Plasma Interface Element2
|
|
- Simon Lane
- 5 years ago
- Views:
Transcription
1 Plasma Interface Element2
2 Interface (backside) & Extraction Lens
3 Extraction Lens (-2000 volts)
4 ION OPTICS IF this positive potential is great enough, a discharge from the plasma into the orifice is observed called secondary discharge ( ARCing ) host of bad effects including - orifice (cone) erosion - multiply charged ions - variance in the kinetic energy of the ions
5 Ion Focusing Purpose - deliver ions to mass analyzer focuses and directs ion beam
6 ION LENS (TRANSFER LENS) STACK
7
8
9 ION LENS (TRANSFER LENS) STACK The Transfer Lens system is used to: 1. extract the ions entering the analyzer section through the orifices of the cones with very high velocity; i.e. supersonic speed; 2. focus the divergent ion beam onto the target (Entrance Slit), 3. correct the direction of the beam to the target (Entrance Slit) 4. accelerate the ions to their full speed by applying high voltage 5. shape the ion beam into a flat shape so as to make it through the Entrance slit. The ions are subsequently travelling with the desired velocity through the focus point (Entrance Slit) and start to diverge again slightly. In order to control the ion beam during the travel path through the Magnetic Field and the Electric Field, the system controls the rotation of the beam and focuses again to the next focus point.
10 The proportion of ions sampled from the plasma that make it through to the detector is actually extremely small (1 part in 10 6 to 10 8 ), therefore, a high ion gain detection system is required if low detection limits are to be achieved
11 Ion Focusing General Assumptions 1. All ions are free particles with positive charge 2. Density of ion beam is not great enough to induce repulsion ( space charge effects) 3. Presence of ions does not change electrostatic fields 4. Vacuum conditions are adequate to give ions necessary mean free path 5. Ions originate with a constant kinetic energy
12 Ion Optics In an ideal world... All ions leaving the plasma would have the same kinetic energy regardless of m/z ratio This would result in uniform ion transmission through the lens stack
13 Ion Optics In the real world... All ions are essentially accelerated to the supersonic velocity of Ar in the supersonic jet This results in a range of kinetic energy that is a function of mass
14 ION ENERGY vs m/z MAX. ION KE (ev) m/z
15 Ion Optics What does this mean? A single set of ion lens settings will not be appropriate for all elements Therefore, must COMPROMISE (unless looking at a narrow mass range)
16
17 Space charge effects The mutual repulsion of ions of like (similar) charge limits the total number of ions that can be compressed into a beam of given size
18 Space Charge Effects Plasma - ion flux is balanced by the electron flux - essentially neutral Supersonic jet - ion flux is balanced by the electron flux - essentially neutral Lens stack - electrons are repelled by negative potential - ion beam gains positive charge
19 Space Charge Effects Remember our assumptions - density of ion beam not great enough to induce space charge effects ASSUMPTION NOT MET -further reason for non-ideal behavior and different response across the mass range
20
21 Question: what elements are most likely to be effected by space charge effects?
22 Space Charge Effects Space charge effect is most strongly felt by lighter mass elements The space charge force (positive-positive repulsion) acts on all ions equally
23 Space Charge Effects Recall most of the ions present are Ar = mass 40 Elements lighter than mass 40 are going to undergo space charge effects even if there is no other matrix element!
24 Question: why are the low mass elements effected by space charge effects to a greater degree?
25 Space Charge Effects Heavy elements are effected less than light elements Heavy matrices cause more problems than light matrices Best case scenario = analysis of uranium in water Worst case scenario = analysis of Li in organicrich solution
26 ESA Detector ELEMENT SCANNING HIGH RES ICP-MS DEVICE Entrance slit Quad lenses Magnet & flight tube Extraction lenses Skimmer Sampler ICP Neb & Spray chamber
27 Attom HIGH RES- ICP-MS INSTRUMENT
28 Detectors The purpose of an electron multiplier is to detect every ion of the selected mass that has passed through the energy (mass) filter of a mass spectrometer. The basic physical process that allows an electron multiplier to operate is referred to as secondary electron emission. When an ion or electron strikes a surface it can cause electrons located within the outer layers of atoms to be released. The number of secondary electrons released depends on the type of incident primary particle, its energy, and characteristic of the incident surface. In general, there are two basic types of electron multipliers commonly used in mass spectrometric analysis: these are discrete-dynode and continuousdynode electron multipliers. The Element 2 and AttoM HR-ICP-MS instruments both contain a discretedynode electron multiplier (manufactured by ETP Electron Multipliers, Australia).
29 Detectors Discrete-dynode electron multipliers amplify the secondary electron emission process by using an array of electrodes referred to as dynodes. Ions hitting the first dynode cause secondary electrons to be emitted from the surface. The optics of the dynodes focuses these secondary electrons onto the next dynode of the array, which in turn emits even more secondary electrons from its surface than the first dynode. Consequently, a cascade of electrons is produced between successive dynodes, with each dynode increasing the number of electrons in the cascade by a factor of 2 to 3. This process is allowed to continue until the cascade of electrons reaches the output electrode where the signal is extracted. A typical discrete-dynode electron multiplier has between 12 and 24 dynodes and is used with an operating gain of between 10 4 and 10 8.
30 Detectors For a new (unused) electron multiplier, the gain is achieved with a lower applied voltage (~1800 volts). With time and usage, the surfaces of the dynodes slowly become covered with contaminants from the high vacuum system, which results in a decrease of their secondary electron emission capacity (and consequently drop in gain ). Thus, the operating high voltage applied to the electron multipliers must be periodically increased in order to maintain the required multiplier gain.
31 ELECTRON MULTIPLIER V ANALOG OUT, GATE GAIN ~ V PULSE COUNTING OUTPUT GAIN ~ 10 8
32 Detectors
33 Detectors discrete dynode electron multiplier
34 Detector cont d Single detector with two stages- Upper ANALOG stage for high intensity signals (>5x10 6 counts per second- cps) Lower PULSE counting stage for low intensity signals (<100,000 cps) Both stages can be used in the range of 100,000 to 5x10 6 cps However, the two stages need to be calibrated against one another
35 Detector Calibration This procedure converts the analog signal to an effective count rate (cps) in order to plot intensity on the same scale from the ppb to ppm range During the calibration, the lens voltage is adjusted to attenuate the ion beam in order to obtain points in the cross calibration region Only one solution is required for this calibration procedure
36
37 Detector Calibration - AttoM The detector system of the AttoM comprises up to three different stages: Pulse counting electron multiplier, attenuated pulse-counting multiplier and Faraday (not available on our instrument) The instrument continuously monitors beam intensity and performs automatic switchover between detector modes as required. The crossover between the modes should be calibrated on a regular basis, depending on the applications and the required precision.
38 Sample Introduction System Liquid Peristaltic pump or automated sampling system Nebulizer Spray chamber Plasma torch
39
40 Sample Introduction System Peristaltic Pump Pump liquid sample towards nebulizer and plasma torch
41 Sample Introduction System NEBULIZER Its function is to mix the liquid sample with the nebulizer gas (Argron) to produce a fine sample aerosol for introduction to the plasma discharge area.
42 Sample Introduction System NEBULIZERS 3 main categories Pneumatic - concentric, cross flow, Babington, v-groove, Cone Spray Ultrasonic Direct insertion
43 Aerosol production Liquid sample aspirated either in free aspiration mode or with a peristaltic pump -usually made of glass or various kinds of polymers (for highly corrosive liquids/samples) Ar gas (0.6 to 1.2 L/min)
44
45 Elemental Scientific Inc. MicroFlow PFA Nebulizer 100% Teflon Self-aspiration: 20 µl/min 50 µl/min 100 µl/min 400 µl/min
46 Concentric nebulizers
47 Concentric nebulizers Self-actuating Solutions are drawn up by the pressure drop generated as the nebulizer gas passes through the orifice also referred to as freerunning or self-aspiration. Thus, a peristaltic pump is not necessarily required. Advantage- Generally, the ion signal is much more stable
48 Concentric nebulizers Disadvantages cannot handle high total dissolved salts (TDS % m/v solids); i.e. 250 mg sample dissolved in 100 g of solution samples with different viscosities will have different flow rates liquid uptake tied to nebulizer gas flow cannot easily increase flow for different samples
49 Optimal Ar gas flow rate
50 Concentric nebulizers However.. Can use concentric nebulizer in conjunction with peristaltic pump - more commonly used than selfaspirating mode viscosity effects are reduced liquid uptake is metered by pump rate pump rate can be changed for each sample Disadvantages - Can occasionally lead to poorer precision due to pulsing of the flow
51 Ion signal pulsing
52 Spray Chamber Its function is to eliminate all droplets with the exception of those that are the correct size and velocity for introduction into the plasma since plasma discharge is inefficient at dissociating large droplets (>10 micron- 1x10-6 metres). The latter are eliminated by gravity and exit through a drain tube. An aerosol with a diameter of ~1-5 microns is considered to have an ideal diameter for introduction into the plasma. Its secondary purpose is to smooth out pulses that occur during the nebulization process
53 SPRAY CHAMBER & SOLVENT REMOVAL Aerosol out Coolant Drain Fig. 21. Cooled spray chambers for solvent removal. a) cooled double pass Scott chamber b) Cyclone chamber, side and top views. In both chambers, most of the large droplets are deposited at the bends, while fine droplets pass out to the plasma.
54
55 Example of wet plasma introduction system -Spray chamber is cooled to 5 C in order to provide thermal stability, minimize the amount of sample entering the plasma, and reducing the quantity of oxide species. -Oxide species (M + O - vs. M + ) should be kept to below 3% of total ion signal; If not, then the plasma has not been correctly fine-tuned.
56 Desolvating Introduction System- Dry Plasma (e.g. DSN-100, Nu Instruments)
57 DSN-100 The main purpose of the heated spray chamber and PTFE membrane is to drive-off water from the sample, and thus reducing the overall size of the aerosols (hence the term dry plasma). This action results in increasing the instrument s sensitivity ; i.e. the DSN-100 introduction system yields ~10 times more ion signal compared to a meinhard nebulizer + cyclonic spray chamber (wet plasma) introduction system.
58 DSN-100 Sample aspiration occurs in free aspiration mode, typically at a rate of 50 to 100 microlitres per minute, with a Meinhard (micromist) nebulizer The nebulized sample (fine aerosols) are introduced into a heated (110ºC) spray chamber, where it is vapourized The vapourized sample is then carried into a heated (110ºC), semi-porous PTFE membrane wall and then transported away by an external gas stream (membrane gas flow)
59 Torches 2 main types: fixed and demountable fixed: 1 piece demountable: injector tube removable
60 Torches typically constructed of quartz glass injector tubes can be made of a variety of materials alumina tubes for HF solutions injector tubes can have varying diameters to accept a range of TDS solutions
61 Sample Analysis Design Solution Mode
62 Sample Analysis Design Step I Sample preparation The quality of your data will only be as good as the quality of your sample i.e. did you adequately prepare your sample in the clean lab? With respect to the destruction of matrices for samples requiring digestion Did you adequately spike samples with the correct internal standard? Sample handling protocol is extremely important, e.g. weighing
63 Sample Analysis Design Solid Samples Analyze in solid state via LA-ICP-MS? Analyze in solid state via SIMS secondary ion mass spectrometry? Convert into a glass bead and analyze via XRF x-ray fluoresence? Take powder and digest into solution with acids?
64 Sample Analysis Design- Liquid (aqueous) samples run as-is? filter then run? dilute then run? acidify, dilute, then run?
65 Sample Analysis Design Method of sample preparation also depends upon the elements of interest e.g. don t analyze your samples in a hydrofluoric acid medium if you wish to measure Si abundances why? Elemental concentration determinations at ultra-trace level (ppb, ppt) are very susceptible to contamination during sample preparation and therefore should be conducted in clean laboratory environments
66 Sample Analysis Design Clean room environment Laboratory clean room is a facility in which the concentration of airborne particles is controlled to specified limits. Eliminating sub-micron airborne contamination is a control-driven process since contaminants are generated by people, process, facilities and equipment. Hence, sub-micron particles must be continually removed from the air.
67 Sample Analysis Design Clean room environment Typical office building air contains from 500,000 to 1,000,000 particles (0.5 microns or larger) per cubic foot of air. A Class 100 cleanroom is designed to never allow more than 100 particles (0.5 microns or larger) per cubic foot of air. Class 1000 and Class 10,000 cleanrooms are designed to limit particles to 1000 and 10,000, respectively
68 Sample Analysis Design Clean room environment A human hair is about microns in diameter. A particle 200 times smaller (0.5 micron) than the human hair can cause major disaster in a clean room. Human hair typically concentrates elements/contaminants such as Pb!
69 Facilities: Sample Analysis Design - Sources of contamination Walls, floors and ceilings Paint and coatings Construction material (sheet rock, saw dust etc.) Air conditioning debris Room air and vapors Spills and leaks
70 People: Sample Analysis Design - Sources of contamination Skin flakes and oil Cosmetics and perfume Spittle Clothing debris (lint, fibers etc.) Hair
71 Sample Analysis Design - Contamination Control HEPA (High Efficiency Particulate Air Filter) - Extremely important for reducing contamination - filter particles as small as 0.3 microns with a 99.97% minimum particle-collective efficiency. Clean room design requires air flow dynamics to be the least disruptive as possible laminar flow Cleaning!
72 Sample Analysis Design - Contamination Control Purity of reagents, acids, cleanliness of digestion vessels, sample bottles, etc can dramatically effect background levels and data quality If possible, use highest purity commercial acids At the minimum - sometimes need to further process reagents e.g. acid distillation in our laboratory Digestion vessels made of disposable fluorinated polymers (teflon, PFTE, PFA, etc) Solutions stored in polypropylene or equivalent
73 Sample Analysis Design Concentration terminology Concentrations are typically expressed as either µg/g, or µg/ml (1 µg - microgram = 1 x 10-6 grams), or ppm, ppb, ppt ppm = parts per million = 1 x 10-6 g/g = 1 µg/g (µg = microgram) ppb = parts per billion = 1 x 10-9 g/g = 1 ng/g (ng = nanogram) ppt = parts per trillion = 1 x g/g = 1 pg/g (pg = picogram)
74 Sample Analysis Design Concentration terminology E.g. Zircon ZrSiO 4 ZrO 2 = 67.2 wt% SiO 2 = 32.8 wt% Atomic mass of Zr= Atomic mass of Si= Atomic mass of O= % Zr in ZrO 2 = /( ( *2)) = 74 % Si in SiO 2 = /( ( *2)) = 46.7
75 Sample Analysis Design Concentration terminology If 100% = 1,000,000 ppm, then 74% Zr (out of 67.2 wt%) = 49.73% or 497,300 ppm (or µg/g) 46.7% Si (out of 32.8 wt%) = 15.32% or 153,200 ppm (or µg/g) If you are asked to weigh out g of zircon, then the amounts of total Zr and Si you would have are: Zr = 497,300 µg/g x g = 4.97 µg Si = 153,200 µg/g x g = 1.53 µg
76 Sample Analysis Design Concentration terminology However, you are asked to prepare a solution of this zircon sample for ICP-MS analysis in solution mode; then what would be the minimum dilution factor required given that the maximal amount of ion signal intensity allowed is 50 x 10 6 cps and the yield for both elements in medium resolution mode is ~60,000 cps/ppb?
77 Sample Analysis Design Concentration terminology Maximum allowable concentration is = Max. count rate/ yield = 50 x 10 6 cps/ 60,000 cps/ppb = 833 ppb (ng/g) 4.97 µg of Zr needs to be diluted into? ml of 5% HNO µg = 4970 ng/833 ng/g = ~5.97 g (ml) of 5% HNO 3
Sample Analysis Design. Solution Mode
Sample Analysis Design Solution Mode Step I Sample preparation The quality of your data will only be as good as the quality of your sample i.e. did you adequately prepare your sample in the clean lab?
More informationInterface (backside) & Extraction Lens
Plasma Interface Interface (backside) & Extraction Lens Extraction Lens (-2000 volts) ION OPTICS Tip of the sampler cone is positioned to be in the region of maximum ionization Ions no longer under control
More informationDetermination of Impurities in Silica Wafers with the NexION 300S/350S ICP-MS
APPLICATION NOTE ICP - Mass Spectrometry Author Kenneth Ong PerkinElmer, Inc. Singapore Determination of Impurities in Silica Wafers with the NexION 300S/350S ICP-MS Introduction The control of impurity
More informationSpectrometric Methods of Analysis. OCN 633 Fall 2013
Spectrometric Methods of Analysis OCN 633 Fall 2013 Plasma Emission and Plasma Mass Spectroscopy Two fields of elemental analysis undergoing the most study Myriad analytical applications Three categories
More informationDirect Analysis of Trace Metal Impurities in High Purity Nitric Acid Using ICP-QQQ
Application Note Semiconductor Direct Analysis of Trace Metal Impurities in High Purity Nitric Acid Using ICP-QQQ Authors Kazuo Yamanaka and Kazuhiro Sakai Agilent Technologies, Tokyo, Japan Introduction
More informationPRINCIPLE OF ICP- AES
INTRODUCTION Non- flame atomic emission techniques, which use electrothermal means to atomize and excite the analyte, include inductively coupled plasma and arc spark. It has been 30 years since Inductively
More informationELEMENT2 High Resolution- ICP-MS INSTRUMENT OVERVIEW
ELEMENT2 High Resolution- ICP-MS INSTRUMENT OVERVIEW Inductively Coupled Plasma Mass Spectrometry (ICP-MS) What is a Plasma? - The magnetic field created by a RF (radio frequency) coil produces
More informationApplication note. Trace level analysis of sulfur, phosphorus, silicon and chlorine in NMP using the Agilent 8800 Triple Quadrupole ICP-MS
Trace level analysis of sulfur, phosphorus, silicon and chlorine in NMP using the Agilent 8800 Triple Quadrupole ICP-MS Application note Semiconductor Author Naoki Sugiyama Agilent Technologies, Tokyo,
More information- A spark is passed through the Argon in the presence of the RF field of the coil to initiate the plasma
THE PLASMA Inductively Coupled Plasma Mass Spectrometry (ICP-MS) What is a Plasma? - The magnetic field created by a RF (radio frequency) coil produces a current within a stream of Argon (Ar) gas, which
More informationAnalysis of high matrix samples using argon gas dilution with the Thermo Scientific icap RQ ICP-MS
TECHNICAL NOTE 4322 Analysis of high matrix samples using argon gas dilution with the Thermo Scientific icap RQ ICP-MS Keywords Argon gas dilution, AGD, High matrix samples, Seawater Goal To critically
More informationInductively Coupled Plasma Mass Spectrometry (ICP-MS) Debjani Banerjee Department of Chemical Engineering IIT Kanpur
Inductively Coupled Plasma Mass Spectrometry (ICP-MS) Debjani Banerjee Department of Chemical Engineering IIT Kanpur Introduction What is ICP-MS? Inductively Coupled Plasma Mass Spectrometry Mass spectrometry
More informationApplications of ICP-MS for Trace Elemental Analysis in the Hydrocarbon Processing Industry
Applications of ICP-MS for Trace Elemental Analysis in the Hydrocarbon Processing Industry Fundamentals and Applications to the Petrochemical Industry Outline Some background and fundamentals of ICPMS
More informationHydride Generation for the Determination of As, Sb, Se and Bi Using the Teledyne Leeman Lab s Prodigy 7 ICP-OES
Application Note - AN1508 Hydride Generation for the Determination of As, Sb, Se and Bi Using the Teledyne Leeman Lab s Prodigy 7 ICP-OES Introduction Page 1 The combination of hydride generation with
More informationThe 30-Minute Guide to ICP-MS
TECHNICAL NOTE The 30-Minute Guide to ICP-MS ICP - Mass Spectrometry A Worthy Member of the Atomic Spectroscopy Team For nearly 30 years, inductively coupled plasma mass spectrometry (ICP-MS) has been
More informationLow level Os isotopic measurements using multiple ion counting
APPLICATION NOTE 30355 Low level Os isotopic measurements using multiple ion counting Authors Introduction Jean Louis Birck, Delphine Limmois, Institut de Physique du Globe de Paris, Sorbonne Paris Cité,
More informationThermo Scientific icap RQ ICP-MS: Typical limits of detection
TECHNICAL NOTE 43427 Thermo Scientific icap RQ ICP-MS: Typical limits of detection Author Tomoko Vincent Keywords BEC, interference removal, KED, LOD Introduction Inductively Coupled Plasma Mass Spectrometry
More informationINDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY
INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY Edited by AKBAR MONTASER George Washington University Washington, D.C. 20052, USA WILEY-VCH New York Chichester Weinheim Brisbane Singapore Toronto CONTENTS
More informationDefining quality standards for the analysis of solid samples
Defining quality standards for the analysis of solid samples Thermo Scientific Element GD Plus Glow Discharge Mass Spectrometer Redefine your quality standards for the elemental analysis of solid samples
More informationRapid and precise calcium isotope ratio determinations using the Apex-ACM desolvating inlet system with sector-field ICP-MS in low resolution
APEX-ACM Ca Ratios Rapid and precise calcium isotope ratio determinations using the Apex-ACM desolvating inlet system with sector-field ICP-MS in low resolution Abstract High resolution ICP-MS is used
More informationDetermination of trace elements in ultrapure semiconductor grade sulfuric acid using the Agilent 8900 ICP-QQQ in MS/MS mode
Determination of trace elements in ultrapure semiconductor grade sulfuric acid using the Agilent 8900 ICP-QQQ in MS/MS mode Application note Semiconductor Authors Michiko Yamanaka, Kazuo Yamanaka and Naoki
More informationMulti-Element Analysis of Petroleum Crude Oils using an Agilent 7900 ICP-MS
Multi-Element Analysis of Petroleum Crude Oils using an Agilent 7900 ICP-MS Application note Energy and fuels Authors Jenny Nelson, Agilent Technologies, USA Ed McCurdy, Agilent Technologies, UK Introduction
More informationMass Spectrometry in MCAL
Mass Spectrometry in MCAL Two systems: GC-MS, LC-MS GC seperates small, volatile, non-polar material MS is detection devise (Agilent 320-MS TQ Mass Spectrometer) Full scan monitoring SIM single ion monitoring
More informationDirect Measurement of Metallic Impurities in 20% Ammonium Hydroxide by 7700s/7900 ICP-MS
Direct Measurement of Metallic Impurities in 20% Ammonium Hydroxide by 7700s/7900 ICP-MS Application Note Semiconductor Authors Junichi Takahashi Agilent Technologies Tokyo, Japan Abstract Ammonium hydroxide
More informationEnhancing the productivity of food sample analysis with the Agilent 7700x ICP-MS
Enhancing the productivity of food sample analysis with the Agilent 77x ICP-MS Application note Foods testing Authors Sebastien Sannac, Jean Pierre Lener and Jerome Darrouzes Agilent Technologies Paris,
More informationChapter 9. Atomic emission and Atomic Fluorescence Spectrometry Emission spectrophotometric Techniques
Chapter 9 Atomic emission and Atomic Fluorescence Spectrometry Emission spectrophotometric Techniques Emission Spectroscopy Flame and Plasma Emission Spectroscopy are based upon those particles that are
More informationICPMS Doherty Lecture 1
ICPMS Doherty Lecture 1 Mass Spectrometry This material provides some background on how to measure isotope abundances by means of mass spectrometry. Mass spectrometers create and separate ionized atoms
More informationTrace Analyses in Metal Matrices Using the ELAN DRC II
www.perkinelmer.com Trace Analyses in Metal Matrices Using the ELAN DRC II Introduction Analyses of matrices containing high levels of metals present a challenge for ICP-MS. First, the concentrations of
More informationHands on mass spectrometry: ICP-MS analysis of enriched 82 Se samples for the LUCIFER experiment
: ICP-MS analysis of enriched 82 Se samples for the LUCIFER experiment Max Planck Institute for Nuclear Physics, Heidelberg, Germany E-mail: mykola.stepaniuk@mpi-hd.mpg.de Stefano Nisi E-mail: stefano.nisi@lngs.infn.it
More informationTechniques for the Analysis of Organic Chemicals by Inductively Coupled Plasma Mass Spectrometry (ICP-MS)
Techniques for the Analysis of Organic Chemicals by Inductively Coupled Plasma Mass Spectrometry (ICP-MS) Petrochemical Authors Ed McCurdy & Don Potter Agilent Technologies Ltd. Lakeside Cheadle Royal
More informationSemiquantitative Screening of Pharmaceutical Antiviral Drugs using the Agilent 7500ce ICP-MS in Helium Collision Mode
Semiquantitative Screening of Pharmaceutical Antiviral Drugs using the Agilent 7500ce ICP-MS in Helium Collision Mode Application Note Pharmaceutical Authors Rebeca Santamaria-Fernandez, SheilaMerson,
More informationICP-MS. High Resolution ICP-MS.
ICP-MS attom ES High Resolution ICP-MS www.nu-ins.com Attom ES Enhanced Sensitivity Enhanced Speed Enhanced Selectivity Enhanced Software The Attom ES from Nu Instruments is a double focussing inductively
More informationApplication. Determination of Trace Metal Impurities in Semiconductor-Grade Hydrofluoric Acid. Authors. Introduction. Abstract.
Determination of Trace Metal Impurities in Semiconductor-Grade Hydrofluoric Acid Application Semiconductor Authors Abe G. Gutiérrez Elemental Scientific 2440 Cuming St Omaha, NE 68131 USA abe@icpms.com
More informationFollowing documents shall be used for reference on quantities, units, prefixes and other technical vocabulary in this document:
SPECIFICATION SPECIFICATION Inductively Coupled Plasma Mass Spectrometry System 1. Scope This specification describes the requirements for an Inductively Coupled Plasma Mass Spectrometry System ( System
More informationDetermination of challenging elements in ultrapure semiconductor grade sulfuric acid by Triple Quadrupole ICP-MS
Determination of challenging elements in ultrapure semiconductor grade sulfuric acid by Triple Quadrupole ICP-MS Application note Semiconductor Authors Junichi Takahashi Agilent Technologies, Japan Introduction
More informationDetermination of ultratrace elements in photoresist solvents using the Thermo Scientific icap TQs ICP-MS
APPLICATION NOTE 43374 Determination of ultratrace elements in photoresist solvents using the Thermo Scientific icap TQs ICP-MS Authors Tomoko Vincent, Product Specialist, Thermo Fisher Scientific Keywords
More informationSecondary ion mass spectrometry (SIMS)
Secondary ion mass spectrometry (SIMS) ELEC-L3211 Postgraduate Course in Micro and Nanosciences Department of Micro and Nanosciences Personal motivation and experience on SIMS Offers the possibility to
More information2101 Atomic Spectroscopy
2101 Atomic Spectroscopy Atomic identification Atomic spectroscopy refers to the absorption and emission of ultraviolet to visible light by atoms and monoatomic ions. It is best used to analyze metals.
More informationThe Characterization of Nanoparticle Element Oxide Slurries Used in Chemical-Mechanical Planarization by Single Particle ICP-MS
A P P L I C AT I O N N O T E ICP - Mass Spectrometry Authors: Lee Davidowski Chady Stephan PerkinElmer, Inc. Shelton, CT The Characterization of Nanoparticle Element Oxide Slurries Used in Chemical-Mechanical
More informationThermo VG PQ EXCELL INDUCTIVELY COUPLED PLASMA MASS SPECTROMETER
www.ietltd.com Proudly serving laboratories worldwide since 1979 CALL 001.847.913.0777 for Certified, Refurbished Lab Equipment Thermo VG PQ EXCELL INDUCTIVELY COUPLED PLASMA MASS SPECTROMETER TECHNICAL
More informationAnalysis of Trace Metal Impurities in High Purity Hydrochloric Acid Using ICP-QQQ
Application Note Semiconductor Analysis of Trace Metal Impurities in High Purity Hydrochloric Acid Using ICP-QQQ Authors Kazuo Yamanaka and Kazuhiro Sakai Agilent Technologies, Japan Introduction Hydrochloric
More informationDetermination of Elements at Sub-ppb Concentrations in Naphtha Mixtures Using the NexION 300 ICP-MS
application Note ICP Mass Spectrometry Authors Stan Smith PerkinElmer, Inc. Oak Brook, IL 60523 Monica Bolchi Riccardo Magarini PerkinElmer, Inc. Monza, Italy Determination of Elements at Sub-ppb Concentrations
More informationSodium Chloride - Analytical Standard
Sodium Chloride - Analytical Standard Determination of Total Mercury Former numbering: ECSS/CN 312-1982 & ESPA/CN-E-106-1994 1. SCOPE AND FIELD OF APPLICATION The present EuSalt Analytical Standard describes
More informationAN INTRODUCTION TO ATOMIC SPECTROSCOPY
AN INTRODUCTION TO ATOMIC SPECTROSCOPY Atomic spectroscopy deals with the absorption, emission, or fluorescence by atom or elementary ions. Two regions of the spectrum yield atomic information- the UV-visible
More informationLecture 8: Mass Spectrometry
intensity Lecture 8: Mass Spectrometry Relative abundance m/z 1 Ethylbenzene experiment CH 2 CH 3 + m/z = 106 CH 2 + m/z = 91 C 8 H 10 MW = 106 CH + m/z = 77 + 2 2 What information can we get from MS spectrum?
More informationLecture 8: Mass Spectrometry
intensity Lecture 8: Mass Spectrometry Relative abundance m/z 1 Ethylbenzene CH 2 CH 3 + m/z = 106 CH 2 + m/z = 91 C 8 H 10 MW = 106 CH + m/z = 77 + 2 2 What information can be obtained from a MS spectrum?
More informationAtomic Absorption Spectrophotometry. Presentation by, Mrs. Sangita J. Chandratre Department of Microbiology M. J. college, Jalgaon
Atomic Absorption Spectrophotometry Presentation by, Mrs. Sangita J. Chandratre Department of Microbiology M. J. college, Jalgaon Defination In analytical chemistry, Atomic absorption spectroscopy is a
More informationFundamentals of Mass Spectrometry. Fundamentals of Mass Spectrometry. Learning Objective. Proteomics
Mass spectrometry (MS) is the technique for protein identification and analysis by production of charged molecular species in vacuum, and their separation by magnetic and electric fields based on mass
More informationMODULE 4.3 Atmospheric analysis of particulates
MODULE 4.3 Atmospheric analysis of particulates Measurement And Characterisation Of The Particulate Content 1 Total particulate concentration 1 Composition of the particulate 1 Determination of particle
More informationFundamentals of Particle Counting
Fundamentals of Particle Counting 1 Particle Counting: Remains the most significant technique for determining the cleanliness level of a fluid Useful as a tool for qualification and monitoring cleanroom
More informationUltra-fast determination of base metals in geochemical samples using the 5100 SVDV ICP-OES
Ultra-fast determination of base metals in geochemical samples using the 5100 SVDV ICP-OES Application note Geochemistry, metals, mining Authors John Cauduro Agilent Technologies, Mulgrave, Australia Introduction
More informationENVG FALL ICP-MS (Inductively Coupled Plasma Mass Spectrometry) Analytical Techniques
ENVG 60500 FALL 2013 ICP-MS (Inductively Coupled Plasma Mass Spectrometry) Analytical Techniques HISTORY In the 1940s, arc and high-voltage spark spectrometry became widely utilized for metal analysis
More information6.5 Optical-Coating-Deposition Technologies
92 Chapter 6 6.5 Optical-Coating-Deposition Technologies The coating process takes place in an evaporation chamber with a fully controlled system for the specified requirements. Typical systems are depicted
More informationThermo Scientific ELEMENT GD PLUS Glow Discharge Mass Spectrometer. Defining quality standards for the analysis of solid samples
Thermo Scientific ELEMENT GD PLUS Glow Discharge Mass Spectrometer Defining quality standards for the analysis of solid samples Redefine your quality standards for the elemental analysis of solid samples
More informationAgilent ICP-MS. Fundamentals of ICP-MS Analysis and Its Applications for Low Level Elemental Determination in Cannabis
Agilent ICP-MS Fundamentals of ICP-MS Analysis and Its Applications for Low Level Elemental Determination in Cannabis High Sample Matrix Tolerance Superior & Simple Interference Removal Ultra Wide Linear
More informationChemistry Instrumental Analysis Lecture 37. Chem 4631
Chemistry 4631 Instrumental Analysis Lecture 37 Most analytes separated by HPLC are thermally stable and non-volatile (liquids) (unlike in GC) so not ionized easily by EI or CI techniques. MS must be at
More informationSample Analysis Design PART II
Sample Analysis Design PART II Sample Analysis Design Generating high quality, validated results is the primary goal of elemental abundance determinations It is absolutely critical to plan an ICP-MS analysis
More information1. The range of frequencies that a measurement is sensitive to is called the frequency
CHEM 3 Name Exam 1 Fall 014 Complete these problems on separate paper and staple it to this sheet when you are finished. Please initial each sheet as well. Clearly mark your answers. YOU MUST SHOW YOUR
More informationIntroduction to GC/MS
Why Mass Spectrometry? Introduction to GC/MS A powerful analytical technique used to: 1.Identify unknown compounds 2. Quantify known materials down to trace levels 3. Elucidate the structure of molecules
More informationSampling. Information is helpful in implementing control measures for reducing pollutant concentration to acceptable levels
Types of pollutant sampling and measurement: Air quality monitoring: Sampling and measurement of air pollutants generally known, as air quality monitoring. It is an integral component of any air pollution
More informationLead isotope analysis: Removal of 204 Hg isobaric interference from 204 Pb using ICP-QQQ in MS/MS mode
Lead isotope analysis: Removal of Hg isobaric interference from using ICP-QQQ in MS/MS mode Application note Authors Geochemistry and isotope analysis Glenn Woods Agilent Technologies, LDA UK Ltd., Stockport,
More informationTANDEM MASS SPECTROSCOPY
TANDEM MASS SPECTROSCOPY 1 MASS SPECTROMETER TYPES OF MASS SPECTROMETER PRINCIPLE TANDEM MASS SPECTROMETER INSTRUMENTATION QUADRAPOLE MASS ANALYZER TRIPLE QUADRAPOLE MASS ANALYZER TIME OF FLIGHT MASS ANALYSER
More informationDISCLAIMER: This method:
Inorganic arsenic determination in fresh mussels using water bath extraction and anion exchange chromatography-inductively coupled plasma mass spectrometry DISCLAIMER: This method: - has to be considered
More informationMass Analyzers. Principles of the three most common types magnetic sector, quadrupole and time of flight - will be discussed herein.
Mass Analyzers After the production of ions in ion sources, the next critical step in mass spectrometry is to separate these gas phase ions according to their mass-to-charge ratio (m/z). Ions are extracted
More informationDirect Analysis of Photoresist Using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) Application
Direct Analysis of Photoresist Using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) Application Semiconductor Author Junichi Takahashi Koichi Yono Agilent Technologies, Inc. 9-1, Takakura-Cho, Hachioji-Shi,
More informationAnalysis of Polar Metabolites using Mass Spectrometry
Analysis of Polar Metabolites using Mass Spectrometry TransMed Course: Basics in Clinical Proteomics and Metabolomics. Oct 10-19, 2012 dd.mm.yyyy Vidya Velagapudi, Ph.D, Adjunct Professor Head of the Metabolomics
More informationTrace elemental analysis of distilled alcoholic beverages using the Agilent 7700x ICP-MS with octopole collision/ reaction cell
Trace elemental analysis of distilled alcoholic beverages using the Agilent 77x ICP-MS with octopole collision/ reaction cell Application note Food testing Author Glenn Woods Agilent Technologies Cheadle
More informationDetermination the elemental composition of soil samples
4. Experiment Determination the elemental composition of soil samples Objectives On this practice you will determine the elemental composition of soil samples by Inductively Coupled Plasma Optical Emission
More informationICP-MS. Inductively Coupled Plasma Mass Spectrometry. A Primer
ICP-MS Inductively Coupled Plasma Mass Spectrometry A Primer Table of Contents ICP-MS Primer Section 1 Introduction to ICP-MS 1 History and Development of ICP-MS 2 Agilent Technologies - History in ICP-MS
More informationSample Analysis Design Polyatomic Interferences
Sample Analysis Design Polyatomic Interferences More serious than isobaric interferences Result from possible, short-lived combination of atomic species in the plasma or during ion transfer Common recombinants
More informationThe Easy Guide to: Inductively Coupled Plasma- Mass Spectrometry (ICP-MS)
The Easy Guide to: Inductively Coupled Plasma- Mass Spectrometry (ICP-MS) By Arianne Bazilio & Jacob Weinrich December 2012 Contents Introduction... 2 Sample Introduction... 3 Torch... 4 Interface... 6
More informationKey Analytical Issues: Sample Preparation, Interferences and Variability. Tim Shelbourn, Eli Lilly and Company
Key Analytical Issues: Sample Preparation, Interferences and Variability Tim Shelbourn, Eli Lilly and Company Presentation Outline Sample preparation objectives and challenges Some common interferences
More informationFundamentals of the ICP-MS Technique and How to Resolve Issues for Pharmaceutical Materials (In 20 Minutes) Tim Shelbourn, Eli Lilly and Company
Fundamentals of the ICP-MS Technique and How to Resolve Issues for Pharmaceutical Materials (In 20 Minutes) Tim Shelbourn, Eli Lilly and Company Why ICP Mass Spectrometry? Ultra-trace multi-element analytical
More informationFEASIBILITY OF IN SITU TXRF
FEASIBILITY OF IN SITU TXRF A. ngh 1, P. Goldenzweig 2, K. Baur 1, S. Brennan 1, and P. Pianetta 1 1. Stanford Synchrotron Radiation Laboratory, Stanford, CA 94309, US 2. Binghamton University, New York,
More informationSecondary Ion Mass Spectroscopy (SIMS)
Secondary Ion Mass Spectroscopy (SIMS) Analyzing Inorganic Solids * = under special conditions ** = semiconductors only + = limited number of elements or groups Analyzing Organic Solids * = under special
More informationICP-OES Application Note Number 35
ICP-OES Application Note Number 35 Rapid measurement of major, minor and trace levels in soils using the Varian 730-ES Vincent Calderon Varian, Inc. Introduction As part of the global strategy for sustainable
More informationAnalysis of Arsenic, Selenium and Antimony in Seawater by Continuous-Flow Hydride ICP-MS with ISIS
ICP-MS Environmental Analysis of Arsenic, Selenium and Antimony in Seawater by Continuous-Flow Hydride ICP-MS with ISIS Application Note Steve Wilbur Analysis of arsenic and selenium in seawater at trace
More informationAgilent 7500a Inductively Coupled Plasma Mass Spectrometer (ICP-MS)
www.ietltd.com Proudly serving laboratories worldwide since 1979 CALL +1.847.913.0777 for Refurbished & Certified Lab Equipment Agilent 7500a Inductively Coupled Plasma Mass Spectrometer (ICP-MS) The Agilent
More informationApplication Note GA-301E. MBMS for Preformed Ions. Extrel CMS, 575 Epsilon Drive, Pittsburgh, PA I. SAMPLING A CHEMICAL SOUP
Application Note MBMS for Preformed Ions, 575 Epsilon Drive, Pittsburgh, PA 15238 (Poster Presented at 45th ASMS Conference on Mass Spectrometry, June 1-5, 1997) In order to accurately characterize a plasma
More informationPortable type TXRF analyzer: Ourstex 200TX
Excerpted from Adv. X-Ray. Chem. Anal., Japan: 42, pp. 115-123 (2011) H. Nagai, Y. Nakajima, S. Kunimura, J. Kawai Improvement in Sensitivity and Quantification by Using a Portable Total Reflection X-Ray
More informationEXPERIMENT 7. Determination of Sodium by Flame Atomic-Emission Spectroscopy
EXPERIMENT 7 Determination of Sodium by Flame Atomic-Emission Spectroscopy USE ONLY DEIONIZED WATER (NOT DISTILLED WATER!) THROUGHOUT THE ENTIRE EXPERIMENT Distilled water actually has too much sodium
More informationSources of Errors in Trace Element and Speciation Analysis
Sources of Errors in Trace Element and Speciation Analysis Zoltan Mester, National Research Council of Canada, Institute for National Measurement Standards Outline Definitions Sources of errors in the
More informationTest Method: CPSC-CH-E
UNITED STATES CONSUMER PRODUCT SAFETY COMMISSION DIRECTORATE FOR LABORATORY SCIENCES DIVISION OF CHEMISTRY 10901 DARNESTOWN RD GAITHERSBURG, MD 20878 Test Method: CPSC-CH-E1001-08 Standard Operating Procedure
More informationICP-3000 Inductively Coupled Plasma Optical Emission Spectrometer
Inductively Coupled Plasma Optical Emission Spectrometer Inductively Coupled Plasma Optical Emission Spectrometer Inductively Coupled Plasma Optical Emission Spectrometer is powerful simultaneous full
More informationMS Goals and Applications. MS Goals and Applications
MS Goals and Applications 1 Several variations on a theme, three common steps Form gas-phase ions choice of ionization method depends on sample identity and information required Separate ions on basis
More informationUltra trace measurement of potassium and other elements in ultrapure water using the Agilent 8800 ICP-QQQ in cool plasma reaction cell mode
Ultra trace measurement of potassium and other elements in ultrapure water using the Agilent 8800 ICP-QQQ in cool plasma reaction cell mode Application note Semiconductor Author Katsuo Mizobuchi Masakazu
More informationM M e M M H M M H. Ion Sources
Ion Sources Overview of Various Ion Sources After introducing samples into a mass spectrometer, the next important step is the conversion of neutral molecules or compounds to gas phase ions. The ions could
More informationThermo Scientific Neptune XT MC-ICP-MS
Thermo Scientific Neptune XT MC-ICP-MS Neptune XT MC-ICP-MS A new edition of the market leading Thermo Scientific Neptune Series MC-ICP-MS, capturing the best of technology for high-precision isotope ratio
More informationAccurate analysis of neptunium 237 in a uranium matrix, using ICP-QQQ with MS/MS
Accurate analysis of neptunium in a uranium matrix, using ICP-QQQ with MS/MS Application note Nuclear, environmental Authors Garry Duckworth, Springfields Fuels Ltd, K, Glenn Woods, Agilent Technologies,
More informationMS Goals and Applications. MS Goals and Applications
MS Goals and Applications 3 Several variations on a theme, three common steps Form gas-phase ions choice of ionization method depends on sample identity and information required Separate ions on basis
More informationPHI 5000 Versaprobe-II Focus X-ray Photo-electron Spectroscopy
PHI 5000 Versaprobe-II Focus X-ray Photo-electron Spectroscopy The very basic theory of XPS XPS theroy Surface Analysis Ultra High Vacuum (UHV) XPS Theory XPS = X-ray Photo-electron Spectroscopy X-ray
More information10/2/2008. hc λ. νλ =c. proportional to frequency. Energy is inversely proportional to wavelength And is directly proportional to wavenumber
CH217 Fundamentals of Analytical Chemistry Module Leader: Dr. Alison Willows Electromagnetic spectrum Properties of electromagnetic radiation Many properties of electromagnetic radiation can be described
More informationAIR-O-CELL CSI. Bioaerosol Sampling Cassette For the collection of viable and non-viable airborne particles. Laboratory & User Manual
AIR-O-CELL CSI Bioaerosol Sampling Cassette For the collection of viable and non-viable airborne particles Laboratory & User Manual Air-O-Cell CSI Sampling Cassette The Air-O-Cell Collector for SEM Identification
More informationAtomic Spectroscopy AA/ICP/ICPMS:
Atomic Spectroscopy AA/ICP/ICPMS: A Comparison of Techniques VA AWWA/VWEA Lab Practices Conference July 25, 2016 Dan Davis Shimadzu Scientific Instruments AA/ICP/ICPMS: A Comparison of Techniques Topics
More informationDEPOSITION OF THIN TiO 2 FILMS BY DC MAGNETRON SPUTTERING METHOD
Chapter 4 DEPOSITION OF THIN TiO 2 FILMS BY DC MAGNETRON SPUTTERING METHOD 4.1 INTRODUCTION Sputter deposition process is another old technique being used in modern semiconductor industries. Sputtering
More informationOptical Atomic Spectroscopy
Optical Atomic Spectroscopy Methods to measure conentrations of primarily metallic elements at < ppm levels with high selectivity! Two main optical methodologies- -Atomic Absorption--need ground state
More informationProtocol Particle size distribution by centrifugal sedimentation (CPS)
Protocol Particle size distribution by centrifugal sedimentation (CPS) 1. Method The CPS Disc Centrifuge separates particles by size using centrifugal sedimentation in a liquid medium. The sedimentation
More information= 6 (1/ nm) So what is probability of finding electron tunneled into a barrier 3 ev high?
STM STM With a scanning tunneling microscope, images of surfaces with atomic resolution can be readily obtained. An STM uses quantum tunneling of electrons to map the density of electrons on the surface
More informationBasic Digestion Principles
Basic Digestion Principles 1 From Samples to Solutions Direct Analytical Method Solid Sample Problems: Mech. Sample Preparation (Grinding, Sieving, Weighing, Pressing, Polishing,...) Solid Sample Autosampler
More informationOPTIMIZING METALS SAMPLE PREP
APPLICATION NOTE OPTIMIZING METALS SAMPLE PREP Utlilizing Single Reaction Chamber (SRC)Technology for Trace Metals Analysis for contract laboratories. Contract analytical laboratories use a variety of
More informationUse of ICP-MS in analysing radioisotopes. Per Roos Risø National Laboratory for Sustainable Energy, Technicial University of Denmark
Use of ICP-MS in analysing radioisotopes Per Roos Risø National Laboratory for Sustainable Energy, Technicial University of Denmark Inductively Coupled Plasma Mass Spectrometry (ICP-MS) History ICP-AES
More information