DRD Trends in Portugal: Updates From Forensic Toxicology Services
|
|
- Lenard Owen
- 5 years ago
- Views:
Transcription
1 Mário Dias EMCDDA Key Indicator Annual Expert Meeting Lisbon, September 1
2 The National Institute of Legal Medicine and Forensic Sciences (NILMFC) is a public institute, endowed with corporate entity and administrative and financial autonomy, subject to the supervision and guardianship of the Minister of Justice. It is an institution responsible for the co-ordination, guidance and supervision of all the country activities related with forensic expertises and other forensic activities.
3 analysis / year GC-MS (8) GC-MS/MS (1) UPLC- MS/MS (3) LC-MS/MS (1) - Post mortem Toxicology - Clinical Toxicology (Emergence; Therapeutic Drug Monitoring) - Human Performance Toxicology (Workplace Drug Testing; Driving)
4
5 Information Flow of Special Mortality Registries EMCDDA, September 2017
6 Unnatural / violent deaths Police investigation / hospital information Magistrate of Public Ministry (According police investigation and hospital information) Waive of medico legal autopsy Medico legal autopsy (NILMFC*) Electronic Death Certificate (SICO) Ministry of Health General Mortality Registers Toxicology request (NILMCF*) Cause of death (NILMCF*) Special Mortality Regist (NILMCF*) Electronic Death Certificate (SICO) Ministry of Health General Mortality Registers Autopsy report Magistrate of Public Ministry Ministry of Justice National Focal Point (SICAD) Ministry of Health *NILMCF National Institute of Legal Medicine and Forensic Sciences (Ministry of Justice)
7 RESULTS
8 8% Positive cases for DOA - Distribution by Illicit Substance ( n = 7575 ) 17,89% 23,10% 0,80% 0,80% 0,93% 2,54% Morfina 0,80% Codeína 0,40% 2,27% 1,87% 1,74% 6-MAM 8,81% Metadona EDDP 7,74% Benzoilecgona EME Cocaína Cocaetileno 4,81% 0,53% THCCOOH 11-OH-THC THC Anfetamina Efedrina MDA 24,97% MDMA
9 10 % 8 %
10 What reality are we seeing through these numbers
11 Magistrate of Public Ministry: Waive of medico legal autopsy Pathologist: Request or not drug testing Toxicologist: Target substances and cut-off values (Screening); Criteria for identification and limits of detection (Confirmation) Pathologist: Interpretation of results and reference values
12 TOXICOLOGY ANALYSIS
13 SAMPLING AND STORAGE Peripheral Blood (femoral) Central Blood (cardiac) Urine Gastric Content Vitreous Humor 10 ml ml 30 ml 50 g 1 ml Post Mortem Interval (PMI) < 48 h Samples collected to Polypropylene (PP) tubes Blood samples preserved with Sodium Fluoride Storage at 10 ºC
14 TARGET SUBSTANCES Prevalence of substances Equipment available (Screening and Confirmation) Budget SCREENING (IMMUNOASSAY) Cut-Off Selectivity Specificity Validated Methods (cut-off) Opiates 50 ng/ml Cocaine 50 ng/ml Cannabis 50 ng/ml Amphetamine 50 ng/ml Methamphetamine 50 ng/ml Benzodiazepines 10 ng/ml
15 IDENTITY CONFIRMATION OF THE ANALYTES (GC; LC; UPLC) Quadrupole (MS) Triple Quadrupole (MS/MS) Validated Methods (International Standards) CHROMATOGRAPHIC CRITERIA The Relative Retention Time (RRT) of the peak of interest is measured relative to a chromatographic reference compound (CRC): When the CRC is not a stable isotope-labeled analyte, the RRT of the analyte in the Sample shall not differ by more than ± 1% from that of the same analyte in a Positive Spyked Sample or Reference Material analyzed in the same analytical batch. When the CRC is the stable isotope-labeled analyte, the RRT of the analyte in the Sample shall not differ by more than ± 0.5% from that of the same analyte in a Positive Spiked Sample or Reference Material analyzed in the same analytical batch.
16 IDENTITY CONFIRMATION OF THE ANALYTES (GC; LC; UPLC) Quadrupole (MS) Triple Quadrupole (MS/MS) Validated Methods (International Standards) MASS SPECTROMETRIC IDENTIFICATION CRITERIA MS criteria for identification are based on the presence and relative abundance of a number of ions defined as diagnostic for the analyte during validation of the method. The following identification criteria are applied: When using single-stage MS, at least three (3) diagnostic ions shall be acquired When using multiple-stage MS (e.g. MS/MS), at least two (2) precursor-product ion transitions (i.e. two SRM transitions) shall be monitored. The signal-to-noise (S/N) ratio of all diagnostic ions shall be greater than three to one (3:1)
17 IDENTITY CONFIRMATION OF THE ANALYTES (GC; LC; UPLC) Quadrupole (MS) Triple Quadrupole (MS/MS) Validated Methods (International Standards) MASS SPECTROMETRIC IDENTIFICATION CRITERIA The Relative Abundance of any of the diagnostic ions shall not differ by more than the amount specified in the following Table from the corresponding Relative Abundances of the same ions acquired from a Spiked Positive Control Sample or Reference Material. Relative Abundance in the reference sample (% of base peak) Maximum tolerance windows for the relative abundance in the sample (absolute) Relative abundance (% of peak base) Example Tolerance window (% of peak base) % (relative) (absolute) > 0-8
18 QUALITY CONTROL INTERNAL QUALITY CONTROL (IQC) The preparation of the control samples and the interpretation of results are handled within the laboratory Includes personal, instrumentation, document control, reagent control and corrective actions It s used on daily basis in decision to accept or reject results, and enables the laboratory monitor the quality of its work EXTERNAL QUALITY CONTROL (EQC) The estimation of a test method s accuracy is obtain from the results of analysis of unknown samples sent to different laboratories Permits a comparison of quality between laboratories and it is used to confirm results of IQC
19 In vivo INTERPRETATION OF RESULTS Post-mortem
20 INTERPRETATION OF THE RESULTS (REFERENCE VALUES)
21 INTERPRETATION OF THE RESULTS (REFERENCE VALUES) Sampling (sample type and storage) Specimen collection (post-mortem interval) Stability of the substances Post-mortem redistribution Acute or chronic poisoning Tolerance Metabolism (parent compound and active metabolites) Association of substances (Drug + Drug; Drug + Alcohol) Analytical methods (specificity, sensitivity, LOD and LOQ) Inter-individual variability (pharmacogenetics) Association of substances Age and sex Other pathologies
22 CONCLUSIONS More uniform analytical approaches will allow the collection of more robust data concerning DRD and provides important contribution to both public safety and public health. To allow the comparability of the results it will be important to elaborate recommendations for operation standards for laboratories involved in DRD toxicological analysis that should include: Sampling and Storage Sample preparation Method validation Core substances Screening methods Confirmation methods Minimum required performance levels for detection and identification
WADA Technical Document TD2015IDCR
MINIMUM CRITERIA FOR CHROMATOGRAPHIC-MASS SPECTROMETRIC CONFIRMATION OF THE IDENTITY OF ANALYTES FOR DOPING CONTROL PURPOSES. The ability of a method to identify an analyte is a function of the entire
More informationWADA Technical Document TD2003IDCR
IDENTIFICATION CRITERIA FOR QUALITATIVE ASSAYS INCORPORATING CHROMATOGRAPHY AND MASS SPECTROMETRY The appropriate analytical characteristics must be documented for a particular assay. The Laboratory must
More informationProposal: criteria for positive identification in LC-MS analysis
Proposal: criteria for positive identification in LC-MS analysis Lubertus Bijlsma, Maria Bronze, Emma Gracia Lor, Susana Simoes Any analytical methodology should comply with several quality requirements,
More informationTechnical Procedure for Blood Cannabinoid Liquid-Liquid Extraction (BCLLE) for Analysis by LC-MS/MS
Technical Procedure for Blood Cannabinoid Liquid-Liquid Extraction (BCLLE) for Analysis by LC-MS/MS 1.0 Purpose - This procedure specifies the required elements for the extraction and quantitation of THC,
More informationHANDBOOK OF DRUG ANALYSIS
HANDBOOK OF DRUG ANALYSIS APPLICATIONS IN FORENSIC AND CLINICAL LABORATORIES Ray H. Liu Daniel E. Gadzala American Chemical Society Washington, DC Contents Dedication Foreword Preface About the Authors
More informationPsychoactive Drugs Urine LC-MS/MS Analysis Kit User Manual
Page 1 / 18 Psychoactive Drugs Urine LC-MS/MS Analysis Kit User Manual ZV-2001-0200-20 200 2-8 C Page 2 / 18 Table of Contents 1. INTENDED USE... 3 2. SUMMARY AND EXPLANATION... 3 3. TEST PRINCIPLE...
More informationBenzoylecgonine in Urine by SAMHSA GC/MS
application Note Gas Chromatography/ Mass Spectrometry Author Timothy D. Ruppel PerkinElmer, Inc. Shelton, CT 06484 USA Benzoylecgonine in Urine by SAMHSA GC/MS Introduction The United States Department
More informationAnalysis of Cannabinoids and Amphetamines in Serum by RRLC/Triple Quadrupole Mass Spectrometry Using a Multimode Ion Source. Application.
Analysis of Cannabinoids and Amphetamines in Serum by RRLC/Triple Quadrupole Mass Spectrometry Using a Multimode Ion Source Application Toxicology Authors Jürgen Wendt Agilent Technologies Sales and Support
More informationAnalysis of Serum 17-Hydroxyprogesterone, Androstenedione, and Cortisol by UPLC-MS/MS for Clinical Research
Analysis of Serum 17-Hydroxyprogesterone, Androstenedione, and Cortisol by UPLC-MS/MS for Clinical Research Heather A Brown, 1 Claudia Rossi, 2 and Lisa J Calton 1 1 Waters Corporation, Wilmslow, UK 2
More informationImproved Extraction of THC and its Metabolites from Oral Fluid Using Oasis PRiME HLB Solid Phase Extraction (SPE) and a UPLC CORTECS C 18
Using Oasis PRiME HLB Solid Phase Extraction (SPE) and a UPLC CORTECS C 18 Column Xin Zhang, Jonathan P. Danaceau, and Erin E. Chambers Waters Corporation, Milford, MA, USA APPLICATION BENEFITS Semi-validated
More informationUncontrolled Copy. Table of Contents. 1. Introduction and Principle of Assay Specimens Reagents and Materials...
Table of Contents 1. Introduction and Principle of Assay... 3 2. Specimens... 3 3. Reagents and Materials... 3 4. Standards, Controls, and Solutions... 4 5. Equipment and Special Supplies... 5 6. Instrumentation
More informationPrepared By: R. W. Waggoner, Jr. Effective Date: August 18, 2008
Name of Procedure: Use of the Dade Behring Viva Jr. EMIT Analyzer as a Drug Screen Suggested Uses: This procedure does not cover every aspect of the instrument used. The operator of the instrument should
More informationCharacteristic of Calibration Curve Resulting from the Use of 2 H-analogs of the Analyte as Internal Standards--Methamphetamine Example
FORENSIC SCIENCE JOURNAL SINCE 00 Forensic Science Journal 004;3:59-70 Characteristic of Calibration Curve Resulting from the Use of H-analogs of the Analyte as Internal Standards--Methamphetamine Example
More information[application note] INTRODUCTION EXPERIMENTAL. Specimens. Extraction
Testing for GHB in hair by GC tandem quadrupole MS Marie Bresson, Vincent Cirimele, Pascal Kintz, Marion Villain; Laboratoire Chemtox, Illkirch, France Timothy Jenkins, Waters Corporation, Manchester,
More informationAnalysis of basic compounds in urine by on-line extraction-hplc-dad
T + K (7) 74 (1): 64 Analysis of basic compounds in urine by on-line extraction-hplc-dad Lena Schönberg a,b, Thomas Grobosch a, Dagmar Lampe a and Charlotte Kloft b,c a Berliner Betrieb fuer Zentrale Gesundheitliche
More informationAgenda. Principle of Operation Key Features Key Applications in Toxicology Examples of Toxicology Applications Technical Documentation
Agenda Principle of Operation Key Features Key Applications in Toxicology Examples of Toxicology Applications Technical Documentation LDTD: Laser Diode Thermal Desorption High-Throughput Ion source Plug-and-play
More informationAbstract. Experimental Sample Preparation
Determination of Benzoylecgonine in Human Urine Using Automated, In-Line, ITSP Solid Phase Extraction and Liquid Chromatography Mass Spectrometric Detection Thurman L. Allsup 1, Kenneth C. Lewis 1 and
More informationDetermination of Cannabinoids (THC) in Biological Samples
Determination of Cannabinoids (THC) in Biological Samples Application Note Forensic Toxicology Authors Joe Crifasi Saint Louis University Forensic Toxicology Laboratory Saint Louis, MO, USA Ron Honnold
More informationLaboratory Guidelines
TIAFT The International Association of Forensic Toxicologists Committee of Systematic Toxicological Analysis Thomas Stimpfl, PhD, Chairman Klaus Muller, PhD, Former Chairman Merja Gergov, PhD Marc LeBeau,
More informationOpiates in Urine by SAMHSA GC/MS
application Note Gas Chromatography/ Mass Spectrometry Author Timothy D. Ruppel PerkinElmer, Inc. Shelton, CT 06484 USA Opiates in Urine by SAMHSA GC/MS Introduction The United States Department of Health
More informationTargetScreener. Innovation with Integrity. A Comprehensive Screening Solution for Forensic Toxicology UHR-TOF MS
TargetScreener A Comprehensive Screening Solution for Forensic Toxicology Innovation with Integrity UHR-TOF MS TargetScreener Get the Complete Picture Forensic laboratories are frequently required to perform
More informationStability study of the designer drugs ``MDA, MDMA and MDEA'' in water, serum, whole blood, and urine under various storage temperatures
Forensic Science International 124 2001) 36±42 Stability study of the designer drugs ``MDA, MDMA and MDEA'' in water, serum, whole blood, and urine under various storage temperatures Karine M. Clauwaert,
More informationFORENSIC TOXICOLOGY SCREENING APPLICATION SOLUTION
FORENSIC TOXICOLOGY SCREENING APPLICATION SOLUTION A purpose-built collection of the best-inclass components for forensic toxicology Whether you re challenged to present reliable and secure forensic sample
More informationA Rapid Approach to the Confirmation of Drug Metabolites in Preclinical and Clinical Bioanalysis Studies
A Rapid Approach to the Confirmation of Drug Metabolites in Preclinical and Clinical Bioanalysis Studies APPLICATION BENEFITS Regulatory guidelines and recommendations place a greater emphasis on the detection
More informationComplementary Role of GC/MS in Clinical Laboratory and Beyond
Complementary Role of GC/MS in Clinical Laboratory and Beyond Uttam Garg, PhD, DABCC, FABFT, FACB Professor, University of Missouri School of Medicine Division Chief, Laboratory Medicine Director, Clinical
More informationUncontrolled Copy. Table of Contents. 1. Principle of Assay Specimens Reagents and Materials... 3
Table of Contents 1. Principle of Assay... 3 2. Specimens... 3 3. Reagents and Materials... 3 4. Standards, Controls, and Solutions... 4 5. Equipment and Special Supplies... 5 6. Instrumentation and Parameters...
More informationMulti-residue analysis of pesticides by GC-HRMS
An Executive Summary Multi-residue analysis of pesticides by GC-HRMS Dr. Hans Mol is senior scientist at RIKILT- Wageningen UR Introduction Regulatory authorities throughout the world set and enforce strict
More informationWilmington Police Department Crime Laboratory Quality Management System Procedure Reagent Check
1.0 Purpose This procedure describes ow reagents used in the laboratory are checked for reliability. 2.0 Discussion Reagents prepared in the laboratory are used to aid in the qualitative and quantitative
More informationHigh-sensitivity, high-throughput quantitation of catecholamine metabolites in urine by LC/MS/MS for clinical research
PO-CON1655E High-sensitivity, high-throughput quantitation of catecholamine metabolites in urine by LC/MS/MS for clinical research ASMS 2016 MP-079 Atsuhiko TOYAMA 1, Kumie SATOU 2, Yuki NAKAMURA 2, Ichiro
More informationNew Policies on Chemical Environmental Management in China. Gao Yingxin Chemical Registration Center of MEP September 9, 2010
New Policies on Chemical Environmental Management in China Gao Yingxin Chemical Registration Center of MEP September 9, 2010 Measures on Environmental Management of New Chemical Substances Strengthened
More informationThe role of LC-MS in Toxicology
The role of LC-MS in Toxicology Kjell Mortier, Tom Benijts, Riet Dams, Willy Lambert Laboratory of Toxicology, Ghent University, Belgium http://allserv.rug.ac.be/~wlambert Overview Introduction: comparison
More informationAmphetamines, Phentermine, and Designer Stimulant Quantitation Using an Agilent 6430 LC/MS/MS
Amphetamines, Phentermine, and Designer Stimulant Quantitation Using an Agilent 643 LC/MS/MS Application Note Forensic Toxicology Authors Jason Hudson, Ph.D., James Hutchings, Ph.D., and Rebecca Wagner,
More informationToxicology Extraction Procedure for Base Drugs Using United Chemical Technologies Clean Screen Extraction Columns
Name of Procedure: Toxicology Extraction Procedure for Base Drugs Using United Chemical Technologies Clean Screen Extraction Columns Suggested Uses: This is an extraction procedure for base drugs. The
More informationDRI Ecstasy Assay Application BECKMAN COULTER UniCel DxC and Synchron System(s)
DRI Ecstasy Assay Application BECKMAN COULTER UniCel DxC and Synchron System(s) Beckman Coulter Reorder Number A39935 Homogeneous enzyme immunoassay for the qualitative or semi-quantitative determination
More informationDrug Analysis Service. Training Manual
Drug Analysis Service Training Manual Health Canada is the federal department responsible for helping the people of Canada maintain and improve their health. We assess the safety of drugs and many consumer
More informationGC/MS is not dead yet!!
Complementary Role of GC/MS in Clinical Laboratory and Beyond Uttam Garg, PhD, DABCC, FABFT, FACB Professor, University of Missouri School of Medicine Division Chief, Laboratory Medicine Director, Clinical
More informationDefinitive EtG/EtS LC-MS/MS Analysis:
Definitive / LC- Analysis: A Rugged 4-Min Method for High-Throughput Labs By Justin Steimling and Frances Carroll Abstract Methods for monitoring alcohol consumption biomarkers and are generally limited
More informationORGANIZATION OF AMERICAN STATES
ORGANIZATION OF AMERICAN STATES INTER-AMERICAN DRUG ABUSE CONTROL COMMISSION GROUP OF EXPERTS CONCERNING CHEMICAL COMPREHENSIVE TRAINING ON ISSUES RELATING TO CHEMICAL Colombia Lima, Peru COMPREHENSIVE
More informationContact Information. Speaker Financial Disclosure Information. Fitting Linear Quadrupoles and Round Flight Tubes into the Square Clinical Laboratory
Fitting Linear Quadrupoles and Round Flight Tubes into the Square Clinical Laboratory The What, Where and Why of Clinical Mass Spectrometry Frederick G. Strathmann 2014 Institute for Learning Quarterly
More informationPerfluorinated Alkyl Acids (PFAA) in Water by LC/MS/MS - PBM
Organics Revision Date: July 19, 2017 Perfluorinated Alkyl Acids (PFAA) in Water by LC/MS/MS - PBM Parameter Perfluorinated Alkyl Acids (Perfluorobutane Sulphonate (PFBS), Perflourooctane Sulphonate (PFOS),
More informationASB Standard 036, First Edition Standard Practices for Method Validation in Forensic Toxicology
ASB Standard 036, First Edition 2018 Standard Practices for Method Validation in Forensic Toxicology Standard Practices for Method Validation in Forensic Toxicology ASB Approved XXXX 2018 ANSI Approved
More informationUncontrolled Copy. Table of Contents. 1. Principle of Assay Specimens Reagents and Materials... 4
Table of Contents 1. Principle of Assay... 3 2. Specimens... 3 3. Reagents and Materials... 4 4. Standards, Controls, and Solutions... 4 5. Equipment and Special Supplies... 4 6. Instrumentation and Parameters...
More informationTechnical Procedure for Solid Phase Extraction of THC and THC-COOH for GC-MS Analysis
Technical Procedure for Solid Phase Extraction of THC and THC-COOH 1.0 Purpose - This procedure specifies the required elements for the extraction of THC and THC-COOH using United Technologies Styre Screen
More informationYun W. Alelyunas, Mark D. Wrona, Russell J. Mortishire-Smith, Nick Tomczyk, and Paul D. Rainville Waters Corporation, Milford, MA, USA INTRODUCTION
Quantitation by High Resolution Mass Spectrometry: Using Target Enhancement and Tof-MRM to Achieve Femtogram-level On-column Sensitivity for Quantitation of Drugs in Human Plasma Yun W. Alelyunas, Mark
More informationAgilent TOF Screening & Impurity Profiling Julie Cichelli, PhD LC/MS Small Molecule Workshop Dec 6, 2012
1 Agilent TOF Screening & Impurity Profiling Julie Cichelli, PhD LC/MS Small Molecule Workshop Dec 6, 2012 Review: Technology for Accurate Mass Analysis: TOF LC/MS Mass measurements accurate to several
More informationRapid and Accurate Forensics Analysis using High Resolution All Ions MS/MS
Rapid and Accurate Forensics Analysis using High Resolution All Ions MS/MS Application Note Forensic Toxicology Authors Martin Josefsson, and Markus Roman National Board of Forensic Medicine Linköping,
More informationTechnical Procedure for ELISA Drug Screen Version 3 Toxicology Unit Effective Date: 02/15/2013. ELISA Drug Screen
ELISA Drug Screen 1.0 Purpose - This procedure specifies the required elements for the calibration and use of the Tecan Freedom EVO 75 Workstation for an ELISA Drug Screen. 2.0 Scope This procedure applies
More informationOverview. Introduction. André Schreiber AB SCIEX Concord, Ontario (Canada)
Quantitation and Identification of Pharmaceuticals and Personal Care Products (PPCP) in Environmental Samples using Advanced TripleTOF MS/MS Technology André Schreiber AB SCIEX Concord, Ontario (Canada)
More information1.11 Measurement Uncertainty
Document #: 4968 Page 1 of 10 1.11 Measurement Uncertainty In an effort to comply with accreditation requirements, and because scientific measurements in general are subject to variability, a budget estimating
More informationAnalyte Targeting for NPS Identification in Seized Drugs and Toxicology
Analyte Targeting for NPS Identification in Seized Drugs and Toxicology Alex J. Krotulski, MS Research Scientist Center for Forensic Science Research & Education Background Explosion and expansion of NPS
More informationJournal of Analytical Toxicology Advance Access published April 24, 2012
Journal of Analytical Toxicology Advance Access published April 24, 2012 Journal of Analytical Toxicology 2012;00:1 5 doi:10.1093/jat/bks039 Article Analysis of Tetrahydrocannabinol and its Metabolite,
More informationGeneral. Power requirements: 110/220 Volts 50/60 VAC. Dimensions: Width 80 cm x Height 45 cm x Depth 58 cm. Weight: 57 Kg.
General Power requirements: 110/220 Volts 50/60 VAC Dimensions: Width 80 cm x Height 45 cm x Depth 58 cm Weight: 57 Kg. Features Reagents cooling Cuvettes washer Continuous input of samples Auto re-run
More informationUncontrolled Copy. SOP 109 Ethylene Glycol Screen by Gas Chromatography/Mass Spectrometry. Table of Contents. 1. Principle of Assay...
Table of Contents 1. Principle of Assay... 3 2. Specimens... 3 3. Reagents and Materials (HPLC grade)... 3 4. Standards, Controls, and Solutions... 4 5. Equipment and Special Supplies... 5 6. Instrumentation...
More informationQuantitative analysis of small molecules in biological samples. Jeevan Prasain, Ph.D. Department of Pharmacology & Toxicology, UAB.
Quantitative analysis of small molecules in biological samples 100 Jeevan Prasain, Ph.D. Department of Pharmacology & Toxicology, UAB % 0 300 500 700 900 1100 1300 1500 1700 m/z Class Overview Introduction
More informationTOX. Scheme Description. Toxicology Proficiency Testing Scheme
TOX Toxicology Proficiency Testing Scheme Scheme Description LGC Standards Proficiency Testing 1 Chamberhall Business Park Chamberhall Green Bury Lancashire BL9 0AP United Kingdom Telephone: +44 (0) 161
More informationThe Emergence of Benchtop Tandem Quadrupole Mass Spectrometers as a Routine Tool in Quantitative GC/MS/MS Applications
The Emergence of Benchtop Tandem Quadrupole Mass Spectrometers as a Routine Tool in Quantitative GC/MS/MS Applications Doug Stevens Waters Corp. Introduction The range of GC/MS instrument types has expanded
More informationVMA, HVA, 5-HIAA Urine LC-MS/MS Analysis Kit User Manual
Page 1 / 11 VMA, HVA, 5-HIAA Urine LC-MS/MS Analysis Kit User Manual ZV-3030-0200-20 200 2-8 C Page 2 / 11 Table of Contents 1. INTENDED USE... 3 2. SUMMARY AND EXPLANATION... 3 3. TEST PRINCIPLE... 3
More informationFUTURE CONFIRMATORY CRITERIA
FUTURE CONFIRMATORY CRITERIA Revision CD 2002/657 Marco Blokland, Bjorn Berendsen, Hans Mol, Leen van Ginkel, Saskia Sterk REVISION 2 Revision 2002/657 EU Commission has explicitly asked for a revision
More informationSWGDRUG GLOSSARY. Independent science-based organization that has the authority to grant
SWGDRUG GLOSSARY These definitions were developed and adopted by the SWGDRUG Core Committee from a variety of sources including The United Nations Glossary of Terms for Quality Assurance and Good Laboratory
More informationAnalysis of Synthetic Cannabinoids and Metabolites: Adding New Compounds to an Existing LC-MS/MS Method
Analysis of Synthetic Cannabinoids and Metabolites: Adding New Compounds to an Existing LC-MS/MS Method By Sharon Lupo and Frances Carroll Abstract The analysis of synthetic cannabinoids and their metabolites
More informationCompounding insights Thermo Scientific Compound Discoverer Software
Compounding insights Thermo Scientific Compound Discoverer Software Integrated, complete, toolset solves small-molecule analysis challenges Thermo Scientific Orbitrap mass spectrometers produce information-rich
More informationA Practical Approach to Determination of Laboratory GC-MS Limits of Detection*
A Practical Approach to Determination of Laboratory GC-MS Limits of Detection* Paula J. Underwood t, Gerald E. Kananen, and Edwin K. Armitage Forensic Toxicology Drug Testing Laboratory, 2490 Wilson Street,
More informationForensic and toxicological drug screening using liquid chromatography-tandem mass spectrometry with MS/MS library based identification
POCON696E Forensic and toxicological drug screening using liquid chromatographytandem mass spectrometry with MS/MS library based identification MSACL 6 EU Alan Barnes, Tiphaine Robin, Neil Loftus, Pierre
More informationFundamentals Of Analytical Toxicology PDF
Fundamentals Of Analytical Toxicology PDF The analytical toxicologist may be required to detect, identify, and in many cases measure a wide variety of compounds in samples from almost any part of the body
More informationUncontrolled Copy. Table of Contents. 1. Principle of Assay Specimens Reagents and Materials... 4
Table of Contents 1. Principle of Assay... 3 2. Specimens... 3 3. Reagents and Materials... 4 4. Standards, Controls, and Solutions... 4 5. Equipment and Special Supplies... 5 6. Instrumentation and Parameters...
More informationCopyright and moral rights for this thesis are retained by the author
Harun, Norlida (2010) Application of molecularly imprinted solid phase extraction, enzyme-linked immunosorbent assay and liquid chromatography tandem mass spectrometry to forensic toxicology. PhD thesis.
More information1 Introduction 1 STA. High performance liquid chromatography (HPLC) Basic and acidic extract (plasma) Automated screening system, Bio-Rad (urine)
1 Introduction 1 1 Introduction 1.1 Systematic Toxicological Analysis Acute intoxication represents an emergency case. Fast and reliable diagnosis is very important for the prognosis and further treatment.
More informationPART III B METHODS OF ANALYSIS/ANALYTICAL SCHEME FOR IDENTIFICATION OF DRUGS OR CHEMICALS
PART III B METHODS OF ANALYSIS/ANALYTICAL SCHEME FOR IDENTIFICATION OF DRUGS OR CHEMICALS The purpose of PART III B is to recommend minimum requirements for the forensic identification of seized drugs
More informationSimultaneous analysis for forensic drugs in human blood and urine using ultra-high speed LC-MS/MS
Simultaneous analysis for forensic drugs in human blood and urine using ultra-high speed LC-MS/MS TIAFT 204 Toshikazu Minohata, Keiko Kudo 2, Kiyotaka Usui 3, Noriaki Shima 4, Munehiro Katagi 4, Hitoshi
More informationCOLA Mass Spec Criteria
Wednesday April 5, 2017 2pm COLA Mass Spec Criteria Kathy Nucifora, MPH, MT(ASCP) COLA, Accreditation Division Director Columbia, MD DESCRIPTION: Kathy Nucifora, COLA Accreditation Division Director, will
More informationMassHunter TOF/QTOF Users Meeting
MassHunter TOF/QTOF Users Meeting 1 Qualitative Analysis Workflows Workflows in Qualitative Analysis allow the user to only see and work with the areas and dialog boxes they need for their specific tasks
More informationQuantitative Analysis of EtG and EtS in Urine Using FASt ETG and LC-MS/MS
Quantitative Analysis of EtG and EtS in Urine Using FASt ETG and LC-MS/MS UCT Part Numbers: CSFASETG203 - CLEAN SCREEN FASt ETG, 200mg / 3mL tube SLETG100ID21-3UM - Selectra ETG HPLC column, 100 x 2.1
More informationDirect Analysis using Paper-Spray Mass Spectrometry: Method Development for the Rapid Screening of Drugs of Abuse for Forensic Toxicology
Direct Analysis using Paper-Spray Mass Spectrometry: Method Development for the Rapid Screening of Drugs of Abuse for Forensic Toxicology Maria C. Prieto Conaway, 1 Nicholas E. Manicke, 2 Marta Kozak 1
More informationAnalysis of Drugs in Hair using GC/GC/MS CAT Meeting 3/2/07
Analysis of Drugs in Hair using GC/GC/MS CAT Meeting 3/2/07 Objective Develop procedures for the analysis of drugs in hair using two dimensional GC systems Christine Moore, Cynthia Coulter, Sumandeep Rana
More informationAB SCIEX SelexION Technology Used to Improve Mass Spectral Library Searching Scores by Removal of Isobaric Interferences
AB SCIEX SelexION Technology Used to Improve Mass Spectral Library Searching s by Removal of Isobaric Interferences Differential Mobility Used as a Tool to Address Selectivity Challenges Adrian M. Taylor
More informationHplc Lc Ms And Gc Method Development And Validation Guideline For Academic And Industrial Scientists Involved In Method Development And Validation
Hplc Lc Ms And Gc Method Development And Validation Guideline For Academic And Industrial Scientists Involved We have made it easy for you to find a PDF Ebooks without any digging. And by having access
More informationAccelerated Impurity Profiling Workflow for Bulk Drugs and Formulations using an Accurate Mass Workhorse
Accelerated Impurity Profiling Workflow for Bulk Drugs and Formulations using an Accurate Mass Workhorse Suma Ramagiri, Loren lson, Gary Impey, Joe Fox AB SCIEX, Concord, ntario and Framingham, Massachusetts
More informationAgilent Technologies at TIAFT 2013
Agilent Technologies at TIAFT 2013 Analytical approaches for the measurement of trace metals in forensic samples Funchal, Madeira September 2-6 CRIMINALISTIC TOXICOLOGY DNA INVESTIGATION DOCUMENT EXAMINATION
More informationA Comprehensive, Fast, and Sensitive Method for the Quantitation of Synthetic Cannabinoids using the Elute UHPLC Coupled to an EVOQ LC-TQ MS
A Comprehensive, Fast, and Sensitive Method for the Quantitation of Synthetic Cannabinoids using the Elute UHPLC Coupled to an EVOQ LC-TQ MS Rapid and Sensitive Quantitation of Synthetic Cannabinoids in
More informationHAZARD COMMUNICATION PROGRAM
HAZARD COMMUNICATION PROGRAM A. General Information 1. The Texas Hazard Communication Act (THCA), codified as Chapter 502 of the Texas Health and Safety Code (HSC), requires all public employees in Texas
More informationTOXICOLOGY & FORENSIC APPLICATIONS
TOXICOLOGY & FORENSIC APPLICATIONS New Developments of Confirmation Instruments Applications in the Poison Control Centre's Thermo Scientific Instrumentation & their integrated solution s specialize in
More informationAll Ions MS/MS: Targeted Screening and Quantitation Using Agilent TOF and Q-TOF LC/MS Systems
All Ions MS/MS: Targeted Screening and Quantitation Using Agilent TOF and Q-TOF LC/MS Systems Technical Overview Introduction All Ions MS/MS is a technique that is available for Agilent high resolution
More informationForensic Toxicology in Postmortem Investigations
Forensic Toxicology in Postmortem Investigations Tech Com: Toxicology by Alphonse Poklis, Ph.D., D.A.B.F.T. Simply stated, toxicology is the study of poisons and concentrates on the chemical and physical
More informationFast Screening and Quantitation of Perfluorinated Sources from Textiles using Chemical Ionization GC-MS
PO-CON1731E Fast Screening and Quantitation of Perfluorinated Sources from Textiles using Chemical Ionization GC-MS ASMS 2017 TP-295 Hui Xian Crystal Yeong 1, Stephany Olivia 2, Lai Chin Loo 1 1 Application
More informationOF ANALYSIS FOR DETERMINATION OF PESTICIDES RESIDUES IN FOOD (CX/PR 15/47/10) European Union Competence European Union Vote
1 April 2015 European Union s CODEX COMMITTEE ON PESTICIDE RESIDUES 47 th Session Beijing, China, 13 18 April 2015 AGENDA ITEM 8 PROPOSED DRAFT GUIDELINES ON PERFORMANCE CRITERIA SPECIFIC FOR METHODS OF
More informationIntroduction to E&Ls 1
Introduction to E&Ls 1 Overview What industries need to determine E&Ls Define extractables and leachables Basic overview of an E&L study Regulatory landscape 2 A leader in plastics analysis Jordi Labs
More informationUltrafast Analysis of Methadone and Metabolite EDDP in Urine by the Agilent RapidFire High-Throughput Mass Spectrometry System
Ultrafast Analysis of and Metabolite in Urine by the Agilent RapidFire High-Throughput Mass Spectrometry System Application Note Forensic Toxicology Authors Mohamed Youssef and Vaughn P. Miller Agilent
More informationDevelopment and application of methodology for designer drugs
Development and application of methodology for designer drugs Determination of synthetic cannabinoids in urine by UPLC-MS/MS Solfrid Hegstad The challenge of new designer drugs by LC-Q-TOF Wenche Rødseth
More informationLC-MS/MS Analysis of Phytocannabinoids and their
POSTER NOTE 64922 LC-MS/MS Analysis of Phytocannabinoids and their LC-MS/MS Analysis of Phytocannabinoid Metabolites in Urine, Oral Fluid and Blood Rory M Doyle, Sherry Gregory*, Thermo Fisher Scientific,
More informationMETHADONE and EDDP in urine by GC-MS Code GC Method of Confirmation by GC-MS
METHADONE and in urine by GC-MS Code GC48010 Method of Confirmation by GC-MS INTRODUCTION is a synthetic opioid used as a drug of choice in the detoxification of heroin (and / or opiates). is metabolized
More informationConfirmation and Quantitation of THC in Oral Fluid Using an MRM Method on a GC-Triple Quadrupole MS
Technical Note: 10306 Confirmation and Quantitation of THC in Oral Fluid Using an MRM Method on a GC-Triple Quadrupole MS Eric Chi, Jason Cole, Thermo Fisher Scientific, Austin, TX, USA Key Words TSQ Quantum
More informationMass Spectrometry in Forensic Science. Erin Shonsey March 16, Overview
Mass Spectrometry in Forensic Science Erin Shonsey March 16, 2011 Overview Introduction to forensic sciences Uses of mass spectrometry in forensic sciences Typical instrumentation in forensic sciences
More informationQuantitative Analysis of EtG and EtS in Urine Using FASt ETG and LC-MS/MS
Quantitative Analysis of EtG and EtS in Urine Using FASt ETG and LC-MS/MS UCT Part Numbers: CSFASETG203 - CLEAN SCREEN FASt ETG, 200mg / 3mL tube SLETG100ID21-3UM - Selectra ETG HPLC column, 100 x 2.1
More informationEvaluation of a New HPLC, a New Tandem MS and a New Data Processing Software for General Clinical Use
Evaluation of a New HPLC, a New Tandem MS and a New Data Processing Software for General Clinical Use Shih-Tse Jason Lai, Jia Wang, Brad Hart, Kristine Van Natta, Marta Kozak, Jorge Valdivia, Haibo Wang,
More informationRegulatory and Alternative Analytical Procedures are defined as follows 2 :
Title: Alternative Analytical Method Validation in Pharmaceuticals: Replacing a Regulatory Analytical Method in Cleaning Validation Authors: Stephen Lawson, Will McHale and Brian Wallace This re titled
More informationMass Spectrometry. Quantitative Mass Spectrometry Chiral Mass Spectrometry
Mass Spectrometry Quantitative Mass Spectrometry Chiral Mass Spectrometry Quantitation by MS Goal is to develop methodology to sensitively, specifically, accurately and rapidly measure one or more compounds
More informationThe Analysis of Drugs of Abuse
Health and Life Sciences Faculty Course Title: Biological and Forensic Science Module code: 211 BMS Module Title: Principles of Forensic Science The Analysis of Drugs of Abuse Ciobanu Maria Alice Word
More informationUncontrolled Copy. Table of Contents. 1. Principle of Assay Specimens Reagents and Materials... 4
Table of Contents 1. Principle of Assay... 3 2. Specimens... 4 3. Reagents and Materials... 4 4. Standards, Controls, and Solutions... 4 5. Equipment and Special Supplies... 5 6. Instrumentation and Parameters...
More informationThermo Scientific Pesticide Explorer Collection. Start-to-finish. workflows for pesticide analysis
Thermo Scientific Pesticide Explorer Collection Start-to-finish workflows for pesticide analysis Comprehensive Pesticide Analysis Solutions Pesticide Explorer Collection Selection table Lab Profile Routine
More information6. Name of Employee 12. Location of Workplace, Bldg., and Room No.
STATE OF NORTH CAROLINA OFFICE OF STATE PERSONNEL POSITION DESCRIPTION FORM (PD-102R-92) Approved Classification: Effective Date: Analyst: (This space for Personnel Department Use Only) 1. Present Classification
More information