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1 Geeral Lear Model Parts of materal: courtes of Tobas Sommer-Blöchl Isttute for Sstems Neuroscece Uverst Medcal Ceter Hamburg-Eppedorf (UKE)
2 Bascs GLM: (multple) regresso = a + b+ Error : depedet varable (Krterumsvarable) : depedet varable, regressor, model (Prädktorvarable) 0,77 5,63 50,44 75,0 00,5,7,6,5,4,3, descrbe the relatoshp betwee ad Multple regressors j = a + a + + a m m +b+e : weghted lear combato of regressors j
3 m m m m m m m m 0,,,,,, 0,,,,,, m m m m m m m m,,,,,, b a a a m m Deped. varable Weghted regressors Costat Error X Matr otato Scalar product (Kreuzprodukt)
4 Choosg a model What s the hpothess about the - relatoshp? Whch regressors are to be cluded the model?
5 Reacto tmes Choosg a model eample: lear relatoshp X,77 0,63 5,44 50,0 75,5 00 : Vsblt,77 0,63 5, ,0 75, : : Y-Achseabschtt Slope (Stegug)
6 Choosg a model eample: lear relatoshp b 0 b
7 Parameter estmato Get the best betas Mmal error Crtero of least sum of squares (LSS) (mmale Summe der Abwechugsquadrate)
8 Model optmzato Add further regressors Eample: average error rate per level of vsblt RT [ms],77 0 0,5,63 5 0,5, ,3,0 75 0,,5 00 0,,7,6,5,4,3,
9 Reacto tmes 0, 00 0, 75 0,3 50 0,5 5 0,5 0,54,04,443,69,765 0 Vsblt Error rate Model optmzato
10 Tme course fmri = BOLD sgal test tme course a gve voel Volume (Sca) Sgal test
11 fmri Rest Fger tappg Rest Hpotheses: ) Checkerboards vs. ITI vsual corte ) Red vs. gree checkerboard motor corte Programmg: Mareke Mez, ISN, UKE
12 fmri choosg a model Hpotheses: ) Checkerboards vs. ITI vsual corte ) Red vs. gree checkerboard motor corte Bo car : checkerboard () ITI (0) caocal hemodamc respose fucto (hrf) Covoluto wth hrf (Faltug)
13 Reacto tmes Choosg a model eample: lear relatoshp X,77 0,63 5,44 50,0 75,5 00 : Vsblt,77 0,63 5, ,0 75, : : Y-Achseabschtt Slope (Stegug)
14 fmri choosg a model Checkerboard regressor Costat Volumes (Scas) 0 b
15 fmri parameter estmate maps (beta mages) b vsual effect separate GLM EVERY voel ( mass uvarate approach ) Bra: Chrsta Paret, ow ZI Mahem
16 fmri Rest Fger tappg Rest Hpotheses: ) Checkerboards vs. ITI vsual corte ) Red vs. gree checkerboard motor corte
17 fmri choosg a model Volumes (Scas) Checkerboard Regressor (Rest) Checkerboard Regressor (Tappg) Costat 0 b b
18 Reacto tmes 0, 00 0, 75 0,3 50 0,5 5 0,5 0,54,04,443,69,765 0 Vsblt Error rate Model optmzato
19 fmri parameter estmate maps b - b motor effect
20 fmri parameter estmate maps b + b Vsual effect calculate effects through lear combatos of beta mages ( cotrasts ) co mages
21 fmri eample stud Implct ecodg of pctures (5 vsblt levels) Crossed wth cogtve task (-back, dffcult levels) Subsequet memor test: old/ew decso %
22 fmri eample stud E C C -back target A
23 0% vsblt 5% vsblt 50% vsblt 75% vsblt 00% vsblt 0% vsblt 5% vsblt 50% vsblt 75% vsblt 00% vsblt fmri eample stud -back -back Costat 0 beta maps b...b 0 Cotrasts: Vsblt Cogtve load Iteracto Iverse teracto varous co maps
24 Summar GLM: (multple) regresso = a + b+ Error depedet varable, depedet varable (regressor), error regresso weght (parameter estmate) b e X Model choce: tpe ad umber of regressors e Parameter estmato: LSS (mmal ) fmri: = BOLD tme seres a voel covoluto wth hemodamc respose fucto mass uvarate approach cotrasts: lear combato of beta maps
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