DERWENT MARKUSH RESOURCE NOW AVAILABLE ON STN. BRIAN LARNER IP & SCIENCE 10 Dec 2015
|
|
- Samson Parsons
- 5 years ago
- Views:
Transcription
1 DERWENT MARKUSH RESOURCE NOW AVAILABLE ON STN BRIAN LARNER IP & SCIENCE 10 Dec 2015
2 AGENDA Introduction to DWPI chemical structure indexing Coverage of Markush Indexing Indexing of organics Inorganics & organometallics Coverage of Polymers Substance descriptors Roles 2
3 WHAT IS CHEMICAL INDEXING? Markush structural indexing for generic structures Created for all Markush Structures that meet the criteria for being indexed Also created to cover generic disclosures described only in words (eg cleaning solution containing a 2-8C alcohol) DCR indexing for specific compounds Created for any specific compounds mentioned in the patent Some compounds may be covered in Markush structure if system limits are exceeded Fragmentation coding auto-generated from the above 3
4 DWPI structure databases on STN SUBX DWPIM > 1.9 M structures DWPI > 3.2 M patents DCR > 2.5 M structures REFX Each structure has a unique Markush Compound Number (MCN) or DCR number (DCR) which is used as the basis of the cross-file search. 4
5 DERWENT MARKUSH RESOURCE ON STN Approximately 1.9 million structures from around 780,000 patents Covers 33 patent issuing authorities (as basic patent country) Can be searched in conjunction with DCR, MARPAT and CAS REGISTRY on STN In most cases using the same structure query Gives the most comprehensive chemical structure search possible 5
6 DWPI COUNTRY COVERAGE FOR CHEMICAL INDEXING 6
7 CHEMICAL STRUCTURE INDEXING IN DWPI - CRITERIA To receive structural indexing a DWPI record must meet the following criteria Classified in Sections B, C and / or E From a major country* 7
8 WHAT IS INDEXED Compounds claimed to be new Compounds produced by a new process Compounds having a new use Components of compositions Novel catalysts and known specific catalysts Specific reagents and starting materials in production processes (DCR only) Materials detected, detecting agents, detection media Materials recovered or purified in new ways Materials removed and removing agents 8
9 TYPES OF STRUCTURES INDEXED Non-polymeric organic molecules Organometallic compounds Inorganic structures Simple inorganic molecules Extended structures such as clays, zeolites and heteropolyacids Partially defined structures Polymeric structures Only for pharmaceutical and agrochemical patents Includes peptides as well as synthetic polymers 9
10 CHEMICAL INDEXING GUIDELINES Markush structures are indexed from: the patent claims the embodiment if a 'wider disclosure' is indicated Specific compounds are indexed from: the claims the main (best) example further examples at the analyst's discretion if the patent claims do not contain specific compounds, the analyst selects representative compounds from the examples and embodiment 10
11 MARKUSH COVERAGE IN OLDER PATENTS Prior to the introduction of DCR in 1999/2000 the policy was different Both specific and generic structures were covered by Markush structures, often as part of the same structure Some commonly occurring compounds were indexed using Derwent Compound Numbers It was the analysts choice whether to use these or combine them into a Markush These have now been converted to DCR records and can found by a DCR search But are still included in the Derwent Markush Resource 11
12 ORGANIC MOLECULES IN THE DERWENT MARKUSH RESOURCE Generally speaking they are indexed as shown in the Patent Counter ions are sometimes ignored (but not in the example below) Derwent Markush Resource Version In the patent 12
13 WHY THE CORE STRUCTURE CAN DIFFER FROM THE ONE DRAWN IN THE PATENT Indexing conventions Keto-enol tautomerism (keto form is the preferred one) Amidine normalisation (amidine/guanidine groups have normalised bonds not single and double bonds) Use of DWPI markush terminology and shortcuts Use of Superatoms terms (CHK, ARY etc.) & shortcuts (CO2, SO3 etc.) Allowing for variable attachments Replace all the parts of the structure where the attachment can be made by a variable group Allowing for exceptions mentioned in the patent For example where at least one of R1 & R2 is not H Allowing for system limits Means sometimes one structure is split into 2 or more 13
14 SUPERATOMS AND THEIR MEANING (ORGANIC) Superatom Definition STN query node CHK Fully saturated alkyl chain Ak CHE CHY Carbon chain containing at least one double bond (no triple bonds) Carbon chain containing at least one triple bond (optionally with double bonds) CYC Non-aromatic carbocyclic ring Cb ARY Carbocyclic ring system containing at least one benzene ring or quinoid variant HEA 5 membered ring with 2 double bonds or 6 membered ring with 3 double bonds HET Any mononuclear heterocyclic ring other than HEA HEF Fused heterocyclic ring system Hy Ak Ak Cb Hy Hy See also: DWPIM Reference Manual, Table 3, Page
15 SUPERATOMS AND THEIR MEANING (INORGANIC OR NON-SPECIFIC) Superatom Definition STN query node HAL Halogen excluding At X AMX Alkali(ne earth) metal M A35 Group 3 to 5 metal M TRM Transition metal M LAN Lanthanide (excluding Lanthanum) M ACT Actinide or other trans-uranic metal M MX Unspecified metal M XX UNK Unspecified group but not hydrogen, mostly used for unspecified substituent groups Unspecified group (no longer used but may be present in some older structures) See also: DWPIM Reference Manual, Tables 4-6, Pages
16 SUPERATOMS USED FOR DISPLAY ONLY Superatom ACY DYE PRT PEG POL Definition Acyl group (derived from any organic acid, not just carboxylic) Undefined dye chromophore Protecting group Polymer end group Polymer group Please note Derwent Superatoms will become directly searchable in a subsequent release of the Derwent Markush resource on New STN See also: DWPIM Reference Manual, Table 6, Page
17 ATTRIBUTES Attributes can be applied to Superatoms to restrict the scope of the group they describe. For carbon chain Superatoms (CHK, CHE, CHY) we have the following Describing chain length LOW (1-6C), MID (7-10C) & HI (>10C) Describing chain structure STR (Straight) & BRA (Branched) For ring Superatoms we have the following Type of ring system - MON (Monocyclic) & FU (Fused) Degree of saturation SAT (Saturated) & UNS (Unsaturated) MON & FU are not applied to HEA SAT & UNS are not applied to HEA and ARY See also: DWPIM Reference Manual, Table 18, Page
18 EXAMPLE OF STRUCTURE THAT MUST BE SPLIT 18
19 WOULD BECOME 2 STRUCTURES G 1 O G 3 G 2 G 1 S G 3 G 2 Markush 1 Markush 2 G1 is the group R, G2 is the group Q and G3 represents NR1R2 (which can be a ring) 19
20 SUBSTANCE DESCRIPTORS (FILE SEGMENTS IN MMS TERMINOLOGY) These are assigned to all Markush structures You can use them to filter your results There are three types of substance descriptor Technology related define the technology area the structure relates to Structure related - define the type of structure the Markush describes Miscellaneous identifies a Markush which contains structure which are components of a composition At least one technology related Substance Descriptor and at least one structure related Substance Descriptor is applied to each Markush 20
21 SUBSTANCE DESCRIPTORS RELATING TO STRUCTURE C : Structure is a co-ordination complex (includes metallocenes) F : Any polymer not covered by P or N L : Oligomer M : Alloy (only indexed in Sections B and C) N : Natural Polymer (other than polypeptide) P : Polypeptide (3 amino acids or above) V : Ordinary organic compound (non-polymeric) W : Extended structure (eg zeolite) Z : Salt with at least one organic component 7 : Inorganic compound See also: DWPIM Reference Manual, Table 17, Page
22 OTHER SUBSTANCE DESCRIPTORS Relating to technology area A : Patent is classified in Section A (polymers) it must also be classified in at least one section chosen from B, C or E) B : Patent is classified in Section B and / or C E : Patent is classified in Section E (Chemistry) Miscellaneous Y : Substance indexed is a component of a mixture It is possible for one Markush to cover two different components of the same composition See also: DWPIM Reference Manual, Table 17, Page
23 SUBSTANCE DESCRIPTOR COMBINATIONS VZ : Compound and its salts VC : Compound and it s complexes CZ : Used when it is unclear if a compound is a salt or a complex VW : Fullerenes and other nanostructures VP : For tripeptides VL : For oligomers 23
24 INORGANIC STRUCTURES Salts are drawn as discrete ions with charges added whenever they are shown or can be easily deduced More complex structures are indexed by listing each element present as a separate entity with zero valency Compounds formed entirely of non metallic elements are mostly shown with covalent bonds in much the same way as for organics 24
25 EXAMPLE SIMPLE INORGANICS Markush of alkali metal hypochlorites, especially Sodium or Potassium 25
26 METALLOCENES Are indexed with the cyclopentadienyl or other π bonded ligands shown disconnected from the metal atom The valency on the metal is reduced by 1 for each bond to a cyclopentadienyl ring For example Ti in titanocene dichloride is shown as 2 valent (a +2 charge would be placed on the Ti atom) 26
27 PHTHALOCYANINES These are drawn fully normalized The central metal atom used to be bonded to all 4 N atoms but now (since 2000) it is disconnected 27
28 POLYMER OR OLIGOMER Substance Substance descriptors BC definition E definition Oligopeptide VP 3 amino acids 3 amino acids Polypeptide P >=4 amino acids >=4 amino acids Oligosaccharide L 3-6 sugar units 3-9 sugar units Polysaccharide N >= 7 sugar units >=10 sugar units* Other oligomer L 3-8 repeat units 3-9 repeat units Other polymer F >=9 repeat units >=10 repeat units* BC definition refers to definition used when indexing pharmaceutical and agrochemical patents (Sections B and / or C) E definition refers to the definition used when indexing general chemistry patents (Section E) If a patent is classified in Section E as well as Section B and / or Section C the BC definitions are used * Not indexed unless part of a dye molecule 28
29 SEARCHING FOR POLYMERS Addition polymers are indexed as the monomer with role Q applied For addition copolymers all the separate monomers are indexed with roles Q + M They can be indexed as part of one Markush structure Condensation polymers are indexed using the structural repeat unit when this is given in the document This structure would receive the substance descriptor F or N Condensation polymers are indexed in terms of the starting materials if the structure of the polymer is not given with roles Q + M 29
30 POLYMER DRUG CONJUGATES There are several ways this can be indexed depending on the information provided If the point of attachment is not shown then the Polymer and drug are normally indexed separately with roles Q + M If the polymer is not specific it may be indexed as a Markush with the POL superatom and the drug shown as disconnected entities and appropriate polymer substance descriptors If the point of attachment is shown then the drug is shown bonded to the Polymer (represented by the POL superatom in most cases) 30
31 ROLES OF MARKUSH RECORDS Role A C D M N P Q R U X Definition Compound is analyzed or detected Catalyst Detecting agent Component of a mixture (at least 2 components have been indexed) New compound Compound is produced or purified Compound defined in terms of starting materials Removing or purifying agent New use of compound Compound is removed See also: DWPIM Reference Manual, Table 15, Page
32 THANK YOU! Customer Service For subscriptions, pricing and renewals Technical Support For access, content, searching, troubleshooting and technical issues. Training For Thomson Innovation training options. Contact Us US, Canada & Latin America Phone: Europe, Middle East and Africa Tel: +44 (0) Japan Phone: ts.info.jp@thomsonreuters.com Asia Pacific (Singapore office) Phone: ts.support.asia@thomsonreuters.com 32
33 Derwent Markush Resource (DWPIM) now available on STN Part 2: Searching on STN
34 Agenda Introduction to new STN DWPI structure databases on new STN DWPIM precision search tools Search examples
35 New STN workflow is oriented around projects 3 To create a project, click the icon. Projects allow you to: Easily return to previous work Reuse common queries Update searches with the most current information
36 The new STN interface puts query, history and results at your fingertips 4 Structure Editor Query Builder panel History panel Results panel
37 Select databases 5....
38 6 DWPI structure databases on STN DCR contains specific structures from patents DWPIM contains generic structures from patents A single structure query can be searched in both DCR and DWPIM Use REFX Cross File Search to find DWPI references
39 DWPI structure databases on STN 7 SUBX DWPIM > 1.9 M structures DWPI > 3.2 M patents DCR > 2.5 M structures REFX Each structure has a unique Markush Compound Number (MCN) or DCR number (DCR) which is used as the basis of the cross-file search.
40 8 DWPIM allows comprehensive and precise structure searches Why does precision matter? All DWPIM answers are valid answers, regardless of precision settings When building a DWPIM query, anticipate acceptable candidate answers DWPIM precision search tools Generic Definitions, e.g. saturation, high or low carbon count, etc. Match Level: ATOM, CLASS, ANY Element Count and Element Count Level: Limited versus Unlimited
41 Match Levels in DWPIM mirror the specificity typical of patent Markush structures 9 Most specific Least specific ATOM CLASS ANY Methyl, Phenyl CHK, ARY XX ( R-node ) CHK = saturated alkyl ARY = aromatic carbocycle XX = represents concepts that cannot be drawn and are described in the patent using text, such as substituent, electron-withdrawing group, leaving group, linker, group to form a ring, etc.
42 10 Match Level functions the same for real atoms or generic variables in queries ATOM matches at the specific atom level CLASS matches at both the generic CLASS level and specific atoms ANY matches at ATOM and CLASS, including indefinitely defined substitutions MATCH LEVEL ATOM CLASS ANY Specific RETRIEVAL Specific or Generic Specific or Generic or Indefinite
43 11 Structure queries automatically include a default Match Level assignment This assignment is only taken into account when searching Markush databases The default settings for Match Levels are QUERY NODES Ring atoms Cb, Cy, Hy Chain atoms Ak DEFAULT MATCH LEVEL ATOM CLASS (Limited)
44 Search example 12 Search Question: R1 = Ring system Thiophene: ML = Atom Benzene: ML = Atom Carbonyl: ML = Class Heterocycle: ML = Atom Default settings.
45 Prepare structure queries using the structure editor 13 By default ring atoms are set to Match Level ATOM and chain nodes are set to Match Level CLASS. This has no effect on DCR. Right mouse click to change Node or Bond attributes. Click OK to add the query to the structures tab of the history panel.
46 Option: turn Automatic Cross File Search ON 14 Automatic Cross File Search between DWPIM and DWPI is OFF by default. Check this box to enable automatic Cross File search.
47 Search the structure query and review DCR structures 15 Click on any structure to enlarge (zoom). Automatic Cross File Search is set ON.
48 Crossover using REFX to retrieve corresponding DWPI records with in-context DCR hit structures 16 Use the REFX operator to retrieve corresponding DWPI references (L2). DCR hit structures are included in the DWPI detailed display full view.
49 Repeat the structure query and review DWPIM structures 17 Click on a Markush compound number, e.g , for detailed display views (next). Query relevant G-group hit fragments are represented as an assembled structure. Click on any structure to enlarge (zoom).
50 DWPIM detailed display Brief view 18 Unassembled DWPIM Markush base structure. Query relevant G- groups (G3, etc.). Hit fragments are combined to form the assembled structure. Hit fragments are highlighted.
51 19 Detailed display allows you to choose a preferred view Brief unassembled hit Markush base structure with complete hit G-groups related to the query Hit fragments within hit G-groups are highlighted Full unassembled hit Markush base structure with all G-groups, including those not related to the query Hit fragments within hit G-groups are highlighted
52 Settings for DWPIM default detailed display view 20 Default displays can be toggled between either of the two views in the detailed display. * * This setting only relates to CAplus.
53 Crossover using REFX to retrieve corresponding DWPI records with in-context hit structures from DWPIM 21 Use the REFX operator to retrieve corresponding DWPI references (L4). DWPIM hit structures in both Assembled and Full views are available.
54 Search history 22 Extending the search to include DWPIM, retrieved 12 additional, potentially relevant results (L4).
55 Search example using variable query nodes 23 Search Query: = No R1 further = Ring substitution system on Ak (Locked) Thiophene: ML = Atom Benzene: Carbocycle ML (Cb): = Atom ML = Atom Carbonyl: Alkyl (Ak): ML = Class Heterocycle: (Hy): ML = ML Atom = Atom Default settings.
56 Prepare structure queries using the structure editor 24 By default ring variables Cb and Hy are set to Match Level ATOM and the chain variable Ak is set to Match Level CLASS. This has no effect on DCR. Block substitution with the lock atoms tool. Click OK to add the query to the structures tab of the history panel.
57 Search history 25 Using variable query nodes with ATOM match, retrieved 15 additional, potentially relevant results (L6).
58 Example with specific node hits for Ak, Cb and Hy 26
59 Search example revisiting MATCH level 27 Search Query: = No R1 further = Ring substitution system on Ak (Locked) Thiophene: ML ML = Atom = Atom Carbocycle Benzene: (Cb): ML = ML Atom = Atom Class Alkyl Carbonyl: (Ak): ML = = Class Heterocycle: (Hy): ML ML = Atom = Atom Class Default settings.
60 Class Match Level relationship between Variable Query Nodes and the Generic Nodes (Superatoms) in DWPIM 28 Ak Cy Cb Hy CHK CHE CHY ARY CYC HEF HEA HET = Structure Editor Variable Query Node
61 STN variable query nodes retrieve DWPIM generic nodes 29 STN variable query nodes DWPIM retrieved generic nodes DWPIM generic nodes for Ak CHK CHE CHY DWPIM generic nodes for Cb ML = Class ARY CYC DWPIM generic nodes for Hy HEA HET HEF
62 STN node attributes retrieve DWPIM indexed attributes 30 STN node attributes, e.g. Ak ML = Class DWPIM retrieved attributes DWPIM alkyl (no limitation) CHK CHE CHY ML = Class DWPIM alkyl (low) CHK CHK LOW ML = Class DWPIM alkyl (straight) CHK CHK STR
63 STN variable query nodes retrieve DWPIM generic nodes 31 STN search query Typical DWPIM assembled hits STN query nodes with Match Level Class, retrieve corresponding generic and specific nodes in DWPIM. 4 DWPIM attributes are also accessible, e.g. MON = monocyclic, FUS = Fused
64 Prepare structure queries using the structure editor 32 Cb and Hy nodes have been set to Class match. Changes from defaults are indicated with an asterisk. This has no effect on DCR. Right click on a node to change Attributes, e.g. Match Level. Click OK to add the query to the structures tab of the history panel.
65 Search history 33 Using variable query nodes with CLASS match, retrieved 80 additional, potentially relevant results (L8).
66 Example with generic node hits for Cb and Hy 34
67 35 Element Count and Element Count Level Any specific atom, chain, or ring in a query has an implied element count, e.g. phenyl ring = 6 C, isopropyl = 3 C The variable nodes Ak, Cb, Cy and Hy can have element counts added (example on next slide) For class MATCH, when an element count is implied or added, you can also set the Element Count Level to Limited (default) or Unlimited Limited (default) only retrieves patents that have a specified element count in the indexed structures
68 Example: assigning an Element Count, and Match Level CLASS, Element Count Level LIMITED, to an Hy node 36 A Right click on a node to change Attributes. B
69 Match Level CLASS, Element Count Level LIMITED 37 Query -CH2CH2CH3 (Locked) -Ak (no element count) -Ak (element count 1-4 C) Example retrieval -CH2CH2CH3, npr, CHK LOW, CHK LOW,C=1-4 -CH3, Et, npr, CHK LOW,C=1-4, CHK, CHE, CHY -CH3, COOH, Et, CHK LOW, CHE LOW, CHK LOW,C=1-4 -Q N, Cl, B, HAL, TRM N (Locked) N, HEA C=2-5, N=1-3, HEAC=4-5, N=1-2 -Hy (1 N, zero O, zero S), HEA N=1-3, HEF N=0-5,S=0-5 -Cy (no element count) N, CYC, ARY, HET, HEA N=1-3, HEF N=0-5,S=0-5 N
70 Match Level CLASS, Element Count Level UNLIMITED 38 Query -CH2CH2CH3 (Locked) -Ak (no element count) -Ak (element count 1-4 C) Example retrieval -CH2CH2CH3, npr, CHK LOW, CHK LOW,C=1-4, CHK -CH3, Et, npr, CHK LOW,C=1-4, CHK, CHE, CHY -CH3, COOH, Et, CHK LOW, CHE LOW, CHK LOW,C=1-4, CHK, CHE -Q N, Cl, B, HAL, TRM N (Locked) N, HEA C=2-5, N=1-3, HEA C=4-5, N=1-2, HEA -Hy (1 N, zero O, zero S), HEA N=1-3, HEF N=0-5,S=0-5, HEA, HEF -Cy (no element count) N, CYC, ARY, HET, HEA N=1-3, HEF N=0-5,S=0-5 N
71 New STN will allow simultaneous search with a single query structure 39 STN search conventions preserved: Bond types & values Generic nodes Attributes Match Level Element Count Level Query Structure DCR DWPIM MARPAT CAS Registry SM ~ 2.5 M structures ~ 1.9 M structures ~ 1.1 M structures ~ 100 M structures
72 Multi-database search example Diazepam 40 Note: Since the focus of this example is multi-database searching, default settings are used with a simple Closed Substructure Search (CSS) query. Click OK to add the query to the structures tab of the history panel.
73 Search the structure query and review structures 41 Closed Substructure Search (CSS). Query relevant G-group hit fragments are represented as an assembled structure. Click Submit to retrieve multidatabase structure hits (L1). Click on any structure to enlarge (zoom).
74 Crossover using REFX to retrieve corresponding DWPI and CAplus bibliographic records 42 Use the REFX operator to retrieve corresponding DWPI and CAplus references (L2).
75 Use Create Term List to identify unique hits 43
76 Use Create Term List to identify unique hits (cont.) 44 Manage Term lists. L2 = CAplus and DWPI combined search results. Q38 = patent number/kind taken from DWPI (L2). Patent records only found in CAplus (L3).
77 Resources 45 DWPIM Reference Manual Recorded Events Unified Markush Search on new STN MARPAT on new STN Substance and Chemical Structure Searching in CAS Registry and DCR on new STN
78 For more information CAS Support and Training: FIZ Karlsruhe Support and Training:
Comprehensive DWPI SM structure searching using DCR and DWPIM on STN
Comprehensive DWPI SM structure searching using DCR and DWPIM on STN Brian Larner, IP & Science, Thomson Reuters Robert Austin, Senior STN Trainer, FIZ Karlsruhe 19 May 2016 AGENDA Introduction to DWPI
More informationDemonstration: Searching patents based on chemical structure using SciFinder
Demonstration: Searching patents based on chemical structure using SciFinder Christian Skotte, CAS and Prof. John Nielsen, UCPH www.cas.org What criteria must a substance meet to be included in the CAS
More informationHow to Create a Substance Answer Set
How to Create a Substance Answer Set Select among five search techniques to find substances Since substances can be described by multiple names or other characteristics, SciFinder gives you the flexibility
More informationSearching Substances in Reaxys
Searching Substances in Reaxys Learning Objectives Understand that substances in Reaxys have different sources (e.g., Reaxys, PubChem) and can be found in Document, Reaction and Substance Records Recognize
More informationStructure-based approaches to the indexing and retrieval of patent chemistry. Tim Miller Head of Research May 2010
Structure-based approaches to the indexing and retrieval of patent chemistry Tim Miller Head of Research May 2010 TOPICS Chemistry in Patents Structure Indexing of patents New developments Challenges yet
More informationDECEMBER 2014 REAXYS R201 ADVANCED STRUCTURE SEARCHING
DECEMBER 2014 REAXYS R201 ADVANCED STRUCTURE SEARCHING 1 NOTES ON REAXYS R201 THIS PRESENTATION COMMENTS AND SUMMARY Outlines how to: a. Perform Substructure and Similarity searches b. Use the functions
More informationTable of Contents. Scope of the Database 3 Searching by Structure 3. Searching by Substructure 4. Searching by Text 11
Searrcchiing fforr Subssttanccess and Reaccttiionss iin Beiillsstteiin and Gmelliin 1 Table of Contents Scope of the Database 3 Searching by Structure 3 Introduction to the Structure Editor 3 Searching
More informationSEARCHING DWPI POLYMER INDEXING ON NEW STN
SEARCHING DWPI POLYMER INDEXING ON NEW STN BRIAN LARNER IP & SCIENCE THOMSON REUTERS JIM BROWN SENIOR KEY ACCOUNT MANAGER - FIZ KARLSRUHE 19 th November 2015 AGENDA Introduction to DWPI Polymer Indexing
More informationSEARCHING VALUE ADDED POLYMER INDEXING IN DWPI, DCR & DWPIM ON NEW STN BRIAN LARNER & JIM BROWN OCTOBER 2016
SEARCHING VALUE ADDED POLYMER INDEXING IN DWPI, DCR & DWPIM ON NEW STN BRIAN LARNER & JIM BROWN OCTOBER 2016 AGENDA 01 02 03 04 05 06 07 08 What is polymer indexing? Why use it? How to carry out searches
More informationBasic Techniques in Structure and Substructure
Truncating Molecules Basic Techniques in Structure and Substructure Searching for Information Professionals Judith Currano Head, Chemistry Library University of Pennsylvania currano@pobox.upenn.edu Acknowledgements
More informationDeveloping CAS Products for Substructure Searching by Chemists. Linda Toler
Developing CAS Products for Substructure Searching by Chemists Linda Toler Developing CAS Products for Substructure Searching Evolution of the CAS Registry Development of substructure searching for CAS
More informationReaxys Pipeline Pilot Components Installation and User Guide
1 1 Reaxys Pipeline Pilot components for Pipeline Pilot 9.5 Reaxys Pipeline Pilot Components Installation and User Guide Version 1.0 2 Introduction The Reaxys and Reaxys Medicinal Chemistry Application
More informationStructure Searching in CrossFire Beilstein. DiscoveryGate SM Version 1.4 Participant s Guide
Structure Searching in CrossFire Beilstein DiscoveryGate SM Version 1.4 Participant s Guide Structure Searching in CrossFire Beilstein DiscoveryGate SM Version 1.4 Participant s Guide Elsevier MDL 14600
More informationChem 1075 Chapter 19 Organic Chemistry Lecture Outline
Chem 1075 Chapter 19 Organic Chemistry Lecture Outline Slide 2 Introduction Organic chemistry is the study of and its compounds. The major sources of carbon are the fossil fuels: petroleum, natural gas,
More informationInformation Retrieval: SciFinder
Information Retrieval: SciFinder Second Edition DAMON D. RIDLEY School of Chemistry, The University of Sydney WI LEY A John \Viley and Sons, Ltd., Puhliratimt Contents Preface xi 1 SciFinder : Setting
More informationThe shortest path to chemistry data and literature
R&D SOLUTIONS Reaxys Fact Sheet The shortest path to chemistry data and literature Designed to support the full range of chemistry research, including pharmaceutical development, environmental health &
More informationSearching CrossFire Beilstein Using DiscoveryGate. DiscoveryGate Version 2.2 Participant s Guide
Searching CrossFire Beilstein Using DiscoveryGate DiscoveryGate Version 2.2 Participant s Guide Searching CrossFire Beilstein using DiscoveryGate DiscoveryGate Version 2.2 Participant s Guide Elsevier
More informationExam 1 (Monday, July 6, 2015)
Chem 231 Summer 2015 Assigned Homework Problems Last updated: Friday, July 24, 2015 Problems Assigned from Essential Organic Chemistry, 2 nd Edition, Paula Yurkanis Bruice, Prentice Hall, New York, NY,
More informationStructure Drawing. March Use the New Features. Keyboard Shortcuts and Paste from ChemDraw
Use the New Features March 2010 SciFinder offers many new structure drawing, reaction search and display, answer set manipulation, and results postprocessing features and enhancements. Improved performance
More informationChapter 21: Hydrocarbons Section 21.3 Alkenes and Alkynes
Section 21.1 Introduction to Hydrocarbons Section 1 Objectives: Explain the terms organic compound and organic chemistry. Section 21.2 Alkanes Chapter 21: Hydrocarbons Section 21.3 Alkenes and Alkynes
More informationSearching Inorganic Chemistry
Searching Inorganic Chemistry Agenda: Focus Inorganic Chemistry 1. Content in SciFinder 2. Indexing of Inorganic Substances 3. Appropriate Search Strategies Chemical Name Searching Molecular Formula Structure
More informationIntroducing the New SciFinder. Veli Pekka Hyttinen Regional Marketing Manager, Central and Eastern Europe Jasna April 1, 2014
Introducing the New SciFinder Veli Pekka Hyttinen Regional Marketing Manager, Central and Eastern Europe Jasna April 1, 2014 Hyttinen, CAS 1 ( 20 ) Jasna, April 1, 2014 Chemical Abstracts Service A non
More informationPSI Chemistry. 3) How many electron pairs does carbon share in order to complete its valence shell? A) 1 B) 2 C) 3 D) 4 E) 8
Organic Chemistry HW PSI Chemistry Name I - Organic Introduction 1) Organic chemistry is a science based on the study of A) functional groups. B) vital forces interacting with matter. C) carbon compounds.
More informationPOC via CHEMnetBASE for Identifying Unknowns
Table of Contents A red arrow is used to identify where buttons and functions are located in CHEMnetBASE. Figure Description Page Entering the Properties of Organic Compounds (POC) Database 1 CHEMnetBASE
More informationA powerful site for all chemists CHOICE CRC Handbook of Chemistry and Physics
Chemical Databases Online A powerful site for all chemists CHOICE CRC Handbook of Chemistry and Physics Combined Chemical Dictionary Dictionary of Natural Products Dictionary of Organic Dictionary of Drugs
More informationAliphatic Hydrocarbons Anthracite alkanes arene alkenes aromatic compounds alkyl group asymmetric carbon Alkynes benzene 1a
Aliphatic Hydrocarbons Anthracite alkanes arene alkenes aromatic compounds alkyl group asymmetric carbon Alkynes benzene 1a Hard coal, which is high in carbon content any straight-chain or branched-chain
More informationPIOTR GOLKIEWICZ LIFE SCIENCES SOLUTIONS CONSULTANT CENTRAL-EASTERN EUROPE
PIOTR GOLKIEWICZ LIFE SCIENCES SOLUTIONS CONSULTANT CENTRAL-EASTERN EUROPE 1 SERVING THE LIFE SCIENCES SPACE ADDRESSING KEY CHALLENGES ACROSS THE R&D VALUE CHAIN Characterize targets & analyze disease
More informationVersion 1.2 October 2017 CSD v5.39
Mogul Geometry Check Table of Contents Introduction... 2 Example 1. Using Mogul to assess intramolecular geometry... 3 Example 2. Using Mogul to explain activity data... 5 Conclusions... 8 Further Exercises...
More informationOrganic Chemistry 112 A B C - Syllabus Addendum for Prospective Teachers
Chapter Organic Chemistry 112 A B C - Syllabus Addendum for Prospective Teachers Ch 1-Structure and bonding Ch 2-Polar covalent bonds: Acids and bases McMurry, J. (2004) Organic Chemistry 6 th Edition
More informationUnit 5 Test. Name: Score: 37 / 37 points (100%)
Name: Score: 37 / 37 points (100%) Unit 5 Test Matching (1 point each) Match each item with the correct statement below a activity series j product b chemical equation k reactant c coefficient l reduction
More informationFinding Polymer Information Part 2: Advanced. Dr. Thomas Haubenreich
Finding Polymer Information Part 2: Advanced Dr. Thomas Haubenreich Agenda Polymers in SciFinder for Advanced Users Functionalized Polymers and post polymerization treated Polymers Manually registered
More informationSearch for Substance Data
Search for Substance Data Virtual class structure Part 1 Find property data for a substance Retrieve chemical supplier information for a substance Part 2 Import a structure and conduct an exact structure
More informationOrganic Chemistry is the chemistry of compounds containing.
Chapter 21 Lecture Notes Organic Chemistry Intro Organic Chemistry is the chemistry of compounds containing. The Bonding of Carbon Because carbon has four valence electrons, it can form covalent bonds.
More informationMolecular Geometry: VSEPR model stand for valence-shell electron-pair repulsion and predicts the 3D shape of molecules that are formed in bonding.
Molecular Geometry: VSEPR model stand for valence-shell electron-pair repulsion and predicts the 3D shape of molecules that are formed in bonding. Sigma and Pi Bonds: All single bonds are sigma(σ), that
More informationHydrocarbons. Chapter 22-23
Chapter 22-23 Hydrocarbons Organic Compounds All Carbon containing compounds Except carbon oxides, carbides, and carbonates which are inorganic. CO & CO2 Na4C CaCO3 +8 oxidation change CH 4 + O 2 CO 2
More informationName Date Class HYDROCARBONS
22.1 HYDROCARBONS Section Review Objectives Describe the relationship between number of valence electrons and bonding in carbon Define and describe alkanes Relate the polarity of hydrocarbons to their
More informationElsevier R&D Solutions. Tool Sheet. Exploring a chemical reaction
Elsevier R&D Solutions Exploring a chemical reaction Exploring a chemical reaction Use Ask Reaxys to explore reactions, substances and concepts Learning objectives Use Ask Reaxys as an entry point to browse
More informationReaxys Medicinal Chemistry Fact Sheet
R&D SOLUTIONS FOR PHARMA & LIFE SCIENCES Reaxys Medicinal Chemistry Fact Sheet Essential data for lead identification and optimization Reaxys Medicinal Chemistry empowers early discovery in drug development
More information2/25/2015. Chapter 4. Introduction to Organic Compounds. Outline. Lecture Presentation. 4.1 Alkanes: The Simplest Organic Compounds
Lecture Presentation Outline Chapter 4 Introduction to Organic Compounds 4.2 Representing Structures of Organic Compounds Julie Klare Fortis College Smyrna, GA Alkanes are structurally simple organic compounds
More informationPOC via CHEMnetBASE for Identifying Unknowns
Table of Contents A red arrow was used to identify where buttons and functions are located in CHEMnetBASE. Figure Description Page Entering the Properties of Organic Compounds (POC) Database 1 Swain Home
More informationInformation Extraction from Chemical Images. Discovery Knowledge & Informatics April 24 th, Dr. Marc Zimmermann
Information Extraction from Chemical Images Discovery Knowledge & Informatics April 24 th, 2006 Dr. Available Chemical Information Textbooks Reports Patents Databases Scientific journals and publications
More informationNORTH CENTRAL HIGH SCHOOL NOTE & STUDY GUIDE. Honors Biology I
NOTE/STUDY GUIDE: Unit 1-2, Biochemistry Honors Biology I, Mr. Doc Miller, M.Ed. North Central High School Name: Period: Seat #: Date: NORTH CENTRAL HIGH SCHOOL NOTE & STUDY GUIDE Honors Biology I Unit
More informationReaxys Training. How to Find Organometallic and Coordination Compounds in Reaxys
Reaxys Training How to Find Organometallic and Coordination Compounds in Reaxys March 2013 Reaxys application version: 2.13618.7 MarvinSketch version 5.10.5 Reaxys and the Reaxys trademark are owned and
More informationOECD QSAR Toolbox v.4.1. Step-by-step example for building QSAR model
OECD QSAR Toolbox v.4.1 Step-by-step example for building QSAR model Background Objectives The exercise Workflow of the exercise Outlook 2 Background This is a step-by-step presentation designed to take
More informationChapter 2 The Chemistry of Life
Chapter 2 The Chemistry of Life I. Water Liquid Naturally occurring It expands liquid to solid Covers more than 75% of our surface Most abundant in living organisms most important inorganic compound for
More informationLarge Scale Evaluation of Chemical Structure Recognition 4 th Text Mining Symposium in Life Sciences October 10, Dr.
Large Scale Evaluation of Chemical Structure Recognition 4 th Text Mining Symposium in Life Sciences October 10, 2006 Dr. Overview Brief introduction Chemical Structure Recognition (chemocr) Manual conversion
More informationChapter 6 Chemistry in Biology
Section 1: Atoms, Elements, and Compounds Section 2: Chemical Reactions Section 3: Water and Solutions Section 4: The Building Blocks of Life Click on a lesson name to select. 6.1 Atoms, Elements, and
More informationvideo 14.4 isomers isomers Isomers have the molecular formula but are rearranged in a structure with different properties. Example: Both C 4 H 10
video 14.4 isomers isomers Isomers have the molecular formula but are rearranged in a structure with different properties. Example: Both C 4 H 10 Butane Methylpropane 1 match the isomers drawing an isomer
More informationChapter 13 Alkenes and Alkynes Based on Material Prepared by Andrea D. Leonard University of Louisiana at Lafayette
Chapter 13 Alkenes and Alkynes Based on Material Prepared by Andrea D. Leonard University of Louisiana at Lafayette 1 Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
More informationThieme Chemistry E-Books
www.thieme-connect.com/chemistry-ebooks Thieme Chemistry E-Books SERIES Science of Synthesis Houben-Weyl MONOGRAPHS Protecting Groups Spectroscopic Methods Synthetic Methods of Organometallic and Inorganic
More informationChemistry 14CL. Worksheet for the Molecular Modeling Workshop. (Revised FULL Version 2012 J.W. Pang) (Modified A. A. Russell)
Chemistry 14CL Worksheet for the Molecular Modeling Workshop (Revised FULL Version 2012 J.W. Pang) (Modified A. A. Russell) Structure of the Molecular Modeling Assignment The molecular modeling assignment
More informationChapter 25: The Chemistry of Life: Organic and Biological Chemistry
Chemistry: The Central Science Chapter 25: The Chemistry of Life: Organic and Biological Chemistry The study of carbon compounds constitutes a separate branch of chemistry known as organic chemistry The
More informationDRUG DISCOVERY TODAY ELN ELN. Chemistry. Biology. Known ligands. DBs. Generate chemistry ideas. Check chemical feasibility In-house.
DRUG DISCOVERY TODAY Known ligands Chemistry ELN DBs Knowledge survey Therapeutic target Generate chemistry ideas Check chemical feasibility In-house Analyze SAR Synthesize or buy Report Test Journals
More informationThe now-banned diet drug fen-phen is a mixture of two synthetic substituted benzene: fenfluramine and phentermine.
The now-banned diet drug fen-phen is a mixture of two synthetic substituted benzene: fenfluramine and phentermine. Chemists have synthesized compounds with structures similar to adrenaline, producing amphetamine.
More informationCompletions Multiple Enrollment in same semester. 2. Mode of Instruction (Hours per Unit are defaulted) Hegis Code(s) (Provided by the Dean)
CALIFORNIA STATE UNIVERSITY CHANNEL ISLANDS COURSE MODIFICATION PROPOSAL Courses must be submitted by November 2, 2009, to make the next catalog (2010--2011) production DATE (CHANGE DATE EACH TIME REVISED):
More informationChapter 22. Organic and Biological Molecules
Chapter 22 Organic and Biological Molecules The Bonding of Carbon Organic chemistry is the chemistry of compounds containing carbon. Because carbon can form single, double, and triple bonds, the following
More informationChapter 22 Hydrocarbon Compounds
Chapter 22 Hydrocarbon Compounds 1 ORGANIC COMPOUNDS Organic compounds are carbon compounds and there are over a million. The simplest organic compounds are hydrocarbons and they are composed of hydrogen
More informationTOK: The relationship between a reaction mechanism and the experimental evidence to support it could be discussed. See
Option G: Further organic chemistry (15/22 hours) SL students study the core of these options and HL students study the whole option (the core and the extension material). TOK: The relationship between
More informationGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR (preparation of carboxylic acid esters by telomerisation C07C 67/47; telomerisation C08F)
CPC - C07B - 2017.08 C07B GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR (preparation of carboxylic acid esters by telomerisation C07C 67/47; telomerisation C08F) General methods for the preparation
More informationChapter 1 Reactions of Organic Compounds. Reactions Involving Hydrocarbons
Chapter 1 Reactions of Organic Compounds Reactions Involving Hydrocarbons Reactions of Alkanes Single bonds (C-C) are strong and very hard to break, therefore these compounds are relatively unreactive
More informationIntroduction to Spark
1 As you become familiar or continue to explore the Cresset technology and software applications, we encourage you to look through the user manual. This is accessible from the Help menu. However, don t
More informationCHEM 203 Exam 1. Name Multiple Choice Identify the letter of the choice that best completes the statement or answers the question.
CHEM 203 Exam 1 Name Multiple Choice Identify the letter of the choice that best completes the statement or answers the question. 1. Which of the following elements is a large percentage of both the earth's
More informationCarbon and Molecular Diversity - 1
Carbon and Molecular Diversity - 1 Although water is the most abundant compound of living organisms, and the "medium" for the existence of life, most of the molecules from which living organisms are composed
More informationTable 8.2 Detailed Table of Characteristic Infrared Absorption Frequencies
Table 8.2 Detailed Table of Characteristic Infrared Absorption Frequencies The hydrogen stretch region (3600 2500 cm 1 ). Absorption in this region is associated with the stretching vibration of hydrogen
More informationDEPARTMENT: Chemistry
CODE CHEM 204 TITLE: Organic Chemistry II INSTITUTE: STEM DEPARTMENT: Chemistry COURSE DESCRIPTION: A continuation of CHEM-203, students will extend their studies into topics including aromatic hydrocarbons,
More informationBIOLOGY 101. CHAPTER 4: Carbon and the Molecular Diversity of Life: Carbon: the Backbone of Life
BIOLOGY 101 CHAPTER 4: Carbon and the Molecular Diversity of Life: CONCEPTS: 4.1 Organic chemistry is the study of carbon compounds 4.2 Carbon atoms can form diverse molecules by bonding to four other
More informationICM-Chemist How-To Guide. Version 3.6-1g Last Updated 12/01/2009
ICM-Chemist How-To Guide Version 3.6-1g Last Updated 12/01/2009 ICM-Chemist HOW TO IMPORT, SKETCH AND EDIT CHEMICALS How to access the ICM Molecular Editor. 1. Click here 2. Start sketching How to sketch
More information12.1 The Nature of Organic molecules
12.1 The Nature of Organic molecules Organic chemistry: : The chemistry of carbon compounds. Carbon is tetravalent; it always form four bonds. Prentice Hall 2003 Chapter One 2 Organic molecules have covalent
More informationStructure and Reaction querying in Reaxys
Structure and Reaction querying in Reaxys A short history Dr. Jürgen Swienty-Busch, Derrick Umali April 5 2017 1 2 Agenda The History: where do we come from? The Present: Reaxys content today Indexing
More informationQSAR Modeling of ErbB1 Inhibitors Using Genetic Algorithm-Based Regression
APPLICATION NOTE QSAR Modeling of ErbB1 Inhibitors Using Genetic Algorithm-Based Regression GAINING EFFICIENCY IN QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS ErbB1 kinase is the cell-surface receptor
More informationOpen PHACTS Explorer: Compound by Name
Open PHACTS Explorer: Compound by Name This document is a tutorial for obtaining compound information in Open PHACTS Explorer (explorer.openphacts.org). Features: One-click access to integrated compound
More informationAlkyl phenyl ketones are usually named by adding the acyl group as prefix to phenone.
Aldehydes, Ketones and Carboxylic Acids Nomenclature of aldehydes and ketones Aldehydes: Often called by their common names instead of IUPAC names. Ketones: Derived by naming two alkyl or aryl groups bonded
More informationApplication Note. U. Heat of Formation of Ethyl Alcohol and Dimethyl Ether. Introduction
Application Note U. Introduction The molecular builder (Molecular Builder) is part of the MEDEA standard suite of building tools. This tutorial provides an overview of the Molecular Builder s basic functionality.
More informationThe Case for Use Cases
The Case for Use Cases The integration of internal and external chemical information is a vital and complex activity for the pharmaceutical industry. David Walsh, Grail Entropix Ltd Costs of Integrating
More informationFundamentals of Organic Chemistry
Fundamentals of Organic Chemistry CHEM 109 For Students of Health Colleges Credit hrs.: (2+1) King Saud University College of Science, Chemistry Department CHEM 109 CHAPTER 3. AROMATIC HYDROCARBONS Aromatic
More informationName Date Class. aryl halides substitution reaction
23.1 INTRODUCTION TO FUNCTIONAL GROUPS Section Review Objectives Explain how organic compounds are classified Identify the IUPAC rules for naming halocarbons Describe how halocarbons can be prepared Vocabulary
More informationUNIT 4 REVISION CHECKLIST CHEM 4 AS Chemistry
UNIT 4 REVISION CHECKLIST CHEM 4 AS Chemistry Topic 4.1 Kinetics a) Define the terms: rate of a reaction, rate constant, order of reaction and overall order of reaction b) Deduce the orders of reaction
More informationOrganic Chemistry. Organic chemistry is the chemistry of compounds containing carbon.
Organic Chemistry Organic Chemistry Organic chemistry is the chemistry of compounds containing carbon. In this chapter we will discuss the structural features of organic molecules, nomenclature, and a
More informationDiscoveryGate. One place for the answers you need. Chulalongkorn University, Thailand
DiscoveryGate One place for the answers you need Chulalongkorn University, Thailand Presented by: Doreen Tan Title: Product Sales Manager, Life Science Date: 1 Sep 2005 DiscoveryGate The DiscoveryGate
More informationORGANIC CHEMISTRY. Classification of organic compounds
ORGANIC CHEMISTRY Organic chemistry is very important branch of chemistry and it study the compounds which contain carbon (C) and hydrogen (H), in general, and may contains other atoms such as oxygen (O),
More informationMSC. ISMAIL M.ALI DEPARTMENT OF CHEMICAL ENGINEEING COLLEGE OF ENGINEERING TIKRIT UNIVERSITY
LECTURE 1 SYLLABUS FOR FIRST CLASS 2013-2014 MSC. ISMAIL M.ALI DEPARTMENT OF CHEMICAL ENGINEEING COLLEGE OF ENGINEERING TIKRIT UNIVERSITY MANDATORY CLASS: 1ST ORGANIC CHEMISTRY CH 122 Teaching scheme:
More informationA stand alone calculator (not part of your cell phone) (preferably a scientific calculator).
COMMUNITY COLLEGE of RHODE ISLAND Chemistry Department Course Information Package CHEM-1000, Chemistry of Our Environment Section 001 T, Th; 9:00 10:25 Lecture, Room 3046 T 1:00 3:50 Lab (Room 3046) Spring,
More informationOFFICE Room 3268; Tel Chemistry for Changing Times, 14 th Edition, -- Fourth Custom Edition for CCRI - by Hill and McCreary Other Supplies
COMMUNITY COLLEGE of RHODE ISLAND Chemistry Department Course Information Package CHEM-1000, Chemistry of Our Environment Section 001 T, Th; 9:00 10:25 Lecture, Room 3046 T 1:00 3:50 Lab (Room 3046) Spring,
More informationPipeline Pilot Integration
Scientific & technical Presentation Pipeline Pilot Integration Szilárd Dóránt July 2009 The Component Collection: Quick facts Provides access to ChemAxon tools from Pipeline Pilot Free of charge Open source
More informationChapter 25. Organic and Biological Chemistry. Organic and
Chapter 25 Calculate grade: (Add exam1 - exam 4 scores)x1.5 Add 7 best quizzes (each quiz is worth 29) Gives you the # points you have so far. Final (worth 200 points) Grades: 800-4 750-3.5 700-3 650-2.5
More informationHow to add your reactions to generate a Chemistry Space in KNIME
How to add your reactions to generate a Chemistry Space in KNIME Introduction to CoLibri This tutorial is supposed to show how normal drawings of reactions can be easily edited to yield precise reaction
More informationChemistry 1110 Exam 4 Study Guide
Chapter 10 Chemistry 1110 Exam 4 Study Guide 10.1 Know that unstable nuclei can undergo radioactive decay. Identify alpha particles, beta particles, and/or gamma rays based on physical properties such
More informationDEPARTMENT OF CHEMISTRY KHEMUNDI COLLEGE, DIGAPAHANDI; GANJAM Course Objective and Course Outcome
1 DEPARTMENT OF CHEMISTRY KHEMUNDI COLLEGE, DIGAPAHANDI; GANJAM Course Objective and Course Outcome Class: BSc Semester: 1st B.sc. Semester -I (C-1 Inorganic chemistry-1) To make students to know about
More informationبه نام خدا. New topics in. organic chemistry. Dr Morteza Mehrdad University of Guilan, Department of Chemistry, Rasht, Iran
به نام خدا New topics in 2 organic chemistry Dr Morteza Mehrdad University of Guilan, Department of Chemistry, Rasht, Iran m-mehrdad@guilan.ac.ir Combinatorial chemistry 1 http://www.combichemistry.com/
More informationSciFinder Premier CAS solutions to explore all chemistry MethodsNow, PatentPak, ChemZent, SciFinder n
ACS International Ltd vhyttinen@cas.org SciFinder Premier CAS solutions to explore all chemistry MethodsNow, PatentPak, ChemZent, SciFinder n Veli-Pekka Hyttinen May 23, 2018 CAS Hyttinen CAS supports
More informationScience of Synthesis Guided Examples
Science of Synthesis Guided Examples 1 Science of Synthesis Guided Examples Compiled by: Dr. Thomas Krimmer Table of Contents 1 Exact Structure Search...2 2 Houben-Weyl...5 3 Reaction Search...6 4 Outbound
More informationOECD QSAR Toolbox v.4.1. Tutorial on how to predict Skin sensitization potential taking into account alert performance
OECD QSAR Toolbox v.4.1 Tutorial on how to predict Skin sensitization potential taking into account alert performance Outlook Background Objectives Specific Aims Read across and analogue approach The exercise
More informationORGANIC CHEMISTRY. Fifth Edition. Stanley H. Pine
ORGANIC CHEMISTRY Fifth Edition Stanley H. Pine Professor of Chemistry California State University, Los Angeles McGraw-Hill, Inc. New York St. Louis San Francisco Auckland Bogota Caracas Lisbon London
More informationIR, MS, UV, NMR SPECTROSCOPY
CHEMISTRY 318 IR, MS, UV, NMR SPECTROSCOPY PROBLEM SET All Sections CHEMISTRY 318 IR, MS, UV, NMR SPECTROSCOPY PROBLEM SET General Instructions for the 318 Spectroscopy Problem Set Consult the Lab Manual,
More informationKeynotes in Organic Chemistry
Keynotes in Organic Chemistry Second Edition ANDREW F. PARSONS Department of Chemistry, University of York, UK Wiley Contents Preface xi 1 Structure and bonding 1 1.1 Ionic versus covalent bonds 1 1.2
More informationOrganic Chemistry. Unit 10
Organic Chemistry Unit 10 Halides Primary Carbons Secondary Carbons Tertiary Carbons IMPORTANCE?? REACTIONS!! Benzene C6H6 Aromatic functional group - C6H5 (IUPAC name - phenyl) Substitution Reactions
More informationUnit 7 ~ Learning Guide Name:
Unit 7 ~ Learning Guide : Instructions: Using a pencil, complete the following notes as you work through the related lessons. Show ALL work as is explained in the lessons. You are required to have this
More informationUNIT 1: BIOCHEMISTRY
UNIT 1: BIOCHEMISTRY UNIT 1: Biochemistry Chapter 6.1: Chemistry of Life I. Atoms, Ions, and Molecules A. Living things consist of atoms of different elements 1. An atom is the smallest basic unit of matter
More informationChapter 15 Reactions of Aromatic Compounds
Chapter 15 1 Chapter 15 Reactions of Aromatic Compounds Electrophilic Aromatic Substitution Arene (Ar-H) is the generic term for an aromatic hydrocarbon The aryl group (Ar) is derived by removal of a hydrogen
More information2/25/2013. Electronic Configurations
1 2 3 4 5 Chapter 2 Chemical Principles The Structure of Atoms Chemistry is the study of interactions between atoms and molecules The atom is the smallest unit of matter that enters into chemical reactions
More information