Ac 2 O, py. Keywords: silyl hydrides silanes organosilanes chiral silanes hydrosilylation dehydrogenative
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1 VII Abstracts 2015 p Silyl ydrides R. W. Clark and S. L. Wiskur This chapter is an update to the earlier article in Science of Synthesis (Section 4.4.4) covering the synthesis and use of silyl hydrides. Recent advances in synthetic preparations of silyl hydrides are explored, as well as the use of silyl hydrides for hydrosilylation, reduction, and dehydrogenative silylation. Si Rh(acac)(C) 2 (0.1 mol%) C (68 atm), benzene, 60 o C Si TBAF TF, heat Ac 2, py Ac Ac 83%; dr (1,5-anti/1,5-syn) 7:1 Keywords: silyl hydrides silanes organosilanes chiral silanes hydrosilylation dehydrogenative silylation reduction 2015 p Vinylsilanes E. A. Anderson and D. S. W. Lim This chapter is an update to the earlier Science of Synthesis contribution (Section ) describing methods for the synthesis of vinylsilanes. It focuses on the literature published in the period , with aparticular emphasis on metal-catalyzed methods. (1 10 mol%) Cy 2 R 3 tcl 2 (0.5 5 mol%), TF, o C, 1 12 h R 3 + Si Si Keywords: vinylsilanes vinylmetals transition-metal catalysis hydrosilylation alkynes silylmetalation alkynylsilanes hydrogenation hydrometalation coupling reactions dehydrogenative silylation alkenes carbometalation metathesis rearrangements
2 VIII Science ofsynthesis Abstracts 2015 p Fluoroarenes A. arsanyi and G. Sandford This chapter is an update to the earlier Science of Synthesis contribution (Section 31.1) describing methods for the synthesis of fluoroarenes. It focuses on the literature published in the period , with aparticular emphasis on transition-metal-mediated fluorination processes. Ar 1 Tf Ar 1 M d/l, CsF F + source M=Sn 3,d, Ag [Cu] F + source Ar 1 F [Cu], AgF Ar 1 B( ) 2 Ar 1 I Keywords: organofluorine fluoroarenes fluoroaromatics fluorination transitionmetal-mediated fluorination 2015 p Chloroarenes S.. Stanforth This chapter updates the previous Science of Synthesis contribution (Section 31.2) published in Methods for the chlorination of arenes are described. The application of chloroarenes in synthesis, principally in transition-metal-catalyzed cross-coupling reactions, is discussed. chlorination =carbon- or heteroatom-based group Cl cross-coupling reaction Cl =any atom or group; =carbon- or heteroatom-based group Keywords: chlorination cross-coupling reactions transition-metal-catalyzed reactions aryl-carbon bond formation aryl-heteroatom bond formation
3 Abstracts I 2015 p omoarenes S.. Stanforth This chapter updates the previous Science of Synthesis contribution (Section 31.3), published in 2007, describing the preparation of bromoarenes and their applications in synthesis. In recent years, the use of bromoarenes in transition-metal-catalyzed cross-coupling reactions has attracted considerable interest. electrophilic bromination =carbon- or heteroatom-based group transition-metal-catalyzed cross-coupling reaction =any atom or group; =carbon- or heteroatom-based group Keywords: bromoarenes bromination cross-coupling reactions Suzuki reaction Sonogashira reaction Buchwald artwig reaction hydrodebromination transhalogenation 2015 p ypervalent Iodoarenes and Aryliodonium Salts V. V. Zhdankin This chapter provides an update to the earlier Science of Synthesis contribution (Section ) describing the preparation and synthetic applications of hypervalent iodoarenes and aryliodonium salts. Recently, the chemistry of hypervalent iodine compounds has experienced several significant new developments, the most important of which are represented by the discovery of catalytic reactions promoted by in situ generated hypervalent iodine species, the development of highly enantioselective reactions of chiral hypervalent iodine reagents, and the preparation and synthetic application of numerous recyclable hypervalent iodine reagents. Me 2 C C 2 Me Ar 1 I Ac Ac Ms 2 N, C 2 Cl 2,0o C 95% ee Ar 1 NMs 2 NMs 2 Keywords: iodine iodonium compounds alkynylation arylation trifluoromethylation oxidation oxidative cleavage catalysts chiral compounds fluorination iodination ofmann rearrangement
4 Science ofsynthesis Abstracts 2015 p Arylphosphine xides and eteroatom Derivatives. M. Demchuk, M. Stankevič, and K. M. ietrusiewicz This chapter is an expanded update to the earlier Science of Synthesis contribution (Section 31.41), describing methods for the synthesis of arylphosphine oxides, arylphosphine sulfides, arylphosphine selenides, and aryl(imino)phosphoranes. Classical routes to arylphosphine chalcogenides involve the oxidation of parent phosphines by the pertinent chalcogenide oxidant. ther methods involve the formation of the lacking -C bond(s) in oxidized electrophilic, nucleophilic, and radical phosphorus(v) precursors. Newer methods are based on hydrophosphinylation and coupling processes catalyzed by transition-metal complexes. Classical synthesis of aryl(imino)phosphoranes involves the reaction of the parent phosphines with organic azides (the Staudinger reaction), but methods based on the use of aminophosphonium intermediates are also reviewed. Approaches involving modifications of the carbon skeleton in existing arylphosphine chalcogenides are included as well. R 3 oxidation Staudinger coupling Arbuzov udovik Kabachnik Fields R 3 Michaelis Becker nucleophilic substitution Michael LG Keywords: phosphorus compounds phosphines phosphine oxides phosphine sulfides phosphine selenides iminophosphoranes phosphorus heterocycles phosphinylation addition reactions nucleophilic substitution coupling reactions cycloadditions 1,3-dipolar cycloaddition oxidation radical addition -C bond formation -C bond cleavage
5 Abstracts I 2015 p Synthesis by Addition across C=C Bonds G. Dagousset and G. Masson This chapter is an update to the earlier Science of Synthesis Section , written by Troll in 2006, on the synthesis of 1-bromo-n-heteroatom-functionalized alkanes (n 2), with both functions formed simultaneously by addition across C=C bonds. It focuses on recent advances in the field of bromofunctionalization of alkenes in the period , in particular on catalytic enantioselective syntheses. (10 mol%) Et NBS (1.2 equiv), C 2 Cl 2,0 o C 81 96%; 81 87% ee Et =, 4-2 NC 6 4 S 2 N Keywords: bromine compounds carbon-bromine bonds carbon-heteroatom bonds bromination of alkenes alkoxybromination of alkenes bromolactonization aminobromination catalytic enantioselective reactions
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