2 "Things should be made as simple as possible, but not any simpler." Albert Einstein 1.1 Review of Basic NMR Concepts NMR analysis is a complex
More informationIn a solution, there are thousands of atoms generating magnetic fields, all in random directions.
Nuclear Magnetic Resonance Spectroscopy: Purpose: onnectivity, Map of - framework Process: In nuclear magnetic resonance spectroscopy, we are studying nuclei. onsider this circle to represent a nucleus
More informationCHM 223 Organic Chemistry I Prof. Chad Landrie. Lecture 10: September 20, 2018 Ch. 12: Spectroscopy mass spectrometry infrared spectroscopy
M 223 Organic hemistry I Prof. had Landrie Lecture 10: September 20, 2018 h. 12: Spectroscopy mass spectrometry infrared spectroscopy i>licker Question onsider a solution that contains 65g R enantiomer
More informationStructure Determination
There are more than 5 million organic compounds, the great majority of which are colourless liquids or white solids. Identifying or at least characterising determining some of its properties and features
More informationChemistry 416 Spectroscopy Fall Semester 1997 Dr. Rainer Glaser
Chemistry 416 Spectroscopy Fall Semester 199 Dr. Rainer Glaser First 1-Hour Examination NMR Spectroscopy Monday, October 6, 199, :40-9:0 Name: Answer Key Question 1 (Spectra) 20 Question 2 (Equivalence)
More informationNuclear Magnetic Resonance Spectroscopy: Purpose: Connectivity, Map of C-H framework
Nuclear Magnetic Resonance Spectroscopy: Purpose: Connectivity, Map of C- framework Four Factors of Proton NMR (PMR OR NMR):. Symmetry: Number of chemically different protons (symmetry) as shown by number
More informationKeywords: structure of organic molecules, nuclear magnetic resonance, mass spectrometry.
ORGANIC SPECTROSCOPY Mauro A. Cremonini and Giorgio Bonaga Department of Food Science, University of Bologna, Italy Keywords: structure of organic molecules, nuclear magnetic resonance, mass spectrometry.
More information