R.B.V.R.R. WOMEN S COLLEGE ( AUTONOMOUS) M.Sc CHEMISTRY SYLLABUS To be implemented for the Batches admitted in the Academic Year

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1 R.B.V.R.R. WOMEN S COLLEGE ( AUTONOMOUS) M.Sc CHEMISTRY SYLLABUS To be implemented for the Batches admitted in the Academic Year SEMESTER-I THEORY PAPERS: PAPER1:CH 101 (INORGANC CHEMISTRY) PAPER-II(CH 102) (ORGANIC CHEMISTRY): PAPER-III CH 103 :(PHYSICAL CHEMISTRY): PAPER-IV (CH 104): (MATHEMATICS/BIOLOGY AND SPECTROSCOPY) LAB PAPERS: PAPER CH 151: INORGANIC CHEMISTRY LAB COURSE PAPER CH 152 ORGANIC CHEMISTRY LAB COURSE PAPER CH 153-PHYSICAL CHEMISTRY LAB COURSE

2 PAPER1:CH 101(INORGANC CHEMISTRY) Unit -1 IC 01: Symmetry of Molecules Unit -2 IC 02: Reaction mechanism of transition metal complexes Unit-3 IC 03: Coordination Equilibria Unit -4 IC 04: Bonding in metal complexes-i PAPER-II(CH 102) (ORGANIC CHEMISTRY): OC 01: Stereochemistry-I OC 02: Reaction Mechanism-I OC 03: Carbohydrates & Proteins UNIT-4 OC 04: Heterocyclic compounds PAPER-III CH 103 :(PHYSICAL CHEMISTRY): PC-01: Thermodynamics-I PC-02: Electrochemistry-I PC-03: Quantum Chemistry-I UNIT-4 PC-04: Chemical Kinetics-I PAPER-IV (CH 104): (MATHEMATICS/BIOLOGY AND SPECTROSCOPY) M/B 01: Biology and Mathematics SP 02: NMR Spectroscopy-I SP 03: Rotational and Vibrational Spectroscopy UNIT-4 SP 04: Electronic Spectroscopy Paper CH 151: INORGANIC CHEMISTRY LAB COURSE I. Calibrations:Calibration of weights, pipettes,standard flasks & burette. II.EDTA back- titrations: Estimation of Ni 2+ &Al 3+ III.EDTA substitution- titration:estimation of Ca 2+ IV.Preparation of complexes:tris (acetylacetonato) manganese &Tris (ethelenediamine) nickel (II) thiosulphate. V. Preparation of complexes and calculation of % purity: (i) Sodium trioxalato ferrate (III) and estimation of C 2 O 4 2- and Fe 2+ and calculation of % purity. PAPER CH 152 ORGANIC CHEMISTRY LAB COURSE: SYNTHESIS OF THE FOLLOWING COMPOUNDS:Acetanilide, aspirin P-bromo acetanilide, p-bromoanililne, 2, 4, 6-tribromo aniline, 1, 3, 5-tribromo benzene, tetrahydrocarbazole, 7-hydroxy-4-methyl coumarin, m-dinitro benzene, m-dinitroaniline, hippuric acid, azalactone, anthracene-maleic anhydride adduct, phthalimide, 2, 4- dihydroxyacetophenon PAPER CH 153-PHYSICAL CHEMISTRY LAB COURSE: Physical properties: Determination of density, surface tension and viscosity of liquids Distribution:

3 Distribution of acetic acid between n-butanol and water Distribution of iodine between CCl 4 and water Chemical kinetics: Acid-catalyzed hydrolysis of methyl acetate Peroxydisulphate- I - reaction (overall order) Oxidation of iodide ion by hydrogen peroxide- iodine clock reaction Conductometry: Titration of strong acid vs. strong base Titration of weak acid vs. strong base Determination of cell constant Determination of dissociation constant of a weak acid Potentiometry: Titration of strong acid Vs strong base Titration of weak acid Vs strong base Determination of dissociation constant of a weak acid Determination of single electrode potential Polarimetry: Determination of specific rotation of sucrose Acid-catalyzed hydrolysis of sucrose (inversion of sucrose) Adsorption and others: Adsorption of acetic acid on animal charcoal or silica gel Determination of critical solution temperature of phenol-water system Effect of added electrolyte on the CST of phenol-water system.

4 SEMESTER-II THEORY PAPERS: PAPER1:CH 101 (INORGANC CHEMISTRY) PAPER-II(CH 102) (ORGANIC CHEMISTRY): PAPER-III CH 103 :(PHYSICAL CHEMISTRY): PAPER-IV (CH 104): (SPECTROSCOPY & ELECTRO ANALYTICAL TECHNIQUES LAB PAPERS: PAPER CH 151: INORGANIC CHEMISTRY LAB COURSE PAPER CH 152 ORGANIC CHEMISTRY LAB COURSE PAPER CH 153-PHYSICAL CHEMISTRY LAB COURSE

5 PAPER 1: CH 201(INORGANC CHEMISTRY) Unit-1 IC 05: Ligational aspects of diatomic molecules Unit-2 IC 06: Bonding in metal complexes-ii Unit-3 IC 07: Metal Clusters Unit -4 IC 08: Biocoordination Chemistry PAPER-II(CH 202) (ORGANIC CHEMISTRY): OC 05:Conformational Analysis (Acyclic Systems) OC 06: Reaction Mechanism-II OC 07: Reactive Intermediates & Molecular Rearrangements UNIT-4 OC 08:Natural Products PAPER-III (CH 203) (PHYSICAL CHEMISTRY) PC-05: Thermodynamics-II PC-06: Photochemistry-I PC-07 Quantum Chemistry-II UNIT-4 PC-08: Solid state chemistry PAPER-IV (CH 204): (SPECTROSCOPY AND ELECTRO ANALYTICAL TECHNIQUES SP 05: NMR Spectroscopy-II SP 06: Mossbauer, ESR, Photoelectron Spectroscopy SP 07: Mass spectrometry UNIT -4 EA 08: Electro analytical techniques PAPER CH 251: INORGANIC CHEMISTRY LAB COURSE I. One component gravimetric estimations (Use of sintered glass crucible): (i). Estimation of Zn 2+ (ii). Estimation of Ba 2+ (as BaSO 4 ). II. Analysis of Two component mixture: (i).separation of Ni 2+ and Cu 2+ in a mixture and estimation of Ni 2+ (gravimetric) and Cu 2+ (Volumetric). III. Analysis of three component mixture: (i).separation of (Fe 2+ and Cu 2+ from Zinc (Zn 2+ ) in the given mixture and estimation of Zinc (gravi). (ii). Separation of (Ni 2+ and Cu +2 ) from (Mg 2+ ) in the given mixture and estimation of Mg 2+ (gravi). IV. Ion exchange methods of analysis: (i). Determination of capacity of an ion exchange resin. (ii).separation of Zinc and Magnesium on an anion exchange resin and estimation of Mg 2+ and Zn 2+ V. Preparation of complexes: (i) Hexamine Ni (II) chloride. (ii) Mercury tetrathiocyanatocobaltate (II). VI. Preparation of complexes and calculation of % purity: (i) Tetrammine copper (II) sulphate and estimation of NH 3 and calculation of % purity (ii) Pentaammine (chloro) cobalt (III) chloride and estimation of Cl - and calculation of % purity.

6 PAPER CH 252 ORGANIC CHEMISTRY LAB COURSE : IDENTIFICATION OF ORGANIC COMPOUNDS SYSTEMATIC QUALITATIVE ANALYSIS: Physical data- BP/MP, ignition test, solubility-classification, extra elements-n,s, & X (Lassaign s sodium fusion test, beilstein test) functional group tests, preparation of crystalline derivatives & determination of their MP s & reference to literature to identify the compounds.a minimum of 8 of the following compounds to be studied as unknown covering atleast one from each of the solubility classes. Glucose, benzoic acid, 2-chlorobenzoic acid, anisic acid, Para nitro benzoic acid, p-cresol, p- chloro phenol, 2- naphthol, aniline, o/m/p chloro anilines, N-methyl anilines, N-Ethyl anilines, N,N-dimethyl anilines, Benzamide, Benzaldehyde, Anisaldehyde, acetophenone, Benzophenone, ethyl benzoate, methylbenzoate, nitrobenzene, chloro&bromo benzene, Naphthalene, biphenyl,anthracene. PAPER CH 253 :PHYSICAL CHEMISTRY LAB: Distribution: Distribution of I 2 between CCl 4 and aq.ki solution- calculation of equilibrium constant. Study of complex formation between ammonia and metal ion Chemical Kinetics 1. Stoichiometry of peroxydisulphide- iodide reaction 2. Peroxydisulphide- iodide reaction: order w.r.t [I - ] by isolation method 3. Peroxydisulphide- iodide reaction: order w.r.t [S 2 O 8 2- ] by initial rate method Condutometry: 1. Titration of a mixture of strong and weak acids vs strong base 2. Determination of the hydrolysis constant of aniline hydrochloride 3. Determination of solubility product Potentiometry: 1) Titration of Fe +2 vs Cr 2 O 7-2 (redox titration) 2) Titration of Cl - vs Ag+ (precipitation titration) 3) Determination of solubility product Polarimetry: 1) Determination of specific rotation of glucose and fructose 2) Enzyme catalysed inversion of sucrose Colorimetry: 1) Verification of Beer s law and calculation of molar absorption coefficient using CuSO 4 and KMnO 4 solutions phmetry: 1) Calibration of a ph meter and measurement of ph of different solutions 2) Preparation of phosphate buffers Solutions: 1) Determination of molecular weight of a non volatile substance by cryoscopic method 2) Determination of degree of dissociation by cryoscopic method 3) Study of surface tension-concentration relationship for solutions (Gibbs equation)

7 SEMESTER-III THEORY PAPERS PAPER 1 CH (O) 301 CONFORMATIONAL ANALYSIS, ASYMMETRIC SYNTHESIS, PROTECTING GROUPS PAPER 2 CH (O) 302 MODERN ORGANIC SYNTHESIS PAPER 3 CH (O) 303 ORGANIC SPECTROSCOPY, PHOTOCHEMISTRY & AROMATICITY PAPER 4 CH (O) 304 PERICYCLIC REACTIONS & SYNTHETIC STRATEGIES. LABORATORY PAPERS PAPER 6 CH (O) 351 MULTI STEP SYNTHESIS OF ORGANIC MOLECULES AND ISOLATION OF NATURAL PRODUCTS PAPER 5 CH (O) 352 SPECTROSCOPIC IDENTIFICATION OF ORGANIC COMPOUNDS AND CHROMATOGRAPHY (TLC & COLUMN CHROMATOGRAPHY)

8 Paper I CH (O) 301 Conformational Analysis, Asymmetric Synthesis, Protecting groups OC09- Conformational Analysis (cyclic systems) OC10- Principles of Asymmetric synthesis OC11- Methodology of asymmetric synthesis UNIT-4 OC12- Protecting Groups Paper II CH (O) 302 Modern Organic Synthesis OC13- Synthetic Reagents (Oxidations &Reductions) OC 14- Organometallics and Organic reactions of synthetic importance OC 15-New Synthetic Reactions UNIT-4 OC 16-New techniques and concepts in organic synthesis Paper III CH (O) 303 Organic Spectroscopy, Photochemistry &Aromaticity UNIT-4 OC C NMR spectroscopy OC-18 2D NMR techniques and ORD OC-19 Photochemistry OC-20 Aromaticity and Effect of Structure on Reactivity Paper IV CH (O) 304 Pericyclic Reactions & Synthetic Strategies: UNIT-4 OC-21 Pericyclic Reactions-I OC-22Pericyclic Reactions-II OC-23 Synthetic Strategies-I OC-24 Synthetic Strategies-II Semester III :Laboratory Courses Paper CH 351: Synthesis of organic molecules & Isolation of natural products: (A) Laboratory synthesis of the following compounds: 2-Phenyl indole (Fischer indole synthesis), 7-hydroxy-3 -methyl flavone (BakerVenkatraman reaction), 2,5-Dihydroxy acetophënone (Fries reaction),4- Chlorotoluene from 4-toluidine ( Sandmeyer reaction), Benzilic acid from benzoin (rearrangement), Benzpinacol (photochemical reaction), 7-hydroxy coumarin(pechmansynthesis), Photo-dimerization of maleic anhydride, benzophenone(friedel-crafts reaction), Benzanilide(Beckmann rearrangement), Vanillyl alcohol from vanillin ( NaBH 4 reduction), 2- and 4- nitrophenols (nitration and separation by steam distillation), Acridone from orthophthalic anhydride (B) Isolation of the following natural products: Caffeine from tea leaves (solvent extraction), Piperine from pepper (Soxhlet extraction), Eucalyptus oil from leaves (steam distillation), Lycopene from tomatoes(solvent extraction). Paper CH 352: Spectroscopic identification of organic compounds and Chromatography 1. Identification of unknown organic compounds by interpretation of IR, UV, 1 H nmr, 13 Cnmr and mass spectra. 2. Thin layer chromatography & Column Chromatography

9 M.Sc. IV SEMESTER Theory papers Paper 1 CH (O) 401: Drug Design and mode of action of Drugs Paper 2 CH (O) 402: Advanced Heterocyclic Chemistry (Elective - IIA) Medicinal chemistry (Elective - IIB) Paper 3 - CH (O) 403: Advanced Natural Products (Elective - IIIA) Pesticides (Elective III - B) Paper4- CH (O) 404: Biomolecules, Green Chemistry, Combinatorial Synthesis&Chiral Drugs. Laboratory Papers: Paper-5- CH 451: Separation of Two component & three component mixtures, Synthesis & analysis of Drugs Paper 6 CH (O) 452: Project work

10 Paper- 1 CH (O) 401:Drug Design and mechanism of action of Drugs UNIT-4 OC- 25 Principles of Drug design and drug discovery OC-26 SAR and QSAR studies OC 27 Basic concepts of mechanism of drug action, drugs acting on ion channels,immune systems, specific enzymes and receptors OC 28 Drugs acting on metabolic process, cell walls and genetic material Paper-2 CH (O) 402: Advanced Heterocyclic chemistry (Elective-IIA) UNIt-4 HC-1 Nonaromatic heterocyclics HC-2 Five and Six membered heterocycles with two hetero atoms HC-3 Heterocycles with more than two hetero atoms HC-4 Larger ring heterocyles Paper-3 CH (O) 403 Advanced Natural Products (Elective-IIIA) UNIT-4 NP-1: Biosynthesis of Secondary metabolites NP-2: Alkaloids, Terpenoids&Rotenoids NP-3: Steroids, Hormones &Porphyrins NP-4: Retrosynthesis& Total Stereoselective synthesis of natural products Paper-4 CH (O) 404:Biomolecules, Green Chemistry & Combinatorial Synthesis UNIT-4 OC- 29 Enzymes, Lipids & nucleic acids. OC- 30 Green Chemistry OC -31 Combinatorial synthesis OC-32 Chiral Drugs Laboratory courses Paper CH (O) Separation and identification oforganic compoundsseparation of two component mixtures by chemical methods.checking by the two components by TLC 2. Separation of three component mixtures by chemical methods. A minimum of 2 mixtures should be separated. 3.Synthesis of drugs: Benzocaine, 6-Methyluracil, Chloritone, 4-Aminobenzene sulfonamide, FIuorescene and antipyrine 4. Estimation of the following drugs:aspirin (titrimetry), Ibuprofen (titrimetry), Chloride in Ringer s lactate(argentometry), ascorbic acid (titrimetry/colorimetry)riboflavin (Colorimetry/UV-Visible Spectrophotometry) and Diazepam (UV-Visible Spectrophotometry /colorimetry) Paper CH (O) 452: Project Work

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