Chronic Granulomatous Disease Medical Management
|
|
- Felix Watkins
- 5 years ago
- Views:
Transcription
1 Chronic Granulomatous Disease Medical Management N I C H O L A S H A R T O G, M D D i r e c t o r o f P e d i a t r i c / A d u l t P r i m a r y I m m u n o d e f i c i e n c y C l i n i c A s s i s t a n t P r o f e s s o r M i c h i g a n S t a t e U n i v e r s i t y C o l l e g e o f H u m a n M e d i c i n e S p e c t r u m H e a l t h / H e l e n D e v o s C h i l d r e n s H o s p i t a l
2 Disclosures H o r i z o n P h a r m a S p e a k i n g a n d c o n s u l t i n g
3
4 Medical Management C o r n e r s t o n e o f T h e r a p y P r e v e n t i n f e c t i o n s L i f e l o n g a n t i b a c t e r i a l a n d a n t i f u n g a l p r o p h y l a x i s I m m u n o m o d u l a t o r y t h e r a p y E a r l y i d e n t i f i c a t i o n o f i n f e c t i o n A g g r e s s i v e t r e a t m e n t o f i n f e c t i o n s
5 Prevention A v o i d a n c e : S w i m i n p o o l o r s a l t w a t e r Avoid freshwater, pond, brackish water A v o i d m u c h / p o t t i n g s o i l Mulch pneumonitis from Aspergillus A v o i d o t h e r p o t e n t i a l m o l d e x p o s u r e Compost, potting plans, damp cellar/basement, demolition, digging in dirt, cutting grass, hay rides, raking leaves, smoking marijuana
6 Identification of Infections E a r l y d i a g n o s i s o f i n f e c t i o n s c r i t i c a l S e r i o u s i n f e c t i o n s c a n b e m i n i m a l l y s y m p t o m a t i c o r a s y m p t o m a t i c a t p r e s e n t a t i o n M o n i t o r f o r o c c u l t i n f e c t i o n Personally I check ESR/CRP every visit, elevation prompts aggressive search for infections P a r e n t s m o n i t o r f o r l y m p h a d e n o p a t h y M o n i t o r f o r m u s c u l o s k e l e t a l c h a n g e s
7 Treatment of Infections C u l t u r e, c u l t u r e, C U L T U R E Unless life threatening infections, need cultures before empiric antimicrobials Bacterial, mycobacterial, and fungal cultures (hold for nocardia) Lymph node excisional biopsy Identification of microbe is critical for treatment A G G R E S S I V E T r e a t m e n t Empiric antifungal and antibacterial after cultures obtained Steroids sometimes used L o o o o o o o n g T r e a t m e n t Typically prolonged IV followed by prolonged oral medication for serious infections
8 Treatment of Infections S u m m a r y 1. Culture identification of microbe critically important in proper treatment 2. Early treatment once cultures done 3. Aggressive treatment IV antifungal and antibiotic after proper cultures 4. Prolonged treatment required for full eradication
9 Triple Therapy
10 Triple Therapy A n t i b a c t e r i a l ie t r i m e t h o p r i m / s u l f a m e t h o x a z o l e ( T M P - S M X ) A n t i f u n g a l ie i t r a c o n a z o l e I m m u n o m o d u l a t o r y I n t e r f e r o n g a m m a - 1b
11 Antibacterial T M P - S M X B a t e r i c i d a l a n d e f f e c t i v e a g a i n s t m o s t c o m m o n p a t h o g e n s ~ 1 L i f e t h r e a t e n i n g i n f e c t i o n e v e r y 1 0 m o n t h s w i t h o u t p r o p h y l a x i s W i t h T M P / S M X ~ 1 l i f e t h r e a t e n i n g i n f e c t i o n e v e r y 4 0 m o n t h s D e c r e a s e d r a t e o f h o s p i t a l i z a t i o n s a n d s u r g e r i e s O t h e r a n t i m i c r o b i a l o p t i o n s a v a i l a b l e i f i n t o l e r a n t t o T M P - S M X
12 Antifungal A s p e r g i l l u s s p p a c c o u n t f o r > 3 5 % o f a l l C G D d e a t h s A n t i f u n g a l ie. I t r a c o n a z o l e, p o s a c o n a z o l e, v o r i c o n a z o l e D e c r e a s e d r a t e s o f s e r i o u s i n v a s i v e f u n g a l i n f e c t i o n > 5 0 % I n c r e a s e d l i f e s p a n
13 Immunomodulatory I n t e r f e r o n g a m m a - 1b s d a t a s h o w e d i n c r e a s e d p h a g o c y t e - m e d i a t e d k i l l i n g w i t h I F N - γ D e c r e a s e d i n f e c t i o n s a n d m o r t a l i t y r a t e Most studies done before antifungals S i d e e f f e c t s Flu like symptoms (fever, chills, fatigue) and injection site pain M e c h a n i s m Largely unknown Increased nitric oxide Enhanced macrophage bactericidal activity L e a s t a g r e e u p o n o f t r i p l e t h e r a p y u s e d l e s s f r e q u e n t l y i n E u r o p e t h a t U S A
14 Effect of Triple Therapy E f f e c t i v e w h e n t a k e n S u r v i v a l 9 0 % a t 1 0 y e a r s o l d B e s t c u r r e n t d a t a median age of death years old Marciano BE, et al. Clin Infect Dis. 2015;60(8):1176.
15 Bone Marrow Transplant S h o u l d w e p e r f o r m a b o n e m a r r o w t r a n s p l a n t?
16 Bone Marrow Transplant
17 Bone Marrow Transplant
18 Bone Marrow Transplant S o u r c e D o n o r s Bone marrow Peripheral blood stem cells Cord blood Related Matched sibling Haploidentical (parents) Do not use X-linked carriers Matched unrelated
19 Bone Marrow Transplant H L A T y p i n g C e l l s u r f a c e m a r k e r s r e c o g n i z e d b y i m m u n e c e l l s P r e s e n t o n e v e r y c e l l
20 Bone Marrow Transplant C o n d i t i o n i n g F u l l y M y e l o a b l a t i v e C o n d i t i o n i n g ( M A C ) More toxicity R e d u c e d - I n t e n s i t y C o n d i t i o n i n g ( R I C ) Various degrees of myelosuppression Higher rates of mixed chimerism Less toxicity R e d u c e d - T o x i c i t y C o n d i t i o n i n g ( R T C )
21 Bone Marrow Transplant R i s k s Death Acute graft vs host disease Chronic graft vs host disease Veno-occlusive disease Loss of future fertility Toxicities from conditioning B e n e f i t s Curative therapy
22 Bone Marrow Transplant W h o t o T r a n s p l a n t? Are risks of transplant less than no transplant? Consider comorbidities and end organ damage Consider HLA matches and cell source Consider experience of transplant center Avoid active infections Steroid dependent inflammatory manifestations No universal criteria to transplant X-linked consider genetics Residual oxidase activity Previous neutrophil transfusions Previous blood transfusions (McLeod phenotype) Time of year
23 Bone Marrow Transplant C u r r e n t r e s u l t s Survival 80-90% Graft vs host disease ~10-15% Improved quality of life Statistics are in studies at experienced centers Connelly, JA, et al. Allogeneic Hematopoietic Cell Trasplantation for CGD: Controversies and State of the Art. JPID supplement 2018
24 Bone Marrow Transplant G o a l Transplant patients who the risk of medical management is greater than the risk of transplant
25 Gene Therapy
26 Gene Therapy
27 Gene Therapy G a m m a r e t r o v i r u s p r e v i o u s s t u d i e s Only can insert into dividing cells High rate of insertional oncogenesis (ie. cancer) L e n t i v i r u s c u r r e n t s t u d i e s Can insert into non-dividing cells Self-inactivating vector (SIN) C R I S P R / C a s 9 May enable repair at native gene site (very specific) Promising pre-clinical data Amount of customization required may limit therapy
28 Gene Therapy C u r r e n t T r i a l Boston, Bethesda, and Los Angeles >23 months old with no HSCT match and history of serious infections or inflammatory complications SIN lentiviral vector Currently ongoing P r o g n o s i s No insertional oncogenesis Promising results in other diseases
29 CGD Associated Colitis Treatment Questions
Indications and outcomes after UD HSCT
Indications and outcomes after UD HSCT Jakob R Passweg 1 Impact on Outcome: Patient Age, Disease Severity I II III Title: Optimization of Therapy for Severe AplasticAnemia Based on Clinical, Biological
More informationMultistate models in survival and event history analysis
Multistate models in survival and event history analysis Dorota M. Dabrowska UCLA November 8, 2011 Research supported by the grant R01 AI067943 from NIAID. The content is solely the responsibility of the
More informationAutologous Bone Marrow Transplant Crossword Puzzle on Discharge Education. Adult Bone Marrow Transplant Autologous Bone Marrow Transplant Puzzle 1
Autologous Bone Marrow Transplant Crossword Puzzle on Discharge Education 1 Across 1. You will not be able to for at least three months following your transplant. This period may be shorter for patients
More informationAllogeneic Bone Marrow Transplant Crossword Puzzle on Discharge Education
Allogeneic Bone Marrow Transplant Crossword Puzzle on Discharge Education Across 1. If you have, it is important to inform their school that you must be notified of communicable diseases like measles,
More information12/1/17 OUTLINE KEY POINTS ELEMENTS WITH UNSTABLE NUCLEI Radioisotopes and Nuclear Reactions 16.2 Biological Effects of Nuclear Radiation
OUTLINE 16.1 Radioisotopes and Nuclear Reactions 16.2 Biological Effects of Nuclear Radiation PET scan X-ray technology CT scan 2009 W.H. Freeman KEY POINTS Radioactivity is the consequence of an unstable
More informationWhat are mitochondria?
What are mitochondria? What are mitochondria? An intracellular organelle. There are 100 to 1000s of mitochondria/cell. Most mitochondria come from the mother. Mitochondria have their own DNA Mitochondria
More informationMulti-state models: prediction
Department of Medical Statistics and Bioinformatics Leiden University Medical Center Course on advanced survival analysis, Copenhagen Outline Prediction Theory Aalen-Johansen Computational aspects Applications
More informationTyphoid Fever Dr. KHALID ALJARALLAH
Dr. KHALID ALJARALLAH kaljarallah@kfmc.med.sa Main objectives General characteristics (G-, Rod, Facultative anaerobe..etc,) Natural Habitat and transmission root Symptoms Pathogenicity Diagnosis and treatment
More informationGuided Notes Unit 6: Classical Genetics
Name: Date: Block: Chapter 6: Meiosis and Mendel I. Concept 6.1: Chromosomes and Meiosis Guided Notes Unit 6: Classical Genetics a. Meiosis: i. (In animals, meiosis occurs in the sex organs the testes
More informationEASTERN ARIZONA COLLEGE Microbiology
EASTERN ARIZONA COLLEGE Microbiology Course Design 2015-2016 Course Information Division Science Course Number BIO 205 (SUN# BIO 2205) Title Microbiology Credits 4 Developed by Ed Butler/Revised by Willis
More informationJanuary NCCTG Protocol No: N0927 Opened: September 3, 2009
January 2011 0915-1 RTOG Protocol No: 0915 Protocol Status: NCCTG Protocol No: N0927 Opened: September 3, 2009 Title: A Randomized Phase II Study Comparing 2 Stereotactic Body Radiation Therapy (SBRT)
More informationTHE IDENTIFICATION OF TWO UNKNOWN BACTERIA AFUA WILLIAMS BIO 3302 TEST TUBE 3 PROF. N. HAQUE 5/14/18
THE IDENTIFICATION OF TWO UNKNOWN BACTERIA AFUA WILLIAMS BIO 3302 TEST TUBE 3 PROF. N. HAQUE Introduction: The identification of bacteria is important in order for us to differentiate one microorganism
More informationDynamic Prediction of Disease Progression Using Longitudinal Biomarker Data
Dynamic Prediction of Disease Progression Using Longitudinal Biomarker Data Xuelin Huang Department of Biostatistics M. D. Anderson Cancer Center The University of Texas Joint Work with Jing Ning, Sangbum
More informationMulti-state Models: An Overview
Multi-state Models: An Overview Andrew Titman Lancaster University 14 April 2016 Overview Introduction to multi-state modelling Examples of applications Continuously observed processes Intermittently observed
More informationPlant and animal cells (eukaryotic cells) have a cell membrane, cytoplasm and genetic material enclosed in a nucleus.
4.1 Cell biology Cells are the basic unit of all forms of life. In this section we explore how structural differences between types of cells enables them to perform specific functions within the organism.
More informationCASE REPORT FORM (April 2012)
CASE REPORT FORM (April 2012) Surveillance of Paediatric Dengue National Paediatric Hospital, Phnom Penh Kingdom of Cambodia Study contact: I am confident that the information supplied in this case record
More informationPlant and animal cells (eukaryotic cells) have a cell membrane, cytoplasm and genetic material enclosed in a nucleus.
4.1 Cell biology Cells are the basic unit of all forms of life. In this section we explore how structural differences between types of cells enables them to perform specific functions within the organism.
More informationSioux Falls School District Anatomy and Physiology Holes Anatomy and Physiology Authors: Shier, Butler, and Lewis Glencoe/ McGraw hill
Sioux Falls School District Anatomy and Physiology Holes Anatomy and Physiology Authors: Shier, Butler, and Lewis Glencoe/ McGraw hill Semester 1 Chapter 1: Introduction to Human Anatomy and Physiology
More informationUnit 1: DNA & the Genome Topic 4: Cellular Differentiation
Unit 1: DNA & the Genome Topic 4: Cellular Differentiation http://commons.wikimedia.org/wiki/embryo#mediaviewer/file:8-cell_stage_embryo.png Learning Outcomes Define the term cellular differentiation.
More informationThis presentation contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform
This presentation contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995, as amended. These forward-looking statements
More informationUnit 2 Benchmark Review. Disease Review:
Match the term with the definition: Unit 2 Benchmark Review Disease Review: 1. Caused by tiny organisms called pathogens B 2. This is responsible for distinguishing between the different kinds of pathogens
More informationLeeuwenhoek s Animacules
Leeuwenhoek s Animacules Early History of Microbiology: 1668 Francesco Redi disproves spontaneous generation 1676 Antony van Leeuwenhoek first observes microbes 1861 Louis Pasteur disproves spontaneous
More informationLeeuwenhoek s Animacules. Early History of Microbiology: Fig. 1.4
Leeuwenhoek s Animacules Early History of Microbiology: 1668 Francesco Redi disproves spontaneous generation 1676 Antony van Leeuwenhoek first observes microbes 1861 Louis Pasteur disproves spontaneous
More informationDIAGNOSTICS NO TOUCH FOREHEAD THERMOMETER
DIAGNOSTICS NO TOUCH FOREHEAD THERMOMETER nu-beca NO TOUCH THERMOMETER : Thank you for purchasing the nu-beca No Touch Forehead Thermometer. Please read this instruction manual first so you can use this
More informationLicense flow for use of nuclear material.
Figure 2.1. License flow for use of nuclear material. Figure 2.2. License flow for the manufacturing business. 1 Figure 2.3. Major legislations and guides governing the safety regulation of fabrication
More informationStatistical Modeling with Spline Functions Methodology and Theory
This is page 1 Printer: Opaque this Statistical Modeling with Spline Functions Methodology and Theory Mark H. Hansen University of California at Los Angeles Jianhua Z. Huang University of Pennsylvania
More informationReview. More Review. Things to know about Probability: Let Ω be the sample space for a probability measure P.
1 2 Review Data for assessing the sensitivity and specificity of a test are usually of the form disease category test result diseased (+) nondiseased ( ) + A B C D Sensitivity: is the proportion of diseased
More informationStatistical Experiment A statistical experiment is any process by which measurements are obtained.
(التوزيعات الا حتمالية ( Distributions Probability Statistical Experiment A statistical experiment is any process by which measurements are obtained. Examples of Statistical Experiments Counting the number
More information1. Poisson distribution is widely used in statistics for modeling rare events.
Discrete probability distributions - Class 5 January 20, 2014 Debdeep Pati Poisson distribution 1. Poisson distribution is widely used in statistics for modeling rare events. 2. Ex. Infectious Disease
More informationAdaptive Prediction of Event Times in Clinical Trials
Adaptive Prediction of Event Times in Clinical Trials Yu Lan Southern Methodist University Advisor: Daniel F. Heitjan May 8, 2017 Yu Lan (SMU) May 8, 2017 1 / 19 Clinical Trial Prediction Event-based trials:
More informationLecture 9. Statistics Survival Analysis. Presented February 23, Dan Gillen Department of Statistics University of California, Irvine
Statistics 255 - Survival Analysis Presented February 23, 2016 Dan Gillen Department of Statistics University of California, Irvine 9.1 Survival analysis involves subjects moving through time Hazard may
More informationA mathematical and computational model of necrotizing enterocolitis
A mathematical and computational model of necrotizing enterocolitis Ivan Yotov Department of Mathematics, University of Pittsburgh McGowan Institute Scientific Retreat March 10-12, 2008 Acknowledgment:
More informationIMPROVING THE OUTCOMES OF BREAST RADIATION THERAPY: THE PRONE POSITION. Kaylyn Olson
IMPROVING THE OUTCOMES OF BREAST RADIATION THERAPY: THE PRONE POSITION Kaylyn Olson BACKGROUND Over 230,000 women will be diagnosed with breast cancer this year and approximately half of these women will
More informationCHAPTER 3 HEART AND LUNG TRANSPLANTATION. Editors: Mr Mohamed Ezani Md. Taib Dato Dr David Chew Soon Ping Dr Ashari Yunus
CHAPTER 3 HEART AND LUNG TRANSPLANTATION Editors: Mr Mohamed Ezani Md. Taib Dato Dr David Chew Soon Ping Dr Ashari Yunus Expert Panel: Mr Mohamed Ezani Md. Taib (Chairperson) Dr Abdul Rais Sanusi Datuk
More informationJordan University of Science & Technology. Faculty of Arts and Sciences. Department of Applied Biological Sciences
Jordan University of Science & Technology Faculty of Arts and Sciences Department of Applied Biological Sciences Course Title Title & Instructor General Biology Course Number BIO 104 Instructor Office
More informationName Date Class. PAP Unit 10: Bacteria, Viruses, Protist, and Fungi TEST REVIEW. d. Do viruses contain nucleic acids/genetic material (Yes or No)?
Name Date Class PAP Unit 10: Bacteria, Viruses, Protist, and Fungi TEST REVIEW Part A: Viruses 1. a. Are viruses biotic or abiotic? b. Are viruses made of cells (Yes or No)? c. Do viruses contain proteins
More informationPDF // IS BACTERIA A PROKARYOTE OR EUKARYOTE
19 January, 2018 PDF // IS BACTERIA A PROKARYOTE OR EUKARYOTE Document Filetype: PDF 222.61 KB 0 PDF // IS BACTERIA A PROKARYOTE OR EUKARYOTE How to Tell the Difference Between Prokaryotes and Eukaryotes.
More informationNETWORK BIOLOGY AND COMPLEX DISEASES. Ahto Salumets
NETWORK BIOLOGY AND COMPLEX DISEASES Ahto Salumets CENTRAL DOGMA OF BIOLOGY https://en.wikipedia.org/wiki/central_dogma_of_molecular_biology http://www.qaraqalpaq.com/genetics.html CHROMOSOMES SINGLE-NUCLEOTIDE
More informationCHAPTER 3 HEART AND LUNG TRANSPLANTATION. Editors: Mr Mohamed Ezani Md. Taib Dato Dr David Chew Soon Ping Dr Ashari Yunus
CHAPTER 3 Editors: Mr Mohamed Ezani Md. Taib Dato Dr David Chew Soon Ping Dr Ashari Yunus Expert Panel: Mr Mohamed Ezani Md. Taib (Chairperson) Dr Abdul Rais Sanusi Datuk Dr Aizai Azan Abdul Rahim Dr Ashari
More informationYou know I m not goin diss you on the internet Cause my mama taught me better than that I m a survivor (What?) I m not goin give up (What?
You know I m not goin diss you on the internet Cause my mama taught me better than that I m a survivor (What?) I m not goin give up (What?) I m not goin stop (What?) I m goin work harder (What?) Sir David
More informationNK cells are part of the innate immune response. Early response to injury and infection
NK cells are part of the innate immune response Early response to injury and infection Functions: Natural Killer (NK) Cells. Cytolysis: killing infected or damaged cells 2. Cytokine production: IFNγ, GM-CSF,
More informationSrdan Verstovsek, MD, PhD Professor, Department of Leukemia, The University of Texas MD Anderson Cancer Center
Efficacy and Safety of Pegylated Interferon Alpha- 2a in Patients with Essential Thrombocythemia (ET) and Polycythemia vera (PV): Results after a Median 7-year Follow-up of a Phase 2 Study Srdan Verstovsek,
More informationDepartment Curriculum and Assessment Outline
Department: Science Year Group: 10 Teaching, learning and assessment during the course: Combined Science 1 2 B1 Key concepts in Biology B2 Cells and control What are the structure and function of cells.
More information7.6. Solve Problems Involving Exponential Growth and Decay. Tools
7.6 Solve Problems Involving Exponential Growth and Decay Exponential relations and their graphs can be used to solve problems in science, medicine, and finance. The ability to analyse data and model it
More informationSupplementary webappendix
Supplementary webappendix This webappendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement to: Elter T, Gercheva-Kyuchukova L, Pylylpenko
More informationChapter 7 Fall Chapter 7 Hypothesis testing Hypotheses of interest: (A) 1-sample
Bios 323: Applied Survival Analysis Qingxia (Cindy) Chen Chapter 7 Fall 2012 Chapter 7 Hypothesis testing Hypotheses of interest: (A) 1-sample H 0 : S(t) = S 0 (t), where S 0 ( ) is known survival function,
More informationIt is one of the most serious oak diseases in the United States, killing thousands of trees each year.
1 Oak Wilt is the disease caused by the pathogenic non-native fungus Ceratocystis fagacearum that affects oaks. Oaks in the red oak group (those with sharply pointed tips- like pin oak and red oak) are
More informationHepatitis C Mathematical Model
Hepatitis C Mathematical Model Syed Ali Raza May 18, 2012 1 Introduction Hepatitis C is an infectious disease that really harms the liver. It is caused by the hepatitis C virus. The infection leads to
More informationCHAPTER 8. Editors: Dr Omar Sulaiman Dr Hooi Lai Seong
CHAPTER 8 DECEASED (CADAVERIC) ORGAN Editors: Dr Omar Sulaiman Dr Hooi Lai Seong Expert Panel: Dr Omar Sulaiman (Chairperson) Dr Hooi Lai Seong Dr Rosnawati Yahya Dato' Dr Sharifah Suraya Syed Mohd Tahir
More informationAssessment of toxicological properties and establishment of risk profiles - genotoxic properties of selected spice compounds
Assessment of toxicological properties and establishment of risk profiles - genotoxic properties of selected spice compounds Frankfurt/Main, September 25 th 212 V.J. Koller 1, V. Auwärter 2, G. Zlabinger
More informationOptimal Patient-specific Post-operative Surveillance for Vascular Surgeries
Optimal Patient-specific Post-operative Surveillance for Vascular Surgeries Peter I. Frazier, Shanshan Zhang, Pranav Hanagal School of Operations Research & Information Engineering, Cornell University
More informationPlant disease. Plant Diseases: Learning objectives: Plant Disease: Any physiological or structural abnormality that is harmful to the plant
Plant disease Plant Diseases: Identification and Control Melodie Putnam Extension Plant Pathologist Learning objectives: Difference between biotic and abiotic diseases and their manifestation Difference
More informationTextbook: Survivial Analysis Techniques for Censored and Truncated Data 2nd edition, by Klein and Moeschberger
Lecturer: James Degnan Office: SMLC 342 Office hours: MW 12:00 1:00 or by appointment E-mail: jamdeg@unm.edu Please include STAT474 or STAT574 in the subject line of the email to make sure I don t overlook
More informationA multi-state model for the prognosis of non-mild acute pancreatitis
A multi-state model for the prognosis of non-mild acute pancreatitis Lore Zumeta Olaskoaga 1, Felix Zubia Olaskoaga 2, Guadalupe Gómez Melis 1 1 Universitat Politècnica de Catalunya 2 Intensive Care Unit,
More informationPig organ transplants within 5 years
www.breaking News English.com Ready-to-use ESL / EFL Lessons Pig organ transplants within 5 years URL: http://www.breakingnewsenglish.com/0509/050911-xenotransplant.html Today s contents The Article 2
More informationOCR Biology Checklist
Topic 1. Cell level systems Video: Eukaryotic and prokaryotic cells Compare the structure of animal and plant cells. Label typical and atypical prokaryotic cells. Compare prokaryotic and eukaryotic cells.
More informationOCR Biology Checklist
Topic 1. Cell level systems Video: Eukaryotic and prokaryotic cells Compare the structure of animal and plant cells. Label typical and atypical prokaryotic cells. Compare prokaryotic and eukaryotic cells.
More informationAntibody Identification I
Antibody Identification I Amanda Smith, MLS(ASCP) CM Immunohematologist Laboratory of Immunohematology and Genomics April 18, 2017 New York Blood Center 1 Introduction Red cell alloantibodies other than
More informationWhy do invasive species do so well?
Why do invasive species do so well? Authors: Jennifer Bowen, Patrick Kearns, Jarrett Byrnes, Sara Wigginton, Warwick Allen, Michael Greenwood, Khang Tran, Jennifer Yu, James Cronin and Laura Meyerson Associate
More informationNatural Genetic Resistance to Infection
Natural Genetic Resistance to Infection The Discovery of Natural Determinants of Susceptibility to Infection in Cattle, especially Tarentaise Steve A Carlson, DVM PhD Tim A Day, PhD PSR Genetics, LLC Scott
More informationHOMEOWNER PLANT DISEASE CLINIC REPORT Holly Thornton, Homeowner IPM Specialist
MARCH 2007 HOMEOWNER PLANT DISEASE CLINIC REPORT Holly Thornton, Homeowner IPM Specialist As March nears an end, sample submission (both Commercial and Homeowner) is beginning to increase as I expected
More informationMNLA Certification Manual Learning Objectives
MNLA Certification Manual Learning Objectives Chapter 5. Laws, Regulations, Guides, Ethics, and Professionalism A. Demonstrate knowledge of Federal, State, and Local Regulations pertaining to the Nursery
More informationSection IX. Introduction to Logistic Regression for binary outcomes. Poisson regression
Section IX Introduction to Logistic Regression for binary outcomes Poisson regression 0 Sec 9 - Logistic regression In linear regression, we studied models where Y is a continuous variable. What about
More informationSecondary Ion Mass Spectrometry (SIMS)
Secondary Ion Mass Spectrometry (SIMS) SIMS: a desorption/ionization technique 1960s - A. Benninghoven, University of Münster, Germany (Benninghoven A., Rudenauer F.G., Werner H.W., Secondary Ion Mass
More informationPrereq: Concurrent 3 CH
0201107 0201101 General Biology (1) General Biology (1) is an introductory course which covers the basics of cell biology in a traditional order, from the structure and function of molecules to the structure
More informationMicrobial Genetics, Mutation and Repair. 2. State the function of Rec A proteins in homologous genetic recombination.
Answer the following questions 1. Define genetic recombination. Microbial Genetics, Mutation and Repair 2. State the function of Rec A proteins in homologous genetic recombination. 3. List 3 types of bacterial
More informationBistability and Bacterial Infections
Bistability and Bacterial Infections Roy Malka 1, Eliezer Shochat 2, Vered Rom-Kedar 3 * 1 Department of Computer Science and Applied Mathematics, The Weizmann Institute of Science, Rehovot, Israel, 2
More informationApplications of Logarithmic and Exponential functions in Biomedical Science
Antibiotics: Chemotherapeutic agent that inhibits growth (bacteriostatic) or kills (bacteriocidal) a bacterium (or fungus or protozoan). How do antibiotics work (bacteria)? Only a very few targets have
More informationInheritance part 1 AnswerIT
Inheritance part 1 AnswerIT 1. What is a gamete? A cell with half the number of chromosomes of the parent cell. 2. Name the male and female gametes in a) a human b) a daisy plant a) Male = sperm Female
More informationSecondary Ion Mass Spectrometry (SIMS) for Surface Analysis
Secondary Ion Mass Spectrometry (SIMS) for Surface Analysis General overview of SIMS - principles, ionization, advantages & limitations SIMS as a surface analysis technique - operation modes, information
More informationLIFE SCIENCES: PAPER I ANSWER BOOKLET
NATIONAL SENIOR CERTIFICATE EXAMINATION NOVEMBER 2012 LIFE SCIENCES: PAPER I EXAMINATION NUMBER ANSWER BOOKLET There are (vi) pages in this Answer Booklet. QUESTION 1 1.1 Select the term in Column B that
More informationRadiation Emergencies -Preparing for Response-
Radiation Emergencies -Preparing for Response- Tribal Lands Forum San Diego, CA August 25, 2010 Tom Clawson US Department of Energy Transportation Emergency Preparedness Program 1 Radiological Training
More information2. The development of revolutionized the of life.
Science 10 Unit 7 Worksheet Chapter 15, Part 1. 1. Briefly describe the three main parts of cell theory: 2. The development of revolutionized the of life. 3. Individual cells need to take in to build and
More informationDetection and Identification of Stachybotrys chartarum
Detection and Identification of Stachybotrys chartarum Microbial Volatile Organic Compounds (MVOCs) On-Site Using a Person-Portable Gas Chromatograph/Mass Spectrometer (GC/MS) with a Thermal Desorption
More informationSecondary Ion Mass Spectrometry (SIMS) for Surface Analysis
Secondary Ion Mass Spectrometry (SIMS) for Surface Analysis General overview of SIMS - principles, ionization, advantages & limitations SIMS as a surface analysis technique - operation modes, information
More informationPackage crrsc. R topics documented: February 19, 2015
Package crrsc February 19, 2015 Title Competing risks regression for Stratified and Clustered data Version 1.1 Author Bingqing Zhou and Aurelien Latouche Extension of cmprsk to Stratified and Clustered
More informationHazard Communication & Chemical Safety. Based on OSHA Standard
Hazard Communication & Chemical Safety Based on OSHA Standard 1910.1200 We use many chemicals We want you to know how to use them safely You will learn about The Hazards of Chemicals Our Written Program
More informationLife Science FROM MOLECULES TO ORGANISMS: STRUCTURES AND PROCESSES
FROM MOLECULES TO ORGANISMS: STRUCTURES AND PROCESSES HS-LS1-1 Construct an explanation based on evidence for how the structure of DNA determines the structure of proteins which carry out the essential
More informationCairns Hospital: Suspected Acute Coronary Syndrome Pathways. DO NOT USE if a non cardiac cause for the chest pain can be diagnosed
Cairns Hospital: Suspected Acute Coronary Syndrome Pathways DO NOT USE if a non cardiac cause for the chest pain can be diagnosed Clinical pathways never replace clinical judgement. Care outlined on this
More informationActivation of STING with Synthetic Cyclic Dinucleotides and Synergy with Checkpoint Inhibition
Activation of STING with Synthetic Cyclic Dinucleotides and Synergy with Checkpoint Inhibition Sarah McWhirter, PhD Director, STING Program Aduro Biotech ICI Boston 2017 Presentation 1 Disclosures Sarah
More informationChapter 8 The Cellular Basis of Reproduction and Inheritance
Chapter 8 The Cellular Basis of Reproduction and Inheritance PowerPoint Lectures Campbell Biology: Concepts & Connections, Eighth Edition REECE TAYLOR SIMON DICKEY HOGAN Lecture by Edward J. Zalisko Introduction
More informationChapter 4 Fall Notations: t 1 < t 2 < < t D, D unique death times. d j = # deaths at t j = n. Y j = # at risk /alive at t j = n
Bios 323: Applied Survival Analysis Qingxia (Cindy) Chen Chapter 4 Fall 2012 4.2 Estimators of the survival and cumulative hazard functions for RC data Suppose X is a continuous random failure time with
More informationA. Environmental Biology B. Historical biology
Biology Introduction 1. Which character differentiates living things from non-living organisms? A. They live in the same ecosystem. B. They are acted upon by the same environment They are highly organized
More informationGeneration Date: 12/07/2015 Generated By: Tristan Wiley Title: Bio I Winter Packet
Generation Date: 12/07/2015 Generated By: Tristan Wiley Title: Bio I Winter Packet 1. Many natural ecosystems have been destroyed by human activity. To better manage our remaining natural ecosystems, we
More informationA Bayesian Stopping Rule for a Single Arm Study: with a Case Study of Stem Cell Transplantation
A Bayesian Stopping Rule for a Single Arm Study: with a Case Study of Stem Cell Transplantation Chao-Yin Chen Kathryn Chaloner University of Minnesota University of Iowa May-15-2002 1 A Case Study: MT9928
More informationUnit D: Controlling Pests and Diseases in the Orchard. Lesson 5: Identify and Control Diseases in the Orchard
Unit D: Controlling Pests and Diseases in the Orchard Lesson 5: Identify and Control Diseases in the Orchard 1 Terms Abiotic disease Bacteria Biotic diseases Cultural disease control Disease avoidance
More informationA SIX MONTH OLD GIRL WITH HEMOLYTIC ANEMIA Case study by Jim Perkins, M.D. ( 2009)
A SIX MONTH OLD GIRL WITH HEMOLYTIC ANEMIA Case study by Jim Perkins, M.D. ( 2009) CLINICAL PRESENTATION A six month old girl presented with lethargy after four days of cough, rhinorrhea, and fever, and
More informationThe topics in this unit are:
The topics in this unit are: 1 Cells 2 Inside the cell 3 Mitosis 4 Meiosis 5 DNA and growth 6 mrna 7 Stem cells 8 Uses of stem cells 9 Therapeutic cloning 10 - Growth in plants 11 Meristems 12 Cuttings
More informationRisk Assessment of Staphylococcus aureus and Clostridium perfringens in ready to eat Egg Products
Risk Assessment of Staphylococcus aureus and Clostridium perfringens in ready to eat Egg Products Introduction Egg products refer to products made by adding other types of food or food additives to eggs
More informationQ2 (4.6) Put the following in order from biggest to smallest: Gene DNA Cell Chromosome Nucleus. Q8 (Biology) (4.6)
Q1 (4.6) What is variation? Q2 (4.6) Put the following in order from biggest to smallest: Gene DNA Cell Chromosome Nucleus Q3 (4.6) What are genes? Q4 (4.6) What sort of reproduction produces genetically
More informationSupplementary Tables and Figures
Supplementary Tables Supplementary Tables and Figures Supplementary Table 1: Tumor types and samples analyzed. Supplementary Table 2: Genes analyzed here. Supplementary Table 3: Statistically significant
More informationPerplexing Observations. Today: Thinking About Darwinian Evolution. We owe much of our understanding of EVOLUTION to CHARLES DARWIN.
Today: Thinking About Darwinian Evolution Part 1: Darwin s Theory Perplexing Observations Mystery of the Black Death?? What is evolution?? And what is this finch doing?!? We owe much of our understanding
More informationThe Future of Healthcare? W H A T D O E S T H E F U T U R E H O L D? The Empowered Consumer
: : The Future of Healthcare? W H A T D O E S T H E F U T U R E H O L D? The Empowered Consumer Dr. Anne Anne W. Snowdon, W. Snowdon, RN, BScN, Chair MSc, PhD World Health Innovation Network, Odette School
More information1. Which of the following is a virus? C D. 2. Which of the following is found in both cells and viruses?
TEKS 4C compare the structures of viruses to cells, describe viral reproduction, and describe the role of viruses in causing diseases such as human immunodeficiency virus (HIV) and influenza 1. Which of
More informationLaboratory Safety Rules
While working in the science laboratory, you will have certain important responsibilities that do not apply to other classrooms. You will be working with materials and apparatus which, if handled carelessly
More informationB1 REVISION CHAPTER 1 KEEPING HEALTHY
B1 REVISION CHAPTER 1 KEEPING HEALTHY What are the 7 components of a healthy diet? 1.. 2.. 3.. 4.. 5.. 6.. 7.. What are the different methods of infection? Describe the issues with being overweight Describe
More informationSurvival Analysis with Time- Dependent Covariates: A Practical Example. October 28, 2016 SAS Health Users Group Maria Eberg
Survival Analysis with Time- Dependent Covariates: A Practical Example October 28, 2016 SAS Health Users Group Maria Eberg Outline Why use time-dependent covariates? Things to consider in definition of
More informationIn vitro the effect of intestinal normal flora on some pathogenic bacteria.
In vitro the effect of intestinal normal flora on some pathogenic bacteria. Abstract: Dr.abbass shaker Ali adel Leena abd Al-Redha The effect of two types of intestinal bacterial normal floral ( and klebsiella)
More informationMicrobiology BIOL 202 Lecture Course Outcome Guide (COG) Approved 22 MARCH 2012 Pg.1
Microbiology BIOL 202 Lecture Course Outcome Guide (COG) Approved 22 MARCH 2012 Pg.1 Course: Credits: 3 Instructor: Course Description: Concepts and Issues 1. Microbial Ecology including mineral cycles.
More informationHow many lessons is it?
Science Unit Learning Summary Content Eukaryotes and Prokaryotes Cells are the basic unit of all life forms. A eukaryotic cell contains genetic material enclosed within a nucleus. Plant and animal cells
More information