DISCLAIMER: This method:

Size: px
Start display at page:

Download "DISCLAIMER: This method:"

Transcription

1 Inorganic arsenic determination in fresh mussels using water bath extraction and anion exchange chromatography-inductively coupled plasma mass spectrometry DISCLAIMER: This method: - has to be considered only as guideline to help the NRLs to approach the analytical problems of inorganic arsenic determination in fresh mussels; - has been developed by the EURL-CEFAO using the facilities available in its laboratories; The laboratories have to study the instrumental conditions appropriate for their own instrumentation. Page 1 of 8

2 CONTENTS 1. SCOPE ACRONYMS AND CONVENTIONS METHOD DESCRIPTION EQUIPMENT REAGENTS AND SAMPLES PROCEDURES INSTRUMENTAL ANALYSIS VALIDATION PARAMETERS FINAL CONSIDERATIONS... 7 Page 2 of 8

3 1. SCOPE The method describes a general guideline for speciation of inorganic arsenic in fresh mussels. 2. ACRONYMS AND CONVENTIONS ICP-MS Inductively Coupled Plasma Mass Spectrometry HPLC High Performance Liquid Chromatography Inorganic Arsenic i-as Ammonium dihydrogen phosphate NH 4 H 2 PO 4 Ammonium nitrate NH 4 NO 3 Methanol CH 3 OH Ammonia NH 4 OH Disodium hydrogen arsenate heptahydrate Na 2 HAsO 4 *7H 2 O sp Suprapure grade up Ultrapure grade c concentration expressed in units of milligrams/micrograms per litre LoD Limit of detection LoQ Limit of quantification RSDr Relative standard deviation under repeatability conditions RSD R Relative standard deviation under within-laboratory reproducibility conditions 3. METHOD DESCRIPTION The determination of i-as is performed by anion exchange chromatography-inductively coupled plasma mass spectrometry after water bath extraction. The proposed extraction procedure leads to the complete oxidation of As(III) into As(V), which results as a well separated peak in the anion exchange HPLC-ICP-MS chromatogram. The i-as is quantified as As(V). The method was validated using samples of Mediterranean mussels containing roughly 3.8 mg/kg of total As. Instrumental quantification is based on at least three point external calibration curve. WARNING: the application of the method includes the use of hazardous materials, operations and equipment. The user is responsible for the appropriate use of safety tools. 4. EQUIPMENT The following apparatus and equipment have been used for the EURL-CEFAO method development: - ICP-MS (ELAN DRC II, Perkin Elmer): Interface Pt skimmer and sampler cones Meinhard quartz concentric nebulizer used in conjunction with a PC3 Peltier-cooled quartz cyclonic spray chamber Page 3 of 8

4 - HPLC system (Perkin Elmer Series 200) - Shaking water bath (VWR International) µm PVDF syringe filters - ph meter - Centrifuge - Hamilton PRP-X100 Column - Polypropylene falcon tubes - Plastic Pasteur pipettes - Polypropylene syringe without needle - Stericup filter units (or similar) - Analytical scale (0.1 mg precision) 5. REAGENTS AND SAMPLES The reagents must have adequate purity. Sp or up grade guarantees that the concentration of the analyte in reagents and water is negligible compared with the level of concentration to be determined. - Nitric acid up (70% v/v) - Hydrogen peroxide sp (30% v/v) - NH 4 H 2 PO 4 (99.99% Suprapur) - NH 4 NO 3 (pro analysis) - CH 3 OH (HPLC grade) - Up-water, specific resistance 17 MΩ cm for all samples preparation and dilutions - Na 2 HAsO 4 *7H 2 O - Certified Element Standard Solutions, c = 1000 µg/ml of As, and Rh - ERM-CE278K - Fresh mussels from the Mediterranean sea (Mytilus spp.) 6. PROCEDURES 6.1 Sample extraction Weigh circa 1.0 g of fresh mussels or 0.3 g of freeze-dried samples in the case of, e.g., lyophilised reference materials in 50 ml polypropylene test tube (e.g. Falcon type). Add 10 ml of a 1% (v/v) HNO 3 and 1% (v/v) H 2 O 2 solution and let stand overnight at room temperature (pre-digestion step). Afterwards, place the tubes in a water bath at 95 C for 1 hour under gentle shaking. Let the samples cool to room temperature and centrifuge the tubes at rpm for at least 10 minutes (centrifuge temperature set at 4 C). Collect the clear supernatant by means of a 3 ml plastic Pasteur pipette in 15 ml polypropylene test tubes after filtration through 0.22 µm filters. If the filtration is particularly difficult, the centrifugation time can be increased and the filtration through 0.22 µm filters can be preceded by a further step performed using 0.45 µm filters. If the extracts are not analysed straight after filtration, aliquot them and store the resulting aliquots at a temperature of -20 C or lower till analysis. Page 4 of 8

5 6.2 Inorganic arsenic determination Preparation of the mobile phase (10mM NH 4 H 2 PO 4, 10mM NH 4 NO 3 2% (v/v) CH 3 OH) Prepare a solution of 2% (v/v) CH 3 OH (at least 1 L of solution). Dissolve circa 1.15 g of NH 4 H 2 PO 4 and 0.8 g of NH 4 NO 3 in 1 L of the solution 2% (v/v) CH 3 OH. Adjust to ph 5.5 adding a diluted solution of ammonia (1:10, v/v) or a solution of diluted HNO 3 while the solution is maintained under stirring. Before use this solution has to be filtered (e.g. by using a stericup filter unit connected to a vacuum pump) Preparation of stock standard solutions All the solutions should be prepared by weight. As (V) 1000 mg/kg (sol A): prepare a 1000 mg/kg aqueous standard solution of arsenate (expressed as As) starting from Na 2 HAsO 4 *7H 2 O (e.g. weigh g Na 2 HAsO 4 *7H 2 O in 50 g up water). The solution has to be stored at - 20 C. As (V) 1.0 mg/kg (sol B): dilute sol A up to 1 mg/kg with up water. This solution has to be properly stored in a freezer or a refrigerator. In any case the actual concentration of As (V) in this solution has to be ascertained by ICP-MS, whereas the chromatographic purity has to be assessed by HPLC-ICP-MS. As 1.0 mg/kg (sol C): prepare an aqueous solution preferably by weight, e.g. weigh 0.05 g of the certified As standard solution at 1000 mg/kg and dilute up to 50 g with acidified (HNO 3; 1% v/v) up water. Rh 1.0 mg/kg (sol D): prepare an aqueous solution preferably by weight, e.g. weigh 0.05 g of the certified Rh standard solution at 1000 mg/kg and dilute up to 50 g with acidified (HNO 3; 1% v/v) up water. 7. INSTRUMENTAL ANALYSIS 7.1 Working standard solutions These solutions must be daily prepared preferably by weight. As (V) 0.1 mg/kg (sol E): prepare an aqueous solution preferably by weight (e.g. weigh 1.0 g of sol B and dilute up to 10 g with up water). This solution is used to check the actual concentration of the sol B so as to correct the title of the starting 1000 mg/kg As (V) solution. It is also used to prepare the calibration curve to quantify the concentration of As (V) in the samples. Rh 0.1 mg/kg (sol IS): prepare an aqueous solution preferably by weight (e.g. weigh 1.0 g of sol D and dilute up to 10 g with up water) As 0.1 mg/kg (sol F): prepare an aqueous solution preferably by weight (e.g. weigh 1.0 g of sol C and dilute up to 10 g with up water). 7.2 Check of the actual concentration of As (V) 1.0 mg/kg Prepare a three point external calibration curve by using sol IS and sol F (e.g. the following calibration points can be used: 50 ppb; 100 ppb; 200 ppb with IS at 5 ppb) and quantify the concentration of sol E on this curve. On the basis of the result correct the concentration of sol B. This right concentration value has to be used for the subsequent analyses and calculations. Page 5 of 8

6 7.3 Speciation of i-as The analysis is performed by HPLC-ICP-MS using a Hamilton PRPX-100 column and the elution is carried out in isocratic mode (total time for each sample: 30 minutes). The samples have to be diluted two-fold (w/w) before the analysis. The i-as is identified as As(V) by comparing the retention time of the chromatographic peak of the samples with that of the peak obtained by spiking the sample extracts with As(V) standard solution. The quantification is based on the measurement of peak areas and is performed using an external calibration curve made of at least three points. The calibration curve has to be reacquired after each series of 6-10 samples. ArCl interference on m/z 75 is assessed by monitoring m/z equal to 77 and 82. The operating conditions of the HPLC-ICP-MS system are summarized in Table 1. A typical chromatogram of an extract of the samples used for this validation is shown in Figure 1. Table 1. Operating conditions HPLC-ICPMS HPLC Column Hamilton PRPX-100 (250 x 4.6 mm, 5µm particle size) Temperature 22 C Injection volume 50 µl Mobile phase 10 mm NH 4 H 2 PO 4 +NH 4 NO 3 2% CH 3 OH (ph=5.5) Flow rate 1.0 ml/min Elution mode Isocratic Run time 30 minutes As(V) retention time 10 minutes ICP-MS Plasma flow 15 L/min Auxiliary gas flow 1.0 L/min Nebulizer gas flow Daily optimized RF Power 1500 W Figure 1. Typical chromatogram obtained for an extract of the Mediterranean mussels used for validation AsV Mussels 1% HNO 3 + 1% H 2 O 2 water bath extraction Page 6 of 8

7 8. VALIDATION PARAMETERS The following validation parameters have been assessed: LoD, LoQ, repeatability, within-laboratory reproducibility, accuracy. LoD and LoQ were determined using 20 samples of fresh mussels from Mediterranean sea with a low content of i-as. In particular, the standard deviation was multiplied by 3 and 10 so as to calculate the LoD and LoQ, respectively. Repeatability and within-laboratory reproducibility were assessed by analyzing samples of Mediterranean mussels containing higher amounts of i-as abd 3.8 mg/kg of total arsenic. As far as the accuracy is concerned, it was assessed using a Reference Material (ERM- CE278K) and recovery rates of spiked As(III). The satisfactory recovery of As(III) as As(V) confirmed the complete oxidation of As(III) into As(V). The reference value of i-as in ERM- CE278K (0.086 mg/kg ± mg/kg) was the value assigned in a dedicated collaborative trial (IMEP-41). The parameters obtained during the method validation are summarized in table 2. Table 2. Parameters of the EURL-CEFAO validation Parameter Parameter value LoD (mg/kg) LoQ (mg/kg) a) RSDr (%) 5.0 b) RSD R (%) 9.2 Recovery (%): c) As(III) 108 ERM-CE278K 94 a) Mean concentration value of i-as = mg/kg b) Mean concentration value of i-as = mg/kg c) Spiked concentration As(III) = mg/kg A provisional value of expanded uncertainty equal to 19% (k=2) was estimated using a formula that combined the within-laboratory reproducibility and the uncertainty of the bias. Please, note that this value was calculated using the assigned value and the relevant uncertainty of the ERM-CE278K as derived from the IMEP-41 trial. The value was assessed by considering the analysis in triplicate. 9. FINAL CONSIDERATIONS During method development particular attention was paid to the use of a shaking water bath as extraction tool since it allows to obtain a greater sample throughput compared with microwave systems. Each extract sample was analyzed with three different anion-exchange HPLC-ICP-MS methods based on two different columns (Hamilton PRP-X100 and ICSep ION-120). As for the quantification of the i-as, both external and standard addition calibration approaches were applied in order to evaluate the occurrence of matrix effects. Due Page 7 of 8

8 to the good preliminary results obtained the method consisting in the extraction with a HNO 3 /H 2 O 2 mixture and elution with ammonium phosphate and ammonium nitrate in 2% methanol (ph=5.5) on Hamilton PRPX-100 column was considered for validation. In particular, both microwave ovens and shaking water baths were evaluated as extractive apparatus and no difference resulted between the two procedures. Extraction with water bath is less expensive (use of polypropylene disposable tubes and water bath compared with expensive TFM vessels and microwave ovens) and less time consuming, allowing the operator to extract a greater number of samples than with microwaves (roughly 60 vs 10). Furthermore, the difference in repeatability and accuracy between samples extracted with microwave oven and shaking water bath was found to be negligible, leading to the selection of the latter procedure as the one to be implemented. The elution through the Hamilton PRPX-100 was performed in isocratic mode and the i-as was determined as a single species, i.e. As(V), using both external and standard addition calibration for quantification. The comparison of the results showed no differences between the two approaches so the external calibration was selected as quantification method being easier to perform. Both the undiluted and two-fold diluted samples were tested: also in this case no significant differences were found; the two-fold dilution was selected as it implied both a minor wear and tear of the column and a better resolution of the chromatographic peaks. Page 8 of 8

Direct Determination of Cadmium and Lead in honey by Electrothermal Atomization Atomic Absorption Spectrometry with Zeeman Effect Correction

Direct Determination of Cadmium and Lead in honey by Electrothermal Atomization Atomic Absorption Spectrometry with Zeeman Effect Correction NOTICE: This method: Direct Determination of Cadmium and Lead in honey by Electrothermal Atomization Atomic Absorption Spectrometry with Zeeman Effect Correction - has to be considered only as guideline

More information

NOTICE: This method: The laboratories have to study the instrumental conditions appropriate for their own instrumentation.

NOTICE: This method: The laboratories have to study the instrumental conditions appropriate for their own instrumentation. Determination of Cadmium and Lead in powdered infant formula by Electrothermal Atomization Atomic Absorption Spectrometry with Zeeman Effect Correction NOTICE: This method: - has to be considered only

More information

Direct Determination of Aluminium in Milk by Graphite Furnace Atomic Absorption Spectrometry

Direct Determination of Aluminium in Milk by Graphite Furnace Atomic Absorption Spectrometry Direct Determination of Aluminium in Milk by Graphite Furnace Atomic Absorption Spectrometry NOTICE: This method has been developed by the EURL-CEFAO using the facilities available in its laboratories.

More information

--> Buy True-PDF --> Auto-delivered in 0~10 minutes. GB Translated English of Chinese Standard: GB5009.

--> Buy True-PDF --> Auto-delivered in 0~10 minutes. GB Translated English of Chinese Standard: GB5009. Translated English of Chinese Standard: GB5009.17-2014 www.chinesestandard.net Sales@ChineseStandard.net NATIONAL STANDARD OF GB THE PEOPLE S REPUBLIC OF CHINA National Food Safety Standard-Determination

More information

The analysis of organic acid content of additives, premix, feed, and water.

The analysis of organic acid content of additives, premix, feed, and water. The analysis of organic acid content of additives, premix, feed, and water. Contents Foreword Introduction Warnings 1. Scope 2 1.1 LOD and LOQ 3 2. Normative References 3 3. Definitions 3 3.1 Feed (or

More information

Rapid determination of five arsenic species in polished rice using HPLC-ICP-MS

Rapid determination of five arsenic species in polished rice using HPLC-ICP-MS Rapid determination of five arsenic species in polished rice using HPLC-ICP-MS Application note Food safety Authors Bing Yue China National Center For Food Safety Risk Assessment, Beijing, China Juane

More information

DETERMINATION OF DRUG RELEASE DURING DISSOLUTION OF NICORANDIL IN TABLET DOSAGE FORM BY USING REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

DETERMINATION OF DRUG RELEASE DURING DISSOLUTION OF NICORANDIL IN TABLET DOSAGE FORM BY USING REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY CHAPTER 9 DETERMINATION OF DRUG RELEASE DURING DISSOLUTION OF NICORANDIL IN TABLET DOSAGE FORM BY USING REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY CHAPTER 9 Determination of drug release during

More information

IDENTIFICATION AND DETERMINATION OF HYDROQUINONE IN COSMETIC PRODUCTS 2 14/11/17 ACM 003 BY TLC AND HPLC

IDENTIFICATION AND DETERMINATION OF HYDROQUINONE IN COSMETIC PRODUCTS 2 14/11/17 ACM 003 BY TLC AND HPLC A. IDENTIFICATION BY TLC 1. SCOPE AND FIELD OF APPLICATION The method describes the identification of hydroquinone in cosmetic products. 2. PRINCIPLE Hydroquinone is identified by thin layer chromatography

More information

IDENTIFICATION OF STEROIDS IN COSMETIC PRODUCTS BY TLC AND HPLC 1 02/12/2005 ACM 007 A. THIN LAYER CHROMATOGRAPHY (TLC)

IDENTIFICATION OF STEROIDS IN COSMETIC PRODUCTS BY TLC AND HPLC 1 02/12/2005 ACM 007 A. THIN LAYER CHROMATOGRAPHY (TLC) Document A. THIN LAYER CHROMATOGRAPHY (TLC) 1. SCOPE AND FIELD OF APPLICATION The method describes the identification of hydrocortisone acetate, dexamethasone, betamethasone, betamethasone 17-valerate

More information

Sulfotepp impurities in Chlorpyrifos EC formulations

Sulfotepp impurities in Chlorpyrifos EC formulations Page 1 of 16 Method DAS-AM-01-058 Sulfotepp impurities in Chlorpyrifos EC formulations A. ABSTRACT Method DAS-AM-01-058 has been validated for the analysis of the relevant impurity sulfotepp in chlorpyrifos

More information

DETERMINATION OF BIOPHENOLS IN OLIVE OILS BY HPLC

DETERMINATION OF BIOPHENOLS IN OLIVE OILS BY HPLC INTERNATIONAL OLIVE COUNCIL COI/T.20/Doc No 29/Rev.1 2017 ENGLISH Original: ITALIAN Príncipe de Vergara, 154 28002 Madrid España Telef.: +34 915 903 638 Fax: +34 915 631 263 - e-mail: iooc@internationaloliveoil.org

More information

Simultaneous Arsenic and Chromium Speciation by HPLC/ICP-MS in Environmental Waters

Simultaneous Arsenic and Chromium Speciation by HPLC/ICP-MS in Environmental Waters Simultaneous Arsenic and Chromium Speciation by HPLC/ICP-MS in Environmental Waters Introduction Many elements can exist in a variety of oxidation states which have differing impacts on health and the

More information

7. Stability indicating analytical method development and validation of Ramipril and Amlodipine in capsule dosage form by HPLC.

7. Stability indicating analytical method development and validation of Ramipril and Amlodipine in capsule dosage form by HPLC. 7. Stability indicating analytical method development and validation of and in capsule dosage form by HPLC. 7.1 INSTRUMENTS AND MATERIALS USED 7.1.1 INSTRUMENTS 1. Shimadzu LC-2010 CHT with liquid chromatograph

More information

A Comparison of Arsenic Speciation

A Comparison of Arsenic Speciation A Comparison of Arsenic Speciation Methods for Biological Tissues Tamas Ugrai (tamas@brooksrand.com) Authors: T. Ugrai, T. Ellis, M. Nguyen, P. Petrov, J. Creswell, A. Carter, and M. Briscoe Brooks Rand

More information

Rapid Screening and Confirmation of Melamine Residues in Milk and Its Products by Liquid Chromatography Tandem Mass Spectrometry

Rapid Screening and Confirmation of Melamine Residues in Milk and Its Products by Liquid Chromatography Tandem Mass Spectrometry Rapid Screening and Confirmation of Melamine Residues in Milk and Its Products by Liquid Chromatography Tandem Mass Spectrometry Application Note Food Authors Jianqiu Mi, Zhengxiang Zhang, Zhixu Zhang,

More information

Final Report. Characterisation of Sample Report. Job No 2016/11/12-34 AS No. 1234A. Client Example Contact Sample. Signed Date 2017.

Final Report. Characterisation of Sample Report. Job No 2016/11/12-34 AS No. 1234A. Client Example Contact Sample. Signed Date 2017. Final Report Title Characterisation of Job No 2016/11/12-34 AS No. 1234A Client Contact Sample Author report Signed Date 2017 Easy Reach Report 2017 v2.docx 1 of 33 Contents 1. Study Summary Page 3 2.

More information

This method describes the identification of the following prohibited colorants in cosmetic products:

This method describes the identification of the following prohibited colorants in cosmetic products: A. IDENTIFICATION BY TLC 1. SCOPE AND FIELD OF APPLICATION This method describes the identification of the following prohibited colorants in cosmetic products: Names C I number Pigment Orange 5 12075 Metanil

More information

Technical Procedure for Concentration Determination of Methamphetamine in Liquids via HPLC

Technical Procedure for Concentration Determination of Methamphetamine in Liquids via HPLC Technical Procedure for Concentration Determination of 1.0 Purpose This procedure specifies the required elements for the preparation and use of the Agilent 1100/1200 series High Performance Liquid Chromatograph

More information

Title Revision No date DETERMINATION OF HEAVY METALS (ARSENIC, CADMIUM, LEAD AND MERCURY) IN COSMETIC PRODUCTS

Title Revision No date DETERMINATION OF HEAVY METALS (ARSENIC, CADMIUM, LEAD AND MERCURY) IN COSMETIC PRODUCTS 1. SCOPE AND FIELD OF APPLICATION The method describes the determination of heavy metals (arsenic, cadmium, lead and mercury) in cosmetic products. 2. PRINCIPLE Organic matter in sample is digested by

More information

Authors: C. Derrick Quarles, Jr. *, Patrick Sullivan, M. Paul Field, Hwan Kim, and Daniel R. Wiederin

Authors: C. Derrick Quarles, Jr. *, Patrick Sullivan, M. Paul Field, Hwan Kim, and Daniel R. Wiederin Elemental Scientific prepfast IC: Inline Autodilution Method to Eliminate Species Interconversion for LC-ICPMS Based Applications Authors: C. Derrick Quarles, Jr. *, Patrick Sullivan, M. Paul Field, Hwan

More information

Analytical method related to authorised feed additive - 1i534

Analytical method related to authorised feed additive - 1i534 Title DETERMINATION OF MESO-TARTARIC ACID, (D- + L-TARTARIC ACID), OXALIC ACID, MONO- AND DIHYDROXYMALONIC ACID IN mta-solutions Subtitle Liquid chromatography 1 SCOPE Determination of 50-60 mg of meso-tartaric

More information

Determination of Total Bromine and Iodine Emission Spectrometric Method (ICP-OES) EuSalt/AS

Determination of Total Bromine and Iodine Emission Spectrometric Method (ICP-OES) EuSalt/AS Determination of Total Bromine and Iodine Page 2 of 5 1. SCOPE AND FIELD OF APPLICATION The present EuSalt Analytical Standard describes an inductively coupled plasma optical emission spectrometry method

More information

CORESTA Recommended Method No. 86

CORESTA Recommended Method No. 86 Cooperation Centre for Scientific Research Relative to Tobacco Tobacco and Tobacco Products Analytes Sub-Group CORESTA Recommended Method No. 86 DETERMINATION OF SELECT CARBONYLS IN TOBACCO AND TOBACCO

More information

Draft Method proposal: determination of glucoheptonic acid (HGA) in fertilizers.

Draft Method proposal: determination of glucoheptonic acid (HGA) in fertilizers. Draft Method proposal: determination of glucoheptonic acid (HGA) in fertilizers. 1 Scope This document describes a chromatographic method which allows the identification as well as the determination of

More information

ICP-OES Application Note Number 35

ICP-OES Application Note Number 35 ICP-OES Application Note Number 35 Rapid measurement of major, minor and trace levels in soils using the Varian 730-ES Vincent Calderon Varian, Inc. Introduction As part of the global strategy for sustainable

More information

Impact factor: 3.958/ICV: 4.10 ISSN:

Impact factor: 3.958/ICV: 4.10 ISSN: Impact factor: 3.958/ICV: 4.10 ISSN: 0976-7908 99 Pharma Science Monitor 9(4), Oct-Dec 2018 PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES Journal home page: http://www.pharmasm.com

More information

Speciation of Bromine Compounds in Ozonated Drinking Water using Ion Chromatography and Inductively Coupled Plasma Mass Spectrometry

Speciation of Bromine Compounds in Ozonated Drinking Water using Ion Chromatography and Inductively Coupled Plasma Mass Spectrometry APPLICATION NOTE Speciation of Bromine Compounds in Ozonated Drinking Water using Ion Chromatography and Inductively Coupled Plasma Mass Spectrometry AN43227 Antonella Guzzonato 1, Shona McSheehy Ducos

More information

Direct Analysis of Trace Metal Impurities in High Purity Nitric Acid Using ICP-QQQ

Direct Analysis of Trace Metal Impurities in High Purity Nitric Acid Using ICP-QQQ Application Note Semiconductor Direct Analysis of Trace Metal Impurities in High Purity Nitric Acid Using ICP-QQQ Authors Kazuo Yamanaka and Kazuhiro Sakai Agilent Technologies, Tokyo, Japan Introduction

More information

GB Translated English of Chinese Standard: GB NATIONAL STANDARD OF THE

GB Translated English of Chinese Standard: GB NATIONAL STANDARD OF THE Translated English of Chinese Standard: GB5009.28-2016 www.chinesestandard.net Buy True-PDF Auto-delivery. Sales@ChineseStandard.net NATIONAL STANDARD OF THE GB PEOPLE S REPUBLIC OF CHINA GB 5009.28-2016

More information

Appendix II- Bioanalytical Method Development and Validation

Appendix II- Bioanalytical Method Development and Validation A2. Bioanalytical method development 1. Optimization of chromatographic conditions Method development and optimization of chromatographic parameters is of utmost important for validating a method in biological

More information

Multi-Element Analysis of Petroleum Crude Oils using an Agilent 7900 ICP-MS

Multi-Element Analysis of Petroleum Crude Oils using an Agilent 7900 ICP-MS Multi-Element Analysis of Petroleum Crude Oils using an Agilent 7900 ICP-MS Application note Energy and fuels Authors Jenny Nelson, Agilent Technologies, USA Ed McCurdy, Agilent Technologies, UK Introduction

More information

Method Development and Validation for the Estimation of Darunavir in Rat Plasma by RP-HPLC

Method Development and Validation for the Estimation of Darunavir in Rat Plasma by RP-HPLC World Journal of Pharmaceutical Sciences ISSN (Print): 2321-3310; ISSN (Online): 2321-3086 Published by Atom and Cell Publishers All Rights Reserved Available online at: http://www.wjpsonline.org/ Original

More information

GAFTI Analytical method for ISO/TS 16179:2012 Detection and Determination of Organotin Compounds in Footwear and Apparel Materials by GC-MS

GAFTI Analytical method for ISO/TS 16179:2012 Detection and Determination of Organotin Compounds in Footwear and Apparel Materials by GC-MS GAFTI Analytical method for ISO/TS 16179:2012 Detection and Determination of Organotin Compounds in Footwear and Apparel Materials by GC-MS 1. Scope This method is applicable for determining the presence

More information

Product Safety Reference Manual. Book 5 - Laboratory Policies and Procedures C

Product Safety Reference Manual. Book 5 - Laboratory Policies and Procedures C Book 5 - Laboratory Policies and Procedures C03-1 2009-06-15 1 Scope 1.1 This method describes a general procedure for the determination of leachable arsenic, selenium, cadmium, antimony, and barium in

More information

Macrolides in Honey Using Agilent Bond Elut Plexa SPE, Poroshell 120, and LC/MS/MS

Macrolides in Honey Using Agilent Bond Elut Plexa SPE, Poroshell 120, and LC/MS/MS Macrolides in Honey Using Agilent Bond Elut Plexa SPE, Poroshell 120, and LC/MS/MS Application Note Food Testing and Agriculture Author Chen-Hao (Andy) Zhai and Rong-jie Fu Agilent Technologies (Shanghai)

More information

Development and Validation of a HPLC Method for Chlorphenamine Maleate Related Substances in Multicomponents Syrups and Tablets

Development and Validation of a HPLC Method for Chlorphenamine Maleate Related Substances in Multicomponents Syrups and Tablets Development and Validation of a HPLC Method for Chlorphenamine Maleate Related Substances in s Syrups and Tablets Larisa Alagić-Džambić*, Midhat Vehabović, Edina Čekić, Mirsad Džambić Development Department,

More information

A RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF PARA- PHENYLENEDIAMINE IN PURE FORM AND IN MARKETED PRODUCTS

A RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF PARA- PHENYLENEDIAMINE IN PURE FORM AND IN MARKETED PRODUCTS A RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF PARA- PHENYLENEDIAMINE IN PURE FORM AND IN MARKETED PRODUCTS CH.MOUNIKA*, M.KINNERA Research Article SIR.C.R.REDDY COLLEGE OF PHARMACEUTICAL SCIENCES, ELURU.

More information

DEVELOPMENT AND VALIDATION OF A HPLC METHOD FOR IN-VIVO STUDY OF DICLOFENAC POTASSIUM

DEVELOPMENT AND VALIDATION OF A HPLC METHOD FOR IN-VIVO STUDY OF DICLOFENAC POTASSIUM IJPSR (2013), Vol. 4, Issue 2 (Research Article) Received on 28 September, 2012; received in revised form, 24 November, 2012; accepted, 23 January, 2013 DEVELOPMENT AND VALIDATION OF A HPLC METHOD FOR

More information

Annex 2 Formaldehyde

Annex 2 Formaldehyde Annex 2 Formaldehyde The 2 methods are analytical procedures for the determination of formaldehyde CH2O, PM/Ref. No 17260, and hexamethylenetetramine (HMTA) C6H12N4, PM/Ref. No 18670, in food simulants

More information

METHOD 7060A ARSENIC (ATOMIC ABSORPTION, FURNACE TECHNIQUE)

METHOD 7060A ARSENIC (ATOMIC ABSORPTION, FURNACE TECHNIQUE) METHOD 7060A ARSENIC (ATOMIC ABSORPTION, FURNACE TECHNIQUE) 1.0 SCOPE AND APPLICATION 1.1 Method 7060 is an atomic absorption procedure approved for determining the concentration of arsenic in wastes,

More information

INTERNATIONAL CHEMISTRY TESTING. 258 Main Street- Suite 311- Milford, MA Tel: Fax:

INTERNATIONAL CHEMISTRY TESTING. 258 Main Street- Suite 311- Milford, MA Tel: Fax: SOP TITLE: DETERMINATION OF TOTAL PROANTHOCYANIDINS BY REACTION WITH DIMETHYLAMINOCINNAMALDEHYDE (DMAC) SOP NUMBER: 803-02 EFFECTIVE DATE: 03/01/14 SUPERSEDES: 803-01 NEW ISSUE DATE: 3/24/20 INTRODUCTION

More information

RESOLUTION OENO 33/2004 DETERMINATION OF SHIKIMIC ACID IN WINE BY HPLC AND UV-DETECTION

RESOLUTION OENO 33/2004 DETERMINATION OF SHIKIMIC ACID IN WINE BY HPLC AND UV-DETECTION DETERMINATION OF SHIKIMIC ACID IN WINE BY HPLC AND UV-DETECTION The GENERAL ASSEMBLY, Considering Article paragraph iv of the agreement establishing the International organisation of vine and wine Upon

More information

NEVIRAPINE ORAL SUSPENSION Final text for addition to The International Pharmacopoeia (February 2009)

NEVIRAPINE ORAL SUSPENSION Final text for addition to The International Pharmacopoeia (February 2009) February 2009. NEVIRAPINE ORAL SUSPENSION Final text for addition to The International Pharmacopoeia (February 2009) This monograph was adopted at the Forty-third WHO Expert Committee on Specifications

More information

Application Note. Gas Chromatography/Mass Spectrometry/Food Safety. Abstract. Authors

Application Note. Gas Chromatography/Mass Spectrometry/Food Safety. Abstract. Authors Trace-Level Analysis of Melamine in Milk Products on Agilent 789A/5975C GC/MSD Using a ew Agilent J&W DB-5ms Ultra Inert Column and SampliQ SCX Cartridges Application ote Gas Chromatography/Mass Spectrometry/Food

More information

Supporting Information

Supporting Information 1 Supporting Information 2 3 Discovery and implications of C 2 and C 3 perfluoroalkyl sulfonates in aqueous film forming foams (AFFF) and groundwater 4 Krista A. Barzen-Hanson a and Jennifer A. Field b*

More information

H 3 CO H 3 CO S CH 3

H 3 CO H 3 CO S CH 3 FENITROTHION 35 H 3 CO P H 3 CO S O CH 3 NO 2 ISO common name Chemical name Fenitrothion O,O-Dimethyl O-4-nitro-m-tolyl phosphorothioate (IUPAC) O,O-Dimethyl O-(3-methyl-4-nitrophenyl)- phosphorothioate

More information

Analysis of trace elements in polymer samples to ensure compliance with WEEE-RoHS standards using the Thermo Scientific icap 7200 ICP-OES

Analysis of trace elements in polymer samples to ensure compliance with WEEE-RoHS standards using the Thermo Scientific icap 7200 ICP-OES APPLICATION NOTE 43145 Analysis of trace elements in polymer s to ensure compliance with WEEE-RoHS standards using the Thermo Scientific icap 7200 ICP-OES Authors Introduction Sanja Asendorf, Application

More information

Uncontrolled Copy. SOP 109 Ethylene Glycol Screen by Gas Chromatography/Mass Spectrometry. Table of Contents. 1. Principle of Assay...

Uncontrolled Copy. SOP 109 Ethylene Glycol Screen by Gas Chromatography/Mass Spectrometry. Table of Contents. 1. Principle of Assay... Table of Contents 1. Principle of Assay... 3 2. Specimens... 3 3. Reagents and Materials (HPLC grade)... 3 4. Standards, Controls, and Solutions... 4 5. Equipment and Special Supplies... 5 6. Instrumentation...

More information

Determination of Impurities in Silica Wafers with the NexION 300S/350S ICP-MS

Determination of Impurities in Silica Wafers with the NexION 300S/350S ICP-MS APPLICATION NOTE ICP - Mass Spectrometry Author Kenneth Ong PerkinElmer, Inc. Singapore Determination of Impurities in Silica Wafers with the NexION 300S/350S ICP-MS Introduction The control of impurity

More information

Test method for the determination of NDMA and NDEA by LC-MS/MS in Sartan containing film coated tablets

Test method for the determination of NDMA and NDEA by LC-MS/MS in Sartan containing film coated tablets Test method for the determination of NDMA and NDEA by LC-MS/MS in Sartan containing film coated tablets Contact: Oliver el-atma Chemisches und Veterinäruntersuchungsamt (CVUA) Karlsruhe, Germany (OMCL

More information

British American Tobacco Group Research & Development. Method - Determination of ammonia in mainstream smoke

British American Tobacco Group Research & Development. Method - Determination of ammonia in mainstream smoke British American Tobacco Group Research & Development Method - Determination of ammonia in mainstream smoke 1 SCOPE OF APPLICATION The method is applicable to quantitative determination of the yields of

More information

Analysis of domestic sludge using the Agilent 4200 MP-AES

Analysis of domestic sludge using the Agilent 4200 MP-AES Analysis of domestic sludge using the Agilent 4200 MP-AES Application note Environmental Authors Neli Drvodelic Agilent Technologies, Melbourne, Australia Introduction Managing the treatment and disposal

More information

TECHNETIUM-99 IN SOIL

TECHNETIUM-99 IN SOIL Analytical Procedure TECHNETIUM-99 IN SOIL 1. SCOPE 1.1. This procedure describes a method to separate and measure technetium-99 in soil. 1.2. This method does not address all aspects of safety, quality

More information

25-OH VITAMIN D 3 AND 25-OH VITAMIN D 2 IN PLASMA BY UV / VIS FAST CODE Z19710

25-OH VITAMIN D 3 AND 25-OH VITAMIN D 2 IN PLASMA BY UV / VIS FAST CODE Z19710 25-OH VITAMIN D 3 AND 25-OH VITAMIN D 2 IN PLASMA BY UV / VIS FAST CODE Z19710 BIOCHEMISTRY Quantification of 25-hydroxyvitamin D 3 (25-hydroxycholecalciferol) in serum is the best established indicator

More information

Total Elemental Analysis of Food Samples for Routine and Research Laboratories, using the Thermo Scientific icap RQ ICP-MS

Total Elemental Analysis of Food Samples for Routine and Research Laboratories, using the Thermo Scientific icap RQ ICP-MS Total Elemental Analysis of Food Samples for Routine and Research Laboratories, using the Thermo Scientific icap RQ ICP-MS Tomoko Vincent 1, Simon Lofthouse 2, Daniel Kutscher 1 and Shona McSheehy Ducos

More information

637. Thiamethoxam. HPLC method

637. Thiamethoxam. HPLC method 637. Thiamethoxam HPLC method CIPAC Collaborative Trial according to CIPAC Information Sheet N o 293 Dr. Sven Adolph Syngenta Crop Protection Münchwilen AG CH-4333 Münchwilen Switzerland May 212 page 1

More information

Determination of underivatized aflatoxins B2, B1, G2, and G1 in ground hazelnuts by immunoaffinity solid-phase extraction with HPLC-FLD detection

Determination of underivatized aflatoxins B2, B1, G2, and G1 in ground hazelnuts by immunoaffinity solid-phase extraction with HPLC-FLD detection APPLICATION NOTE 72686 Determination of underivatized aflatoxins,, G2, and in ground hazelnuts by immunoaffinity solid-phase extraction with HPLC-FLD detection Authors Sylvia Grosse, Mauro De Pra, Frank

More information

CHAPTER V ANALYTICAL METHODS ESTIMATION OF DICLOFENAC. Diclofenac (gift sample from M/s Micro Labs Ltd., Pondicherry)

CHAPTER V ANALYTICAL METHODS ESTIMATION OF DICLOFENAC. Diclofenac (gift sample from M/s Micro Labs Ltd., Pondicherry) CHAPTER V ANALYTICAL METHODS ESTIMATION OF DICLOFENAC A UV spectrophotometric method based on the measurement of absorbance at 276nm in phosphate buffer of p H 7.4 was used in the present study of the

More information

Diquat 1,1 -ethylene-2,2 -bipyridium dibromide salt Paraquat 1,1 -dimethyl-4,4 -bipyridium dichloride salt Initial Preparation

Diquat 1,1 -ethylene-2,2 -bipyridium dibromide salt Paraquat 1,1 -dimethyl-4,4 -bipyridium dichloride salt Initial Preparation EPA Method 549.2 Revision 1.0 Determination of Diquat and Paraquat in Drinking Water by Liquid-Solid Extraction and High Performance Liquid Chromatography with Ultraviolet Detection* UCT Products: ENVIRO-CLEAN

More information

Analytical Method Development and Validation of Lafutidine in Tablet dosage form by RP-HPLC

Analytical Method Development and Validation of Lafutidine in Tablet dosage form by RP-HPLC International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-4290 Vol. 3, No.3, pp 1403-1407, July-Sept 2011 Analytical Method Development and Validation of Lafutidine in Tablet dosage form

More information

Enhancing the productivity of food sample analysis with the Agilent 7700x ICP-MS

Enhancing the productivity of food sample analysis with the Agilent 7700x ICP-MS Enhancing the productivity of food sample analysis with the Agilent 77x ICP-MS Application note Foods testing Authors Sebastien Sannac, Jean Pierre Lener and Jerome Darrouzes Agilent Technologies Paris,

More information

Fast methods for the determination of ibuprofen in drug products

Fast methods for the determination of ibuprofen in drug products APPLICATION NOTE 779 Fast s for the determination of ibuprofen in drug products Authors Sylvia Grosse, Mauro De Pra, Frank Steiner, Thermo Fisher Scientific, Germering, Germany Keywords Pharmaceutical,

More information

Available online Journal of Chemical and Pharmaceutical Research, 2012, 4(6): Research Article

Available online  Journal of Chemical and Pharmaceutical Research, 2012, 4(6): Research Article Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2012, 4(6):3275-3279 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Development and validation of a matrix solid-phase

More information

--> Buy True-PDF --> Auto-delivered in 0~10 minutes. GB Translated English of Chinese Standard: GB5009.

--> Buy True-PDF --> Auto-delivered in 0~10 minutes. GB Translated English of Chinese Standard: GB5009. Translated English of Chinese Standard: www.chinesestandard.net Sales@ChineseStandard.net NATIONAL STANDARD OF THE GB PEOPLE S REPUBLIC OF CHINA GB 5009.15-2014 National Food Safety Standard Determination

More information

Thermo Scientific icap TQ ICP-MS: Typical limits of detection

Thermo Scientific icap TQ ICP-MS: Typical limits of detection TECHNICAL NOTE 43287 Thermo Scientific icap TQ ICP-MS: Typical limits of detection Authors Tomoko Vincent Keywords BEC, LOD, SQ-KED, TQ mass shift, TQ on mass, typical performance Introduction Inductively

More information

Dartmouth Trace Element Analysis Core: Lab methods

Dartmouth Trace Element Analysis Core: Lab methods Dartmouth Trace Element Analysis Core: Lab methods General All prices are based on analysis of up to 14 elements of interest to the investigator. More analytes can be included in the run after discussion

More information

Determination of Pb, Cd, Cr and Ni in Grains Based on Four Chinese National Methods via Zeeman GFAAS

Determination of Pb, Cd, Cr and Ni in Grains Based on Four Chinese National Methods via Zeeman GFAAS Determination of Pb, Cd, Cr and Ni in Grains Based on Four Chinese National Methods via Zeeman GFAAS Application Note Food Testing Author John Cauduro Agilent Technologies, Australia Introduction Trace

More information

VMA, HVA, 5-HIAA Urine LC-MS/MS Analysis Kit User Manual

VMA, HVA, 5-HIAA Urine LC-MS/MS Analysis Kit User Manual Page 1 / 11 VMA, HVA, 5-HIAA Urine LC-MS/MS Analysis Kit User Manual ZV-3030-0200-20 200 2-8 C Page 2 / 11 Table of Contents 1. INTENDED USE... 3 2. SUMMARY AND EXPLANATION... 3 3. TEST PRINCIPLE... 3

More information

DEVELOPMENT OF HPLC METHOD FOR ANALYSIS OF NITRITE AND NITRATE IN VEGETABLE

DEVELOPMENT OF HPLC METHOD FOR ANALYSIS OF NITRITE AND NITRATE IN VEGETABLE Journal of Agricultural, Food and Environmental Sciences UDC 635.546.173/.175]:543.544.5.068.7 Original scientific paper DEVELOPMENT OF HPLC METHOD FOR ANALYSIS OF NITRITE AND NITRATE IN VEGETABLE A. Najdenkoska*

More information

National standard of People s Republic of China

National standard of People s Republic of China National standard of People s Republic of China GB 5413.22 2010 National food safety standard Determination of phosphorus in foods for infants and young children, milk and milk products Issued on 2010-03-26

More information

PROCEDURES. Pharmacopeial Forum 2 Vol. 36(1) [Jan. Feb. 2009]

PROCEDURES. Pharmacopeial Forum 2 Vol. 36(1) [Jan. Feb. 2009] 2 Vol. 36(1) [Jan. Feb. 2009] BRIEFING h233i Elemental Impurities Procedures. This proposed new general test chapter is the second of two being developed to replace the general test chapter Heavy Metals

More information

A Comparison of Three Methods for Arsenic Speciation in Biological Tissues. May Nguyen Brooks Rand Labs Seattle, WA

A Comparison of Three Methods for Arsenic Speciation in Biological Tissues. May Nguyen Brooks Rand Labs Seattle, WA A Comparison of Three Methods for Arsenic Speciation in Biological Tissues May Nguyen Brooks Rand Labs Seattle, WA Select Arsenic Species Inorganic Species arsenite [As(III)] arsenate [As(V)] Organic Species

More information

Fumonisin. Fumonisin B 1 Fumonisin B 2. Fumonisin B 3. CAS No.:

Fumonisin. Fumonisin B 1 Fumonisin B 2. Fumonisin B 3. CAS No.: Fumonisin Fumonisin B 1 Fumonisin B 2 Fumonisin B 3 Fumonisin B 1 Fumonisin B 2 H H H H H H H H NH 2 H H NH 2 H C 34 H 59 N 15 MW: 721.8 CAS No.: 116355-83-0 H C 34 H 59 N 14 MW: 705.8 CAS No.: 116355-84-1

More information

CIPAC. CIPAC Free relevant impurities methods:

CIPAC. CIPAC Free relevant impurities methods: CIPAC COLLABORATIVE INTERNATIONAL PESTICIDES ANALYTICAL COUNCIL LIMITED Commission Internationale des Méthodes d'analyse des Pesticides (CIMAP) CIPAC Free relevant impurities methods: Methods for relevant

More information

Development and Validation of Stability Indicating RP-HPLC Method for the Determination of Anagrelide HCl in Pharmaceutical Formulation

Development and Validation of Stability Indicating RP-HPLC Method for the Determination of Anagrelide HCl in Pharmaceutical Formulation ISSN 0976 3333 Available Online at www.ijpba.info International Journal of Pharmaceutical & Biological Archives 2013; 4(2): 342-346 ORIGINAL RESEARCH ARTICLE Development and Validation of Stability Indicating

More information

Anethole. Gas chromatograhpy determination of trans-anethole in Spirit srinks of viti-vinicultural origin

Anethole. Gas chromatograhpy determination of trans-anethole in Spirit srinks of viti-vinicultural origin OIVMABS15 Anethole. Gas chromatograhpy determination of transanethole in Type II method SCOPE This method is suitable for the determination of transanethole in aniseedflavoured spirit drinks using capillary

More information

2017 Reaction of cinnamic acid chloride with ammonia to cinnamic acid amide

2017 Reaction of cinnamic acid chloride with ammonia to cinnamic acid amide 217 Reaction of cinnamic acid chloride with ammonia to cinnamic acid amide O O Cl NH 3 NH 2 C 9 H 7 ClO (166.6) (17.) C 9 H 9 NO (147.2) Classification Reaction types and substance classes reaction of

More information

National Research Council Institute for Ecosystem Study Verbania Pallanza - Italy

National Research Council Institute for Ecosystem Study Verbania Pallanza - Italy Tot-N UV220 pag. 1 National Research Council Institute for Ecosystem Study Verbania Pallanza - Italy Water Chemistry Laboratory Analytical Methods for internal use - http://www.idrolab.ise.cnr.it Gabriele

More information

25-OH VITAMIN D 3 IN PLASMA BY UV FAST CODE Z19610

25-OH VITAMIN D 3 IN PLASMA BY UV FAST CODE Z19610 25-OH VITAMIN D 3 IN PLASMA BY UV FAST CODE Z19610 BIOCHEMISTRY Quantification of 25-hydroxyvitamin D 3 (25-hydroxycholecalciferol) in serum is the best established indicator of vitamin D status. Vitamin

More information

Pelagia Research Library

Pelagia Research Library Available online at www.pelagiaresearchlibrary.com Der Pharmacia Sinica, 2011, 2 (2): 68-73 ISSN: 0976-8688 CODEN (USA): PSHIBD Method development and validation for determination of methane sulphonic

More information

Analysis of Arsenic, Selenium and Antimony in Seawater by Continuous-Flow Hydride ICP-MS with ISIS

Analysis of Arsenic, Selenium and Antimony in Seawater by Continuous-Flow Hydride ICP-MS with ISIS ICP-MS Environmental Analysis of Arsenic, Selenium and Antimony in Seawater by Continuous-Flow Hydride ICP-MS with ISIS Application Note Steve Wilbur Analysis of arsenic and selenium in seawater at trace

More information

CHAPTER - IV. Acharya Nagarjuna University, Guntur 105

CHAPTER - IV. Acharya Nagarjuna University, Guntur 105 CHAPTER - IV Acharya Nagarjuna University, Guntur 105 A STABILITY-INDICATING LC METHOD FOR LENALIDOMIDE Lenalidomide, 3-(4-amino-1-oxo-3H-isoindol-2-yl) piperidine-2, 6-dione (fig. 4.1), is a novel oral

More information

METHOD DEVELOPMENT AND VALIDATION OF RALTEGRAVIR POTASSIUM AND RILPIVIRINE HCL BY HPLC AND HPTLC METHODS

METHOD DEVELOPMENT AND VALIDATION OF RALTEGRAVIR POTASSIUM AND RILPIVIRINE HCL BY HPLC AND HPTLC METHODS CHAPTER 6 METHOD DEVELOPMENT AND VALIDATION OF RALTEGRAVIR POTASSIUM AND RILPIVIRINE HCL BY HPLC AND HPTLC METHODS School of Pharmaceutical Sciences, Vels University 106 METHOD DEVELOPMENT AND VALIDATION

More information

Pharmacopeial Forum Vol. 36(1) [Jan. Feb. 2010] 1

Pharmacopeial Forum Vol. 36(1) [Jan. Feb. 2010] 1 Vol. 36(1) [Jan. Feb. 2010] 1 Page 1 of 23 Time:10:03 Date:10/14/09 Instance: g:/pf/production/final PF36(1)/m5193.xml Template:s:/Pf/Template/PFRedesign/Pf353/PFR-pf-server-2009.3f BRIEFING h233i Elemental

More information

PYRIPROXYFEN TECHNICAL

PYRIPROXYFEN TECHNICAL WHO/IS/TC/715/2001 TECHNICAL TECHNICAL 1. Specification 1.1 Description Interim specification WHO/IS/TC/715/2001 The material shall consist of pyriproxyfen together with related manufacturing impurities.

More information

Determination of Phosphorus and Sulfur with Dynamic Reaction Cell ICP-MS

Determination of Phosphorus and Sulfur with Dynamic Reaction Cell ICP-MS FIELD APPLICATION REPORT ICP MASS SPECTROMETRY Determination of Phosphorus and Sulfur with Dynamic Reaction Cell ICP-MS Authors: Kenneth R. Neubauer, Ph.D. Perkin Elmer Life and Analytical Sciences 710

More information

A Simple, Novel Validated Stability Indicating RP-HPLC method for estimation of Duloxetine HCl in Capsule Pharmaceutical Formulation

A Simple, Novel Validated Stability Indicating RP-HPLC method for estimation of Duloxetine HCl in Capsule Pharmaceutical Formulation Pharmaceutical Research A Simple, Novel Validated Stability Indicating RP-HPLC method for estimation of Duloxetine HCl in Capsule Pharmaceutical Formulation Manisha Puranik* a, Sailesh Wadher b and Kritika

More information

Application Note. Author. Abstract. Food Safety. Syed Salman Lateef Agilent Technologies, Inc. Bangalore, India

Application Note. Author. Abstract. Food Safety. Syed Salman Lateef Agilent Technologies, Inc. Bangalore, India Analysis of fumonisin, FB1 and FB2 mycotoxins in corn food and feed samples using the Agilent 1120 Compact LC System coupled to the Agilent 6140 Single Quadrupole LC/MS System Application Note Food Safety

More information

Maximizing Triple Quadrupole Mass Spectrometry Productivity with the Agilent StreamSelect LC/MS System

Maximizing Triple Quadrupole Mass Spectrometry Productivity with the Agilent StreamSelect LC/MS System Maximizing Triple Quadrupole Mass Spectrometry Productivity with the Agilent StreamSelect LC/MS System Application Note Authors Kevin McCann, Sameer Nene, Doug McIntyre, Edmond Neo, Dennis Nagtalon, and

More information

Basic Digestion Principles

Basic Digestion Principles Basic Digestion Principles 1 From Samples to Solutions Direct Analytical Method Solid Sample Problems: Mech. Sample Preparation (Grinding, Sieving, Weighing, Pressing, Polishing,...) Solid Sample Autosampler

More information

Development and validation a RP-HPLC method: Application for the quantitative determination of quetiapine fumarate from marketed bulk tablets

Development and validation a RP-HPLC method: Application for the quantitative determination of quetiapine fumarate from marketed bulk tablets Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2016, 8(1):142-146 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Development and validation a RP-HPLC method: Application

More information

GB Translated English of Chinese Standard: GB NATIONAL STANDARD OF

GB Translated English of Chinese Standard: GB NATIONAL STANDARD OF Translated English of Chinese Standard: GB31604.11-2016 www.chinesestandard.net Buy True-PDF Auto-delivery. Sales@ChineseStandard.net NATIONAL STANDARD OF GB THE PEOPLE S REPUBLIC OF CHINA GB 31604.11-2016

More information

Structural effects on catalytic activity of carbon-supported magnetite. nanocomposites in heterogeneous Fenton-like reactions

Structural effects on catalytic activity of carbon-supported magnetite. nanocomposites in heterogeneous Fenton-like reactions Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2018 Supplementary Information Structural effects on catalytic activity of carbon-supported magnetite

More information

Journal of Pharmaceutical and Biomedical Analysis Letters. Analysis Letters

Journal of Pharmaceutical and Biomedical Analysis Letters. Analysis Letters Naga Jyothi. C et al, JPBMAL, 2015, 3(1): 242 246 ISSN: 2347-4742 Journal of Pharmaceutical and Biomedical Analysis Letters Journal Home Page: www.pharmaresearchlibrary.com/jpbmal Research Article Open

More information

International Journal of Pharmacy and Pharmaceutical Sciences Vol 2, Issue 1, 2010

International Journal of Pharmacy and Pharmaceutical Sciences Vol 2, Issue 1, 2010 International Journal of Pharmacy and Pharmaceutical Sciences Vol 2, Issue 1, 2010 RP HPLC ESTIMATION OF EZETIMIBE IN TABLET DOSAGE FORMS NAGARAJU. P *, KRISHNACHAITHANYA. K, CHANDRABABU. D, SRINIVAS.

More information

Using FIMS to Determine Mercury Content in Sewage Sludge, Sediment and Soil Samples

Using FIMS to Determine Mercury Content in Sewage Sludge, Sediment and Soil Samples A P P L I C A T I O N N ot e Atomic Absorption Using FIMS to Determine Mercury Content in Sewage Sludge, Sediment and Soil Samples Introduction The Flow Injection Mercury System (FIMS) is a dedicated system

More information

Technical Report. Determination of Nitrite and Nitrate in Smokeless Tobacco Products by Ion Chromatography and Continuous Flow Analysis

Technical Report. Determination of Nitrite and Nitrate in Smokeless Tobacco Products by Ion Chromatography and Continuous Flow Analysis Tobacco and Tobacco Products Analytes Sub-Group Technical Report Determination of Nitrite and Nitrate in Smokeless Tobacco Products by Ion Chromatography and Continuous Flow Analysis 2016 Collaborative

More information

METHOD 3010A ACID DIGESTION OF AQUEOUS SAMPLES AND EXTRACTS FOR TOTAL METALS FOR ANALYSIS BY FLAA OR ICP SPECTROSCOPY

METHOD 3010A ACID DIGESTION OF AQUEOUS SAMPLES AND EXTRACTS FOR TOTAL METALS FOR ANALYSIS BY FLAA OR ICP SPECTROSCOPY METHOD 3010A ACID DIGESTION OF AQUEOUS SAMPLES AND EXTRACTS FOR TOTAL METALS FOR ANALYSIS BY FLAA OR ICP SPECTROSCOPY 1.0 SCOPE AND APPLICATION 1.1 This digestion procedure is used for the preparation

More information

LEAD (Colorimetric) 2. Muffle Furnace: Equipped with pyrometer and capable of operating at controlled temperatures up to 500 C

LEAD (Colorimetric) 2. Muffle Furnace: Equipped with pyrometer and capable of operating at controlled temperatures up to 500 C LEADX.01-1 LEAD (Colorimetric) PRINCIPLE SCOPE Organic matter in the sample is destroyed by ignition in the presence of sulfuric acid. The residue is dissolved in dilute acid, and the lead is complexed

More information

METHOD 9210 POTENTIOMETRIC DETERMINATION OF NITRATE IN AQUEOUS SAMPLES WITH ION-SELECTIVE ELECTRODE

METHOD 9210 POTENTIOMETRIC DETERMINATION OF NITRATE IN AQUEOUS SAMPLES WITH ION-SELECTIVE ELECTRODE METHOD 9210 POTENTIOMETRIC DETERMINATION OF NITRATE IN AQUEOUS SAMPLES WITH ION-SELECTIVE ELECTRODE 1.0 SCOPE AND APPLICATION 1.1 This method can be used for measuring total solubilized nitrate in drinking

More information