1. Which of the following drugs has not been in use for greater than 1000 years?

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1 Chemistry 106 Bonus Exercise Spring 2018 The following bonus exercise contains 20 questions valued at 0.25 points per question (5 points overall). Since we have not covered all of the individuals found within this quiz and their contributions to understanding drug action, it will not be due until the end of class on Wednesday (5/2). However, I would advise looking it over, doing what you can now, and bringing it with you to class Tuesday and Wednesday. Please place your answers on a ½ sheet Scantron. Name 1. Which of the following drugs has not been in use for greater than 1000 years? a. Ethanol b. Cannabis c. Peyote d. Tobacco e. N/A; all have been in use for greater than 1000 years 2. Which of the following occurred first? a. The development of writing b. The development of the scientific method c. The isolation of citric acid from limes d. The use of limes to extract the active compound from areca nut e. The use of limes by British sailors to prevent scurvy 3. Which of the following occurred first? a. The use of drugs to balance humours b. The use of drugs to expel demonic possession c. The use of drugs to lower blood pressure d. The use of drugs to combat infection e. The use of drugs to raise batting average

2 4. Which of the following individuals was the first physician? a. Imhotep b. Hippocrates c. Galen d. Al-Razi e. Dr. Suess 5. Which of the following occurred first? a. The identification of the enzyme aspirin blocks b. The identification of the endogenous ligand aspirin blocks the creation of c. The acetylation of salicylic acid to generate aspirin d. The isolation of salicylic acid from willow e. The use of willow as a drug 6. Which of the following is the definition of an endogenous ligand? a. A drug that activates a receptor b. A drug that blocks a receptor c. A compound made by the body that activates a receptor d. A compound made by the body that blocks a receptor e. An enzyme 7. Who wrote De Materia Medica (On Medical Matters)? a. Galen b. Theophrastus c. Dioscorides d. Hippocrates e. Pliny the Elder 8. Who wrote The Canon of Medicine (al-qanun fi at-tibb)? a. Abulcasis (Abu Al Qasim Al-Zahrawi) b. Al-Razi (Abu Bakr Al-Razi) c. Alhazen (Ibn al-haytham) d. Avicenna (Abu Ali Al-Hussain Ibn Abdallah Ibn Sina) e. Hunayn Ibn Ishaq

3 9. Who was responsible for translating many major medical texts from Arabic into Latin? a. Hunayn Ibn Ishaq b. Avicenna c. Abulcasis d. Gerardo de Cremona e. Paracelsus 10. Which of the following is the correct chronological order? a. Avicenna, Galen, Gerardo de Cremona, Paracelsus b. Paracelsus, Avicenna, Galen, Gerardo de Cremona c. Galen, Gerardo de Cremona, Avicenna, Paracelsus d. Galen, Avicenna, Gerardo de Cremona, Paracelsus e. Galen, Avicenna, Paracelsus, Gerardo de Cremona 11. Which of the following is the correct chronological order? a. Imhotep, Hippocrates, Galen, Al-Razi b. Hippocrates, Imhotep, Galen, Al-Razi c. Galen, Hippocrates, Imhotep, Al-Razi d. Imhotep, Hippocrates, Al-Razi, Galen e. Hippocrates, Imhotep, Al-Razi, Galen 12. Which of the following is the correct chronological order? a. Lavoisier, Leeuwenhoek, Lefkowitz, Lister b. Lister, Lavoisier, Leeuwenhoek, Lefkowitz c. Lavoisier, Leeuwenhoek, Lister, Lefkowitz d. Leeuwenhoek, Lavoisier, Lister, Lefkowitz e. Lefkowitz, Leeuwenhoek, Lavoisier, Lister 13. Which of the following individuals was not instrumental in advancing the scope of microscopy? a. Robert Hooke b. Antoni van Leeuwenhoek c. Joseph Jackson Lister d. Eduard Buchner e. N/A; all played a role in the advancement of the microscope

4 14. Who is credited with creating the first vaccine? a. Hippocrates b. Galen c. Mary Wortley Montagu d. Edward Jenner e. Waldemir Haffkine 15. Who was the first person to create a drug by synthesizing it from unrelated compounds 1? a. Hippocrates b. Dioscorides c. Galen d. William Withering e. Paul Ehrlich 16. Who was responsible for creating an antibiotic 2? a. Gerhardt Domagk b. Paul Ehrlich c. Alexander Fleming d. Edward Jenner e. All of the above individuals were responsible for creating antibiotics 17. Which of the following occurred first? a. Development of mass spectrometry b. Development of microscopy c. Development of nuclear magnetic resonance spectrometry d. Development of X-ray diffraction analysis e. Development of automated DNA sequencing 18. Which of the following occurred last? a. Development of mass spectrometry b. Development of microscopy c. Development of nuclear magnetic resonance spectrometry d. Development of X-ray diffraction analysis e. Development of automated DNA sequencing 1 As opposed to semisynthetic drugs like heroin, which relies on the plant derived core structure of morphine in order to be made 2 Antibiotic comes from the term antibiosis literally, against life

5 19. Which of the following individuals did not make substantial contributions to the elucidation of the human DNA sequence (human genome project)? a. Frederick Sanger b. Leroy Hood c. Francis Collins d. J. Craig Venter e. N/A; all made substantial contributions to the human genome project 20. Which of the following individuals did not hail from the Northwestern US? a. Robert Koch b. Leroy Hood c. Linus Pauling d. Walter Brattain e. N/A; all grew up in the Northwestern United States