Br OAc. OAc. Problem R-11L (C 16 H 21 BrO 10 ) 270 MHz 1 H NMR spectrum in CDCl 3 Source: Ieva Reich (digitized hard copy) g. AcO. AcO H.
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1 Problem R-11L (C O ) 270 Mz 1 NMR spectrum in CDCl z
2 Problem R-11M (C O ) 270 Mz 1 NMR spectrum in CDCl z
3 30 Problem R-11L and R-11M. From the 270 Mz 1 NMR spectra of two stereoisomeric bromo pentaacetoxy cyclohexanes assign stereochemistry and conformation ("interpret" means give, J and multiplicity). (a) Interpret the signal at 4.5 in R-11L. Suggest possible part structures. Circle the proton at 4.5 (b) Interpret the signal at 5.2 in R-11L. Suggest possible part structures. Circle the proton at (c) Identify other significant multiplets in the expansion ( ) on the right (R-11L), draw coupling trees, and identify part structures. INT: these are all first order (d) Complete the structure for R-11L below by placing bromo and acetoxy groups with the appropriate stereochemistry on the structure. R-11L
4 (e) What do the signals at 2 tell you about the structure of R-11M (compare them to the 2 signals of R-11L). (f) Assign and interpret the signal at 4.0 in R-11M. Suggest possible part structures. (g) Analyze the rest of the NMR spectrum of R-11M. Point out significant features of the spectrum which can be used to assign stereochemistry. INT: there are some second-order effects in the multiplet (h) Complete the structure of R-11M below by placing bromo and acetoxy groups with the appropriate stereochemistry on the structure. R-11M
5 Problem R-11L (C O ) 270 Mz 1 NMR spectrum in CDCl z
6 Problem R-11M (C O ) 270 Mz 1 NMR spectrum in CDCl z
7 30 Problem R-11L and R-11M. From the 270 Mz 1 NMR spectra of two stereoisomeric bromo pentaacetoxy cyclohexanes assign stereochemistry and conformation ("interpret" means give, J and multiplicity). (a) Interpret the signal at 4.45 in R-11L. Suggest possible part structures. Circle the proton at , t, J = 3.9 z (really a dd) - the chemical shift suggests a C proton, the small couplings must be ee or ae: Curphy-Morrison: 2.2, : 3.45 (b) Interpret the signal at 5.19 in R-11L. Suggest possible part structures. Circle this proton. 5.19, dd, J = 9.8, must be an axial proton ( z J) with one neighboring eq and one ax - probably coupled to 4.45 proton (the one at 5.7 has a 5.19 smaller J, and leaning suggests it is coupled to the t at 5.59) Any stereochem here Less likely, but possible (c) Identify other significant multiplets in the expansion ( ) on the right (R-11L), draw coupling trees, and identify part structures. INT: these are all first order , t (J = ), axial proton, axial on both sides 5.56, t (J = ), axial proton, axial on both sides 5.59, t (J = 3.3), equatorial proton 5.70, dd (J =, 3.3), axial on one side, equatorial on other 5.43 and 5.56 are coupled to each other - hence adjacent 4 (d) Complete the structure for R-11L below by placing bromo and acetoxy groups with the appropriate stereochemistry on the structure R-11L The two adjacent triplets (5.43 and 5.56) means that there must be four adjacent axial hydrogens. The other two protons (4.45, 5.59) must be equatorial (triplets with J <4 z) a 5.56 a 3.3 e a a e 3.9
8 (e) What do the signals at 2 tell you about the structure of R-11M (compare them to the 2 signals of R-11L). 3 O The C 3 -C signals are in a 2:2:1 ratio, so there is likely a symmetry element in the molecule (there are 5 different ones in R-11L) (f) Assign and interpret the signal at 4.0 in R-11M. Suggest possible part structures , t (J =.7), 1 From the shift, this must the C proton. The.7 z triplet means the proton is axial, and so are both flanking protons (g) Analyze the rest of the NMR spectrum of R-11M. Point out significant features of the spectrum which can be used to assign stereochemistry. INT: there are some second-order effects in the multiplet , t (J = 9 z), , probably a dd J =.8, 9.2 z) 2 There is a third proton at ca 5.27 (1), which shows some second order effects (it is probably coupled to the overlapping 5.35 proton), but is basically also a triplet with J =. Thus all protons are of the axial type, The 5.27 can't be an equatorial proton, because that will cause 2 other protons to have one small coupling. (h) Complete the structure of R-11M below by placing bromo and acetoxy groups with the appropriate stereochemistry on the structure R-11M This has a plane of symmetry, so there are only 4 kinds of C protons (in a 1:2:2:1 ratio) and 3 kinds of acetate Me (in a 2:2:1 ratio).
9 Problem R-11L (C O ) 270 Mz 1 NMR spectrum in CDCl z
10 Problem R-11M (C O ) 270 Mz 1 NMR spectrum in CDCl z
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