SYNCHROM EVO III. Choose your application of. Syn. processowner. runtime min. tracer reaction reactor purification. radiochemical.

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2 Choose your application of SYNCHROM EVO III 131 / 123 I-MIBG labeling nucleophilic 68 Ga-DOTATOC labeling complexation tracer reaction reactor purification processowner radiochemical yield % runtime min 1 prep HPLC raytest yes yes 1 SPE raytest yes yes F-DOPA electrophil 1 prep HPLC raytest yes yes F-Uracil electrophil 1 prep HPLC raytest yes yes IQ OQ F-Tyrosine electrophil 1 prep HPLC raytest yes yes FDG nucleophil 1 SPE raytest yes yes [ 11 C] Acetat nucleophil 1 SPE raytest FLT nucleophil 1 prep HPLC raytest yes yes FDDNP nucleophil 1 prep HPLC FTHA nucleophil 1 prep HPLC F-benperidol nucleophil 1 prep HPLC F-M-piperone nucleophil 1 prep HPLC F-Altanserin nucleophil 1 prep HPLC customer F-Misodiazol nucleophil 1 prep HPLC customer F-BMS nucleophil 1 prep HPLC F-FET nucleophil 2 SPE raytest yes yes F-FEC nucleophil 2 SPE raytest yes yes F-FDG-dual nucleophil 2 SPE raytest yes yes F-diprenorphen nucleophil 2 prep HPLC F-estradiol nucleophil 2 prep HPLC F-FMZ nucleophil 1 prep HPLC F-FHBG nucleophil 1 prep HPLC F-FFAU nucleophil 1 prep HPLC F-FESP nucleophil 1 prep HPLC F-FEAU nucleophil 2 prep HPLC F-praclitaxel nucleophil 2 prep HPLC [ F]-FDDPA nucleophil 2 prep HPLC

3 GAIA peptide labeling fluidic processor APPLICATION 68 Gallium peptides single-use synthesis kits no cross contamination compact design GAIA Concept Gaia is a synthesis unit for the labeling of peptides Iike DOTAToc with radioactive metals (e.g. 68 Ga). Other labeling procedures can also be adapted as long as they don t include distillation steps and are not conducted under inert atmosphere. Gaia was developed with regard on the following guidelines: compact design smooth surfaces, that are easy to clean reduction of the required electrical connections to the absolute minimum complete abdication of compressed gases economized application of the single-use materials in order to minimize the running costs for the user short synthesis times for less yield loss due to decay easy handling of both the soft- and the hardware The materials in the synthesis kits are available widespread, can be sterilized and can be set up as a modular system. Comprehensive Software The new Gaia software was optimized for quick and easy synthesis control and evaluation. It offers a touch -controlled interface and full visualisation of a running process. Due to the fact that the interface was designed to manual input on a touch-sensitive screen, the software is executed on a a panel computer, which complies industrial standards. The method editor is full interactive and offers a graphical editor for the process layout, a timetable with graphical display of the actual flow paths and an SOP editor. A report generator and full user management with an electronical signature system is also implemented. Gaia Performance The main application of Gaia is the labeling of peptides with 68 Ga. After the elution of the 68 Ga / 68 Ge generator three different procedures can be implemented (the respective procedure depends on the type of generator and on the local formalities): labeling with the eluate without previous cleaning labeling with the eluate after fractionated elution in order to separate other metals in large part trapping and elution of 68 Ga with efficient separation of other metals In addition, both cleaning procedures can be combined in order to achieve the best possible purification result of the eluate. Results of the 68 Ga-DOTAToc synthesis with Gaia (uncorrected yields): no intermediate cleaning procedure: % = very short synthesis time fractionated elution: % = good purification = very short synthesis time Trapping and elution: % yield = very good purification Fractionation, trapping and elution: 55-65% = Best purification 78

4 GAIA 68 Ga synthesis control / preparation and reports TECHNICAL DATA GAIA communication: computer: width / height: depth: weight: power requirement: USB or LAN Windows 7 or higher, 32 or 64 bit 420 mm / 350 mm 410 mm (open: 560 mm) 25 kg 230 V power consumption max.: 230 V / 100 VA humidity max.: 70 % relative temperature: C over pressure stability: 5 bar installation requirements: See document Gaia installation requirements COMPONENTS peristaltic pump: number of valves: 3 x 5 number of syringe holder: 2 number of reactors: 1 SENSORS radioactivity detectors: +/-1 to +/-300 rpm, with rotation and lid sensor 3 scmi conductor detectors for process control 1 semiconductor detector for fractioning gas pressure sensor: 1 pressure sensor accuracy: to 7000 mbar: +/- 10 mbar REACTOR COOLING AND HEATING cooling & Heating method: electrical dynamic range: C temperature accuracy: +/- 1.0 C speed of heating: 25 C 100 C < 50 s speed of cooling: 100 C 30 C < 75 s FEATURES Operation The operation of Gaia was optimized with regard on a fast and simple production of common tracers. The synthesis kit can be mounted on an integrated working surface without the use of cassettes. The mentioned working surface constitutes the front Iid and is hinged down in order to equip the construction. By folding the lid up, the operational state is set up easily. After each synthesis run the kit is disposed; a cleaning procedure is not necessary. Due to the fact that all components, which get in contact with the reagents, are part of the single-use kit, no concerns regarding a possible crosscontamination by previous synthesis runs are raised. Therefore different tracers can be produced under GMP conditions on one single synthesis unit. Via a colour code a light strip in the upper region of the construction gives information about the working condition of the synthesis unit. In addition this light strip illuminates the working surface while the synthesis kit is mounted. At the start of each synthesis run the kit is tested for integrity. The software is also optimized with regard on a fast and simple production. The required preparation steps are recorded and defined within the software. Prior to each production process the user needs to sign the synthesis run with a name and a batch number. These signed preparation steps are part of the all-over documentation of the production process and are not only mentioned in the production report but optional also in the Raphaela RS batch report. The latter collects and records additionally the QC data of the production. ORDERING INFORMATION GAIA GMP peptide labelling fluid processor GAIA synthesis kit for 68 Ga-DOTAToc

5 Chrom FDG PET-automatic-synthesis-unit for FDG production APPLICATION PET synthesis of: [ F]-FDG, single unit PET synthesis of: [ F]-FDG, twin unit The Chrom FDG system has been developed & designed to produce [ F]-FDG based on nucleophilic substitution. The system is based on the raytest Chrom R&D system without the hardware which is not required for the FDG synthesis process. raytest is supplying the entire process documentation as well as the responsibility for the successful FDG production on this device. The Chrom FDG unit is equipped with one of the unique raytest transparent reactor systems. The entire process is visible. The 500 W electrical air heater system & the compressed air cooling enables ultra fast temperature changes in the synthesis reagent solvent. The system monitors the real solvent temperature. Temperature range 20 C to +0 C. Chrom FDG is equipped with very fast, low hold up volume, solvent resistant and pressure tight ( 4 bars ) magnetic flipper valves. All solvents are transported directly into the reaction vessel without any solvent cross contamination. The built in pressure sensor continuously displays the actual system ( reactor ) pressure. This pressure sensor is also used for automatic gas leakage test after the synthesis unit cleaning procedure. During the process this sensor also observes the process for unexpected accidents with selectable warning and shutdown levels. The reactor system is also equipped with a magnetic stirrer mixing system & a tube lifting system. The unit contains a builtin lead shielding housing for the F trap as well as a shielded target water collecting vial with radiation detectors for observation, analysis and reporting. (both can be used also without a self owned cyclotron). The target activity delivery can be done directly to the F trap or via the target vial Close to the reactor further shielded radiation detectors are installed to monitor the actual process activity. Target or QMA + product radiation detectors are used for automatic calculation of the yield. (EOB / EOS / EOP, uncorrected and/or corrected) The system contains a O water recovery vial and on request a second water recovery vial (for flushing target). The built-in double membrane high performance, solvent resistant vacuum pump (40 mbar) allows ultra fast drying of the solvent. The product will be purified by single use cartridges. All detectors are designed for a dynamic range from 10 mci to 5 Ci at minimum crosstalk. The entire unit is tested up to 5 Ci. The unit is controlled by GINA Star Chrom software with an almost unlimited flexibility for process optimization. FEATURES one transparent reactor systems fully visible process ultra fast reactor heating / cooling magnetic stirrer mixing system tube lifting system cartridge product purification built in vacuum pump built in pressure control on line process control interactive process diagram fully automatic operation reported manual intervention online / offline process development interface GLP / GMP / 21 CFR part 11 compliant highest reliability highest yield ( > 55 %) acid or base hydrolysis possible

6 Chrom F FDG acid Chrom FDG twin TECHNICAL DATA ORDERING INFORMATION Chrom FDG scnumber of valves: 15 liquid nitrogen cooling Dewar: solvent container: 6 product vessel: magnetic stirrer: 2 radioactivity detectors: gas pressure sensor: 1 reactor systems: reactor cooling method: shielded cartridge trap positions: 2 vacuum pump: overall dimension: weight: power: humidity: temperature: 1 l 25 ml 4 GM tubes 1 glass or Sigradur ml compressed air 40 mbar solvent resistant 380 mm width 520 mm width incl. cold trap 490 mm depth 500 mm height 36 kg V 200 W max 70 % relative C require dedicated quotation; please contact your localraytest partner reactor transperable for visible process solvent container & connection Lead LAN Control Computer GINA Star Hot Cell

7 Chrom FLT PET-automatic-synthesis-unit for FLT production APPLICATION PET synthesis of: [ F]-FLT The Chrom FLT system has been developed & designed to produce [ F]-FLT based on nucleophilic substitution. The system is based on the raytest Chrom R&D system without the hardware which is not required for the FLT synthesis process.raytest is supplying the entire process documentation as well as the responsibility for the successful FLT production on this device. The Chrom FLT unit is equipped with one of the unique raytest transparent reactor systems. The entire process is visible. The 500 W electrical air heater system & the compressed air cooling enables ultra fast temperature changes in the synthesis reagent solvent. The system monitors the real solvent temperature.temperature range 20 C to +0 C. Chrom FLT is equipped with very fast, low hold up volume, solvent resistant and pressure tight (4 bars) magnetic flipper valves. All solvents are transported directly into the reaction vessel without any solvent cross contamination. The built-in pressure sensor continuously displays the actual system ( reactor ) pressure. This pressure sensor is also used for automatic gas leakage test after the synthesis unit cleaning procedure. During the process this sensor also observes the process for unexpected accidents with selectable warning and shutdown levels. The reactor system is also equipped with a magnetic stirrer mixing system and a tube lifting system. The unit contains a built-in lead shielding housing for the F trap as well as a shielded target water collecting vial with radiation detectors for observation, analysis and reporting. (both can be used also without a self owned cyclotron). The target delivery can be done directly to the F trap or via the target vial. The Chrom FLT close to the reactor a further shielded radiation detector is installed to monitor the actual process activity. Target or QMA + product radiation detectors are used for automatic calculation of the yield. (EOB / EOS / EOP, uncorrected and/or corrected) The system containes a O water recovery vial and on request a second water recovery vial (for flushing target). The built-in double membrane high performance, solvent resistant vacuum pump (40 mbar) allows ultra fast drying of the solvent. For purifications of the product the system contains a built-in semi-preparative HPLC system. The automatic injector with a sample loop for the entire reaction vessel volume is controlled by the IR liquid detector for automatic detection of the injection time (reactor empty). The built-in radioactivity flow through detector detects the main peak and the built-in fraction collector automatically collects it. All detectors are designed for a dynamic range from 10 mci to 2 Ci at minimum crosstalk. The entire unit is tested up to 5 Ci. The unit is controlled by GINA Star Chrom software with an almost unlimited flexibility for process optimization. 82

8 reactor transperable for visible process Flow diagram FLT TECHNICAL DATA Chrom FLT number of valves: 25 liquid nitrogen cooling Dewar: 1l HPLC pump: 10 ml / min, isocr. 400 bar UV detector: 254 nm autom. injector loop: 3 5 ml liquid sensor: IR solvent container: 11 product vessel: 20 ml magnetic stirrer: 3 or 4 radioactivity detectors: 5 GM tubes gas pressure sensor: 1 reactor systems: 1 glass or Sigradur ml reactor cooling method: compressed air shielded cartridge trap positions: 1 vacuum pump: 40 mbar solvent resistant overall dimension: 520 mm wide 490 mm deep 500 mm high weight: 36 kg power: V 200 W humidity: max 70 % relative temperature: C ORDERING INFORMATION require dedicated quotation, please contact your local raytest partner FEATURES very compact 1 transparent reactor systems fully visible process ultra fast reactor heating / cooling magnetic stirrer mixing system tube lifting system built-in HPLC purification system built-in vacuum pump built-in pressure control on-line process control interactive process diagram fully automatic operation reported manual intervention online/offline process development interface GLP/GMP/21 CFR part 11 compliant highest reliability highest yield recording value of various sonsors over time

9 Chrom F-Dopa/F 2 PET-automatic-synthesis-unit for [ F]FDopa production APPLICATION PET synthesis of: F-Dopa electrophil Chrom F-Dopa is a fully automatic PET-synthesis unit for [ F]FDopa production via electrophilic substitution processes. The Chrom F-Dopa unit is based on the raytest Chrom F 2 system. Different to that system raytest delivers together with the Chrom F-Dopa the entire chemical process description. raytest guarantees the successful F-Dopa production. SOP, solvent description & comprehensive documentation is available. The system contains the unique raytest transparent reactor system. The entire process is visible. The first synthesis step requires a very low temperature. Chrom F-Dopa has a nitrogen gas cooled (liquid nitrogen pre cooled) reactor and a 500 W electrical air heater. This enables ultra fast temperature changes in the synthesis reagent solvent. The system monitors the real solvent temperature. Temperature range 40 C to +0 C Chrom F-Dopa is equipped with very fast, low hold up volume, solvent resistant and pressure tight (4 bars) magnetic flipper valves. All solvents are transported directly into the reactor vessel, without any solvent cross contamination. The built-in pressure sensor displays the actual system (reactor) pressure. This pressure sensor is also used for pressure / vacuum tightness test after the synthesis unit cleaning procedure. During the process this sensor also observes for unexpected events with settable warnings and shutdown levels. The ml reactor is equipped with a magnetic stirrer solvent mixing system and a tube lifting system. The reactor is equipped with a lead shielded radiation detector to monitor the actual delivered activity and to automatically calculate the yield. (EOB / EOS). For purification of the product the unit contains a built-in semipreparative HPLC system consisting of a isocratic pump, UV detector, automatic injector with a sample loop for the entire reaction vessel volume and a liquid detector for automatic de tection of the injection time (reactor empty). The required HPLC separation column is included on request. The built-in radioactivity flow sensor detects the main peak and the built-in fraction collector automatically collects it. All detectors are designed for a dynamic range from 10 mci up to 2 Ci at minimum crosstalk. The entire unit is tested up to 2 Ci. F 2 target is required. FEATURES very compact on line process display interactive process diagram fully automatic manual intervention GLP / GMP / 21 CFR part 11 compliant highest reliability highest yield 84

10 reactor transperable for visible process flow diagram TECHNICAL DATA Chrom F-Dopa: number of valves: 14 liquid nitrogen Dewar: reaction vessel: reactor temp. range: HPLC pump: UV-detector: autom. injector loop: liquid sensor: 1 l ml Sigradur or Duran -40 C to +0 C 10 ml/min, 400 bar 254 nm 5 ml F 2 -flow: mass flow detector / regulator (optional) solvent container: product vessel: radioactivity detectors: pressure sensor: 1 vacuum pump: overall dimension: power: environment humidity: environment temp.: IR 1 x 20 ml, 3 x 8 ml 20 ml (illuminated) 3 x GM (lead shielded) 40 mbar / solvent resistant 520 mm wide 490 mm deep 500 mm high V / 200 W max 70 % relative C ORDERING INFORMATION require dedicated quotation, please contact your local raytest partner recording sensor values over time

11 Chrom FEC PET-automatic-synthesis-unit for [ F]FEC production APPLICATION PET synthesis of: [ F]FEC The Chrom FEC system has been developed & designed to produce [ F]FEC based on nucleophilic substitution. The system is based on the raytest Chrom R&D system without the hardware which is not required for the [ F]FEC synthesis process. raytest is supplying the entire process documentation as well as the responsibility for the successful [ F]FEC production on this device. The Chrom FEC unit is equipped with two of the unique raytest transparent reactor systems. The entire process is visible. The 500 W electrical air heater system and the compressed air cooling enables ultra fast temperature changes in the synthesis reagent solvent. The system monitors the real solvent temperature. Temperature range 20 C to +0 C. Chrom FEC is equipped with very fast, low hold up volume, solvent resistant and pressure tight (4 bars) magnetic flipper valves. All solvents are transported directly into the reaction vessel without any solvent cross contamination. The built in pressure sensor continuously displayes the actual system ( reactor ) pressure. This pressure sensor is also used for automatic gas leakage test after the synthesis unit cleaning procedure. During the process this sensor also observes the process for unexpected accidents with selectable warning and shutdown levels. The reactor systems are also equipped with magnetic stirrer mixing systems and tube lifting systems. The unit contains a built-in lead shielding housing for the F trap as well as a shielded target water collecting vial with radiation detectors for observation, analysis and reporting (both can be used also without a self owned cyclotron). The target delivery can be done directly to the F trap or via the target vial Close to the reactors further shielded radiation detectors are installed to monitor the actual process activity. Target or QMA + product radiation detectors are used for automatic calculation of the yield. (EOB / EOS / EOP, uncorrected and/or corrected) The system containes a O water recovery vial and on request a second water recovery vial (for flushing target). The built in double membrane high performance, solvent resistant vacuum pump (40 mbar) allows ultra fast drying of the solvent. For purifications of the product the system is equipped with a cartridge purification. All detectors are designed for a dynamic range from 10 mci to 5 Ci at minimum crosstalk. The entire unit is tested up to 5 Ci. The system will be delivered with the raytest FEC 2 step process with cartridge purification. Entire chemical process description available on request. The unit is controlled by GINA Star Chrom software with an almost unlimited flexibility for process optimization. FEATURES very compact 2 transparent reactor systems fully visible process ultra fast reactor heating / cooling magnetic stirrer mixing system tube lifting system Cartridge purification system built-in vacuum pump built-in pressure control on-line process control interactive process diagram fully automatic operation reported manual intervention online/offline process development interface GLP / GMP / 21 CFR part 11 compliant highest reliability highest yield (raytest process)

12 Example run FEC Chrom FEC flow diagram TECHNICAL DATA Chrom FEC number of valves: 30 liquid nitrogen cooling Dewar: 1 l solvent container: 11 product vessel: magnetic stirrer: 4 radioactivity detectors: gas pressure sensor: 1 reactor systems: reactor cooling method: cartridge trap positions: 3 vacuum pump: overall dimension: weight: power: humidity: temperature: 25 ml 5 GM tubes 2 glass or Sigradur ml compressed air 40 mbar, solvent res. 520 mm wide 490 mm deep 500 mm high 36 kg 115 or 230 V / 200 W max 70 % relative C ORDERING INFORMATION require dedicated quotation, please contact your local raytest partner reactor transperable for visible process

13 Chrom FET PET-automatic-synthesis-unit for [ F]FET production APPLICATION PET synthesis of: [ F]FET The Chrom FET system has been developed and designed to produce [ F]FET based on nucleophilic substitution. The system is based on the raytest Chrom R&D system without the hardware which is not required for the[ F]FET synthesis process. raytest is supplying the entire process documentation as well as the responsibility for the successful [ F]FET production on this device. The Chrom FET unit is equipped with two of the unique raytest transparent reactor systems. The entire process is visible. The 500 W electrical air heater systems and the compressed air cooling enables ultra fast temperature changes in the synthesis reagent solvent. The system monitors the real solvent temperature. Temperature range 20 C to +0 C. Chrom FET is equipped with very fast, low hold up volume, solvent resistant and pressure tight (4 bars) magnetic flipper valves. All solvents are transported directly into the reaction vessel without any solvent cross contamination. The built in pressure sensor continuously displays the actual system (reactor) pressure. This pressure sensor is also used for automatic gas leakage test after the synthesis unit cleaning procedure. During the process this sensor also observes the process for unexpected accidents with selectable warning and shutdown levels. The reactor systems are also equipped with a magnetic stirrer mixing system and a tube lifting system. The unit contains a built-in position for the F trap as well as a position for the target water collecting vial with radiation detectors for observation, analysis and reporting. (both can be used also without a direct attached cyclotron). The target delivery can be done directly to the F trap or via the target vial Close to the reactors two further shielded radiation detectors are installed to monitor the actual process activity. Target (or QMA) + product radiation detectors are used for automatic calculation of the yield. (EOB / EOS / EOP, uncorrected and/or corrected) The system containes a O water recovery vial and on request a second water recovery vial (for flushing target). The built-in double membrane high performance, solvent resistant vacuum pump (40 mbar) allows ultra fast drying of the solvent. For purifications of the product, the system contains a radiation detector observed cartridge position. No semi-preparative HPLC system is required. All detectors are designed for a dynamic range from 10 mci to 2 Ci at minimum crosstalk. The entire unit is tested up to 5 Ci. The unit is controlled by GINA Star Chrom software with an almost unlimited flexibility for process optimization. The system (hard as well as software) is GLP / GMP / 21 CFR part 11 compliant. FEATURES very compact 2 transparent reactor systems fully visible process ultra fast reactor heating / cooling magnetic stirrer mixing system tube lifting system Cartridge purification system built-in vacuum pump built-in pressure control on-line process control interactive process diagram fully automatic operation reported manual intervention online/offline process development interface GLP / GMP / 21 CFR part 11 compliant highest reliability highest yield (raytest process)

14 Flow diagram Chrom FET Example run [ F]FET TECHNICAL DATA Chrom FET number of valves: 30 liquid nitrogen cooling Dewar: 1 l solvent container: 11 product vessel: 20 ml magnetic stirrer: 4 radioactivity detectors: 7 GM tubes gas pressure sensor: 1 reactor systems: 2 glass or Sigradur ml reactor cooling method: compressed air cartridge trap positions: 3 vacuum pump: 40 mbar, solvent res. overall dimension: 520 mm wide 490 mm deep 500 mm high weight: 36 kg power: 115 or 230 V / 200 W humidity: max 70 % relative temperature: C ORDERING INFORMATION require dedicated quotation Please contact your local raytest partner Various solvent container dimensions reactor transperable for visible process

15 Chrom R&D PET-automatic-synthesis-unit for nucleophilic substitution APPLICATION PET synthesis of: FEC, FLT, FET, FDDNP, [ F] F-Misodiazol, FTHA, [ F] F-Altanserin, F-BMS [ F] FDG, FFAU, [ F] F-diprenorphen, [ F] F-benperidol, FESP, [ F] F-m-piperone, FEAU, [ F] F-estradiol, FMZ, [ F] F-Paclitaxel, FHBG, [ F] F-Octreotide others The Chrom R&D system has been developed and designed to afford the transfer of the radio chemist s idea of a chemical synthesis process from an on hand, published or known process to a fully automatic synthesis system. Also the entire chemical process development can be done on this unit. Almost all synthesis processes can be applied. With the optional reactor pre-cooling device even electrophilic substitution processes can be adapted. The Chrom R&D unit is equipped with one or two unique raytest transparent reactor systems. The entire process is visible. The 500 W electrical air heater system and the compressed air cooling enables ultra fast temperature changes in the synthesis reagent solvent. The system monitors the real solvent temperature. Temperature range 20 C to +0 C. Chrom R&D is equipped with very fast, low dead volume, solvent resistant and pressure tight (4 bars) magnetic flipper valves. All solvents are transported directly into the reaction vessel without any solvent cross contamination. The built in pressure sensor continuously displays the actual system (reactor) pressure. This pressure sensor is also used for automatic gas leakage test after the synthesis unit cleaning procedure. During the process this sensor also observes the process for unexpected accidents with selectable warning and shutdown levels. The reactor system is also equipped with a magnetic stirrer mixing system and a tube lifting system. The unit contains a built-in lead shielded housing for the F trap as well as a shielded target water collecting vial with radiation detectors for observation, analysis and reporting. (both can be used also without an on site cyclotron). The target delivery can be done directly to the F trap or via the target vial. Close to the reactors further shielded radiation detectors are installed to monitor the actual process activity. Target or QMA + product radiation detectors are used for automatically calculation of the yield (EOB / EOS / EOP, uncorrected and/or corrected). The system contains a O water recovery vial and on request a second water recovery vial (for flushing target). The built-in double membrane high performance, solvent resistant vacuum pump (40 mbar) allows ultra fast drying of the solvent. For purifications of the product the system contains a built-in semipreparative HPLC system. The automatic injector with a sample loop for the entire reaction vessel volume is controlled by the IR liquid detector for automatic detection of the injection time (reactor empty). The built-in radioactivity flow through detector detects the main peak and the built-in fraction collector automatically collects it. All detectors are designed for a dynamic range from 10 mci to 2 Ci at minimum crosstalk. The entire unit is tested up to 5 Ci. A lead shielded cartridge trap housing is installed behind the HPLC product separation and fractioning to allow organic solvent trapping. The unit is controlled by GINA Star Chrom software with an almost unlimited flexibility for process optimization. 90

16 Chrom F R&D flow diagram ransperable reactor for visible process TECHNICAL DATA Chrom R&D number of valves: 30 liquid nitrogen cooling Dewar: HPLC pump: UV detector: autom. injector loop: liquid sensor: 1 l 10 ml / min, isocr. 400 bar 254 nm 3 5 ml IR solvent container: 11 product vessel: 20 ml magnetic stirrer: 3 or 4 radioactivity detectors: gas pressure sensor: 1 reactor systems: reactor cooling method: shielded cartridge trap positions: 3 vacuum pump: overall dimension: weight: power: humidity: temperature: 7 GM tubes 1 or 2 glass or Sigradur ml compressed air or pre-cooled nitrogen 40 mbar, solvent res. 520 mm wide 490 mm deep 500 mm high 36 kg 115 or 230 V / 200 W max. 70 % relative C ORDERING INFORMATION require dedicated quotation Please contact your local raytest partner FEATURES very compact 1 or 2 reactor systems transparent reactor systems fully visible process ultra fast reactor heating / cooling magnetic stirrer mixing system tube lifting system built in HPLC purification system built in vacuum pump built in pressure control on line process control interactive process diagram full automatic operation reported manual intervention online/offline process development interface GLP / GMP / 21 CFR part 11 compliant highest reliability