EPA CompTox Chemistry Dashboard an online resource for environmental chemists
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1 EPA CompTox Chemistry Dashboard an online resource for environmental chemists Antony Williams, Chris Grulke, Jennifer Smith, Kamel Mansouri, Andrew McEachran, Grace Patlewicz, Jeremy Fitzpatrick, Ann Richard, and Jeff Edwards National Center for Computational Toxicology U.S. Environmental Protection Agency, RTP, NC The views expressed in this presentation are those of the author and do not necessarily reflect the views or policies of the U.S. EPA April 2017 ACS Spring Meeting, San Francisco, CA
2 Who is NCCT? National Center for Computational Toxicology part of EPA s Office of Research and Development Research driven by EPA s Chemical Safety for Sustainability Research Program Develop new approaches to evaluate the potential chemical toxicity Integrate advances in biology, biotechnology, chemistry, exposure science and computer science Goal - To identify environmental chemical exposures that may disrupt biological processes and cause adverse outcomes. 1
3 Exposure Data Has Not Kept Pace with Regulatory Needs TSCA: > 84,000 P.P. Egeghy et al. Sci Total Environ. 414 (2012)
4 The CompTox Chemistry Dashboard: An Overview A publicly accessible website delivering access: ~750,000 chemicals and related property data Links to other agency websites and public data resources Literature searches for chemicals using public resources Integration to biological assay data for 1000s of chemicals Information regarding consumer products containing chemicals Batch searching for thousands of chemicals Day-to-day curation efforts for data quality 3
5 Comptox Chemistry Dashboard ~750,000 chemicals >15 years of data 4
6 Comptox Chemistry Dashboard ~ 750,000 chemicals >15 years of data 5
7 Comptox Chemistry Dashboard ~750,000 chemicals >15 years of data 6
8 Chemical Page 7
9 Physicochemical Properties 8
10 Names and Identifiers 9
11 Active vs Deleted CASRN 10
12 Collisions in CAS Numbers 11
13 How Bad Can It Get?? 12
14 How Bad Can It Get? This one is 316 Deleted CASRN 13
15 Links to Other Resources 14
16 Example External Links 15
17 Example External Links 16
18 Product Composition Details 17
19 In vitro Bioassay Data In vitro bioassays are used to determine the biological activity of a substance ToxCast and Tox21 projects A decade of measurements, and millions of dollars of data integrated into the dashboard 18
20 Integrated Literature Searching 19
21 Integrated Literature Searching 20
22 Integrated Literature Searching 21
23 Integrated Literature Searching 22
24 Integrated Literature Searching 23
25 Integrated Literature Searching 24
26 Integrated Literature Searching 25
27 Crowdsourced Data Curation Maintaining high-quality data is a challenge Every user can contribute to improving the data! 26
28 Not just structures 27
29 Batch Searching for Data for Thousands of Chemicals What are these chemicals? 28
30 Batch Searching for Data for Thousands of Chemicals 29
31 Access to associated data for review, modeling & download 30
32 Access to associated data for review, modeling & download 31
33 Real World Applications From chemical names to chemical data 32
34 Data Available for Download 33
35 ~720,000 structures on ios 34
36 Future Work Continue expansion and curation of data and types. Provide programmatic access to all data connect to other Agency resources and allow other scientists to integrate their scientific applications. Continue to assemble and enhance chemical lists and data for specific projects. Make available to Agency researchers and for public use. Integration of Global Health and Safety Data 35
37 Conclusion The CompTox Chemistry Dashboard provides access to data for ~750,000 chemicals An Integration Hub to data toxicity, environmental, property, bioassay, and expanding Data downloads allows for reuse in other systems and integration of resources to support research 36
38 Contact Antony Williams US EPA Office of Research and Development National Center for Computational Toxicology (NCCT) ORCID: 37
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