TOXICOLOGY & FORENSIC APPLICATIONS

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1 TOXICOLOGY & FORENSIC APPLICATIONS

2 New Developments of Confirmation Instruments Applications in the Poison Control Centre's Thermo Scientific Instrumentation & their integrated solution s specialize in a wide range of Confirmatory Testing & Evidence analysis. Drug Monitoring/Toxicology High-quality Thermo Scientific instruments, such as our LC, LC-MS and LC/MS/MS, GC and GC/MS, ICP and ICP-MS, Nicolet microscopes and FT-IR Raman Spectroscopy provide the necessary highquality tools necessary to separate and identify everything from street drugs to volatile compounds to DNA. Associated columns and sample preparation systems complete the portfolio necessary to process any evidence sample. Targeted Drug testing Instrumentation and reagents for existing and newly launched assays. Our reagents serve laboratories of all sizes in specialty testing, including therapeutic drug monitoring, toxicology and drugs of abuse testing. Well-proven homogeneous immunoassay technologies are used to guarantee the best possible result and patient outcome.

3 GC, Head Space & GC-MS / GC-MS/MS Gas Chromatography & Mass Spectrometry Helping your chromatography laboratory meet the challenges of today, our GC, HS, GC-MS, GC- MS/MS, columns, sample prep, and vials deliver the results you need for Clinical and Toxicology Applications: Gas Chromatography ( GC ) systems TRACE* 1310 GC The Thermo Scientific* TRACE 1310 GC is ideal for large routine and contract laboratories and features a complete icon-based touch screen interface for direct instrument control when method development is required. The new TRACE 1300 Series GC offers the most versatile GC platform in the market, with unique "instant connect" modularity for ground-breaking ease of use and performance, setting a new era in GC technology. While retaining all of the capabilities and performance of the TRACE 1300 Series GC platform, it also provides local status update of the oven, injectors and detectors, maintenance commands, run log, multiple language capabilities and video tutorials to drive simple instrument interaction. Environmental, food safety, toxicology, and forensic gas chromatography applications are more demanding than ever. Our portfolio of GC, GC-HS, GC-MS, and GC-MS/MS are geared to meet the challenge. TriPlus RSH Autosampler for Liquids & Head Space The Thermo Scientific* TriPlus RSH Autosampler features robotic sample handling for flexible, automated sampling & Head Space Techniques for outstanding productivity in GC and GC-MS analysis. The Thermo Scientific TriPlus RSH autosampler expands automated capabilities beyond sample injections to advanced sample handling cycles. Automating the whole workflow, from sample pipetting to injection, increases precision and reproducibility and enables unprecedented flexibility and productivity in GC and GC-HS, GC-MS/MS sampling. Gas Chromatography Mass Spectrometry : GC-MS & GC-MS/MS The Thermo Scientific* ISQ* GC-MS system offers rugged and reliable performance and nonstop productivity. The Thermo Scientific ISQ GC-MS features a new source design ideal for continuous high-throughput operation. The vacuum interlock enables source removal without venting the system for nonstop productivity. GC-MS systems tailored to meet the rigorous demands of lab professionals in both research and routine applications. Industry-leading mass spectrometry solutions offering unmatched performance, reliability, and value. TSQ Quantum Ultra Triple Quadrupole GC-MS/MS The Thermo Scientific* TSQ Quantum Ultra delivers the highest sensitivity with femtogram-range limits of detection and unrivaled performance in GC-MS/MS structure selective detection for multicomponent target compound quantitation. The TSQ Quantum XLS improves laboratory efficiency and throughput. The robust design of the system offers greater flexibility, high-speed data acquisition and more sample runs, further increasing laboratory productivity.

4 HPLC, LC - MS and LC-MS/MS Liquid Chromatography & Mass Spectrometry Industry-leading HPLC, U-HPLC & Mass spectrometry solutions including innovative OPRBITRAP Technology LC-MS, and Isotope Ratio MS instruments combined with proven application-specific software to solve a range of analytical challenges in both research and routine laboratories. High-end research and a growing number of biological, environmental and drug development applications demand not only the identification, but precise quantification of organic molecules, proteins and inorganic elements. We offer powerful solutions that deliver precise data, more efficiently and faster than ever before. Regardless of your application or the amount of data, our intuitive software will help you capture, analyze and report your results. Our robust MS solutions can reduce sample analysis time from hours to minutes. Liquid Chromatography Systems ( HPLC, U-HPLC, Nano HPLC ) The Thermo Scientific Dionex UltiMate 3000 HPLC series provides excellent chromatographic performance while maintaining easy and reliable operation. Select from a wide variety of systems for applications at all scales, from conventional HPLC, to Rapid Separation LC for high-speed and highresolution LC, to U-HPLC & ultra sensitive Nano LC. Select from a wide variety of systems for applications at all scales. Whichever UltiMate* 3000 LC system configuration you choose, you will get a highly integrated solution with optimum fluidic connections, single-point and intelligent control through the Thermo Scientific Dionex Chromeleon Chromatography Data System, and seamless inter-module communication. Liquid Chromatography Mass Spectrometry : LC-MS & LC-MS/MS ToxSpec Analyser - LC-MS/MS ToxSpec Analyser A Turn-Key Forensic, Toxicology, Drug Screening Solution What is ToxSpec Analyzer A complete LC/MS/MS based automated turn key solution for forensic drug screening in plasma, urine and whole blood Well established, tested SPE protocol (other options also available) Fast and robust LC separation protocol (13 or 30 min method) Extremely specific and sensitive ion trap MS ID (10-100ng/ml) Built-in library for drug identification Powerful and user friendly reporting software Prequalified performance and high confidence in drug ID A Complete Toxicology Screening workflow for Drugs and Toxic Compounds in Urine and Plasma Using LC-MS/MS LC-MS Systems - Exactive Plus & Q-Exactive Thermo Scientific* Exactive Plus* Mass spectrometer is the ultimate screening machine for confident identification and quantification of compounds in complex samples. This bench top LC-MS system delivers high resolution, accurate mass data and fast scanning capabilities to increase both confidence and throughput. The Exactive Plus Mass Spectrometer is an easy-to-use bench top system combining premium performance with a simple, intuitive interface in an LC-MS system that is smaller, faster and affordable for virtually any lab. It can be fully upgraded on-site to the Q-Exactive. Q Exactive : This benchtop LC- MS/MS combines high-performance quadrupole precursor selection with high-resolution, accuratemass (HR/AM) Orbitrap detection to deliver high performance and tremendous versatility. Our industry-leading LC/MS systems provide the tools necessary to solve problems in a variety of applications, including: clinical research, drug discovery and development, environmental analysis, food safety, forensics, general analytical science and proteomics.

5 ICP and ICP-MS Elemental Analysis Solutions : AA, ICP, and ICP-MS Analyzers AA, ICP-OES and ICP-MS solutions for accurate, effortless identification of trace level elements.. Organic and inorganic analysis in environmental, health and industrial applications require instruments that can handle high sample volumes and demanding detection limits. Results need to be reliable, fast and easy to obtain. Our range of atomic spectroscopy and combustion elemental analyzers are designed specifically to enable laboratories to analyze more samples with greater accuracy, simplicity and cost-effectiveness. Inductively Coupled Plasma ( ICP ) Spectrometers icap 7000 Series ICP Spectrometer Thermo Scientific* icap* 7000 Series ICP Spectrometer is small in size, yet big on performance, offering the best detection capability of any optical ICP, with enhanced productivity and the optimum in application flexibility. Trace element analysis laboratories seeking rapid, cost-effective analysis with low detection limits choose the icap 6000 Series ICP Emission Spectrometer. This compact instrument offers exceptional analytical performance, while improving productivity and running costs. Its customer-focused technologies include simple sample introduction design, high-performance optics and innovative CID detector design. Environmental, food safety, toxicology, and forensic gas chromatography applications are more demanding than ever. Our portfolio of AAS, ICP-OES & ICP-MS are geared to meet the challenge. ICP-MS Spectrometers icap Q ICP-MS The Thermo Scientific* icap Q ICP-MS is a dramatically different ICP-MS for total reliability with maximized up-time and a dramatically simplified workflow. The radical design simplifies the user experience and dramatically improves laboratory efficiency. The icap Q ICP-MS has been developed with groundbreaking technology to enable advanced highperformance analysis combined with total reliability and ultra-flexibility. Ergonomically designed quadrupole ICP-MS with smallest bench space available Innovative RAPID (Right Angle Positive Ion Deflection) lens technology (90 ion optics done right) for separation of ions and neutrals Innovative interface with skimmer cone featuring unique, user-replaceable inserts mounted behind the cone tip to control memory effects The only ICP-MS system to include proprietary QCell technology combining proven He KED interference reduction capabilities with a flatapole low mass cut-off High-performance quadrupole analyzer is pumped by a novel split flow turbo pump backed by a single rotary New, simultaneous analog/pc detector with real time multi-channel analyzer electronics provides >9 orders of dynamic range suitable for both steady state and transient signal analysis The combination of an advanced inlet system, the RAPID lens and QCell provide enhanced performance for outstanding signal to background among quadrupole ICP-MS New, exceptionally robust RF generator with fast dynamic frequency impedance matching for high plasma stability without need for a shield Instrument and accessories are fully computer controlled by the new Qtegra software. Qtegra provides integrated plug-ins for autosamplers, autodiluters, as well as major chromatography and laser ablation systems.

6 Improved Throughput Solutions : Preconfigured for easy expansion to TurboFlow or Multiplexing Technology Transcend* System with Multiplexing and TurboFlow* Technology Thermo Scientific* Transcend system combines the power of automated online sample preparation and multiplexing to increase the efficiency of your mass spectrometry workflow. The Transcend system is optimized to increase productivity, enhance efficiency and boost throughput to your mass spectrometer - without compromising data quality or sensitivity. The unique Thermo Scientific multiplexing technology brings the productivity of up to four separate, parrallel LC systems to a single mass spectrometer. Proprietary Thermo Scientific TurboFlow technology is an automated, online technique that helps reduce sample preparation up to 95%. Turbo Flow Technology A revolutionary Break thru in Minimizing Sample Preparation : Proprietary TurboFlow* Technology Minimizes Sample Preparation inject biological samples directly into LC/MS system Reduces Ion Suppression through higher specificity Saves Time by simplifying complex sample preparation protocols Simplifies Method Development use the same method for different matrices Why Couple TurboFlow Extraction to LC-MS? Maximize sample throughput by Multiplexing Automating on-line extraction Improve data quality by Processing samples in a closed system On-line extraction and transfer of analytes to LC-MS Minimizes sample adulteration by contamination or oxidation Removing sample matrix effects via TurboFlow chromatography Allowing large sample injections if necessary Extend HPLC column life Keep MS source clean Multiplexing Technology Multiplexing HPLC or LC-MS/MS systems Multiplexing Significant Efficiency Improvements Multiplexing HPLC or LC-MS/MS systems Automatically switching between LC systems coupled to one detector Data window must be a fraction of the total run time Multiplexing, allowing you to get 4 X the throughput on the same MS system. Less Cost Per Sample 4 discrete channels Same method on all 4 with intelligence Different methods Job of 4 MS done by 1 (efficiency improvement) TurboFlow methods or Regular UHPLC methods Turboflow systems are also great for reducing of ion suppression and fast method development.

7 RESULTS MATTER Connecting all of science for one answer YOURS!!