Antibiotic Resistance in Enterobacteriaceae
|
|
|
- Margery Mitchell
- 6 years ago
- Views:
Transcription
1 Antibiotic Resistance in Enterobacteriaceae Prof. P. Nordmann 16 es JNI, Nancy, du 10 au 12 juin
2 16 es JNI, Nancy, du 10 au 12 juin 2015
3 16 es JNI, Nancy, du 10 au 12 juin 2015
4 16 es JNI, Nancy, du 10 au 12 juin 2015
5 Main microbial pathogens for humans Gram positives Staphylococcus Gram negatives Enterobacteriaceae (E. coli, K.pneumoniae ) Pseudomonas aeruginosa Enterococcus, Streptococcus Acinetobacter baumannii 16 es JNI, Nancy, du 10 au 12 juin 2015
6 Emerging resistance threats, CDC USA-2014 Enterobacteriaceae producing extended-spectrum β-lactamases (ESBL) Multi-resistant Staphylococcus aureus Urgent threat Serious threat Possible threat Carbapenem-resistant Enterobacteriaceae Antibiotic resistant Mycobacterium tuberculosis 16 es JNI, Nancy, du 10 au 12 juin 2015
7 Extended-spectrum ß-lactamases (ESBL) Penicillin/Amino-penicillins Penicillin G Ureido-penicillins Ticarcillin 1/2nd generation cephalosporins Cefazolin 3 rd generation cephalosporins Ceftriaxone 4/5thgeneration cephalosporins Cefepime Ampicillin Amoxicillin Piperacillin Cefuroxime Ceftazidime Ceftaroline ESBL: increasing resistance towards beta-lactam antibiotics 16 es JNI, Nancy, du 10 au 12 juin 2015
8 Multidrug resistance of ESBL-producing Escherichia coli 16 es JNI, Nancy, du 10 au 12 juin 2015 ß-Lactams Non- ß-lactams
9 16 es JNI, Nancy, du 10 au 12 juin 2015
10 Resistance to expanded-spectrum cephalosporins. Infections. Enterobacteriaceae in Europe 2005 E.coli K. pneumoniae es JNI, Nancy, du 10 au 12 juin 2015
11 ESBL prevalence in E. coli and K. pneumoniae Low prevalence Intermediate prevalence High prevalence 16 es JNI, Nancy, du 10 au 12 juin 2015 Hawser et al ; Rhomberg et al ; Bell et al ; Gagliotti et al. 2011
12 Enterobactericeae ESBL (+) in France in 2012 (n=50,378) ESBL Prevalence (%) Courtesy R. Bonnet 16 es JNI, Nancy, du 10 au 12 juin 2015
13 E. coli from bloodstream infections: turning nasty Fluoroquinolones: 2001/13 16 es JNI, Nancy, du 10 au 12 juin rd Generation cephalosporins: 2001/13
14 Treatment of infections due to ESBL producers Activity spectrum + in-vitro activity spectrum+ co-resistances Urinary infections (per os) Sepsis )IV) Amino, ureidopencillins Amoxicillin/clav Piperacilline/Tazobactam Cephalosporines 3/4 th generations Carbapenem Aminoglycosides Quinolones/Fluoroquinolones Trimethoprim/Sulfamethoxazole Colistin Tigecycline Fosfomycin/Nitrofuarantoine 16 es JNI, Nancy, du 10 au 12 juin 2015
15 Day 14 mortality per antibiotic class for bloostream infections due to ESBL producers Paterson 16 es et JNI, al., Nancy, CID, du au 12 juin 2015
16 16 es JNI, Nancy, du 10 au 12 juin 2015
17 Broad-spectrum ß-lactamases in gram negatives Penicillins Cephalosporins Carbapenems Extended-spectrum ß-lactamases (ESBL); CTX-M Carbapenemases: NDM, KPC, OXA es JNI, Nancy, du 10 au 12 juin 2015
18 Emergence of carbapenemases in Enterobacteriaceae KPC Klebsiella pneumoniae OXA-48 Klebsiella pneumoniae NDM-1 Klebsiella pneumoniae NmcA Enterobacter cloacae IMP-1 Serratia marcescens 2004 FRANCE (TURKEY) Poirel, Heritier, Tolün, Nordmann AAC 2004 : 48: SWEDEN (INDIA) Yong, Toleman, Giske, Cho, Sundman, Lee, Walsh AAC 2009 : 53: es JNI, Nancy, du 10 au 12 juin 2015
19 16 es JNI, Nancy, du 10 au 12 juin 2015
20 16 es JNI, Nancy, du 10 au 12 juin 2015
21 16 es JNI, Nancy, du 10 au 12 juin 2015 K. pneumoniae
22 16 es JNI, Nancy, du 10 au 12 juin 2015 The importance of E.coli
23 16 es JNI, Nancy, du 10 au 12 juin 2015
24 Carbapenemase producers in France Selection criteria ; ertapenem 1 mg/l imipenem meropenem 4mg/L ertapenem 16 es JNI, Nancy, du 10 au 12 juin 2015
25 Episodes d EPC, France, , par mois de signalement Bilan au 04 septembre 2014 (N= 1210 épisodes) E. coli; 28% 1210 épisodes au total 2009 : 10, 2010 : 28, 2011 : 113, 2012 : 233, 2013 : 405, 2014 : es JNI, Nancy, du 10 au 12 juin 2015
26 Carbapenemase producers in Enterobacteriaceae- France- Antibiotic Resistance Reference Center Species n K. pneumoniae 410 E. coli 116 E. cloacae % 1.4% 2.8% 4.6% K. pneumoniae E. coli E. cloacae Enterobacter spp. Citrobacter spp. Autres Enterobacter spp. 9 Citrobacter spp. 24 Autres 26 Total % 64.5% 16 es JNI, Nancy, du 10 au 12 juin 2015 X 3 in 2 years of time P. Nordmann, personal and unpublished data
27 16 es JNI, Nancy, du 10 au 12 juin 2015 Carbapenemases in the community
28 16 es JNI, Nancy, du 10 au 12 juin 2015
29 16 es JNI, Nancy, du 10 au 12 juin 2015 Carbapenemase producers, France: the future
30 16 es JNI, Nancy, du 10 au 12 juin 2015 The impact of carbapenemase producers in the USA
31 16 es JNI, Nancy, du 10 au 12 juin 2015
32 16 es JNI, Nancy, du 10 au 12 juin 2015 Kp KPC-2
33 Fighting back against antibiotic resistance Four Core Actions to Prevent Antibiotic Resistance 1. Preventing infections, preventing the spread of resistance 4.Developing novel diagnostic tests and new drugs 2. Tracking 3. Improving antibiotic prescription/stewardship 16 es JNI, Nancy, du 10 au 12 juin 2015
Toronto General Hospital ANTIBIOGRAM Emergency Department January 1, December 31, 2016
IV (meningitis) IV (non-meningitis) (meningitis) (non-meningitis) Blood Isolates % Susceptible 644 18 36 70 78 74 59 69 75 262 100 19 64 75 100 92 54 72 78 76 68 89 86 99 Escherichia coli 153 58 30 67
Why the CDS? The unique advantages of using an Australian antimicrobial susceptibility testing method
Why the CDS? The unique advantages of using an Australian antimicrobial susceptibility testing method Peter Newton Medical Microbiologist Wollongong Hospital, Wollongong, NSW Where do I come from? SEALS
EUCAST Expert Rules Version 3.1. Intrinsic Resistance and Exceptional Phenotypes Tables
EUCAST Expert s Version 3.1 Intrinsic Resistance and Exceptional Phenotypes Tables EUCAST Expert s version 2.0 was published on 29 October 2011(http://www.eucast.org/expert_rules). The expert rules have
Most common dose (mg) 1g x 1 1g x 1 1g x 1 1g x 1 1g x 1 1g x 1. Maximum dose schedule (mg) 1g x 1 1g x 1 1g x 1 1g x 1 1g x 1 1g x 1
Ertapenem Rationale for the EUCAST clinical breakpoints, version 1.3 1 st June 2009 Introduction Ertapenem is a carbapenem, available only for parenteral use. Ertapenem is relevant for therapy of septicaemia,
Antimicrobial Activities of Ceftazidime/Avibactam and Comparator Agents against Clinical. Bacteria Isolated from Patients with Cancer.
AAC Accepted Manuscript Posted Online 23 January 2017 Antimicrob. Agents Chemother. doi:10.1128/aac.02106-16 Copyright 2017 American Society for Microbiology. All Rights Reserved. 1 2 Antimicrobial Activities
Validation of EUCAST zone diameter breakpoints against reference broth microdilution
ORIGINAL ARTICLE BACTERIOLOGY Validation of EUCAST zone diameter breakpoints against reference broth microdilution S. Bengtsson 1, C. Bjelkenbrant 1 and G. Kahlmeter 1,2 1) Department of Clinical Microbiology,
The Genetic Epidemiology of Antibiotic Resistance
The Genetic Epidemiology of Antibiotic Resistance Professor Neil Woodford Antimicrobial Resistance & Healthcare Associated Infections (AMRHAI) Reference Unit Crown copyright The forensics of AMR Resistance
Increasing Carbapenem-Resistant Gram-Negative Bacilli and Decreasing Metallo-β-Lactamase Producers over Eight Years from Korea
Brief Communication http://dx.doi.org/10.3349/ymj.2015.56.2.572 pissn: 0513-5796, eissn: 1976437 Yonsei Med J 56(2):572-577, 2015 Increasing Carbapenem-Resistant Gram-Negative Bacilli and Decreasing Metallo-β-Lactamase
Phenotypic and Molecular Characteristics of Carbapenem-Non-Susceptible Enterobacteriaceae from a Teaching Hospital in Wenzhou, Southern China
Jpn. J. Infect. Dis., 66, 96-102, 2013 Original Article Phenotypic and Molecular Characteristics of Carbapenem-Non-Susceptible Enterobacteriaceae from a Teaching Hospital in Wenzhou, Southern China Tieli
Implementation of Public Health Surveillance of Carbapenemase- Producing Enterobacteriaceae in Victoria, Australia
Implementation of Public Health Surveillance of Carbapenemase- Producing Enterobacteriaceae in Victoria, Australia C.R. Lane*, J. Brett, M.B. Schultz, K. Stevens, A. van Diemen, S.A. Ballard, N.L. Sherry,
Value of the Modified Hodge test for detection of emerging. carbapenemases in Enterobacteriaceae
JCM Accepts, published online ahead of print on 23 November 2011 J. Clin. Microbiol. doi:10.1128/jcm.05247-11 Copyright 2011, American Society for Microbiology and/or the Listed Authors/Institutions. All
«Minor» ESBLs T. NAASN AAS, Microbiology department (P. Nordmann) Bicêtre hospital, South Paris Medical School France CENTRE HOSPITALIER
CENTRE HOSPITALIER UNIVERSITAIR E BICÊTRE «Minor» ESBLs T. NAASN AAS, Microbiology department (P. Nordmann) Bicêtre hospital, South Paris Medical School France ß-lactamases Serine b-lactamases Metallo
μ gyra parc Escherichia coli Klebsiella pneumoniae Pseudomonas aeruginosa E. coli gyra E. coli parc gyra parc gyra Escherichia coli E. coli E.
gyra parc Escherichia coli Klebsiella pneumoniae Pseudomonas aeruginosa E. coli μ E. coli gyra parc gyra parc gyra parc μ μ gyra parc Key words Escherichia coli gyra parc Escherichia coli E. coli gyra
Gentamicin Rationale for the EUCAST clinical breakpoints, version th February, 2009
Gentamicin Rationale for the EUCAST clinical breakpoints, version 1.2 16 th February, 2009 Introduction The aminoglycosides are a group of naturally occurring or semi-synthetic compounds with bactericidal
Detection of carbapenemase producers in Enterobacteriaceae. using a novel screening medium
JCM Accepts, published online ahead of print on 22 February 2012 J. Clin. Microbiol. doi:10.1128/jcm.06477-11 Copyright 2012, American Society for Microbiology. All Rights Reserved. 1 2 Detection of carbapenemase
Multicenter Comparison of In Vitro Activities of FK-037, Cefepime, Ceftriaxone, Ceftazidime, and Cefuroxime
ANTIMICROBiAL AGENTS AND CHEMOTHERAPY, Aug. 3, p. 6-66-/93/6-5$./ Copyright 3, American Society for Microbiology Vol. 3, No. Multicenter Comparison of In Vitro Activities of,,,, and J. A. WASHINGTON,"*
A multicenter surveillance of antimicrobial resistance in Serratia marcescens in Taiwan
Journal of Microbiology, Immunology and Infection (2014) 47, 387e393 Available online at www.sciencedirect.com journal homepage: www.e-jmii.com ORIGINAL ARTICLE A multicenter surveillance of antimicrobial
Most common dose (mg) 1 g x 3 1 g x mg -1.0 g x 3 1 g x mg -1 g x mg -1 g x 3
Meropenem Rationale for the EUCAST clinical breakpoints, version 1.5 1 st June 2009 Introduction Meropenem is a carbapenem, available only for parenteral use. Meropenem is relevant for therapy of septicaemia,
Stability. Received for publication 1 August to be fl-lactamase-producing strains.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Apr. 1978, p. 584-588 0066-4804/78/0013-0584$02.00/0 Copyright X) 1978 American Society for Microbiology Vol. 13, No. 4 Printed in U.S.A. Cefaclor: In Vitro Spectrum
REVIEW. Extended-spectrum b-lactamases and the permeability barrier
REVIEW Extended-spectrum b-lactamases and the permeability barrier L. Martínez-Martínez Service of Microbiology, University Hospital Marqués de Valdecilla, Santander, Spain ABSTRACT The outer membrane
AAC Accepts, published online ahead of print on 20 August 2007 Antimicrob. Agents Chemother. doi: /aac
AAC Accepts, published online ahead of print on 20 August 2007 Antimicrob. Agents Chemother. doi:10.1128/aac.00614-07 Copyright 2007, American Society for Microbiology and/or the Listed Authors/Institutions.
ESCMID Online Lecture Library
E. coli producing extendedspectrum β lactamases Luis Martínez Martínez Dept. Molecular Biology, University of Cantabria Service of Microbiology Hosp. Univ. Marqués de Valdecilla Santander, Spain Barcelona
Nitroxoline Rationale for the NAK clinical breakpoints, version th October 2013
Nitroxoline Rationale for the NAK clinical breakpoints, version 1.0 4 th October 2013 Foreword NAK The German Antimicrobial Susceptibility Testing Committee (NAK - Nationales Antibiotika-Sensitivitätstest
Ian Morrissey, 1 Samuel K. Bouchillon, 2 Meredith Hackel, 2 Douglas J. Biedenbach, 2 Stephen Hawser, 1 Daryl Hoban 2 and Robert E.
Journal of Medical Microbiology (2014), 63, 556 561 DOI 10.1099/jmm.0.068981-0 Evaluation of the Clinical and Laboratory Standards Institute phenotypic confirmatory test to detect the presence of extended-spectrum
by author ESCMID Online Lecture Library Epidemiological cutoff values (ECOFFs) and Low Level resistance Gunnar Kahlmeter
Epidemiological cutoff values (ECOFFs) and Low Level resistance ECCMID 2010 Gunnar Kahlmeter Sweden Gunnar.Kahlmeter@ltkronoberg.se The epidemiological cutoff value ECOFF When breakpoints fail to detect
Research Article Evaluation of Verigene Blood Culture Test Systems for Rapid Identification of Positive Blood Cultures
BioMed Volume 2016, Article ID 1081536, 6 pages http://dx.doi.org/10.1155/2016/1081536 Research Article Evaluation of Verigene Blood Culture Test Systems for Rapid Identification of Positive Blood Cultures
ACCEPTED. *Corresponding author. Mailing address: Faculdade de Medicina Veterinária, Av. da
AAC Accepts, published online ahead of print on 10 November 2008 Antimicrob. Agents Chemother. doi:10.1128/aac.00896-08 Copyright 2008, American Society for Microbiology and/or the Listed Authors/Institutions.
STUDY ABOUT ANTIBIOTIC RESISTANCE IN SERRATIA SPP. ISOLATED FROM HOSPITALIZED PATIENTS
Bulletin of the Transilvania University of Braşov Series VI: Medical Sciences Vol. 7 (56) No. 1-2014 STUDY ABOUT ANTIBIOTIC RESISTANCE IN SERRATIA SPP. ISOLATED FROM HOSPITALIZED PATIENTS Mihaela Elena
BMR nouveaux antibiotiques Dubreuil, PhD, PharmD - LIRIC UMR 995 Inserm/Université Lille France
BMR nouveaux antibiotiques Dubreuil, PhD, PharmD - LIRIC UMR 995 Inserm/Université Lille France Lille Octobre 2016 Bad bugs need new drug MRSA LIRIC UMR 995 Dubreuil L S. pneumoniae SFM Mars 2016 Adverse
ANTIBACTERIAL GRAPHENE OXIDE AND METAL PARTICLES NANOCOMPOSITES FOR INHIBITION OF PATHOGENIC BACTERIA STRAINS
21 st International Conference on Composite Materials Xi an, 20-25 th August 2017 ANTIBACTERIAL GRAPHENE OXIDE AND METAL PARTICLES NANOCOMPOSITES FOR INHIBITION OF PATHOGENIC BACTERIA STRAINS Virginija
Comparison of cefotiam and cefazolin activity against Gram-negative bacilli
Journal of Antimicrobial Chemotherapy (1979) 5, 681-685 Comparison of cefotiam and cefazolin activity against Gram-negative bacilli Michio Ogawa, Masayoshi Hama, Goro Kosaki Second Department of Surgery,
INTERPRETATION OF THE GRAM STAIN
INTERPRETATION OF THE GRAM STAIN DISCLOSURE Relevant relationships with commercial entities none Potential for conflicts of interest within this presentation none Steps taken to review and mitigate potential
Tetracycline Rationale for the EUCAST clinical breakpoints, version th November 2009
Tetracycline Rationale for the EUCAST clinical breakpoints, version 1.0 20 th November 2009 Introduction The natural tetracyclines, including tetracycline, chlortetracycline, oxytetracycline and demethylchlortetracycline
Rapid detection of extended-spectrum ß-lactamase-producing. Enterobacteriaceae
JCM Accepts, published online ahead of print on 3 July 2012 J. Clin. Microbiol. doi:10.1128/jcm.00859-12 Copyright 2012, American Society for Microbiology. All Rights Reserved. 1 2 Rapid detection of extended-spectrum
Pseudomonas putida 5
Pseudomonas putida 1 1 2 1 2 1 2 14 1 8 14 12 16 1997 1 21 12 5 Pseudomonas putida 8 27 imipenemipm IPM piperacillinceftazidimeamikacin norfloxacin 27 IPM IMP blaimp P. putida blaimp 27 8 9 4 1 MIC P.
Comparative evaluation of the VITEK 2 Advanced Expert System (AES) in five UK hospitals
Journal of Antimicrobial Chemotherapy (2003) 51, 1191 1202 DOI: 10.1093/jac/dkg234 Advance Access publication 14 April 2003 Comparative evaluation of the VITEK 2 Advanced Expert System (AES) in five UK
New Delhi Metallo-Beta-Lactamase- Producing Enterobacteriaceae in. South Korea Between 2010 and 2015 INTRODUCTION
ORIGINAL RESEARCH published: 29 March 2018 doi: 10.3389/fmicb.2018.00571 New Delhi Metallo-Beta-Lactamase- Producing Enterobacteriaceae in South Korea Between 2010 and 2015 Eun-JeongYoon 1,DaYoungKang
Received 3 April 2002; returned 19 August 2002; revised 4 November 2002; accepted 25 November 2002
Journal of Antimicrobial Chemotherapy (2003) 51, 631 638 DOI: 10.1093/jac/dkg103 Advance Access publication 11 February 2003 Production of CTX-M-3 extended-spectrum β-lactamase and IMP-1 metallo β-lactamase
Product Catalogue 2015 Clinical and Industrial Microbiology
Acinetobacter baumannii ATCC BAA-747 * 89141 Actinomyces odontolyticus ATCC 17929 * 89114 Aeromonas hydrophila ATCC 7966 * 89119 Aggregatibacter aphrophilus ATCC 7901 * 89091 Aspergillus brasiliensis ATCC
By Eliza Bielak Bacterial Genomics and Epidemiology, DTU-Food Supervised by Henrik Hasman, PhD
By Eliza Bielak Bacterial Genomics and Epidemiology, DTU-Food elibi@food.dtu.dk Supervised by Henrik Hasman, PhD 1. Introduction to plasmid biology 2. Plasmid encoded resistance to β- lactams (basic theories)
Three Steps to Antibiotic Resistance?
Three Steps to Antibiotic Resistance? The Development of Tigecycline Resistance in the Gram-Negative Bacteria Escherichia coli and Salmonella typhimurium Minna-Maria Neuvonen Degree project in biology,
ªÕ Õ μ ÈÕ π ßæ πºÿâ À à Àμÿ «ÿ Õß ÈÕμàÕ ªØ «π à«ßªï æ.» ßæ ÿ Æ å π
π«ÿ ««ÿ ªï Ë 7 Ë 2.-. 2556 π æπ åμâπ ªÕ Õ μ ÈÕ π ßæ πºÿâ À à Àμÿ «ÿ Õß ÈÕμàÕ ªØ «π à«ßªï æ.». 2554-2555 ßæ ÿ Æ å π μ ÿ * ƒ å ªí «π * Õ Ÿ Õ ÿ * ««â«õß* æß»åæ» * «π μ À ** àõ ªÕ Õ μ ÈÕ π ßæ ªìπÀπ Ëß πªí
by author What is new in EUCAST?
What is new in EUCAST? Christian G. Giske, MD/PhD Chair of EUCAST Chief consultant physician/assoc. professor Karolinska Institutet and Karolinska University Hospital ECCMID 2018, Madrid EUCAST SC 2018
Bile Chrysoidin Glycerol Agar with MUG
INSTRUCTIONS FOR USE READY-TO-USE PLATED MEDIA PA-257430.04 Rev.: Mar 2013 Bile Chrysoidin Glycerol Agar with MUG INTENDED USE Partially selective medium for the isolation and differentiation of Enterobacteriaceae
Alita Miller, PhD. Head of BioScience. April 24, 2017 ECCMID 2017 Vienna, Austria
ETX5 restoration of sulbactam activity against multidrug resistant Acinetobacter baumannii correlates with β-lactamase inhibition in vitro and in vivo Alita Miller, PhD Head of BioScience April, 07 ECCMID
ENTEROBACTER AEROGENES UNKNOWN BACTERIA FLOW CHART UNKNOWN LAB REPORT, MICROBIOLOGY ENTEROBACTER AEROGENES
ENTEROBACTER AEROGENES UNKNOWN BACTERIA PDF UNKNOWN LAB REPORT, MICROBIOLOGY ENTEROBACTER AEROGENES IDENTIFICATION OF AN UNKNOWN BACTERIAL SPECIES OF 1 / 5 2 / 5 3 / 5 enterobacter aerogenes unknown bacteria
Involvement of efflux pumps in the resistance to peptidoglycan synthesis
AAC Accepts, published online ahead of print on January 0 Antimicrob. Agents Chemother. doi:0./aac.0- Copyright 0, American Society for Microbiology. All Rights Reserved. Involvement of efflux pumps in
Genomic characteristics of NDM-producing Enterobacteriaceae in
AAC Accepted Manuscript Posted Online 19 October 2015 Antimicrob. Agents Chemother. doi:10.1128/aac.01243-15 Copyright 2015, American Society for Microbiology. All Rights Reserved. 1 2 3 Genomic characteristics
Escherichia coli O26 9
15 Vero b- (ESBL) Escherichia coli O26 1 1) 1) 2) 2) 2) 2) 3) 3) 1) 1) 2) 2 3) 16 10 18 16 12 17 Vero b- (Extended-spectrum b-lactamase: ESBL) Escherichia coli O26 9 2004 6 14 16 E. coli O O26 Vero VT1
Product Catalogue 2016 Clinical and Industrial Microbiology
Acinetobacter baumannii ATCC BAA-747 * 89141 Acinetobacter baumannii ATCC 19606 * 89174 Actinomyces odontolyticus ATCC 17929 * 89114 Aeromonas hydrophila ATCC 7966 * 89119 Aeromonas hydrophila ATCC 35654
Resistance to third-generation cephalosporins in human non-typhoidal Salmonella enterica isolates from England and Wales,
Royal College of Surgeons in Ireland e-publications@rcsi Clinical Microbiology Articles Department of Clinical Microbiology 1-4-2014 Resistance to third-generation cephalosporins in human non-typhoidal
Microbial pollutants in stagnant water in an informal settlement in the Western Cape, South Africa
Microbial pollutants in stagnant water in an informal settlement in the Western Cape, South Africa Qenehelo A. Leuta, James P. Odendaal and Arnelia N. Paulse Department of Environmental and Occupational
Mechanisms of colistin resistance in Gram negative bacteria
Mechanisms of colistin resistance in Gram negative bacteria BARON Sophie Interne en biologie médicale 2 st year PhD student Supervisor: ROLAIN Jean-Marc I. Increase of antibiotic resistance. Introduction
Novel antibiotics from symbiotic peptides
HU-NO Research conference and Knowledge exchange 15.02.2018 Novel antibiotics from symbiotic peptides Eva Kondorosi Biological Research Centre Hungarian Academy of Sciences Medicago truncatula-sinorhizobium
Efflux Mechanisms of Fluoroquinolones and β-lactams
Efflux Mechanisms of Fluoroquinolones and β-lactams Paul M. Tulkens, MD, PhD Françoise Van Bambeke, PharmD, PhD Cellular and Molecular Pharmacology Unit Catholic University of Louvain, Brussels, Belgium
Structural and biochemical investigation of Metallo-β-lactamases; Insights into the antibiotic binding sites
FACULTY OF HEALTH SCIENCES DEPARTMENT OF MEDICAL BIOLOGY UNIVERSITY HOSPITAL OF NORTH NORWAY DEPARTMENT OF MICROBIOLOGY AND INFECTION CONTROL REFERENCE CENTRE FOR DETECTION OF ANTIMICROBIAL RESISTANCE
Antibiotic resistance by efflux: from molecular aspects to cinical impact
16-09-2013 University of Notre-Dame, Notre Dame, IN 1 Antibiotic resistance by efflux: from molecular aspects to cinical impact Françoise Van Bambeke & Paul M. Tulkens Pharmacologie cellulaire et moléculaire
Efficient. Colours. Cost. Intense. Dehydrated Media. The Widest Range of Chromogenic Media For Colourful Microbial Detection O F INNOVAT ION YEARS
General Brochure YEARS Cost Efficient ESBL KPC C. difficile O F INNOVAT ION S INCE 1979 Campylobacter Listeria Salmonella Intense Colours E. coli E. coli O157 B. cereus S. aureus MRSA VRE Pseudomonas Cronobacter
Tested Against Tigecycline and Agents Commonly Used for S. maltophilia Infections. David J. Farrell 1*, Helio S. Sader 1,2. and. Ronald N.
AAC Accepts, published online ahead of print on 5 April 2010 Antimicrob. Agents Chemother. doi:10.1128/aac.01774-09 Copyright 2010, American Society for Microbiology and/or the Listed Authors/Institutions.
REDUCING BACTERIAL RESISTANCE THROUGH BETTER ANTIBIOTIC PRESCRIPTION PRACTICES
Virginia Commonwealth University VCU Scholars Compass Theses and Dissertations Graduate School 2008 REDUCING BACTERIAL RESISTANCE THROUGH BETTER ANTIBIOTIC PRESCRIPTION PRACTICES Christine Ouma Virginia
Antibiotic resistance: a real and present danger in our hospitals
Antibiotic resistance: a real and present danger in our hospitals http://www.latimes.com/business/la-fi-hospital-infections-20150218-story.html#page=1 2 The search for new antibacterials HTS based on genetically
Low intestinal colonization of Escherichia coli clone ST131 producing CTX-M-15 in Jordanian infants
Journal of Medical Microbiology (2016), 65, 137 141 DOI 10.1099/jmm.0.000210 Low intestinal colonization of Escherichia coli clone ST131 producing CTX-M-15 in Jordanian infants E. F. Badran, 1 R. A. Qamer
acephamycins, a cephamycin, a carbapenem, and a monobactam. The effect of f-lactamase production on susceptibility
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Mar. 1989, p. 382-386 0066-4804/89/030382-05$02.00/0 Vol. 33, No. 3 Effects of r-lactamases and omp Mutation on Susceptibility to 3-Lactam Antibiotics in Escherichia
b-lactam resistance and b-lactamase expression in clinical Stenotrophomonas maltophilia isolates having defined phylogenetic relationships
Journal of Antimicrobial Chemotherapy Advance Access published December 13, 2005 Journal of Antimicrobial Chemotherapy doi:10.1093/jac/dki453 b-lactam resistance and b-lactamase expression in clinical
Resistance of Escherichia coli and Salmonella typhimurium to Carbenicillin
J. gen. Microbiol. (1969, 58, 301-305 Printed in Great Britain 301 Resistance of Escherichia coli and Salmonella typhimurium to Carbenicillin By H. C. NEU AND H. S,WARZ Department of Medicine, College
Antimicrobial Resistance in Haemophilus influenzae
CLINICAL MICROBIOLOGY REVIEWS, Apr. 2007, p. 368 389 Vol. 20, No. 2 0893-8512/07/$08.00 0 doi:10.1128/cmr.00040-06 Copyright 2007, American Society for Microbiology. All Rights Reserved. Antimicrobial
Evaluation of the Automated Phoenix System for Potential Routine Use in the Clinical Microbiology Laboratory
JOURNAL OF CLINICAL MICROBIOLOGY, Apr. 2004, p. 1542 1546 Vol. 42, No. 4 0095-1137/04/$08.00 0 DOI: 10.1128/JCM.42.4.1542 1546.2004 Copyright 2004, American Society for Microbiology. All Rights Reserved.
The Clinical Aspects of β-lactam-resistant Stenotrophomonas
Yonago Acta medica 2003;46:91 102 The Clinical Aspects of -Lactam-Resistant Stenotrophomonas maltophilia Daisuke Kataoka and Yoshinori Tanaka Division of Microbiology, Department of Microbiology and Pathology,
Report: antimicrobial resistance in commensal E. coli from poultry, pigs, cows and veal calves. 2014
CODA-CERVA Report: antimicrobial resistance in commensal E. coli from poultry, pigs, cows and veal calves. 2014 Vicky Jasson and Pierre Wattiau Veterinary and Agrochemical Research Centre 1 Introduction
European Committee forantimicrobial SusceptibilityTesting (EUCAST) of the European Society of Clinical Microbiologyand Infectious Diseases (ESCMID)
EUCAST DEFINITIVE DOCUMENT E.Def 3.1 JUNE 2000 Determination of minimum inhibitory concentrations (MICs) of antibacterial agents by agar dilution European Committee for SusceptibilityTesting (EUCAST) of
In vitro the effect of intestinal normal flora on some pathogenic bacteria.
In vitro the effect of intestinal normal flora on some pathogenic bacteria. Abstract: Dr.abbass shaker Ali adel Leena abd Al-Redha The effect of two types of intestinal bacterial normal floral ( and klebsiella)
Screening Extended-spectrum b-lactamase Production in Enterobacter cloacae and Serratia marcescens Using Antibiogram-based Methods
J Microbiol Immunol Infect 2010;43(1):26 34 Contents lists available at ScienceDirect Journal of Microbiology, Immunology and Infection Journal homepage: http://www.e-jmii.com Original Article Screening
Characterization of Class 1 Integrons and Antimicrobial Resistance in CTX-M-3-Producing Serratia marcescens Isolates from Southern Taiwan
Jpn. J. Infect. Dis., 60, 250-256, 2007 Original Article Characterization of Class 1 Integrons and Antimicrobial Resistance in CTX-M-3-Producing Serratia marcescens Isolates from Southern Taiwan Chien-Fang
MINIREVIEW. Growing Group of Extended-Spectrum -Lactamases: the CTX-M Enzymes. R. Bonnet*
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Jan. 2004, p. 1 14 Vol. 48, No. 1 0066-4804/04/$08.00 0 DOI: 10.1128/AAC.48.1.1 14.2004 MINIREVIEW Growing Group of Extended-Spectrum -Lactamases: the CTX-M Enzymes
Overview of the major bacterial pathogens The major bacterial pathogens are presented in this table:
Practical Microbiology 30/11/2018 University of Sulaimani college of Pharmacy Year2 Lab. 5: Overview of the major bacterial pathogens The major bacterial pathogens are presented in this table: Major Bacterial
Zoo Animals as Reservoirs of Gram-Negative Bacteria Harboring Integrons and Antimicrobial Resistance Genes
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Oct. 2007, p. 6686 6690 Vol. 73, No. 20 0099-2240/07/$08.00 0 doi:10.1128/aem.01054-07 Copyright 2007, American Society for Microbiology. All Rights Reserved. Zoo
_ + Discriminates aerobic organisms that produce catalase to degrade hydrogen peroxide into water and oxygen
Lab 11 Goals and Objectives: Catalase Test Exercise 39: Oxidation and Fermentation Tests (Catalase) Exercise 67: Staphylococci Identification (MSA & Coagulase) Exercise 68: Streptococci & Enterococci Identification
CEPHALOSPORIN. Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Kashima, Yodogawa-ku, Osaka 532, Japan
790 THE JOURNAL OF ANTIBIOTICS JULY 984 MECHANISM OF ACTION OF THE NEW ORALLY ACTIVE CEPHALOSPORIN FK07 YASUTAKA SHIGI, YOSHIMI MATSUMOTO, YOKO FUJISHITA and HITOSHI Ko o MAMIKO KAIZU, Research Laboratories,
Resistance plasmid families in Enterobacteriaceae
AAC Accepts, published online ahead of print on March 00 Antimicrob. Agents Chemother. doi:0./aac.00-0 Copyright 00, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights
Epidemiology and genetics of CTX-M extended-spectrum β-lactamases in Gram-negative bacteria
Critical Reviews in Microbiology, 2013; 39(1): 79 101 ISSN 1040-841X print/issn 1549-7828 online DOI: 10.3109/1040841X.2012.691460 REVIEW ARTICLE Epidemiology and genetics of CTX-M extended-spectrum β-lactamases
Reading guide. EUCAST disk diffusion method for antimicrobial susceptibility testing
Reading guide EUCAST disk diffusion method for antimicrobial susceptibility testing Version 3.0 April 2013 Modifications to EUCAST reading guide slide show Version Version 3.0 April 2013 Version 2.0 May
Reading guide. EUCAST disk diffusion method for antimicrobial susceptibility testing. Version 2.0 May 2012
Reading guide EUCAST disk diffusion method for antimicrobial susceptibility testing Version 2.0 May 2012 Modifications to EUCAST reading guide slide show Version Version 2.0 May 2012 Version 1.1 December
Factors involved in the enhanced efficacy against Gram-negative bacteria of fourth generation cephalosporins
Journal of Antimicrobial Chemotherapy (1992) 29, Suppl.,4. 1-6 Factors involved in the enhanced efficacy against Gram-negative bacteria of fourth generation cephalosporins Robert E. W. Hancock and Francis
Considerations with Antibiotic Therapy PART
Considerations with Antibiotic Therapy PART 1 The Wonderful World of Microbiology 1 Despite the promises of the household-products industry, almost every surface is covered in microorganisms almost all
AND DEVICES! HANDS, SURFACES ERADICATING EVIL GERMS FROM NASTY NORO, AND PSYCHO PSEUDO! DISINFECTING AGAINST MAD MRSA, Virox.
DISINFECTING AGAINST MAD MRSA, NASTY NORO, AND PSYCHO PSEUDO! Find out more about the epic AHP disinfectant battle at: www.virox.com/peroxigirl ERADICATING EVIL GERMS FROM HANDS, SURFACES AND DEVICES!
BIOL 3702L: MICROBIOLOGY LABORATORY SCHEDULE, SUMMER 2015
BIOL 3702L: MICROBIOLOGY LABORATORY SCHEDULE, SUMMER 2015 Week of May 18 th Introduction to the Microbiology Laboratory: Become familiar with the laboratory and its safety features Review safety rules
Gram negative bacilli
Gram negative bacilli 1-Enterobacteriaceae Gram negative bacilli-rods Enterobacteriaceae Are everywhere Part of normal flora of humans and most animals They are cause of -30-35% septisemia -more than 70%
THE BIOLOGY OF ANTIBIOTIC RESISTANCE PLASMIDS
THE BIOLOGY OF ANTIBIOTIC RESISTANCE PLASMIDS by HOWARD THIEN HUI SAW A thesis submitted to the University of Birmingham for the degree of DOCTOR OF PHILOSOPHY School of Immunity and Infection College
ID Membranes for Microbial Rapid Identification
ID Membranes for Microbial Rapid Identification Chromogenic Reaction by Specific Substrates on Membranes Classical plates are still used today as first steps in modern microbiology. Smart, inexpensive
THE IDENTIFICATION OF TWO UNKNOWN BACTERIA AFUA WILLIAMS BIO 3302 TEST TUBE 3 PROF. N. HAQUE 5/14/18
THE IDENTIFICATION OF TWO UNKNOWN BACTERIA AFUA WILLIAMS BIO 3302 TEST TUBE 3 PROF. N. HAQUE Introduction: The identification of bacteria is important in order for us to differentiate one microorganism
Expansion of Salmonella Typhimurium ST34 clone carrying multiple. resistance determinants in China
AAC Accepts, published online ahead of print on 24 June 2013 Antimicrob. Agents Chemother. doi:10.1128/aac.01174-13 Copyright 2013, American Society for Microbiology. All Rights Reserved. 1 2 Expansion
Characteristics of extended-spectrum cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae isolates from horses
Veterinary Microbiology 124 (2007) 248 255 www.elsevier.com/locate/vetmic Characteristics of extended-spectrum cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae isolates from horses An
3M Food Safety Technical Bulletin
3M Petrifilm Aqua Enterobacteriaceae Count Plates Performance Summary 3M Petrifi lm Aqua Enterobacteriaceae (AQEB) Count Plates are sample ready media plates used in the microbial testing of bottled water.
Characteristics of Plasmids in Multi-Drug-Resistant Enterobacteriaceae Isolated during Prospective Surveillance of a Newly Opened Hospital in Iraq
Characteristics of Plasmids in Multi-Drug-Resistant Enterobacteriaceae Isolated during Prospective Surveillance of a Newly Opened Hospital in Iraq Xiao-Zhe Huang 1 *., Jonathan G. Frye 2., Mohamad A. Chahine
C. elegans as an in vivo model to decipher microbial virulence. Centre d Immunologie de Marseille-Luminy
C. elegans as an in vivo model to decipher microbial virulence Centre d Immunologie de Marseille-Luminy C. elegans : a model organism Mechanisms of apoptosis, RNA interference Neuronal function and development
Antibiotic Resistance in Escherichia coli Iron Transport Mutants
Bowling Green State University ScholarWorks@BGSU Honors Projects Honors College Fall 12-11-2017 Antibiotic Resistance in Escherichia coli Iron Transport Mutants Madeline Brandt mbrandt@bgsu.edu Follow
Synthesis of Multiply Deuterated Cephalosporins
Synthesis of Multiply Deuterated Cephalosporins by Karan Naresh Teckwani A thesis presented to the University of Waterloo in fulfillment of the thesis requirement for the degree of Master of Science in
New developments in PK/PD
Asian PK/PD Educational Workshop New developments in PK/PD drug transport in eucaryotic cells difficult-to-reach compartments intracellular infections This part uses material from presentations made at
First description of a RND-type multidrug efflux pump in Achromobacter xylosoxidans:
AAC Accepts, published online ahead of print on 1 August 2011 Antimicrob. Agents Chemother. doi:10.1128/aac.00341-11 Copyright 2011, American Society for Microbiology and/or the Listed Authors/Institutions.
Reading guide. EUCAST disk diffusion method for antimicrobial susceptibility testing
Reading guide EUCAST disk diffusion method for antimicrobial susceptibility testing Version 4.0 June 2014 Modifications to EUCAST reading guide slide show Version Version 4.0 June 2014 Version 3.0 April