RESUME. Process for PCP substitutes like TCMTB and OITZ has been developed.

Transcription

1 RESUME Dr. P. T. Perumal CSIR-Emeritus Scientist Organic Chemistry Division Central Leather Research Institute Adyar Chennai- 20. Achievements: I am heading a team of more than 25 Scientific staff and Researchers in the Dept. of Organic Chemistry in CLRI. My work is mainly focused on (i)synthesis of Heterocyclic compounds using Inverse Electron Demand Diels-Alder (IED) Strategy (ii) Synthesis of heterocyclic compounds by using Vilsmeier reagent (iii) Multi component reaction, Acylation, alkylation and oxidation reactions and (iv) Green chemistry approach to synthesis of heterocyclic compounds by Ionic liquid mediated reactions; Solvent free reactions; Microwave assisted reactions and Water mediated reactions: Most of the synthesised compounds were tested for their biological activities. This has brought out good number of publications in highly cited journals and also we have generated ECF to some extent. 1. Technology development : (i) (ii) (iii) (iv) (v) Process for PCP substitutes like TCMTB and OITZ has been developed. Process for the extraction and formulation of natural dyes and pigments Suitable for fashion leathers has been standardized. Technical know-how for preparation of a substituted triazole compound, an Agrochemical intermediate has been released to Nagarjuna Agro Chem. Ltd. Hyderabad. Duration : 3 years Technical know-how for preparation of pharmaceutical intermediates has been released Tagros Chemicals Ltd. Chennai. Duration : 2 years. Large scale preparation of p-quinol ethers and hydantion resins (DRDO) 2. Basic research : i) Biocides based on Vilsmeier and Diels-Alder-adducts are available for valuation. (ii) Process for the preparation of syntans having light resistance and filling characteristics have been developed at laboratory level. 3. Patents : (i) A novel process for the preparation of eco-friendly black colourant for leather from myrobalan sludge has been patented.(indian Patent Application No. 1868DEL97).

2 (ii) A process for the preparation of plant based (Punica granatum) acrylate complex has been patented. (Indian Patent Aplication No. 1057DEL2001) 4. Publications : More than300 papers were published in national and international journals with high impact factors. 5. HRD : 27 Research students from this division were awarded Ph.D.degrees till date. 6. Age &Date of birth : 61yrs, Date of joining CSIR : as Scientist-C (IICT) 8. Academic Qualifications M.Sc.(Organic Chemistry) First Class Madurai University 1976 Ph.D (Organic Chemistry) I.I. Sc., Bangalore Research Experience and :35 years in the field of synthetic organic Area of Specialization chemistry and medicinal Chemistry. 10. Visits Abroad PDF (Organic Chemistry) Purdue University, USA. with Prof. H. C. Brown, N.L. Visiting Scientist Univesity of Miami, USA. and Univrsity of Florida, USA. Inivited Lecture 2001 National University of Singapore, Singapore Distinguished Visitor 2005 University of Complutense, Madrid, Spain Visiting Professor 2007 University of Oklahoma, USA Distinguished Visitor 2008 University of Complutense, Madrid, Spain Inivited Lecture 2009 National University of Singapore, Singapore 11. Research Publications : 260 in peer reviewed international journals 12. Research Guidance (Ph. D) : Awarded: 30 Current: Teaching Experience : 31years ( M.Sc. and M.Tech. ) 14. Technical Know-how : Four products into Nagarjuna Agrochemicals, Hyderabad Two products for Tagros, Chennai 15. Prestigious awards received : 1. Tamil Nadu State Council for Science and Technology Award for Chemistry (2002) 2. Chemical Research Society of India (CRSI) Bronze medal (2005) 3. Best Paper award- INDO-US Conference, held at IIT, Chennai, India (2003)

3 4. Prof. S. Swaminathan endowment lecture award Tetrahedron- Most cited Paper award Tetrahedron Letter- Most cited Paper award Best thesis award for my student Dr. G. Savitha Fellow of Tamil Nadu Academy of Science D.Sc degree from the University of Madras Fellow of Madras science Foundation References 1 Prof. S. Chandrasekaran, Dean of Chem. Sciences, Department of Organic Chemistry, Indian Institute of Science, Bangalore 2. Prof. M.Periasamy, School of chemistry, University of Hyderabad. 3. Dr Sourav Pal, Director, NCL, Pune. 17. List of Publications: 1. P. T. Perumal and M. V. Bhatt, Oxidation of aromatic substrates by hydrogen peroxide - hydrochloric acid, Tetrahedron Lett., 1979, P. T. Perumal and M. V. Bhatt, A new method for the conversion of halophenols and halonaphthols to quinones, Synthesis, 1979, P. T. Perumal and M. V. Bhatt, Oxidation of halophenols and sterically hindered phenols by lead tetraacetate, Synthesis, 1980, P. T. Perumal and M. V. Bhat, A facile conversion of benzylic hydrocarbons to aldehydes and ketones, Indian J. Chem., 1981, 20B, M. V. Bhatt and P. T. Perumal, A convenient conversion of electron rich benzylic hydrocarbons to carbonyl compounds by peroxydisulphate, Tetrahedron Lett., 1981, P. T. Perumal and M. V. Bhatt, Oxidation of aromatic substrates by peroxydisulphate in the presence of metal ions, Proceedings of the catsympo-80, India, 1983, H. C. Brown, M. Periasamy, P. T. Perumal, D. P. Kelly and J. J. Gainessiracussa, Structural effects in the solvolytic reactions 45. Carbon - 13 NMR studies of carbocations 9. Variation of the cationic carbon chemical shifts with the electron demand in 1,1 -diaryl -1- ethyl cations. Importance of the inductive -polarization effect in causing deviations from the linearity, J. Am. Chem. Soc., 1983, 105, H. C. Brown, M. Periasamy, P. T. Perumal, D. P. Kelly, Structural effects in solvolytic reactions 46. Carbon -13 NMR studies of carbocations 10. Ananomolous carbon -13 NMR shifts in a supposedly classical 2-aryl-3- methylene-2-norbornyl systems. Further evidence for the importance of the localized inductive -polarization in causing shielded chemical shifts in carbocations, J. Am. Chem. Soc., 1984, 106, H. C. Brown, P. K. Jadhav and P. T. Perumal, Asymmetric methallyl boration of prochiral aldehydes with methallydiisopinocampheyl boranes, Tetrahedron Lett., 1984, 25, H. C. Brown, M. Periasamy, P. T. Perumal, Structural effects in solvolytic reactions 47. The order of stabilizing abilities of carbocations by Carbon -13 NMR chemical shifts of the cationic center in the para alkyl tert. cumyl cations :, J. Org. Chem. 1984, 49, 2754.

4 11. D. P. Kelly, M. Periasamy and P. T. Perumal, Carbon -13 NMR studies of carbocations 12. Effect of increasing electron demand on the Carbon-13 NMR chemical shifts of 1-aryl-1- cycloalkyl-1-ethyl and 1-aryl-2-methyl-1-cycloalkyl cations, J. Org. Chem. 1985, 50, P. T. Perumal, M. V. Bhatt, K. Venkatesan, T. S. Cameron and B. Gillard, Oxidation of 2,2 -dihydroxyl, 1,1 -binaphthyl by periodic acid, the structure of the product, J. Org. Chem., 1985, 50, H. C. Brown, T. Imai, P. T. Perumal and B. Singaram, Organoboranes 41. Reactions of organoboranes with dichloromethyl lithium : Scope and limitations. Synthesis of homologated primary and secondary alochols. J. Org. Chem., 1985, 50, P. K. Jadhav, K. S. Bhat, P. T. Perumal and H. C. Brown, Chiral synthesis via organoboranes 6. Asymmetric allylboration via chiral allyldialkylboranes. Synthesis of homallylic alcohols with exceptionally high enantiomeric excess, J. Org. Chem., 1986, 51, H. C. Brown, K. S. Bhat, M. Zaidlewicz, S. A. Weissman, P. K. Jadhav and P. T. Perumal, Comparison of monoisopinocampheyl borane and its 2-ethyl anologue for the chiral hydroboration of the representative alkeness, J. Org. Chem., 1988, 53, A. Duraikannu, G. Ramamurthy, G. Thyagarajan, K. Vijayalakshmi, C. K. Rao, P. T. Perumal and K. S. Jayaraman, Anilolubricant in leather processing, Leather Science, 1988, 33, P. T. Perumal and M. V. Bhatt, Quinone studies, part III. Metal ion catalysed oxidation of halophenols and halonaphthols by peroxydisulphate, Proc. Ind. Acad. Sci., 1989, 101, H. C. Brown, S. Weissman, P. T. Perumal and U. P. Dhokte, Hydroboration 87. Synthesis and hydroboration of (-)-2-phenyl apopinene. Comparision of mono (2- phenylapopinocampheyl) borane with its 2-methyl and 2-ethyl analogs for the chiral hydroboration of representative alkeness, J. Org.Chem., 1990, 54, P. T. Perumal. Oxidation of alkenes with peroxydisulphate in the presence of copper (II), Synthetic commun., 1990, 20, P. Rajalingam, G. Radhakrishnan., P. T. Perumal and N. Latha and Synthesis and Characterisation containing polyurethanes, J. Polym. Mat., 1990, 7, B. Balasundaram and P.T. Perumal, A new method for the synthesis of substituted 3,5- diphenylisoxaazoles, Synthetic commun., 1990, 20, M. Venugopal and P.T. Perumal, A convenient synthesis of substituted chloroindenes by Vilsmeier reaction, Synthetic commun., 1991, 21, K. S. Rein, Z. Chan, P. T. Perumal. L. Echegogen and R. E. Gawley, Single electron transfer in the addition of chiral dipole stabilised organolithium to carbonyls. Stereochemistry of a chiral nucleophile as a mechanistic probe, Tetrahedron Lett., 1991, 32, M. Venugopal, R. Umarani, P. T. Perumal, A new method for the preparation of substituted tetrahydro-4h-1-benzopyran and 4H-pyrans by Vilsmeier reagent, Tetrahedron Lett., 1991, 32, 3235.

5 25 M. Venugopal and P.T. Perumal, Synthesis of 5-(2- or 5-Substituted aryladehydes)-3- chloropentadienealdienealdehydes by Vilsmeier reactions, Org. Prep. Proce. Int. Inc., 1991, 23, R. J. Bergeron, J. Weigand, J. S. Macmanis and P. T. Perumal, Synthesis and biological evaluation of hydroxyamates based ion chelators, J. Med. Chem., 1991, 34, R. J. Bergeron, J. S. Macmanis, P. T. Perumal and S. Algee, The total synthesis of alcalign, J. Org.Chem., 1991, 56, M. Venugopal and P. T. Perumal, Synthesis of substituted isoxazoline by Vilsmeier-Haack reagent, Proc. Ind. Acad. Science, 1993, 105, B. Balasundaram and P. T. Perumal, Synthesis of 2,4,6-triaryl-2H-1,3-oxazines by Vilsmeier reagent, Indian J. Chem, 1993, 32B, B. Balasundaram, M. Venugopal and P.T. Perumal, Synthetic studies on N-acetyl derivatives of amino acids and thiolactones using Vilsmeier-Haack reagent, Tetrahedron Lett., 1993, 34, M. Venugopal, B. Balasundaram and P. T. Perumal, Synthesis A New Method for the Synthesis of Furan Derivatives, Synthetic Communications, 1993, 23, P. T. Perumal and M. V. Bhatt, Oxidation of substituted benzylic hydrocarbons and naphthalene by peroxydisulphate, Proce. Ind. Acad. Sci., 1995, 107, R. R. Amaresh and P. T. Perumal Ring opening of chalcone epoxides with Vilsmeier reagent, Tetrahedron Lett., 1995, 36, B. Balasundaram, T. P. Veluswamy, D. Velmurugan and P.T. Perumal, A new method for the synthesis of nitrones and their conversion to 3,5-diarylisoxazolines, Indian J. Chem., 1995, 34B, V. J. Majo, A. M. Prince, M. Venugopal and P.T. Perumal, A new route to synthesis of N- formyl derivatives of substituted benzazepin-1-ones and 1-4-benzoxazepin-5-ones using Vilsmeier reagent, Synthetic Commun., 1995, 25, P. T. Perumal, M. Venugopal and T. P. Venuswamy, Synthesis of spirocyclic diketone related to Fredericamycin A, Indian J.Chem., 1996, 35B, V. J. Majo and P. T. Perumal, Dimerization of substituted 2-Aminobenzoic and under vilsmeier conditions. A novel route to the synthesis of 4-(34)-Quinazolinones Tetrahedron letters., 1996, 37, V. J. Majo and P. T. Perumal, one pot synthesis of Heterocyclic -chlorovinylaldehydes using Vilsmeier Reagent, J. Org. Chem., 1996, 61, R. R. Amaresh and P. T. Perumal, A new route to the synthesis of 4-chloro-3- methylquinolines from 1-(2-aminophenyl)-propanones using Vilsmeier reagent, Synthetic commun., 1997, 27, 337.

6 40. G. Babu and P. T. Perumal Imino Diels-Alder reactions catalysed by Indium trichloride (Incl 3 ), Facile synthesis of Quinoline and phenanthridinone derivatives, Tetrahedron Lett., 1997, 38, S. Selvi and P. T. Perumal, Synthetic utility of Vilsmeier reagents: Formation of Vinamidinium salts from acyl ureas, Tetrahedron Lett., 1997, 38, V. J. Majo and P. T. Perumal, The Vilsmeier cyclization of azides. Synthesis of oxazoles and vinyl azides from 2-azidoacetophenones. Tetrahedron Lett., 1997, 38, R. R. Amaresh and P. T. Perumal, A novel one pot synthesis of 4- chloroquinolinecarboxaldehydes, 4-chloroquinolines and 4-chloro-3-ethylquinolines using Vilsmeier reagent, Indian J. Chem., 1997, 36B, G. A. Rajkumar, N. Arunasri, T. Annamalai, M. Swamy and P. T. Perumal, Synthesis and antifungal activity of cypermethric acid derivatives, J. Soc. Leather Technol. Chem., 1997, 81, T. Annamalai, G. A. Rajkumar, N. Arunasri, S. Rajkumar and P. T. Perumal, Synthesis and fungicidal evaluation of compounds analogous to 1,3-oxazine J. Soc. Leather Technol.Chem., 1997, 81, G. Babu and P.T. Perumal, Convenient synthesis of, -Bis(substituted furfurylidene)cycloalkanones and chalcones under microwave irradiation. Synthetic comm., 1997, 27, R. R. Amaresh and P. T. Perumal, A novel one pot synthesis of 2-aminoquinoline derivatives from arylazidolcetones by cyclization under Vilsmeier conditions, Tetrahedron Lett., 1998, 39, G. Babu and P.T. Perumal, Indium trichloride (InCl 3 ) catalysed imino Diels-Alder reactions: An efficient synthesis of cyclopentaquinolines, azabicyclooctanones and azabicyclononanones, Tetrahedron, 1998, 54, G. Babu and P. T. Perumal, Convenient synthesis of pyrano (3,2-c) and indeno (2,1-c) quinolines by imino Diels Alder reactions, Tetrahedron Lett., 1998, 39, V. J. Majo and P. T. Perumal, The intra molecular electrophilic substitution of azides by Iminium species. A convenient and novel method for the construction of nitrogen heterocycles by cyclization under Vilsmeier condition, J. Org. Chem., 1998, 63, R. R. Amaresh and P. T. Perumal, A novel one pot synthesis of 2- aminoquinolines from arylazidoketones by cyclisation under Vilsmeier conditions. Tetrahedron., 1998, 54, L. Vijayalakshmi, V. Parthasarathi, P. T. Perumal and V. J. Majo. 4- (Dimethylaminomethylene)-2-(2-nitrophenyl)-oxazol-5(4H)-one. Acta Cryst., 1998, C54, R. Srinaga, P. Rajalingam and P. T. Perumal, Liquid Crystal Polyesters : Preparation of Polyesters Containing Bisphenol-A, Journal of Polymer Materials., 1998, 15, 419.

7 54. S. Selvi and P. T. Perumal, Synthetic Utility of Vilsmeier Reactions: More Vinamidinium Salts, Synthetic Commun., 1999, 29, R. Krishna, D. Velmurugan, G. Babu and P. T. Perumal, N-H (indole) intermolecular interactions in 3.3 benzylidenediindole Acta Crystallographica., 1999, C 55, G. Babu and P. T. Perumal, A novel synthesis of indolyl and benzo[b]thienyl imines and Diels-Alder reactions promoted by indium trichloride, Tetrahedron, 1999, 55, P. T. Perumal, V. J. Majo and R. Vijaya Anand, The unusual behaviour of substituted 1- aryl-2-(arylamino)ethaonones towards Vilsmeier reagent, Indian J. Chem., 1999, 38B, R. R. Amaresh and P. T. Perumal, A new and convenient synthesis of 2-imino-2Hpyrancarboxaldehydes from -ketoamides using Vilsmeier reagent, Tetrahedron, 1999, 55, J. Jeyakanthan, D. Velmurugan, S. Selvi and P. T. Perumal, 3-(2- hydroyphenyl)-1-(2,4- dinitrophenyl)-4-methyl-1h-pyrazole, Acta Cryst., 1999, C55, S. Shanmuga Sundara Raj, J. Jeyakanthan, S. Selvi, D. Velmurugan, H.-K. Fun and P. T. Perumal, 1-(2,4-Dinitrophenyl)-3-(2-hydroxyphenyl)-1H-pyrazole-4-carboxaldehde, Acta Cryst., 1999, C55, P.T. Perumal, R. R. Amaresh, K. Venkataboopathy and S. Rajkumar, Synthesis and fungicidal evaluation of 2-aminoquinoline derivatives, J. Soc. Leather Technol.Chem., 1999, 83, K. Dinakaran and P.T.Perumal, Microwave induced formation of 3-chloro-5-arylpenta- 2,4-dien-1-als and 3-chloro-(5-formylaryl)penta-2-4-dien-1-als by Vilsmeier reaction, Ind. J. Chem., 2000, 39B, G. Babu and P. T. Perumal, Synthetic applications of indium trichloride catalysed reactions, Aldrichimica Acta, 2000, 33, G. Babu, N. Sridhar and P. T. Perumal, A convenient method of synthesis of bisindolylmethanes: Indium trichloride catalysed reactions of indole with aldehydes and Schiff s bases, Synth. Commun., 2000, 30, G. Babu, R. Nagarajan, R. Natarajan and P. T. Perumal, Indium Trichloride- Catalyzed Imino Diels-Alder Reactions: Synthesis of New Indolylquinoline Derivatives, Synthesis, 2000, R. R. Amaresh and P.T. Perumal, A novel route to the synthesis of 3- pyridine carboxaldehydes by vilsmeier reagent, Synth. Commun., 2000, 30, S. Selvi and P. T. Perumal, Microwave assisted one pot synthesis of substituted 3-formyl benzoates using vilsmeier reagent, Synth. Commun., 2000, 30, R. Shankaranarayanan, D. Velmurugan, S. Shanmuga Sundara Raj, Hoong- Kun Fun, G. Babu and P. T. Perumal, 4-[1-(Phenylsulfonyl)indol-3-yl]-3a,4,5,9b-tetrahydro-3Hcyclopenta[c]quinoline, Acta Cryst., 2000, C56, 475.

8 69. S. Selvi and P. T. Perumal, A facile synthesis of [1]benzopyrano[4,3-c] pyrazole using Vilsmeier reagent, Indian J. Chem., 2000, 39B, P. T. Perumal, R. Amaresh and V. J. Majo, Oxidation of substituted chalcones with potassium peroxydisulphate-copper (II), Oriental J Chem., 2000, 16(3), R. Nagarajan and P. T. Perumal, Imino Diels-Alder reactions catalysed by oxalic acid dihyrate: Synthesis of tetrahydroquinoline derivatives, Synth. Commun., 2001, 31, R. Nagarajan, S. Chitra and P. T. Perumal, Triphenyl phosphonium perchlorate An efficient catalyst for the imino Diels-Alder reaction of imines with electron rich dienophiles. Synthesis of pyraquinoline, furaquinoline and phenanthridine derivatives, Tetrahedron, 2001, 57, S. Selvi and P. T. Perumal, Synthesis of 2- cyano-3-dimethylamino-n-phenyl acrylamides using the Vilsmeier reaction, Organic Preparation and Procedure International, 2001, 33, S. Selvi and P. T. Perumal, Vilsmeier cyclization of 2-amino phenoxyacetic acid, Synth. Commun., 2001, 31, K. Sethusankar, S. Thennarasu, D. Velmurugan, S. Shanmuga Sundara Raj, H.-K. Fun and P. T. Perumal, 5-(1-Acetamido-3-methylbutyl)-5-methyl- imidazolidine-2,4-dione monohydrate. Acta Cryst. 2001, E57, o J. Jeyakanthan, D. Velmurugan, S. Selvi, and P. T. Perumal, 1-(2,4-Dinitrophenyl)-3-(2- hydroxy-5-methylphenyl)-pyrazole-4-carboxaldehde, Acta Cryst. 2001, E57, o S. Thennarasu & P. T. Perumal, Synthesis of new hydantoins as intermediates for diamino acids, Indian J. Chem., 2001, 40B, P. T. Perumal, Synthesis of heterocyclic compounds using Vilsmeier reagent Indian J. Heterocyclic Chem., 2001, 11, R. Nagarajan and P.T. Perumal, InCl 3 and In(OTf) 3 catalysed reactions: Synthesis of 3- Acetyl indoles, bis-indolylmethane and indolylquinoline derivatives., Tetrahedron, 2002, 58, M. Anniyappan, D. Muralidharan and P. T. Perumal, Synthesis of Hantzsch 1,4- Dihydropyridines under Microwave Irradiation, Synthetic Commun., 2002, 32, M. Anniappan, D. Muralidharan and P. T. Perumal, Microwave assisted deoximation of carbonyl compounds using aqueous hydrochloric acid Indian J. Chem., 2002, 41B, R. Nagarajan and P. T. Perumal, Electrophilic substitution of Indoles catalyzed by triphenyl phosphonium perchlorate: synthesis of 3-Acetyl Indoles and bis-indolylmethane derivatives. Synth. Commun., 2002, 32, M. Anniyappan, R. Nagarajan and P.T. Perumal, Urea nitrate catalyzed imino Diels-Alder reactions: Synthesis of cyclopentaquinolines, pyranoquinolines and furoquinoline derivatives Synth. Commun., 2002, 32,

9 84. S. Selvi and P. T. Perumal, Facile synthesis of [1]benzopyrano[4,3-c]pyrazoles, 1-aryl-3- (2-formamidophenyl)pyrazoles and 1-aryl-3-phenyl-4-alkylpyrazoles using Vilsmeier reagent, Indian J. Chem., 2002, 41B, M.Balasubramanian, S. Thennarasu, and P.T.Perumal, Spectrophotometric Determination of Hexamine in Hiprex Using Ninhydrin reagent, Oriental. J. Chem., 2002, 18, M. Anniyappan, D. Muralidharan and P.T. Perumal A novel application of the oxidizing properties of urea nitrate and peroxydisulphte cobalt (II): Aromatization of NAD(P)H model Hantzsch 1,4-dihydropyridines Tetrahedron, 2002, 58, M. Anniyappan, D. Muralidharan, and P. T. Perumal, Diasteroselective Synthesis of cisfused pyrano and fuaranobenzopyrans catalysed by indium trichloide or triphenyl phosphonium perchlorate, Tetrahedron, 2002, 58, S. Thennarasu and P. T. Perumal An Efficient preparation of 1,2-diamino-1- phenylheptane, Molecules, 2002, 7, S. Selvi and P. T. Perumal, A Short, Facile Method for the Synthesis of 1-aryl-3- phenyl-4- alkylpyrazoles using Microwave irradiation. J. Heterocyclic Chemistry, 2002, 39, R. Sankaranarayanan, M. Yogavel, D. Velmurugan, K. Sekar, G. Babu, P.T. Perumal, S. Shanmuga Sundara Raj, H.-K. Fun 8-Chloro-4-[1-(phenylsulfonyl)indol-3-yl]-3a,4,5,9btetrahydro-3H-cyclopenta[C]quinoline, Acta Cryst. 2003, E59, R. Sridhar and P.T. Perumal, Synthesis of novel 1-H-Pyrazole-4-Carboxylic acid esters by conventional and microwave assisted Vilsmeier cyclization of hydrazones, Synth. Commun, 2003, 33, Ompraba, A. Aysha, M. Yogavel, D. Velmurugan, S. Selvi, P. T. Perumal. S. Shanmuga Sundara Raj, S. H.-K. Fun, Z. A. Rafi. 2-Cyano-3-dimethylamino-N-(2,5- methylphenyl)acrylamide, Acta Cryst. 2003, E59, R. Sridhar and P. T. Perumal, Synthesis of acyl azides using the Vilsmeier complex Synth. Commun., 2003, 33, M. Anniyappan, D. Muralidharan and P. T. Perumal Triphenylphosphonium perchlorate an efficient catalyst for mono and bis intramolecular imino Diels-Alder reactions: Synthesis of tetrahydrochromanoquinolines., Tetrahedron Letters 2003, 44, C. Saikumar, K. Venkataboopathy, P. T. Perumal and D. Muralidharan Tanning theories: A view of present and possible options, World Leather, 2003, M. Yogavel, P. G. Aravindan, D. Velmurugan, P. T. Perumal, S. Shanmuga Sundra Raj and H.K.Fun, N,N-Dimethyl-N-phenylformamidinium perchloride Acta Cryst. 2003, E59, S. Thennarasu and P. T. Perumal 5-(1-Acetamido) benzyl-5-methyl Imidazolidin-2,4- dione, Molbank, 2003, M M. Yogavel, P. G. Aravindan, D. Velmurugan, K. Sekar, S. Selvi, P. T. Perumal, S. Shanmuga Sundra Raj and H. K. Fun Supramolecular structures of 2-cyano-3-

10 dimethylamino-n-(4-methylphenyl)acrylamide and 2-cyano-3-dimethylamino-N-(4- methoxyphenyl)acrylamide, Acta Cryst. 2003, C59, S. Baskaran, S. Selvanayagam, D. Velmurugan, K. Ravikumar, M. Anniyappan, D. Muralidharan and P. T. Perumal, N-(4a-Morpholino-2,3,4,4a,9,9a-hexahydro1H-xanthen- 9-yl) phenylamine, Acta cryst. 2003, E59, P. G. Aravindan, S. Selvanayagam, M. Yogavel, D. Velmurugan, K. Ravikumar, R. Nagarajan and P. T. Perumal, 3-Chloro-3-(9-ethyl-6-methyl-9H-carbazol-3-yl)propenal, Acta cryst. 2003, E59, G. Karthikeyan and P. T. Perumal, An ionic liquid mediated efficient oxidatation of alcohols using o-iodoxybenzoic acid (IBX) a simple and eco-friendly protocol, Synlett, 2003, P. G. Aravindan, S. Selvanayagam, D. Velmurugan, K. Ravikumar, R. Nagarajan and P. T. Perumal, C- Halogen interactions in 4-chloro-2-(9-ethylcarbazol-3-yl)-1,2- dihydroquinoline 1-carbaldehyde, Acta cryst. 2003, E59, o1564-o M. Balasubramanian, S. Thennarasu, T. Sudhakaran, P. T. Perumal Spectrophoto-metric and Flurimetric Determination of Hexamine in pure form and its Pharmaceutical Formulation Bio.Pharm.Bull, 2003, 26(8), S. Etti, G. Shanmugam, M. N. Ponnusamy, R. Sridhar, R. Murugan, P. T. Perumal and K. Ravikumar Ethyl 3-methyl-1-(2,4-dinitrophenyl)-1H-pyrazole-carboxylate Acta Cryst. 2003, E59, P. Shanmugam, G. Annie and P. T. Perumal, Synthesis of novel 3,4-dihydropyrimidinones on water soluble solid support catalysed by indium triflate J. Heterocyclic Chem., 2003, 40, P. Shanmugam, P. T. Perumal, 3,4-Dihydropyrimidin-2(1H)-ones by Biginelli condensation promoted by triphenylphosphonium perchlorate, J. Chem. Res. 2003, S. Nandagopal, G. Annie, P. T. Perumal Microwave assisted one pot synthesis of 9-aryl- 3,3,6,6-tetra methyl-3,4,6,7,9,10-hexahedro-1,8(2h, 5H)acridinedione, Indian J. Chem. Sec B, 2003, 42B, M. Balasubramanian, S. Thennarasu, P. T. Perumal and A. B. Mandal, Spectrophotometric, spectrofluorimetric and high performance liquid chromatographic methods for the determination of hexamine in tablets, Indian J. Pharm. Sci. 2003, K. Hemanth Kumar, D. Muralidharan and P. T. Perumal, Indium (III) chloride / silica gel promoted facile and rapid cyclization of 2-amino chalcones to 2-aryl 2,3-dihydroquinolin- 4(1H)-ones under solvent free conditions, Synthesis 2004, R. Nagarajan, C. J. Magesh and P. T. Perumal, Inter- and Intramolecular imino Diels- Alder reactions catalysed by sulfamic acid : A mild and efficient catalyst for a one-pot synthesis of tetrahydroquinolines, Synthesis, 2004, 69.

11 111. P. Shanmugam, C. Sabastein and P. T. Perumal, Synthesis of fused dihydropyrimidinones from cyclic 1,3-dicarbonyl compounds: Modified Biginelli synthesis of 1,2,3,4,5,6,7,8-octahydroquinazolinediones and 3,4-dihydro-1H-indeno[1,2- d]pyrimidine-2,5-diones, Indian J. Chem., 2004, 43B, R. Nagarajan and P. T. Perumal Potassium Hydrogen Sulfate-Catalyzed Reactions of Indoles: A Mild, Expedient Synthesis of Bis-Indolylmethanes, Chemistry Letters, 2004, 33, R. Sridhar and P. T. Perumal, A Novel Method for the Synthesis of 2(3H)- Benzimidazolones, 2(3H)-Benzoxazolone and 2(3H)-Benzothiazolone via In Situ Generated Ortho Substituted Benzoic Acid Azides: Application of Ammonium Azide and Vilsmeier Complex for Acid Azide Generation, Synthetic Communications, 2004, 34, S. Nandagopal, B. Geetha, P. T. Perumal, A facile synthesis of novel 4-aryl- 8-(4-(aryl)- 3a,4,5,9b-tetrahydro cyclopenta[c]quinolin-8-ylmethyl)- 3a,4,5,9b-tetrahydro-3hcyclopenta[c] quinoline: indium trichloride catalyzed intermolecular imino diels-alder reaction of cyclopentadiene with schiff's bases, Synthetic Communications, 2004, 34, M. Anniyappan, D. Muralidharan, P.T. Perumal, Indium trichloride catalysed in situ generation of enamines and cyclisation with imines:a novel route for the synthesis of hexahydroxanthene-9-n-arylamines Tetrahedron, 2004, 60, C. J. Magesh, R. Nagarajan, M. Karthick and P.T. Perumal, Synthesis, characterisation of bis(indolyl)methanes, tris(indolyl)methanes and new diindolylcarbazolylmethanes mediated by Zeokarb-225, as a novel, recyclable, ecobenign heterogenous catalyst. Journal of Applied Catalysis-A, General, 2004, 266, 1-10, 117. C. J. Magesh and P. T. Perumal, Highly diastereoselective inverse electron demand (IED) Diels-Alder reaction mediated by chiral salen-alcl complex: the first, target oriented synthesis of pyranoquinolines as potential antibacterial agent, Bioorganic & Medicinal Chemistry Letters, 2004, 14, R. Nagarajan, and P. T. Perumal, A facile method for the synthesis of acetylcarbazoles and carbazole aldehydes, Synthetic Communications, 2004, 34, Y. Zulykama, R. Nagarajan and P. T. Perumal, Triphenyl Phosphonium Perchlorate catalyzed Imino-Diels-Alder reactions: Diastereoselective Synthesis of Indolylquinolines. Synthetic Communications, 2004,34, R. Nagarajan and P. T. Perumal, A Short route to Heteroarylcarbazoles: Synthesis of Pyrazolylcarbazoles and Carbazolylquinolines Synthesis, 2004, R. Senthil Kumar, R. Nagarajan and P. T. Perumal, Inverse Electron Demand Diels-Alder Reactions of Heterodienes Catalysed by Potassium Hydrogen Sulfate: Diasteroselective, One Pot Synthesis of Pyranobenzopyran, Furanobenzopyran and Tetrahydroquinolines Derivatives Synthesis, 2004, R. Nagarajan, D. Muralidharan and P. T. Perumal, A new and facile method for the synthesis of nitrocarbazoles by urea nitrate, Synthetic communications, 2004, 34,

12 123. K. Hemanth Kumar, S. Selvi and P.T. Perumal A facile synthesis of 4,5- dihydropyrazolo[4,3-c]-quinolines with Vilsmeier reagent. Journal of chemical research, 2004, P. Arumugam, G. Karthikeyan, and P. T. Perumal, A Mild, Efficient, and Inexpensive Protocol for the Selective Deprotection of TBDMS Ethers Using KHSO 4 Chemistry Letters 2004, 33, R. Sridhar, G. Sivaprasad and P. T. Perumal An efficient synthesis of 1H-pyrazole-4- carboxylic acid esters with Vilsmeier reagent under neat conditions Journal of Heterocyclic Chemistry, 2004, 41, P. T. Perumal, M. Anniyappan and D. Muralidharan A Convenient method for deoximation of carbonyl compounds using urea nitrate under microwave irradiation, J. Chem. Sciences (Proceedings of Ind. Acad. Sci.) 2004,116, G. Karthikeyan and P. T. Perumal. A Mild, Efficient and Improved Protocol for the Friedländer Synthesis of Quinolines using Lewis acidic Ionic Liquid Journal of Heterocyclic Chemistry, 2004, 41, K. Hemanth Kumar, D. Muralidharan and P. T. Perumal, An efficient oxidation of 2-aryl- 1, 2,3,4-tetrahydro-4-quinolones employing ferric chloride hexahydrate methanol: synthesis of naturally occurring 4-alkoxy-2-arylquinolines. Tetrahedron Letters, 2004, 45, R. Sridhar, P. T. Perumal, S. Etti, G. Shanmugam, M. N. Ponnuswamy, V. R. Prabavathy and N. Mathivanan, Design, synthesis and ant-microbial activity of 1H-pyrazole carboxylates, Bioorganic and Medicinal Chemistry Letters, 2004, 14, E. Elamparuthi, M. Anniyappan, D. Muralidharan and P. T. Perumal InCl 3 as an efficient catalyst for intramolecular imino Diels-Alder reactions: Synthesis of tetrahydrochromanoquinolines, Arkivoc, 2005, (xi) R. Sridhar, P. T. Perumal, A new protocol to synthesize 1,4-dihydropyridines by using 3,4,5- trifluorobenzeneboronic acid as a catalyst in ionic liquid: synthesis of novel 4-(3- carboxyl-1h-pyrazol-4-yl)-1,4-dihydropyridines, Tetrahedron, 2005, 61, P. Arumugam, G. Karthikeyan, R. Atchudan, D. Muralidharan, and P. T. Perumal A Simple, Efficient and Solvent-Free Protocol for the Friedländer Synthesis of Quinolines by Using SnCl 2 2H 2 O Chemistry Letters, 2005, 34, M. Karthik, C. J. Magesh, P. T. Perumal, M. Palanichamy, B. Arabindoo, V. Murugan, Zeolite-catalyzed ecofriendly synthesis of vibrindole A and bis (indolyl)methanes, Applied Catalysis A: General, 2005, 286, P. Arumugam and P. T. Perumal, A New Purification Process for Pharmaceutical and Chemical Industries, Organic Process Research & Development, 2005, 9, G. Shanthi and P. T. Perumal, Triphenyl Phosphonium Perchlorate- Catalyzed Imino Diels- Alder Synthesis of Azabicyclo(2.2.2)0ctan-5-ones Synth. Commun. 2005, 35,

13 136. R. Senthil Kumar,R. Nagarajan and P. T. Perumal, Sulfamic Acid: An Efficient catalyst for the Diastereoselective, One-Pot Synthesis of Pyrano benzopyrans, Furano benzopyrans and Ethoxy benzopyrans" Letters in Organic Chemistry" 2005, 2, Y. Zulykama, R. Nagarajan and P. T. Perumal A Facile Method For The Synthesis of Pyrazolyl and Pyrazolinyl Carbazoles" Letters in Organic Chemistry" 2005, 2, G. Sivaprasad and P. T. Perumal, Synthesis of novel 4-pyrazolyl-2-oxo-1,2,3,4-tetrahydropyrimidines promoted by phosphotungstic acid, J. Heterocyclic Chem. 2005, 42, K. Hemanth Kumar, and P. T. Perumal, A Novel One-Pot Synthesis of 4-Chloro-2Hchromenes via the Vilsmeier Reaction of 2'-Hydroxychalcones, Chemistry Letters., 2005, 34, R. Murugan, M. Karthikeyan P. T. Perumal and B. S. R. Reddy A mild, efficient and improved protocol for the synthesis of novel indolyl crown ethers, di(indolyl)pyrazolyl methanes and 3-alkylated indoles using H 4 [Si(W 3 O 10 ) 3 ], Tetrahedron, 2005, 61, G. Karthikeyan and P. T. Perumal, Ionic liquid promoted simple and efficient synthesis of β-enaminones from 1,3-dicarbonyl compounds- One-pot three component reaction for the synthesis of substituted pyridines, Can. J. Chem, 2005, 186, R. Nagarajan, J. C. A. Anthonyraj, D. Muralidharan, C. Saikumar & P. T. Perumal, A convenient method for the oxidation of Hantzsch 1,4-dihydropyridines with N-bromo succinimide, Indian J. Chemistry, 2006, 45B, P. T. Perumal and R. Nagarajan, An Unusual Hydrogen addition of Indolo-2, 3- quinodimethanes to Dimethyl indoles in the presence of 1,3-azoles, J. Chem. Sci. (Proceedings of Indian academic of science) 2006, S. Sivaprasad, R. Sridhar and P. T. Perumal, Selective synthesis of some 4,5-dihydro-2hbenzo[g]indazoles and 8,9-dihydro-2h-benzo[e]indazoles via the Vilsmeier-Haack reaction under thermal and microwave assisted conditions, J. Heterocyclic Chem. 2006, 43, R. Sridhar, P. T. Perumal, Chiral shift reagent catalyzed, diastereoselective imino Diels- Alder reaction: Synthesis of pyrazolyl tetrahydroquinolines' Can J. Chem. 2006, 84, G. Sivaprasad, R. Rajesh and P. T. Perumal, Synthesis of quinaldines by Doebner Miller reaction under thermal and microwave irradiation conditions using phosphotungstic Acid, Tetrahedron Lett., 2006, 47, G. Savitha and P. T. Perumal, An efficient one pot synthesis of tetrahydroquinone derivatives via Aza Diels-Alder reaction mediated by ceric ammonium nitrate in the oxidation of heteroarylquinolines, Tetrahedron Lett. 2006, 47, P. Arumugam and P.T. Perumal, SnCl.2 H 2 O - An Alternative to Lewis Acidic Ionic Liquids, Chemistry Letters, 2006, 35, N. Panneer Selvam, C. Saravanan, D. Muralidharan and P. T. Perumal, Water mediated synthesis of quinolines: A new green approach to the Friedländer annulation J. Heterocylic.Chem. 2006, 43,

14 150. K. Sujatha, P. Shanmugam, P. T. Perumal, D. Muralidharan, M. Rajendran Synthesis and cardiac effects of 3,4-dihydropyrimidin 2 (1h) one-5 carboxylates Bioorganic & Medicinal Chemistry Letters, 2006, 16, R. Senthil Kumar and P. T. Perumal, Michael addition of indoles to electron deficient olefins in water catalysed by KHSO 4 J. Heterocylic. Chem. 2006, 43, K. Hemanth Kumar and P. T. Perumal, A simple and facile procedure for the cyclization of 2 -amino and 2 -hydroxychalcones using silica-supported sodium hydrogen sulphate as heterogenous catalyst Can. J. Chem. 2006, 84, N. Panneer Selvam and P. T. Perumal, A new versatile synthesis of acetamidophenols promoted by Ce(SO 4 ) 2 Tetrahedron Letters, 2006, 47, P. Shanmugam and P. T. Perumal Regioselective dehydrogenation of 3,4- dihydropyrimidin-2(1h)-ones mediated by ceric ammonium nitrate Tetrahedron, 2006, 62, G. Sivaprasad, P. T. Perumal, N. Mathivanan, Synthesis Antimicrobial Activity of Pyrazolylbisindoles Bioorganic & Medicinal Chemistry Letters, 2006, 16, R. Komalavalli, C. Saikumar, D. Muralidharan and P. T. Perumal, Studies on addition of schiff base type compounds to wattle tannis for leather application Cuoio Pelli Materi Concianti, 2006, D. Gaythri, D. Velmurugan, K. Ravikumar, G. Savitha and P. T. Perumal, Ethyl 5- hydroxy-3- (3-methoxybenzoyl)-1,5-dimethyl-2 -oxo-4,5-dihydro-1 H-spiro[furan-2(3H), 3 (2 H)-indole]-4-carboxylate Acta Crystallographica Section E, 2006, E62, o5947-o Shanmugam and P. T. Perumal, An unusual oxidation-dealkylation of 3,4- dihydropyrimidin-2(1h)-ones mediated by Co(NO 3 ) 2.6H 2 O/K 2 S 2 O 8 in aqueous acetonitrile, Tetrahedron, 2007, 63, G. Shanthi and P. T. Perumal, A New InCl 3 -Catalyzed, Facile and Efficient method for the synthesis of Spirooxindoles under Conventional and Solvent-free Microwave Condition, Tetrahedron, 2007, 63, P. Shanmugam, K. Hemanth Kumar and P. T. Perumal An efficient Mn(III) acetate mediated diasteroselective [3+2] oxidative addition of 1,3-dicarbonyl compounds to chalcones J. Heterocylic Chem. 2007, 44, Y. Zulykama and P. T. Perumal "Functionalization of Baylis-Hillman bromides with symmetric and unsymmetric bifunctional aromatics" Aust. J. Chem., 2007, 60, G. Savitha, S. K. Nivedhita, D. Muralidharan and P. T. Perumal, An Efficient One-Pot Synthesis of Spiro dihydrofuran Oxindole and Spiro 2-hydroxytetrahydrofuran Oxindole Derivatives via 3+2 Oxidative Cycloaddition Mediated by CAN Tetrahedron Lett. 2007, 48, V. Sridharan, P. T. Perumal, C. Avendafio and J. C. Menendez The First Imino Diels-Alder Reaction involving an α,β-unsaturated Hydrazone as the Dienophile: Three-component,

15 Stereoselective Synthesis of C-4 Functionalized 1,2,3,4-Tetrahydroquinolines Catalyzed by Indium Trichloride Org. Biomol. Chem., 2007, 5, D. Gaythri, D. Velmurugan, K. Ravikumar, G. Savitha and P. T. Perumal, 3-(4- Methoxyphenyl)-1,6,6-trimethyl-4,5,6,7-tetrahydrospiro[1-benzofuran-2,3 (3H,2 H)-1Hindole]-2,4-dione Acta Crystallographica Section E, 2007, E63, o1034-o Gaythri, D. Velmurugan, K. Ravikumar, G. Savitha and P. T. Perumal, 3-(3- Methoxybenzoyl)-1,6,6-trimethyl-4,5,6,7-tetrahydrospiro[benzo[b]furan-2(3H),3 (2 H)- 1H-indole]-4,2 -dione Acta Crystallographica Section E, 2007, E63, o846-o V.Sridharan, P. T. Perumal, C. Avendan o and J. C. Menendez, A new three-component domino synthesis of 1,4-dihydropyridines Tetrahedron, 2007, 63, Gaythri, D. Velmurugan, K. Ravikumar, K.Karthikeyan and P. T. Perumal, 3-[3-(4- Ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-4-nitro-2,5-diphenylisoxazolidine, Acta Crystallo- graphica Section E, 2007, E63, o2216-o Gaythri, D. Velmurugan, K. Ravikumar, Y. Zulykama and P. T. Perumal, 2- (Methoxycarbonyl)-3-phenylprop-2-enyl-3-hydroxynaphthalene-2-carboxylate, Acta Crystallographica Section E, 2007, E63, o2297-o K. Karthikeyan, P. T. Perumal, S. Etti and G. Shanmugam, Diastereoselective syntheses of pyrazolyl isoxazolidines via 1,3-dipolar cycloaddition, Tetrahedran, 2007, 63, K. Hemanth Kumar and P. T. Perumal, A novel one-pot oxidative cyclization of 2 -amino and 2 -hydroxychalcones employing FeCl 3. 6H 2 O-methanol. Synthesis of 4-alkoxy-2-arylquinolines and flavones, Tetrahedron, 2007, 63, P. Shanmugam, P. Boobalan and P. T. Perumal, A novel method for the synthesis of highly functionalized 3,4-dihydropyrimidin-2(1H)-ones through the 1,4-addition on pyrimidin- 2(1H)-ones, Tetrahedron, 2007, 63, G. Shanthi and P. T. Perumal, An eco-friendly synthesis of 2-aminochromenes and indolyl chromenes catalyzed by InCl 3 in aqueous media, Tetrahedron Letters, 2007, 48, N. Panneer Selvam, G. Shanthi and P. T. Perumal, Ceric-sulfate-catalyzed synthesis of 14- aryl- or 14-alkyl-14H-dibenzo[aj]xanthene under conventional heating and microwave irradiation, Can. J. Chem, 2007, 84, K. Hemanth Kumar and P. T. Perumal, A novel One-pot oxidative deformylation of N- Formyldihydroquinolines Employing Ferric Chloride Hexahydrate.Synthesis of 4- phenylquolines and 4-chloro-2-(1,3-diphenyl-1H- pyrazol-4-yl)quinolines, J. Heterocyclic Chem. 2008, A. Rajendran, C. J. Magesh and P.T. Perumal DNA DNA cross-linking mediated by bifunctional [SalenAl III ] + complex Biochimica et Biophysica Acta (BBA) - General Subjects 2008, 1780,

16 176. S. Etti, K. Karthikeyan, G. Shanmugam and P. T. Perumal 3-[3-(4-Bromophenyl)-1- phenyl-1h-pyrazol-4-yl]-5-ethoxy-2-phenylisoxazolidine Acta Cryst. 2008, E64, o N. Panneer Selvam, S. Saranya, and P. T. Perumal A convenient and efficient protocol for the synthesis of symmetrical N,N -alkylidine bisamides by sulfamic acid under solvent-free conditions Can. J. Chem. 2008,86, N. Panneer Selvam and P.T. Perumal A simple and efficient method for the synthesis of amidophenols using iodine as catalyst under neat condition Tetrahedron, 2008, 64, C. Praveen, K. Hemanth Kumar, D. Muralidharan and P.T. Perumal. Oxidative cyclization of thiophenolic and phenolic Schiff s bases promoted by PCC:a new oxidant for 2- substituted benzothiazoles and benzoxazoles Tetrahedron, 2008, 64, D.Gayathri, D. Velmurugan, G. Shanthi, P.T. Perumal and K. Ravikumar 4 -Amino-2,2 - dioxo-2,2, 3,3 -tetrahydro-1h-indole-3-spiro-1 -cyclopent-3 -ene-2 -spiro-3-1h-indole- 3,5,5 -tricarbonitrile dehydrate, Acta Cryst E64, o501-o P. Arumugam and P. T. Perumal Hantzsch Synthesis of Polyhydroquinolines and Polyhydroacridinones-A simple, Efficient and Neat Protocol Indian. J. Chem., Sec. B, 2008, 47B, R. Senthil Kumar, K. Karthikeyan, P.T. Perumal. An efficient procedure for the TEMPOcatalyzed oxidation of alcohols to aldehydes and ketones using ferric chloride as terminal oxidant, Can. J. Chem. 2008, 86, G. Shanthi, P.T. Perumal. An InCl3 catalyzed facile one-pot synthesis of novel dispiro[cyclopent-3 -ene]bisoxindoles, Tetrahedron Letters, 2008, 49, G. Shanthi, P. T. Perumal. Indium-Mediated One-Pot Synthesis of New 4-Allyl-2-amino- 4H-chromenes in Water, Synlett, 2008, G. Savitha, R. Sudhakar, P. T. Perumal. An efficient one-pot synthesis of spiro dihydrofuran fluorene and spiro 2- hydroxytetrahydrofuran fluorene derivatives via [3+2] oxidative cycloaddition mediated by CAN. Tetrahedron Letters, 2008, P. Ramesh, A. Subbiahpandi, P. Thirumurugan, P. T. Perumal and M. N. Ponnuswamy 3- [4-(2,4-Dichlorophenyl)-3,5-dicyano-6-methoxypyridin-2-yl]indole Acta Cryst E64, P. Ramesh, A. Subbiahpandi and P. Thirumurugan, P. T. Perumal and M. N. Ponnuswamy 3-[3-Cyano-4-(2,4-dichlorophenyl)-1,4-dihydro-6-(2-pyridyl)pyridin-2-yl]indole Acta Cryst. 2008, E64, M. Damodiran, R. Senthil Kumar P. M. Sivakumar, M. Doble and P. T. Perumal. A simple protocol for the michael addition of indoles with electron deficient olefins catalyzed by TBAHS in aqueous media and their broad spectrum antibacterial activity, Journal of Chemical Sciences, 2009, 121, P. Thirumurugan, D. Muralidharan and P.T. Perumal. Synthesis and photophysical studies of Quinoxaline and Pyridopyrazine derivatives, Dy es and Pigments, 2009, 81,

17 190. K. Sujatha, P. T. Perumal, D. Muralidharan & M. Rajendran, Synthesis, analgesic and antiinflammatory activities of bis(indolyl)methanes, Indian J. Chem. 2009, 48B, P. Jayashree, G. Shanthi and P. T. Perumal, Indium trichloride catalyzed one-potsynthesis of new (2-amino-3-cyano-4H-chromen-4-yl) phosphonic acid diethyl ester, Synlett., 2009, C. Praveen, Y. W. Sagayaraj, P. T. Perumal, Gold(I) catalyzed sequential cycloisomerization\bis-addition of o-ethynylanilines: and efficient access to bis(indolyl)methanes and di(indolyl)indolin-2-ones, Tetrahedron Lett. 2009, N. Panneer Selvam and P. T. Perumal, Cerium(IV) sulfate one pot three component diastereo selective synthesis of 4-amido tetrahydropyrans, Can. J. Chem., 2009, 87, K. Sujatha, G. Shanthi, N. Panneer Selvam, S. Manoharan, P. T. Perumal & M. Rajendran Synthesis and antiviral activity of 4,4'-(arylmethylene)bis(1H-pyrazol-5-ols) against peste des petits ruminant virus (PPRV), Bioorg. Med. Chem. Lett. 2009, 19, T. Haribabu, G. Shanthi and P. T. Perumal A facile one-pot synthesis of N-substituted tetrahydroquinolines, Tetrahedron Lett. 2009, 50, G. Shanthi and P. T. Perumal InCl 3 catalyzed efficient one-pot synthesis of 2-Pyrrolo-3 - yloxindoles Tetrahedron Lett., 2009, 50, M. N. Mohideen, A. S. Pandi, N. Panneer Selvam, P. T. Perumal and M. Damodiran [1-(3- Nitrophenyl)-2,3-dihydro-1Hnaphtho[1,2-e][1,3]oxazin-3-ylidine]malonaldehyde Acta Cryst. (2009). E65, o N. Panneer Selvam, P.T. Perumal, Cerium(IV) sulfate catalyzed simple and convenient synthesis of β-acetamidocarbonyl compounds, Arkivoc 2009 (x) M. N. Mohideen, A. S. Pandi, N. Panneer Selvam and P. T. Perumal, N-[(2-Hydroxy-1- naphthyl)(3-nitrophenyl)methyl]acetamides, Acta Cryst. 2009, E65, o714 o P. Thirumurugan and P.T. Perumal, A simple one-pot synthesis of functionalised 3-indolyl 2,2'-bipyridine derivatives via multi-component reaction under neat condition, Tetrahedron Let., 2009, 50, M. N. Mohideen, S. Thenmozhi, A. S. Pandi, N. Panneer Selvam and P. T. Perumal, N-[(2- Hydroxy-1-naphthyl)(2-hydroxyphenyl)methyl]acetamides, Acta Cryst E65, o P. Shanmugam, M. Damodiran, K. Selvakumar and P.T. Perumal Synthesis of functionalised 1,2,3-triazole derivatives of 2-indolones from Morita-Baylis-Hillman adducts of isatin via Click Chemistry J. Heterocyclic Chem. 2009, 46, P. Ramesh, A. Subbiahpandi, P. Thirumurugan, P. T. Perumal and M. N. Ponnuswamy 4- (4-Bromophenyl)-6-(1H-indol-3-yl)-2,2 -bipyridine-5-carbonitrile Acta Cryst E65, o P. Ramesh, A. Subbiahpandi P. Thirumurugan, P. T.Perumal and M. N. Ponnuswamy 2- (1H-indol-3-ylcarbonyl)acetonitrile Acta Cryst E65, o447.

18 205. G. Shanthi and P. T. Perumal, Urmila Rao and P.K. Sehgal, Synthesis and antioxidant activity of Indolyl chromenes, Indian J. Chem. 2009, 48B, Y. Zulykama and P. T. Perumal, Synthesis and Cyclo-oligomerization of 2- (Bromomethyl)-3-aryl-2-propenoic acid derivatives, Tetrahedron Lett. 2009, 50, C. Praveen, P. Kiruthiga, P. T. Perumal, Gold(III)bromide catalyzed furannulation of 2- alkynyl-cycloalk-2-enols: An expedient route to fused furans, Synlett. 2009, M. Damodiran, D. Muralidharan and P.T. Perumal, Regioselective Synthesis and biological evaluation of bis(indolyl)methane derivatized 1,4- disubstituted 1,2,3-triazoles as antiinfective agents, Bioorganic and Medicinal Chemistry Lett. 2009, 19, P. Ramesh, S. S. Sundaresan, P. Thirumurugan, P. T. Perumal and M. N. Ponnuswamy, 4- (2,4-Dichlorophenyl)-6-(1H-indol-3-yl)-2,2 -bipyridine-5-carbonitrile Acta Cryst E65, o P. Ramesh, S. S. Sundaresan, P. Thirumurugan, P.T. Perumal and M. N. Ponnuswamy, 4- (4-Chlorophenyl)-6-methoxy-2,2 -bipyridine-5-carbonitrile Acta Cryst E65, o P. Ramesh, S. S. Sundaresan, N. Vidhya Lakshmi, P. T. Perumal and M. N. Ponnuswamy, 3 -Benzyloxy-3-hydroxy-3,3 -bi-1hindole-2,2 (3H,3 H)-dione monohydrate, Acta Cryst E65, o M. NizamMohideen, S. Thenmozhi, A. SubbiahPandi, G. Savitha and P. T. Perumal, Ethyl30-(2,4-dichlorophenyl)-50-hydroxy-50-methyl-40,50-dihydrospiro[fluorene- 9,20(30H) -furan]-40-carboxylate, Acta Cryst E65, o M. Nizam Mohideen, S. Thenmozhi, A. Subbiah Pandi, N. Panneer Selvam and P. T. Perumal, N-[(2-Hydroxy-5-methoxyphenyl)- (3-nitrophenyl)methyl]acetamide, Acta Cryst. 2009, E65, o G. Shanthi, N. Vidhya Lakshmi, and P. T. Perumal, A Simple And Eco-Friendly Synthesis of 3-Indolyl-3-hydroxy oxindoles and 11-Indolyl-11H-indeno[1,2-b]quinoxalin-11-ols in aqueous media, Arkivoc, 2009 (x) Karthikeyan, T. V. Seelan, K. G. Lalitha, P. T. Perumal, Synthesis and Antinociceptive Activity of Pyrazolyl Isoxazolines and Pyrazolyl Isoxazoles, Bioorganic and Medicinal Chemistry Lett. 2009, 19, G. Savitha, K. Felix, P. T. Perumal, Synthesis of Novel 3-Bromo,2H-Chromene derivatives-palladium Catalyzed cyclization of Aryl Propargyl Ethers, Synlett.2009, M. NizamMohideen, M. Damodiran, A. SubbiahPandi and P. T. Perumal, 3-(6-Benzyloxy- 2,2-dimethylperhydrofuro[2,3-d][1,3]dioxol-5-yl)-5-(4-bromophenyl)-2 phenylperhydropyrrolo[3,4-d]-isoxazole-4,6-dione, Acta Cryst. 2009, E65, o S. Nirmala, K. Karthikeyan, E. T. S. Kamala, L. Sudha and P. T. Perumal, 40-(4- Methoxyphenyl)-1,1,1 -trimethyldispiro[indoline-3,2 -pyrrolidine-3,3 -pyrrolidine]- 2,2,5 -trione, Acta Cryst. 2009, E65, o1655.

19 219. N. Panneer Selvam, T. Hari Babu and P.T.Perumal, A simple and convenient approach to the Friedländer synthesis of Pyrano[2,3-b]pyridines, Tetrahedron, 2009, 65, P. Thirumurugan and P. T. Perumal, InCl 3 mediated one-pot synthesis of indol-3-yl pyridine and 2,2'-bipyridine derivatives through multi-component reaction, Tetrahedron, 2009, 65, K. Karthikeyan and P. T. Perumal, Synthesis of highly functionalized Spirobenzofuranols and Spirobenzofuranones by Baylis-Hillman reaction, Synlett, 2009, M. Damodiran, N. Panneer Selvam and P. T. Perumal Synthesis of highly functionalized oxazines by Vilsmeier cyclization of amidoalkyl naphthols, Tetrahedron Lett. 2009, 50, C. Praveen, K. Karthikeyan and P. T. Perumal, Efficient synthesis of 3-substituted indoles through a domino gold(i) chloride catalyzed cycloisomerization/c3-functionalization of 2- (alkynyl)anilines, Tetrahedron, 2009, 65, C. Praveen, P. Jagadesh and P. T. Perumal, Gold(III)chloride catalyzed intermolecular dimerization of 2-ethynylanilines: Synthesis of substituted quinolines, Synlett, 2009, Y. Zulykama, U. Uma, P. Devi, and P. T. Perumal, Chemo and Regioselective Functionalization of Morita Baylis-Hillman Bromides with Anthranilic acid, Can. J. Chem, 2009, 87, M. Damodiran, P. M. Sivakumar, R. Senthil Kumar, D. Muralidharan, B. V. N. Phani Kumar, M. Doble and P.T. Perumal, Antibacterial activity, QSAR and Diastereoselective synthesis of isoxazolidine derivatives via 1,3-dipolar cycloaddition of D-glucose derived nitrone with olefin Chemical Biology & Drug Design, 2009, 74, D. J. Nelson, P. T. Perumal, C. Brammer, N. Panneer Selvam "Effect of Single Walled Carbon Nanotube Association upon Representative amides J. Phys. Chem. C., 2009, 113, K. Karthikeyan, R. Senthilkumar, D. Muralidharan and P. T. Perumal, Diastereoselectivesynthesis of pyrrolidines via 1,3-dipolar cycloaddition of a chiral azomethine ylide Tetrahedron Lett. 2009, 50, P. Ramesh, S. S. Sundaresan, N. Vidhya Lakshmi, P. T. Perumal and M. N. Ponnuswamy, 1 -Methyl-2,2 -dioxoindoline-3-spiro-2 -pyrrolidine-3 -spiro-3 -indoline-4,4 - dicarbonitrile, Acta Cryst E65, o M. NizamMohideen,M. Damodiran, A. SubbiahPandi and P. T. Perumal, 3-(6-Benzyloxy- 2,2-dimethylperhydrofuro[ 2,3-d][1,3]dioxolan-5-yl)-5-(4-chlorophenyl)-4-nitro-2-phenyl- 2,3,4,5-tetrahydroisoxazole, Acta Cryst. E E65, o P. Thirumurugan, A. Nandakumar, D. Muralidharan and P. T. Perumal, A simple and convenient approach to the Kr ohnke pyridine type synthesis of functionalised indol-3-yl pyridine derivatives using 3-cyanoacetyl indole J. Comb. Chem., 2010, 12, 161.