The Study of the Percutaneous Laser Disc Decompression
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1 RESEARCH ARTICLE Copyright 2013 American Scientific Publishers All rights reserved Printed in the United States of America Advanced Science Letters Vol. 19, , 2013 The Study of the Percutaneous Laser Disc Decompression David T. W. Lin and Chih-Chung Chen Institute of Mechatronic System Engineering, National University of Tainan, Tainan 701, Taiwan The purpose of this study is to discuss the temperature and stress distribution problem of the interverbral disc while the surgical operation of PLDD is processing. This study also further discuss the water content of disc changes with age to cause variation of thermal conductivity thermal expansion coefficient specific heat and related parameters, and the effect of thermal conductivity related about the patient s age will be illustrated. The 3D thermal structure conjugated model of the multiphysics analysis algorithm is used to understand the temperature and stress distribution of the whole domain and heat transfer phenomena under the different kinds of laser heating rate and patients. The temperature profile of the intervertebral disk is obtained and reveals the relations among the parameters. The temperature profile is predicted as the heat transfer phenomena can be handled on the surgical process. In the future, we expect that this result can be used to handle the PLDD in the pre-surgical simulation. Keywords: PLDD, Disc, Thermal Structure Conjugated. 1. INTRODUCTION Delivered by Publishing Technology to: CHIH-CHUNG CHEN The percutaneous laser disc decompression (PLDD) is a minimal invasive surgery which through the laser vaporizes the herniation of disc. By this technology, we can remove or release the compression on nerve root and reduce the volume of herniation to decompression. This study is to obtain the thermal structure conjugated phenomena under the different surgical conditions while PLDD is processing. In the past, it made an overlarge wound, much bleeding and long recovery time when the traditional surgical operator was used. In 1986, Choy and Ascher developed PLDD, which used laser to heat the herniation of the nucleus pulposus, and the part of herniation would be vaporized to relief the intervertebral pressure. 1 After 1986, PLDD was widely used. There were no deaths, ligament damaged and nerve root damaged after surgery. 2 PLDD was recommended as the first therapy of disc herniation from Zell et al. used PLDD for twenty patients, and there were sixteen patients have been improved. 3 Many previous researches have studied the cases and the improvement of the PLDD. Base on Choy s experiment, the Nd-YAG Laser of PLDD can decompress 55% compression of disc. According to the MacNab standard, the success rate of PLDD was 89% 90%. The high success rate and low-risk of PLDD is the reason that it is recommended for the best treatment of the herniation of the intervertebral disk. Above the illustrations, PLDD would become the important methods in the clinical operation of the intervertebral disk herniation in the future indeed. In 2006, Gupta et al. 4 Author to whom correspondence should be addressed. evaluate the efficacy of PLDD in treatment of contained herniation of lumbar discs and long term follow up results. It took 40 patients with contained herniation of lumbar discs on MRI and who did not respond to 6 weeks conservative treatment are subjected to PLDD. Gupta et al. concluded that there were still 20% patients felt pain after operation, and 15% need re-treatment. Therefore, the current technology of PLDD still has to improve. In the study of Tsai et al. 5 they found that the disc was a soft bio-tissue with well heat conductivity which is different from brittle substrate. No cracking and debris issue would generate around disc when PLDD was processing, but heat and high temperature remained. How to choose a suitable laser power to be use in PLDD processing which would not harm to disc, this was an issue we need to explore. For understanding the different phenomena while the PLDD was processing under the different kind of conditions further, the results of the thermal structure conjugated phenomena were demonstrated to handle the accuracy of the PLDD. In this study, the complex realistic temperature and stress distributions of the intervertebral disc were obtained. In the future, we expect that these results can build a useful database to compare with the data of clinical operation. Therefore, these simulations will become a major preoperative simulation of the PLDD to enhance clinical safety and accuracy. 2. MATHMATICAL MODEL This study discusses the thermal structure conjugated phenomena of bio-tissue in the intervertebral disc. To obtain the temperature 2872 Adv. Sci. Lett. Vol. 19, No. 10, /2013/19/2872/005 doi: /asl
2 Adv. Sci. Lett. 19, , 2013 RESEARCH ARTICLE evolution and the deformation of the heated disc and achieve a more realistic analysis by the multiphysics analysis package are the purposes of this study. We expect the results could be used in the clinical application of thermal therapy. The governing equation of this study is Pennes bio-heat transfer equation, 6 as follows: c T t = x ( k T x ) + y ( k T ) + t b b c b T a T +Q m +Q r x i y i z i V (1) T x i y i z i t =T b x i y i z i t x i y i z i (2) q n x i y i z i t =q 0 x i y i z i t x i y i z i q (3) q n x i y i z i t =h T x i y i z i t T f t x i y i z i c (4) x i y i z i 0 = o x i y i z i x i y i z i V (10) According to Coulson et al. the simulation model treats properties as temperature dependent. 7 The boundary condition for the Solid, Stress Strain application mode is that both ends, in the length direction of the disc, are fixed with respect to x, y, and z. Fig. 1. The mesh schematic diagram of disc. T x i y i z i O =T o x i y i z i x i y i z i V (5) is modeled by the external heating source on the surgical path. The surgical path starts from (0, 0), and its length, L, is10mm. where We select 9 points on the path and divide it in to 10 sections T the biological tissue temperature field uniformly. This model generates the finer mesh by finite element k thermal conductivity of tissue method to solve the transient problem. Figure 1 is the 3D mesh c heat capacity per unit volume of inter disc. b, c b density and specific heat of blood The disc is a protein colloid. We take real disc size, the majoraxis is 29 mm, the minor-axis is 20 mm and the thickness is b perfusion rate of blood Q m metabolic heat 5 mm. The water content of disc changes with age to cause Q r outer heating source variation of thermal conductivity, thermal expansion coefficient, T a blood temperature specific heat and related parameters. This study also further discusses the difference among the disc that has a different thermal replace to x y z t = T x y z t T x y z 0 conductivity on the results of operations caused. The follow-up T a = T x y z 0 when tissue Delivered temperature by TPublishing minus bloodtechnology temperature T a, Eqs. (1) (5) be rewritten IP: for (6) (10), as follows: On: Fri, each 01 parameter May 2015 alters 03:29:37 at the same time. studyto: will CHIH-CHUNG be discussed further CHEN the affect in different ages when c t = ( k ) + ( k ) + x x y t b b c b +Q m +Q r 4. RESULTS AND DISCUSSION x i y i z i V (6) Laser power processing time and k affects the process and results. Figure 2 is the stress evolution at laser power is 0.02 W, surgery x i y i z i t =T b x i y i z i t T x i y i z i 0 time is 10 s and k is From Figure 2, we notice that the x i y i z i (7) stresses would rise only when PLDD is processing on the path. The stress oscillations are exhibited as the laser passes the specific q n x i y i z i t =q 0 x i y i z i t x i y i z i q (8) point. After simulation of laser heat on the disc, every stress q n x i y i z i t =h x i y i z i t f t x i y i z i c (9) distribution was shown on the processing path (2L/10, 4L/10, 3. SIMULATION DETAILS This study discusses that the transient thermal structure conjugated problem in PLDD. A 3D model is established by finite element method and nine different kinds of surgical conditions are investigated. Three different heated powers (0.01 W, 0.02 W and 0.03 W) and three kinds of thermal conductivities (k = 0 51, 0.61 and 0.71) are studied. The following multiphysics simulation models, the heat transport phenomena, structural stresses and deformations resulting, from the thermal-structure conjugated effect by the general heat transfer equation and the solid, stress-strain model. To simulate the PLDD problem that the laser Fig. 2. 8L/10). The stress evolution at different location (x = 2L/10, 4L/10, 6L/10, 2873
3 RESEARCH ARTICLE Adv. Sci. Lett. 19, , 2013 Fig. 3. The stress results of PLDD on Y Z plane. 6L/10, 8L/10). Because of the stress concentration of bio-tissue, Fig. 5. The schematic diagram of herniation disc. the stress increasing as the heating time. The stress of later heated point on the processing path would higher than the sooner. As Because the disc is a bio-tissue that a small k value causes Figure 2, the stress of 8L/10 is higher than 2L/10. the temperature diffuses difficultly. That means the heat is difficult Figure 3 is the stress results of PLDD on Y Z plane, the to diffuse the high heat capacity, and the high temperature Figure 4 is the stress results of PLDD on X Y plane. In Figure 3, is restricted to the region of the heated path. The temperature the thermal stresses appear as a result of the temperature oscillations are exhibited as the laser passes the specific point. increases. The stresses are together with the resulting deformation Figure 7 is the variation chart of temperature when laser power of the temperature increasing. The prominence of disc takes is 0.02 W; surgery time is 10 s and k is After simulation place a deformation of bending down, but the temperature of of laser heat on the disc, the temperature distribution of each the PLDD processing path is much higher than nose of deformation. point was shown on the processing path (2L/10, 4L/10, 6L/10, The highest stresses occur on the termination of disc. 8L/10. From Figure 7, we notice that the laser move on the path In this study, the processing path is the heating. The stress of with time, the temperature of 2L/10 points up and down with a nose is approximately 3260 KPa. The highest stress in PLDD big slope when laser heating passes. Because of the heat capacity falls in the range near 3260 KPa. Delivered This means by Publishing that the bio-tissue Technology of the to: disc CHIH-CHUNG tissue is high. When CHENeach point is heated, all appear functions without failure for the laser power heats. However, if similar to the situation of 2L/10. The highest temperature on the heating power increases slightly, permanent deformation and possibly failure would occur. According to Figures 5 and 6, we take 4 boundaries of herniation disc, at the 10s, compare with S1, S2, S3 and S4, the displacement of the order for S2 >S3 >S4 >S1. As Figure 5, S2 is the top boundary of herniation disc, so the heat and stress would concentrate on S2 and cause the biggest displacement. Because of farther away from processing path, the heat and stress are smaller. However, S3 is the boundary that contacts directly by laser at 10 s; the heat of S3 is much higher than S1. From Figure 6, we notice that much distance away from processing path and much heat concentrate on these boundaries, such as S2, the stress would arise, as well as has the bigger displacement. 2L/10, the lowest temperature on 8L/10, all highest temperature of each point on path were located between K. Figure 8 is the variation chart of temperature when laser power is different; surgery time is 10s and k is After simulation of laser processing on 5L/10, the laser heating from 0.01 W to 0.03 W of each W to a progressive manner, and we take the data of 5L/10 on processing path. We notice that the higher power, the bigger impact to disc. The residual heat of mid point would rise with the residual heat of power after heated on processing path. Fig. 4. The stress results of PLDD on X Y plane. Fig. 6. The displacement of herniation disc boundary (S1, S2, S3 and S4). 2874
4 Adv. Sci. Lett. 19, , 2013 RESEARCH ARTICLE Fig. 7. The temperature evolution at different location (x = 2L/10, 4L/10, 6L/10, 8L/10. As the laser power is 0.01 W, the highest temperature is about 324 K, the high temperature gradually increases as the processing path by heating the disc. We obtained that when the laser power increases. The highest temperature is 354 K when disc is heated by the same laser power, the lower temperature the laser power is 0.03 W. And, we find the slope changes as distributed region and the smaller slope as the k increases; oppositely, the laser power changes in Figure 8. The higher laser power, the the higher temperature distributed region and the greater greater slope as laser heat approaches 0.03 W. The temperature slope as the k decreases. decreases as the laser departs away from the specific point. As the laser power is 0.02 W, the higher temperature dis- The disc such as bio-tissue has properties like high heat capacity tributed region as the k value decreases. The cases of 0.01 W and thermal resistance. Moreover, disc periphery around the and 0.03 W are also quite similar. This is an evidence for the microvascular. Microvascular Delivered have a utility by topublishing remove thetechnology heat different to: CHIH-CHUNG value of k for surgery s CHENeffect. From this point could of blood. The temperature declines soon IP: as the heat remove with On: Fri, be01 extended May 2015 for age 03:29:37 variation of the disc and temperature for the these properties and blood perfusion rate. Copyright: Therefore, theamerican temper- Scientific effect of human Publishers bio-tissue. This figure illustrated different tem- ature decreases soon as the laser power departs reasonably. Figure 9 is temperature variation chart on the operation time is 10 s. It indicates three k values which are k = 0 51, k = 0 61 and k = 0 71, with three sets of laser power which are 0.01 W, 0.02 W and 0.03 W. According to patients of different age and among minor individually variation, each disc is somewhat diversity that makes the k value different. Consequently, the different water content in disc, the different thermal conductivity is caused. This profile presents the variation of temperature on 5L/10 of Fig. 9. The temperature evolution at x = 5L/10 with different thermal conductivity. perature distributions are heated by different laser power but the same value of k in comparison with figure 8. The highest temperature is 322 K as k = 0 71, laser power is 0.01 W on 5L/10 of processing path. This is the simulation of low laser power with high k of the results of processing; low temperature just has little effect on disc. The highest temperature is almost 360 Kask = 0 51, laser power is 0.03 W on 5L/10 of processing path. This is the simulation of high laser power with low k. High temperature has a huge effect to the disc and around tissues. The value of laser power and k (different age) are the main point when PLDD is processing. From what has been discussed above, we could conclude that the change of k should change with laser power when PLDD is processing. Apparently, thermal properties of bio-tissue are dominating the results of the heat transfer phenomena. In contrast with material properties, the laser power is minor effect among the control parameters. This is a sure method to increase the success of PLDD. Fig. 8. The temperature evolution at x = 5L/10 with different laser power. 5. CONCLUSIONS The purpose of this study is to discuss the thermal structure conjugated problem of the disc such a soft bio-tissue. The COM- SOL that a finite element method package to analyze the heat transfer and stress phenomena of bio-tissue, further to study the temperature and stress evolution of complicated bio-tissue after heating by laser s energy. The COMSOL package can be used for simulation and analysis before processing. It could help to understand the temperature evolution of bio-tissue after heating and improveing the accuracy. 2875
5 RESEARCH ARTICLE Adv. Sci. Lett. 19, , 2013 As the laser power is 0.02 W, the high temperature region is only restricted to the area around processing path. The temperature increases as the laser increases. High heat capacity, low thermal conductivity and blood perfusion makes this conspicuous effect. However, the k values should be changed with the matching age difference. The values of laser power are the key point to success or failure when PLDD is processing, so the laser power should co-operate with k values of different ages. The main point is to be clinical operation. To facilitate the discussions of future related thermal therapy, we expect this study could analysis before PLDD processing in actual clinical operation. For the phenomena of PLDD, people will spend more time solving it. Many modern medicines and laser surgeries are related closely, laser therapy has a significant effect, wound healing, and less risk of infection, less surgery time and smaller scar, those characteristics are superior to traditional operations. And laser is used for many bio-tissue operations, such as skin treatment, remove the tumor, disc herniation and sinusitis. Laser treatment brings new challenges. The risks are still more than benefits at present. To enhance clinical safety and accuracy, an accurate preoperative simulation is necessary to be developed. These results will be expected to build a useful database to compare with the data of clinical operations. References and Notes 1. R. W. Burchfield, The New Fowler s Modern English Usage, 3rd edn., Clarendon Press, Oxford (1986). 2. D. S. J. Choy, Tech. Reg. Anesth. Pain Manage. 9, 50 (2005). 3. M. Zell, M. Scholz, and A. G. Harders, Microsurgical Operation on lumber disc herniations after percutaneous laser-disc-decompression (PLDD), Spine- Lumber Disc Herniation and Spondylosis, Neurosurgical Department, University of Bochum, Germany, July (1997), S165 [P-4-425]. 4. A. K. Gupta, N. K. Bodhey, R. S. Jayasree, T. R. K. Kapilamoorthy, C. Kesavadas, T. Krishnamoorthy, and T. Bejoy, Neurol. India 54, 164 (2006). 5. C. H. Tsai and C. C. Li, Investigation of underwater laser drilling for brittle substrates, Proceedings of the Fourth International WLT Conference on Lasers in Manufacturing 2007, Munich, June (2007). 6. H. H. Pennes, J. Applied Physiol. 1, 93 (1948). 7. J. M. Coulson and J. F. Richardson, Chem. Eng. 1 (1990), Pergamon Press, appendix. Received: 1 March Accepted: 21 April Delivered by Publishing Technology to: CHIH-CHUNG CHEN 2876
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