Analytical Solutions High Purity Solvents and reagents. Europe Middle East Africa PERFORMANCE MATERIALS

Transcription

1 Analytical Solutions High Purity Solvents and reagents Europe Middle East Africa TM PERFORMANCE MATERIALS

2 Lab-Optimized Performance: Enhance the separation and reproducibility, maximize the sensitivity and detecting power of your instrumentation

3 At Avantor Performance Materials, uncompromising performance comes from two proven brands: J.T.Baker brand chemicals application-optimized and function-tested to maximize instrument performance Macron Fine Chemicals brand products providing value through consistent and reliable results for customers around the world. Avantor high purity solvents and reagents give you the performance you need - minimizing the risk of contaminants that can limit accuracy while maximizing instrument sensitivity and detection power in key applications: UHPLC and LC/MS analysis where our ULTRA LC/MS products are ideal for cutting-edge applications such as proteomics, pharmacokinetics, clinical research and drug discovery while our LC/MS products are function-tested and optimized for minimal impurities and interference-free baselines, giving you performance you can trust. HPLC analysis where we offer our pure HPLC products you can trust to improve your processes, obtain high selectivity, reproducibility and accuracy of results. GC analysis where our products are fully characterized and lot controlled by ECD, FID, or other method-specific detectors to deliver the highest level of purity and lot-to-lot consistency. Low UV absorbance, residue after evaporation and low water levels will create a flat base line and extend column life in demanding gas chromatography analysis. Spectrometry our solvents are manufactured to minimize lot-to-lot variability and contaminants that can interfere with UV, and in some cases IR, spectra, including residue after evaporation, and acid and base concentrations.

4 Avantor High Purity Solvents Grade Recommendation Application J.T.Baker BAKER ANALYZED HPLC Reagents J.T.Baker BAKER ANALYZED LC/MS Reagents J.T.Baker BAKER ANALYZED ULTRA LC/MS Reagents J.T.Baker ULTRA RESI- ANALYZED Reagents J.T.Baker BAKER ANALYZED Pesticide Reagents Macron Fine Chemicals ChromAR Solvents HPLC - Conventional HPLC - QC/QA Gas Chromatography (GC) HPLC -Research LC/MS - QC/QA LC/MS - Research LC/MS - Critical Research UHPLC - QC/QA UHPLC - General Research UHPLC - Critical Research Suitable ++ Preferred +++ Ideal General traditional applications where quality is important, primarily assay and UV Conventional does not require extensive characterization of trace metals. Filtration at 0.2 um is sufficient. Assay, UV and RAE (Residue after evaporation) are important specifications. Common in open access/high volume laboratories, initial investigations and compound management Critical requires solvents to have characterization of trace metals, precise function testing and 0.1 um filtration for UHPLC applications Examples of critical research are work in proteomics, small molecule drug discovery and bioanalysis.

5 Avantor High Purity Solvents Testing Parameters Testing Parameters* J.T.Baker BAKER ANALYZED HPLC Reagents J.T.Baker BAKER ANALYZED LC/MS Reagents J.T.Baker BAKER ANALYZED ULTRA LC/MS Reagents J.T.Baker ULTRA RESI- ANALYZED Reagents J.T.Baker BAKER ANALYZED Pesticide Reagents Macron Fine Chemicals ChromAR Solvents Color (APHA) X X ECD and/or FID Sensitive Impurities X x For Organic Residue Analysis X x ESI- Positive mode X X ESI- Negative mode Filtered through a 0.1 micron filter X X Fluorescence Trace Impurities X X X Gradient Test X X X x Residue after Evaporation X X X X x x Substances Reducing Permanganate X Trace Metal Impurities (ppb) X X * NOTE: The testing parameters are typical for the grades listed in the table. For actual testing parameters, please refer to the product specification sheet. UHPLC and LC/MS Analysis The rapid growth of LC/UV and LC/MS and the development of Ultra High-Pressure Liquid Chromatography (UHPLC) technology has created a need for suitable solvents for use in these applications. We have applied our many years of experience in purification, distillation, and blending to develop a line of high purity J.T.Baker brand solvents and blends to ensure optimal instrument performance. The J.T.Baker ULTRA LC/MS product line was developed for the most demanding UHPLC and mass spectrometry (MS) applications, such as proteomics, drug discovery, pharmacokinetics, and clinical research. ULTRA LC/MS solvents are designed to extend the useful life of UHPLC columns by significantly reducing particles and minimizing the occurrence of erroneous peaks caused by the formation of metal adducts or the presence of organic impurities, such as phthalates or polyethylene glycol.

6 Selection guide: Application and MS Analyzer ULTRA LC/MS and LC/MS Solvents Industry/Application Drug discovery LC/MS ULTRA LC/MS Solvents x Drug identification x x Drug formulation x x Biotechnology Food x x ULTRA LC/MS products undergo advanced suitability testing with both electrospray positive and negative modes to strengthen detection of extraneous organic impurities. The result is minimal baseline noise, reduced ion suppression, and improved sensitivity to both small and large molecule detection. Solvents are packaged in borosilicate bottles to minimize leaching of trace metal impurities over time, which reduces metal adduct formation, improves analyte identification and ensures reliable, consistent, and reproducible results. For more routine applications, our LC/MS solvents and blends are function-tested and optimized for minimal impurities and interference-free baselines, giving you performance you can trust in the mobile phase -- every time. J.T.Baker LC/MS solvents and blends are optimized to provide low particulates, polyethylene glycol, phthalates and amides, and extremely low levels of metal ions and non-volatile residue. s are function tested for LC/ MS suitability, ESI+, UV-Vis absorbance, trace metals, residue after evaporation, and assay. Interference-free baselines ensure users can have the highest confidence in solvent performance in their applications. High end research labs University research x x QC testing labs x x Mass Spectrometry Analyzer Single Quadrupole J.T.Baker ULTRA LC/MS s Number* Acetonitrile, Schott DURAN Borosilicate glass bottle 9853 Methanol, Schott DURAN Borosilicate glass bottle 9863 Water, Schott DURAN Borosilicate glass bottle 9823 Schott is a registered trademark of Schott DURAN is a registered trademark of DURAN GROUP GmbH LC/MS x x ULTRA LC/MS Solvents Tandem Quadrupole x x Ion Trap MALDI-TOF MS-MS Hybrids (Quadrupole Time-of-Flight) FT-ICR (Fourier transform ion cyclotron resonance mass spectrometer) x x x x

7 J.T.Baker LC/MS s Number LC/MS Solvents Acetonitrile 9821 Methanol 9822 Water Propanol 9827 Ethyl Acetate 9828 LC/MS Blends 0.1% Formic Acid in Acetonitrile % Formic Acid in Water % Trifluoroacetic Acid in Acetonitrile % Trifluoroacetic Acid in Water % Formic Acid in Acetonitrile % Formic Acid in Water 9826 LC/MS Acids Formic Acid -10 x 1ml ampoules and 2 x 1ml ampoules 9820 Trifluoroacetic acid 4l; 1l; 70ml; 10 x 1ml ampoules and 2 x 1ml ampoules 9810 High Performance Liquid Chromatography (HPLC) Analysis Liquid chromatography (LC) is the most widely used chromatographic technique being done in most laboratories in operation today. The reasons are many ease of use, speed, separation reproducibility, and accuracy of results. LC is also generally non-destructive to the sample components, allowing them to be recaptured as they come off the instrument. For optimum HPLC performance, you need the right solvents and reagents. Whatever your analytical application, Avantor offers the products you need to be successful. J.T.Baker HPLC products are designed to provide rapid, reproducible performance and separation in research and quality control applications. For critical HPLC applications, J.T.Baker solvents and modifiers remain the preferred choice for chemists throughout the world enabling optimum instrument performance and sensitivity. J.T.Baker HPLC solvents are manufactured using multistep purification processes that produce reliable, low backgrounds free of extraneous peaks. s are function tested for assay, water, residue after evaporation, and UV absorbance and fluorescence in critical ranges. Selected J.T.Baker HPLC acids, bases and ion pair reagents enhance the usefulness of HPLC as an analytical technique. s are controlled for solubility in aqueous and organic solutions, UV transparency for optimum sensitivity and metallic impurities which can affect biological activity. Macron Fine Chemicals ChromAR solvents are ideal for use in analytical testing in a wide variety of markets, like industrial, chemical, pharmaceutical, and agricultural, where consistency and reliability are required. These reagents are produced under strict manufacturing practices providing consistent gradient profiles for reproducible results. You can perform a variety of liquid chromatography as well as spectrometry applications, with confidence in the quality of your test results.

8 J.T.Baker HPLC Acids, Salts and Ion-Pair Reagents Acids Number Trifluoroacetic Acid 9470 Acetic Acid, Glacial 9515 Salts Ammonium Acetate 0599 Ammonium Dihydrogen Phosphate 0777 Sodium Acetate Trihydrate 0393 Ion-Pair Reagents 1-Heptanesulfonic Acid Sodium Salt Hexanesulfonic Acid Sodium Salt Octanesulfonic Acid Sodium Salt Pentanesulfonic Acid Sodium Salt Monohydrate 2841 Tetrabutylammonium Hydrogen Sulfate (98%) Tetrabutylammonium Hydroxide, Titrant (0.4M in O) V360 V365 Tetrabutylammonium Hydroxide in Water 9580 Tetrabutylammonium Phosphate V375 J.T.Baker BAKER ANALYZED HPLC Solvents Number Acetone 8142 Acetone, Low Water 9003 Acetonitrile 8257 Acetonitrile, Far UV Gradient Grade 9012 Acetonitrile, Ultra Gradient Grade 9017 Chloroform (Hydrocarbon Stabilized) 9174 Chloroform (Stabilized Ethanol) 9175 Cyclohexane 9292 o-dichlorobenzene 9233 Dichloromethane (Stabilized Amylene) 9410 Ether, Anhydrous 9237 Ethyl Acetate 9282 n-heptane 9177 Hexanes (95% n-hexane) 9304 Isobutyl Alcohol 9048 Methanol 8404 Methanol, Ultra Gradient Grade 8402 Methyl tert-butyl Ether 9042 Methyl Ethyl Ketone 9214 Pentane Propanol 9095 Pyridine, Low Water 9393 Tetrahydrofuran 9441 Tetrahydrofuran (Stabilized) 9440 Tetrahydrofuran, Low Water ,2,4-Trichlorobenzene ,2,4-Trimethylpentane 9480 Water 4218

9 Macron Fine Chemicals ChromAR Solvents Number 1,2-Dichloroethane Butanol Chlorobutane ,2,4-Trimethylpentane Butanon 6206 Acetone 2435 Acetonitrile 2856 Acetonitrile 2856 Acetonitrile 6711 Chloroform (Stabilized Amylene) 4443 Chloroform (Stabilized Ethanol) 6754 Cyclohexane 6720 Dichloromethane (Stabilized Amylene) 6714 Diethyl Ether (Stabilized BHT) 6727 Diethylamine 6728 Dimethyl Sulfoxide 2969 Number Ether (Stabilized Ethanol) 2854 n-heptane, 99.5% 5139 Ethyl Acetate H078 n-hexane, 95% 6752 Heptane fraction 6751 Isopropyl Alcohol (2-Propanol) 3043 Methyl Alcohol, Anhydrous (Methanol) 3041 Methyl Alcohol, Anhydrous (Methanol) 6712 N, N - Dimethylformamide 5362 n-butyl Acetate 6723 n-heptane, 95% 6750 n-heptane, 99% 5410 n-hexane, 99% 6713 NMP (N-Methyl-2-pyrrlidinone) 6392 n-pentane, 95% 6755 n-pentane, 99% 6721 Petroleum Ether, Petroleum Ether, Propyl Alcohol (1-Propanol) 5351 Pyridine 6730 Tert-Butyl Methyl Ether 5398 Tetrachloroethylene 6759 Tetrahydrofuran 2858 Toluene 4483 Water 6795

10 Gas Chromatography The rigorous demands of EPA extraction/concentration protocols inspired the development of J.T.Baker brand solvents for GC analysis. J.T.Baker solvents are designed, manufactured and tested to provide the best performance for any GC application. Avantor solvents are tested and controlled for optimum purity and lot-to-lot consistency for reproducible results at an economical price. J.T.Baker ULTRA RESI-ANALYZED solvents start with the purest raw materials available. They pass through a combination of chemical and non-chemical purification technologies that remove reactive solvent impurities and produce higher assays and narrow solvent fronts, then are packaged to maintain purity. Inert gas blanketing throughout the manufacturing and packaging process, along with our unique stabilizer system, provides unmatched product stability and interference-free results. s are then function-tested on high resolution capillary GC and proven suitable to the ppt/ppb level on both ECD and FID detectors. s are tested to meet EPA requirements for extraction/ concentration procedures and AOAC requirements for pesticide residue analysis. They are also performance-tested to purity levels below the Lower Level of Quantitation (LLQ) for trace analyte detection by standard EPA methods. J.T.Baker BAKER ANALYZED Pesticide Reagent solvents are specially developed for use in evaluation of pesticide (and insecticide) residues in food, feed, water or soil samples as suitable for all analysis of common pesticides such as 2-chlorobiphenyl, Heptachlor, Aldrin, Parathion, Dieldrin, Endrin, DDT, Dioxine etc. They are specified to the required low residue levels (5 ppm) for use in research and quality control laboratories. J.T.BAKER ANALYZED ULTRA-RESI Solvents and Reagents Solvents Number Acetone 9254 Acetonitrile 9255 Carbon Disulfide E350 Chloroform (Stabilized Ethanol) 9257 Cyclohexane 9258 Dichloromethane (Stabilized) 9264 Diethylether (EPA Method 8151A) 9259 Ethyl Acetate 9260 N-Heptane 9338 Hexane (95% n-hexane) 9262 Hexane (99 % n-hexane) N168 Iso-Hexane 9267 Methanol (Purge & Trap) 9077 Methanol 9263 Methyl tert-butyl Ether 9043 N-Pentane 9333 Petroleum Ether C Propanol 9334 Tetrachloroethylene (Stabilized) 9360 Toluene ,2,4-Trimethylpentane 9335 Water 4219 Salts Sodium Sulfate Anhydrous 3375

11 J.T.Baker BAKER ANALYZED Pesticide Reagents Number 2,2,4-Trimethylpentane Propanol 8468 Acetone 5276 Acetonitrile 5283 Chloroform (Stabilized Ethanol) 5285 Cyclohexane 5278 Dichloromethane (Stabilized Amylene) 5275 Diethyl Ether (Stabilized Ethanol) 8467 Ethyl Acetate 5277 Heptane, 95% 8472 Methanol 5279 n-hexane (95% n-hexane) 5274 n-hexane, 99% 8473 n-pentane 5281 Petroleum Ether C 5280 Toluene 8470 J.T.Baker BAKER ANALYZED GC-HS Reagents have been developed for more sensitive GC-headspace analysis of volatile organic impurities. Each solvent is tested to ensure optimal performance with purity and extremely low or levels of residual solvent impurities - certificates of analysis include exact marked impurities. The Purge and Trap process separates and concentrates volatile sample components in a sorbent trap, which is then heated rapidly to desorb the volatile components onto the GC instrument. J.T.Baker ULTRA RESI-ANALYZED Methanol ( Number 9077) was designed specifically for use in Purge and Trap analysis applications. In addition to the usual specifications for GC application, this product is tested for volatile organic traces that could interfere with the purge and trap analysis. J.T.Baker BAKER ANALYZED GC - HS Reagents Number DMF-N,N-dimethylformamide 9753 DMSO-dimethyl sulfoxide 9754 DMA-N,N-dimethylacetamide 9755 UV/Visible/IR Spectrometry The principle of spectrometry is fairly straightforward that the identification and concentration of a species in solution can be determined by measuring the transmittance or absorbance of radiation passed through the solution. It s a simple concept, but to make it work you need a solvent that doesn t interfere with the measurement at the specific wavelength being measured. J.T.Baker PHOTREX solvents are recommended for use in UV, visible, and IR spectrometry applications. They are manufactured to minimize lot-to-lot variability and contaminants that can interfere with UV, and in some cases IR, spectra, including residue after evaporation, and acid and base concentrations. Function testing confirms maximum absorbance in selected wavelengths, and for PHOTREX solvents, 50% to 100% transmittance windows in IR wavelengths are reported. J.T.Baker Spectrometry Solvents Number Alcohol, Anhydrous, Reagent Butanol 9189 Chloroform (Stabilized Ethanol) 7071 Cyclohexane ,2-Dichloroethane ,4-Dioxane 9196 Dichloromethane (Stabilized Amylene) 7305 Dimethyl Sulfoxide 7093 Ethanol, Absolute 8029 Hexane(99% N-Hexane) 8205 Methanol, Absolute 8046 Paraffin Oil 9388 Petroleum Ether, C Propanol 8235 Toluene ,2,4-Trimethylpentane 8715 Xylenes 9516

12 Also available from Avantor Performance Materials: J.T.Baker brand product portfolio Solid-phase extraction J.T.Baker silica- and polymer-based BAKERBOND spe columns and high performance BAKERBOND Speedisk columns and disks improve and simplify sample clean-up and concentration Dissolution Testing Media J.T.Baker dissolution media concentrates are produced in accordance to USP guidelines and containers are filled to +/- 0.5% of target fill volumes to ensure consistent, reproducible results every time. Reduce average prep time by more than 75%. Just add purified water and begin testing Trace metal analysis reagents full range of products to prepare your samples with the utmost consistency, highest purity and stability, offered in three different grades ppt, ppb or ppm trace metal acids Biosolvents sophisticated reagents proven to expand process control, reduce variables, maximize coupling efficiencies and boost yields Bioreagents high purity reagents tested for use in biotechnology applications, such as electrophoresis, and liquid chromatography General reagents J.T.Baker BAKER ANALYZED ACS solvents, acids, salts, solutions provide very high characterization and purity. For standard reagent grades of chemicals, Macron Fine Chemicals AR grade chemicals are designed to provide the best value for the price Phillipsburg, NJ 9001:2008 & 14001:2004 Paris, KY 9001:2008 Mexico City, Mexico 9001:2008 Deventer, the Netherlands 9001:2008, 14001:2004 & 13485:2003 Gliwice, Poland 9001:2008 & 17025:2005 Selangor, Malaysia 9001:2008 Dehradun, India 9001:2008, 14001:2004 & 13485:2003 Mumbai, India 9001:2008 & 17025:2005 Avantor Performance Materials Avantor Performance Materials manufactures and markets high-performance chemistries and materials around the world under several respected brand names, including the J.T.Baker, Macron Fine Chemicals, Rankem, BeneSphera and POCH brands. Avantor products are used in a wide range of industries. Our biomedical and life science solutions are used in pharmaceutical production, laboratory research for academic, industry and quality control, and in medical lab testing. Our electronics materials products are used in the manufacturing of semiconductors. PERFORMANCE MATERIALS TM For additional information please visit or follow Ordering Information and Assistance Customer Service tel: fax: avantor.emea@avantormaterials.com ASK Avantor Our Web site features ASK Avantor, which includes live chat capabilities with customer service representatives. Corporate Headquarters Avantor Performance Materials, Inc Corporate Parkway Suite #200 Center Valley, PA USA Worldwide Locations China Malaysia North America India Mexico Poland Korea The Netherlands Taiwan For contact information at these locations, visit Lit # 9147_E_Analytical_JTBaker_Macron_HighPuritySolvents_Rev _E 2014 Avantor Performance Materials, Inc. All rights reserved. Trademarks are owned by Avantor Performance Materials, Inc. or its affiliates unless otherwise noted.

13 J.T.Baker Brand Reagents for trace Metal Analysis Europe Middle East Africa

14 Lab-Optimized Performance: Function-tested reagents for trace-metal analysis from the brand that delivers quality and purity.

15 Avantor Performance Materials reputation for high-purity acids is based on years of quality, consistency, and innovation. We introduced the purest acids in the world when we launched the J.T.Baker brand ULTREX product line in the 1970 s. Even today, the ULTREX II product line represents the best purity available. Combined with the rest of our offerings, these products are part of the broadest acid portfolio available from a basic manufacturer of acids. Avantor continues to be a leader in the field of analytical chemistry by developing products to meet the needs of specific applications. Our range of acids includes: ULTREX II Reagents acids for critical elemental analysis with less than 10 parts-per-trillion (ppt) levels of up to 65 elements. These high performance acids are for your most critical trace element analysis. Extensively tested and packaged in innovative packaging to ensure ultimate quality BAKER INSTRA-ANALYZED Plus Reagents acids for elemental analysis. Quality is assured for up to 64 trace metals tested to very low parts-per-billion (ppb) levels BAKER INSTRA-ANALYZED Reagents acids for elemental analysis. These trace metal analysis acids are analyzed for up to 35 metals in the low parts-per-billion (ppb) range ensuring low background interference BAKER ANALYZED Reagents acids that meet or exceed ACS specifications and provide exceptional quality and value. These general-purpose acids can double as trace metal acids for qualitative and quantitative elemental analysis. All BAKER ANALYZED reagents with complete characterization are listed in the catalog Instrument Calibration and Standards the availability of reliable, accurate standards is critical to the success of your instrumental analyses. Analytical standards are needed to create calibration curves for quantitative analysis and for standardization of instruments used in a variety of elemental analysis applications. Standards must be stable and contain highly accurate concentrations of the element being tested for Purity and consistency are key requirements for all reagent chemicals, but they are especially important with acids, whether used for trace-metal analysis or for general use. The J.T.Baker brand acid product line includes inorganic acids (in three distinct levels of purity) and organic acids. Our acid packaging is designed with purity, safety and convenience in mind.

16 Key Applications and Industries Industry Examples of Sample Types Methods/Regulations Natural Waters (rivers, lakes, streams) Drinking Water Waste Water US EPA Method 1638 Metals by ICP-MS Method Metals in Drinking Water by ICP-MS EPA Method 1311 Hazardous Waste Environmental/Agriculture Industrial Influents and Effluents EPA Method 6010 Total Metals in Waste Water Sludges SW-846 Methods A Livestock Feed Fertilizers Soil EPA 6010B EPA Method 3050B Plant Tissue Total Metals in Soil by ICPMS Method 6020 ISO Food and Beverage Food Additives Raw/In Process and Finished s US FDA Elemental Analysis Manual for Food and Related s Packaging Materials Nutraceutical Herbal Remedies, Supplements, Medical Foods US FDA Elemental Analysis Manual for Food and Related s Pharmaceutical Drugs, Vaccines, Vitamins US Pharmacopeia - National Formulary Standards Clinical/Biological Tissues (liver, kidney), Blood/Blood s, Urine CDC Metals in Urine 8310 or Elements in Blood and Tissue 8005 Medical Devices Dental Alloys Implants NIOHS

17 Acid Selection Guide Application Detection Limit Instrumentation Grade Critical analysis, ultra-low detection Parts per trillion (ppt) Parts per billion (ppb) Inductively Coupled Plasma (ICP-OES) (ICP-MS), Graphite Furnace (GFAA) Ultrex II Sensitive trace metal analysis, EPA Protocols Parts per billion (ppb) very low Inductively Coupled Plasma (ICP-OES), Graphite Furnace (GFAA) BAKER INSTRA-ANALYZED Plus Routine trace metal analysis, EPA Protocols Parts per billion (ppb) low Inductively Coupled Plasma (ICP-OES) BAKER INSTRA-ANALYZED Qualitative metal analysis Parts per million (ppm) Flame Atomic Absorption (AA), Wet Chemistry BAKER ANALYZED ACS ULTREX II Reagents Designed for Parts-Per-Trillion (ppt) Elemental Analysis ULTREX II acids are the ideal choice for today s most demanding applications. Whether you are doing environmental testing, plasma analysis, microelectronic research, or any other exacting procedure that requires the ultimate in purity, ULTREX II acids are the solution. ULTREX II acids offer: Analysis for up to 65 trace elements to parts-per-trillion (ppt) levels by ICP-MS Specifications of less than 10 parts per trillion (ppt) for 50 elements Total element impurities that typically do not exceed 500 ppt The purest acids with the lowest metal content of any acids available Guaranteed lot-to-lot consistency for exceptional results Packaging in pre-leached, fluoropolymer bottles under Class 100 environment to eliminate cross contamination ULTREX II Reagents Number Acetic Acid, Glacial 6903 Ammonium Hydroxide 4807 Hydrochloric Acid 6900 Hydrofluoric Acid 6904 Hydrogen Peroxide 5155 Nitric Acid 6901 Perchloric Acid 4806 Phosphoric Acid 6908 Sulfuric Acid 6902 Water 6906

18 ULTREX II Dispenser System Reduce the risk of contamination and maintain purity with the ULTREX bottle-top dispenser specifically designed for use with ULTREX II acids. This Teflon PFA or TFM (modified PTFE) constructed dispenser will eliminate leaching and airborne contamination, minimize waste and enhance safe handling. Acid pre-cleaned to maintain < 0.1 ppb metal blank levels in routine use. All wet parts are constructed with Teflon to maintain product purity. Each unit comes with a PTFE air filter to reduce risk of airborne contamination. ULTREX II Dispenser System Number ULTREX Bottle Top Dispenser ULTREX Dispenser Base

19 BAKER INSTRA-ANALYZED Plus Reagents Designed for very low Parts-Per-Billion (ppb) Elemental Analysis BAKER INSTRA-ANALYZED Plus acids offer you the purity you need for meeting the high demanding needs in element analysis - for testing of more trace metals with tighter specifications on low parts-per-billion (ppb) levels. They are packaged in space-saving and environmentallyfriendly HDPE bottles. Features and Benefits Quality assured for up to 64 trace metals tested to low parts-per-billion (ppb) levels Lot to lot consistency ensures reliable results between tests Available in low metallic extractables packaging Enhanced safety with tamper-evident caps Environmentally-friendly recyclable bottles Strict protocols in an ISO facility ensure quality in manufacturing Compatibility for testing more trace metals and tightened specifications on most of the metals already tested BAKER INSTRA-ANALYZED Plus Reagents Number Acetic Acid, Glacial 9375 Ammonium Hydroxide, 20% 9380 Hydrochloric Acid 9385 Hydrochloric Acid, 30% 9600 Hydrofluoric Acid 9387 Nitric Acid 9368 Perchloric Acid, 70% 9359 Sulfuric Acid 9390 Water 9381

20 BAKER INSTRA-ANALYZED Acids Designed for Parts-Per-Billion (ppb) Elemental Analysis ICP-OES/AES has become one of the standards in trace metal analysis techniques due to its excellent limits of detection and linear dynamic range, multi-element capability and reproducibility. BAKER INSTRA-ANALYZED grade of acids were designed for routine trace metal analysis and environmental testing protocols by ICP-OES/AES. BAKER INSTRA-ANALYZED acids are analyzed for up to 35 metals in the low parts-per-billion (ppb) range. For added safety, BAKER INSTRA-ANALYZED acids are packaged in polycoated and polyethylene bottles. BAKER INSTRA-ANALYZED Acids Number Acetic Acid, Glacial 9524 Ammonium Hydroxide 6162 Hydrochloric Acid 9530 Hydrofluoric Acid 9563 Nitric Acid 9598 Perchloric Acid 9653 Sulfuric Acid 9673

21 Instrument Calibration and Standards Avantor understands your needs and provides an array of J.T.Baker branded standards for atomic absorption and ICP applications. We offer single element AA and single plasma standards for your convenience, including many standards specifically for environmental testing protocols and the EPA Contract Laboratory Program (CLP). Atomic Absorption Standards J.T.Baker branded atomic absorption standards are prepared from metals and salts of 99.99% spectral purity in specially selected matrices. Standards are available for 35 elements in 1,000 µg/ml concentrations packaged in 100 ml bottles. All standards are verified against standards traceable to the National Institute of Standards and Technology (NIST) Standard Reference Material (SRM) numbers, which are printed on the label. Atomic Absorption Standards Concentration Solute Number Aluminum 1,000 µg/ml Al 6801 Antimony 1,000 µg/ml Sb 6802 Arsenic 1,000 µg/ml As 6803 Barium 1,000 µg/ml Ba(NO 3 ) Beryllium 1,000 µg/ml Be 6805 Bismuth 1,000 µg/ml Bi 6806 Cadmium 1,000 µg/ml Cd 6807 Calcium 1,000 µg/ml CaCO Chromium 1,000 µg/ml Cr 6809 Cobalt 1,000 µg/ml Co 6810 Copper 1,000 µg/ml Cu 6811 Iron 1,000 µg/ml Fe 6812 Lead 1,000 µg/ml Pb 6813 Magnesium 1,000 µg/ml Mg 6815 Manganese 1,000 µg/ml Mn 6816 Mercury 1,000 µg/ml Hg 6817 Molybdenum 1,000 µg/ml Mo 6818 Nickel 1,000 µg/ml Ni 6819 Potassium 1,000 µg/ml KNO Silver 1,000 µg/ml Ag 6821 Sodium 1,000 µg/ml Na 2 CO Strontium 1,000 µg/ml Sr(NO 3 ) Tin 1,000 µg/ml Sn 6824 Titanium 1,000 µg/ml (NH 4 ) 2 TiF Vanadium 1,000 µg/ml V 2 O Zinc 1,000 µg/ml Zn 6827

22 Single Element Plasma Standards Produced from raw materials with greater than % spectral purity, these J.T.Baker branded standards are packaged in 100 ml bottles that are acid leached and triple rinsed. Each standard is analyzed for the calibrating element, as well as trace impurities of over 70 additional elements. All solutions are NIST traceable. s are available in concentrations of 1,000 µg/ml or 10,000 µg/ml in 100 ml bottles. Single Element Plasma Standards Concentration Solute Matrix Number Aluminum 1,000 µg/ml Al 2% HNO ,000 µg/ml 5716 Antimony 1,000 µg/ml Sb 2% HNO ,000 µg/ml 5717 Arsenic 1,000 µg/ml As 2% HNO ,000 µg/ml 5718 Barium 1,000 µg/ml Ba(NO 3 ) 2% HNO ,000 µg/ml 5719 Beryllium 1,000 µg/ml Be 4 O(C 2 H 3 O 2 ) 6 2% HNO ,000 µg/ml 5720 Bismuth 1,000 µg/ml Bi 2% HNO ,000 µg/ml 10% HNO Boron 1,000 µg/ml H 3 BO 3 2% NH 4 OH ,000 µg/ml 5722 Cadmium 1,000 µg/ml Cd 2% HNO ,000 µg/ml 5723 Calcium 1,000 µg/ml CaCO 3 2% HNO ,000 µg/ml 5% HNO Chromium 1,000 µg/ml Cr 2% HNO ,000 µg/ml 5727 Cobalt 1,000 µg/ml Co 2% HNO ,000 µg/ml 5728 Copper 1,000 µg/ml Cu 2% HNO ,000 µg/ml 5729 Gallium 1,000 µg/ml Ga 1% HNO ,000 µg/ml ,000 µg/ml 5759

23 Single Element Plasma Standards (2) Concentration Solute Matrix Number Gold 1,000 µg/ml Au 5% HCl ,000 µg/ml 5730 Iron 1,000 µg/ml Fe 2% HNO ,000 µg/ml 5731 Lead 1,000 µg/ml Pb 2% HNO ,000 µg/ml 5732 Lithium 1,000 µg/ml Li 2 CO 3 2% HNO ,000 µg/ml 7% HNO Magnesium 1,000 µg/ml Mg 2% HNO ,000 µg/ml 5734 Manganese 1,000 µg/ml Mn 2% HNO ,000 µg/ml 5735 Mercury 1,000 µg/ml Hg 2% HNO ,000 µg/ml 5736 Molybdenum 1,000 µg/ml Mo 2% NH4OH ,000 µg/ml 5737 Nickel 1,000 µg/ml Ni 2% HNO ,000 µg/ml 5738 Niobium 1,000 µg/ml NbCl 5 O/Trace HF ,000 µg/ml 5760 Palladium 1,000 µg/ml Pd 2% HNO ,000 µg/ml 5739 Platinum 1,000 µg/ml Pt 5% HCl ,000 µg/ml 10% HCl 5740 Potassium 1,000 µg/ml KNO 3 2% HNO ,000 µg/ml 5741 Scandium 1,000 µg/ml ScO 3 2% HNO ,000 µg/ml 7% HNO Selenium 1,000 µg/ml Se 2% HNO ,000 µg/ml 5743 Silicon 1,000 µg/ml Si 2% HNO ,000 µg/ml 5744 Concentration Solute Matrix Number Silver 1,000 µg/ml Ag 2% HNO ,000 µg/ml 5745 Sodium 1,000 µg/ml Na 2 CO 3 2% HNO ,000 µg/ml 5746 Strontium 1,000 µg/ml Sr(NO 3 ) 2 2% HNO ,000 µg/ml 5747 Tantalum 1,000 µg/ml TaCl 5 O/Trace HF ,000 µg/ml 1% HF 5748 Tellurium 1,000 µg/ml Te 10% HCl ,000 µg/ml: 40% HCl 5749 Thallium 1,000 µg/ml Tl 2% HNO ,000 µg/ml 5761 Thorium 1,000 µg/ml Th(NO 3 ) 4 2% HNO ,000 µg/ml 5% HNO Tin 1,000 µg/ml Sn 2% HNO 3 / Trace HF ,000 µg/ml 5751 Titanium 1,000 µg/ml Ti 2% HNO 3 /HF ,000 µg/ml 5752 Uranium 1,000 µg/ml U 3 O 8 1% HNO ,000 µg/ml 5753 Vanadium 1,000 µg/ml V 2 O 5 2% HNO ,000 µg/ml 10% HNO Yttrium 1,000 µg/ml Y 2 O 3 1% HNO ,000 µg/ml 5755 Zinc 1,000 µg/ml Zn 2% HNO ,000 µg/ml 5756 Zirconium 1,000 µg/ml ZrCl 2 O 1% HNO ,000 µg/ml 5757

24 Also available from Avantor Performance Materials: J.T.Baker brand product portfolio J.T.Baker brand chemicals are known worldwide for reliable results that help our customers to achieve new heights in chemistry. Our products are application-optimized to help you get the most from high performance specialty instrumentation used across pharmaceutical, environmental, and other markets. ULTRA LC/MS products ideal for cutting-edge applications such as proteomics, pharmacokinetics, clinical research and drug discovery LC/MS products function-tested and optimized for minimal impurities and interference-free baselines, giving you performance you can trust HPLC products pure and trusted chromatography solvents to improve your processes GC products low UV absorbance, residue after evaporation and water levels that create flat base lines and extend column life in demanding gas chromatography analysis applications Dissolution Testing Media J.T.Baker dissolution media concentrates are produced in accordance to USP guidelines and containers are filled to +/- 0.5% of target fill volumes to ensure consistent, reproducible results every time. Reduce average prep time by more than 75%. Just add purified water and begin testing Trace metal analysis reagents full range of products to prepare your samples with the utmost consistency, highest purity and stability, offered in three different grades ppt, ppb or ppm trace metal acids Biosolvents sophisticated reagents proven to expand process control, reduce variables, maximize coupling efficiencies and boost yields Bioreagents high purity reagents tested for use in biotechnology applications, such as electrophoresis, and liquid chromatography General reagents J.T.Baker BAKER ANALYZED ACS solvents, acids, salts, solutions provide very high characterization and purity. For standard reagent grades of chemicals, Macron Fine Chemicals AR grade chemicals are designed to provide the best value for the price Phillipsburg, NJ 9001:2008 & 14001:2004 Paris, KY 9001:2008 Mexico City, Mexico 9001:2008 Deventer, the Netherlands 9001:2008, 14001:2004 & 13485:2003 Gliwice, Poland 9001:2008 & 17025:2005 Selangor, Malaysia 9001:2008 Dehradun, India 9001:2008, 14001:2004 & 13485:2003 Mumbai, India 9001:2008 & 17025:2005 Avantor Performance Materials Avantor Performance Materials manufactures and markets high-performance chemistries and materials around the world under several respected brand names, including the J.T.Baker, Macron Fine Chemicals, Rankem, BeneSphera and POCH brands. Avantor products are used in a wide range of industries. Our biomedical and life science solutions are used in pharmaceutical production, laboratory research for academic, industry and quality control, and in medical lab testing. Our electronics materials products are used in the manufacturing of semiconductors. For additional information please visit or follow Ordering Information and Assistance Customer Service tel: fax: avantor.emea@avantormaterials.com ASK Avantor Our Web site features ASK Avantor, which includes live chat capabilities with customer service representatives. Corporate Headquarters Avantor Performance Materials, Inc Corporate Parkway Suite #200 Center Valley, PA USA Worldwide Locations China Malaysia North America India Mexico Poland Korea The Netherlands Taiwan For contact information at these locations, visit Lit # 9132 rev _e 2014 Avantor Performance Materials, Inc. All rights reserved. Trademarks are owned by Avantor Performance Materials, Inc. or its affiliates unless otherwise noted.

25 J.T.Baker Brand SOLID PHASE EXTRACTION PRODUCTS Europe Middle East Africa

26 Function-tested performance: For faster, more precise, cost-effective separations, superior reproducibility and accurate results in analytical chromatography

27 In the world of analytical chemistry, chromatography has become the most widely used analytical technique due to the convenience, speed of separations, reproducibility, and quantitative accuracy of results that are inherent to the techniques. As instrument sensitivity continues to improve, suitable high purity solvents for the mobile phase and an effective sorbent stationary phase are becoming even more vital to success in the laboratory. At Avantor Performance Materials, we manufacture innovative chromatography media products that support diverse separation techniques and applications, as well as high purity solvents to maximize separation performance and reliability in chromatography applications. Our highly efficient chromatography products are designed to deliver optimum performance, reproducibility and easy scale-up, without changing the quality of established method. Sample Preparation For as long as scientists have been analyzing compounds, there has been a need for sample preparation to extract and purify sample components. Today s technology for sample preparation, Solid Phase Extraction (SPE), is grounded in the principles of chromatography and offers increased speed, reduced hazardous solvent use and exposure, and improved reproducibility of the separation when compared to other wet chemistry methods, such as liquid/liquid extraction. Our scientists have been using and perfecting this method in our research and development labs since the 1970 s. The purpose of sample preparation Sample clean up necessary to eliminate impurities and/or isolate the component of interest from the matrix. This helps to increase lifetime of the analytical column, prevents contamination of equipment, thereby protecting expensive instrumentation. Sample concentration in order to reach the detection limits of the analytical equipment. Sample preparation selectively concentrates the components of interest prior to analysis.

28 Silica-based Columns Avantor carefully defines and controls critical surface chemistry parameters to ensure performance consistency. Our knowledge and experience have led to the development of wide range of silica products, both endcapped, which offer high hydrolytic stability, and non-endcapped, which are used in extraction of more polar analytes. SPE silica-based sorbents provide predictable and consistent extractions for discrete subsets of a broad range of sample types. Mixed-mode sorbents can be used for the extraction of compounds from more complex matrixes. Avantor s product line offers a complete solution, with both weak and strong cation and anion exchange sorbents. J.T.Baker brand Sample Preparation s Following market needs for improved purity, detection, and quantification limits in analytical techniques, Avantor offers a variety of J.T.Baker brand silica- and polymer-based BAKERBOND spe columns, high performance J.T.Baker BAKERBOND Speedisk columns and disks, and J.T.Baker standard vacuum processors to improve and simplify sample clean-up and concentration. We recommend J.T.Baker BAKERBOND spe columns when standard performance with good economy is needed. J.T.Baker BAKERBOND Speedisk columns are recommended when higher levels of speed and performance are required. Polymer-based Columns In addition to SPE sorbents, Avantor offers polymeric sorbents that improve the recovery of sample preparation. J.T.Baker BAKERBOND spe SDB phase sorbents have a large surface area and are highly rigid and stable over whole ph range. J.T.Baker BAKERBOND Speedisk polymer columns are packed with polymer resins, products of our ultra-clean polymer micro particle technology. These resin particles have a large surface area and are highly rigid and stable over ph range 1 14, in addition to being water-wettable and not impacted by sorbent drying. Columns are available in hydrophobic, hydrophilic, and ion exchange forms, suitable when advanced detection methods will be used.

29 Standard Vacuum Processors for Extraction Columns and Disks J.T.Baker standard vacuum processors offer the flexibility of processing SPE devices of different heights, diameters, or formats during the same experiment. The vacuum processor design is familiar throughout the industry and supports all devices and accessories with luer-type fittings such as J.T.Baker BAKERBOND spe, J.T.Baker BAKERBOND Speedisk columns, and J.T.Baker BAKERBOND Speedisk extraction disks. The J.T.Baker BAKERBOND Speedisk Expanded Extraction Station includes a six-port vacuum manifold and the accessories needed to support the extraction of analyte by J.T.Baker BAKERBOND Speedisk laminar extraction disks For application notes and other technical information concerning specific use of our products in applications, please visit General product overview table Attribute Silica based SPE products Polymer based SPE products J.T.Baker BAKERBOND spe columns Standard J.T.Baker BAKERBOND spe 1, 3 and 6ml columns, round-rimmed and earshaped in ultraclean polypropylene and glass Reverse phase Normal phase Ion exchange Adsorption Drug of abuse SDB * Activated Spherical Carbon J.T.Baker BAKERBOND Speedisk Columns J.T.Baker BAKERBOND Speedisk 1, 3 and 6 ml columns are configured to run 9 times faster than traditions SPE columns, operating with smaller solvent volumes and having higher capacity per milligram sorbent than conventional SPE columns Reverse phase Normal phase Ion exchange Adsorption Drug of abuse O-Philic DVB ** O-Philic SC-DVB ** O-Phobic DVB ** O-Phobic SC-DVB ** J.T.Baker BAKERBOND Speedisk Extraction Disks 50 mm disks that are the correct choice for samples from 200 ml to 2 L. They are neither cartridge nor membrane. A thin bed of J.T.Baker BAKERBOND sorbent micro particles is supported in a laminar structure to maintain speed and capacity and enhance reproducibility of adsorption. Extraction disks for manual extraction stations and for automated extractors Extraction disks for manual extraction stations and for automated extractors *Styrene Divinylbenzene; ** Divinylbenzene Summary of Separation Mechanisms for Solid Phase Separations Separation Mechanism Analyte Type Dissolving solvents Eluting solvents Normal Phase (Silica) Slightly to Moderately Polar Low eluotropic strength e.g., hexane,chloroform High eluotropic strength e.g.,methanol Normal Phase (Polar Bonded Phase) Moderately to Strongly Polar Low eluotropic strength e.g., hexane,chloroform High eluotropic strength e.g.,methanol Reversed Phase (Nonpolar Bonded Phase) Nonpolar High eluotropic strength e.g.,methanol/water acetonitrile/water For nonpolar analytes: Low eluotropic strength e.g.,hexane,chloroform For polar analytes: High eluotropic strength e.g.,methanol Anion Exchange (SAX,WCX) Ionic Acid Water or buffer (ph=pka+2) * 1. Buffer (ph=pka-2) 2. ph where sorbent or analyte is neutral 3. Solvent with high ionic strength Cation Exchange (SCX,WCX) Ionic Base Water or buffer (ph=pka-2) 1. Buffer (ph=pka+2) 2. ph where sorbent or analyte is neutral 3. Solvent with high ionic strength Size Exclusion Proteins Water or buffer Water or buffer * pka = - logka where Ka is a measure of the ionic activity of the analyte

30 J.T.Baker BAKERBOND spe Columns With J.T.Baker BAKERBOND spe columns, customers can choose the solid phase extraction column that best fits their sample size and performance requirements. Standard J.T.Baker BAKERBOND spe 1ml, 3ml, and 6ml ultraclean polypropylene and glass columns, packed with mg sorbent, are suitable for samples from 0.2 to 10 ml when standard speed, recovery, and final concentration with good economy are needed. J.T.Baker BAKERBOND Speedisk Columns & Disks J.T.Baker BAKERBOND Speedisk columns reduce SPE run times by 60-80% and may eliminate other time consuming sample preparation steps, such as pre-filtration and an additional evaporation/reconstitution step, often required with conventional SPE columns. The patented, laminar design of J.T.Baker BAKERBOND Speedisk columns is especially useful in clinical and pharmaceutical drug application, as it provides shorter run times, higher capacity, optimum recovery, and more effective separation when tested against like products. J.T.Baker BAKERBOND Speedisk extraction disks are the correct choice for samples from 200 ml to 2 L. Our patented disk is pre-assembled for use in preparing aqueous samples for analysis. J.T.Baker BAKERBOND Speedisk columns and disks are disposable, ultraclean, polypropylene, pre-packed with high performance micro particles of 10µm (silica-based) and 25µm (polymer-based). These are available in a wide range of formats to meet all your separation needs. BAKERBOND Speedisk s are protected by U.S. Patent No. 5,595,653 J.T.Baker BAKERBOND spe and BAKERBOND Speedisk Columns Performance Comparison Sample preparation step J.T.Baker BAKERBOND spe columns J.T.Baker BAKERBOND Speedisk columns Column Size / Sorbent 1 cc / 100 mg 1 cc /20 mg Particle Size 40 µm 25 µm Sample volume 2 ml 1 ml Column conditioning 2 ml (20 40 sec) 0.5 ml (5 10 sec) Sample addition 2 ml (100 sec) 50µl -0.5 ml (50 sec) Washing 1.5 ml (15 20 sec) 0.4 ml (2 5 sec) Elution 1 2 ml ml Sample concentration/ evaporation 3 10 minutes Reduced or eliminated

31 The following tables list the various sorbents that we offer pre-packaged in J.T.Baker BAKERBOND spe and BAKERBOND Speedisk columns. J.T.Baker BAKERBOND spe Silica-based Columns Functional Mode General Applications Particle size, shape Pore size Å Typical loading End capped Number* Octadecyl (C 18 ) Reverse Phase Non-ionic, non-polar to moderately polar analytes Octadecyl (C 18 ) LightLoad Reverse Phase Non-ionic, non-polar to polar analytes PolarPlus Octadecyl (C 18 ) Reverse Phase Non-ionic, basic, non-polar to polar analytes Octyl (C 8 ) Reverse Phase Non-ionic, non-polar to moderately polar analytes 40µm, irregular % C Yes 7020-xx 40µm, irregular 60 12% C No 7189-xx 40µm, irregular % C No 7466-xx 40µm, irregular % C Yes 7087-xx Ethyl (C 2 ) Reverse Phase Polar and Basic Analytes 40µm, irregular % C Yes 7273-xx Phenyl (C 6 H 5 ) Reverse Phase Polar from non-polar/polar solvents using hydrogen bonding like mechanisms 40µm, irregular % C Yes 7095-xx Spe 500* ((C )ach 3 Reverse Phase Organichlorine pesticides from water 40µm, irregular 60 N/A Yes Cyano (CN) Reverse Phase/ Normal Phase Non-ionic, non-polar to polar analytes 40µm, irregular %C 2.4% N Yes 7021-xx Diol (COHCOH) Normal Phase Non-ionic, polar analytes 40µm, irregular % C Yes 7094-xx Amino (N ) Normal Phase Lipids (fatty acids, cholesterol) 40µm, irregular %C 2.2% N Yes 7307-xx Diamino (N /N ) Quaternary Amine (N + ) Aromatic Sulfonic Acid (ArSO 2 OH) Propyl Sulfonic Acid (SO 2 OH) Carboxylic Acid (COOH) Normal Phase/ Ion Exchange Strong Anion Exchange Strong Cation Exchange Strong Cation Exchange Weak Cation Exchange Lipids (fatty acids, cholesterol) 40µm, irregular meq/g Yes 7089-xx Ionic, acidic analytes 40µm, irregular meq/g Yes 7091-xx Ionic, basic analytes 40µm, irregular meq/g No 7090-xx Ionic, basic analytes 40µm, irregular meq/g Yes 7155-xx Ionic, basic analytes 40µm, irregular meq/g Yes 7211-xx Florisil (Mg 2 SiO 3 ) Adsorption Low to moderately polar analytes from nonaqueous solutions Silica Gel (SiOH) Adsorption Polar analytes from non-polar solvents like hydrocarbons and less polar esters and ethers Alumina Neutral Adsorption Weakly or moderately polar compounds µm, irregular xx 40µm, irregular xx µm, irregular xx Narc-1 ( 9-carboxy THC) Mixed Mode Carboxy-tetrahydrocannabinol (THC) 40µm, irregular 60 N/A yes 7221-xx Narc-2 (Cocaine, BEC) Mixed Mode Hydrophobic/basic analytes (Cocaine, Benzoylecgonine) Wide Pore Butyl (C 4 ) Reverse Phase Small peptides, separations where C 18 gives excessive retention or poor recovery 40µm, irregular 60 N/A N/A 7225-xx 40µm, irregular % C yes 7216-xx Wide Pore CBX Weak Cation Exchanger Weak bases such as purines, pyrimidines, vitamin B6, cyclic hydroxyamines 40µm, irregular % C no 7217-xx Sephadex Size Exclusion Desalting, removal of small molecular weight compounds µm, irregular xx *xx-different number for every pack size. For detailed product listings and technical information, please visit

32 J.T.Baker BAKERBOND spe Special Application Columns Extraction Columns for Drugs of Abuse Narc-1 - rapid, reproducible extraction of THC-carboxylic acid from urine using a unique, patented carboxy ester bonded phase. Narc-1 has a high selectivity for THC-carboxylic acid and provides highly consistent recoveries without co-extracting many other common drugs Number* 500 mg Narc-2 -for the extraction of basic compounds, such as opiates, LSD, phencyclidine, aminebased drugs, cocaine, and others. Narc-2 columns can be used for basic drug screening, as well as acidic/neutral drugs 125 mg 250 mg 500 mg Extraction Columns for PAH Applications For the extraction and clean-up of Poly Aromatic Hydrocarbons (PAH), including the 16 priority pollutant EPA PAH s PAH SOIL - designed for the clean-up of PAH s in soil extracts 500mg Cyano (top)/1000mg SiOH PAH AQUA - is designed for the extraction of PAH s from water (DIN mg NH2 (top)/ 500 mg C PAH AQUA - is designed for the extraction of PAH s from water (DIN mg NH2 (top)/ 1000 mg C Extraction Columns for PCB Applications For the extraction and clean-up of PCB s PCB-N - for the extraction of PCB s from oil (DIN 51527, part 1) 500mg Ar-SO 3 (top) / 500 mg SiOH PCB-A - for the extraction of PCB s in oil (dirty samples) 500 mg Sulfuric Acid treated SiOH (top) / 500 mg Ar-SO Extraction Columns for Acrylamide Applications Activated Carbon (spherical) - for the extraction and purification of organic compounds such as acrylamide and other polar compounds Extraction Columns for Pesticides Applications 500 mg 1000 mg For the extraction of pesticides from water 500 mg C 18 (top) / 200 mg SDB For the extraction of pesticides from water 250 mg C18 Polar Plus (top) / 100 mg SDB Extraction Column for Pesticide Residue Analysis Carbon/Amino - for the removal of matrix components when performing the clean-up of pesticide residues in, especially, food and feed analysis 500 mg Carbon (top) / 500 mg Amino Extraction Columns and Sorbents for Mineral Oil Index Application Clean-up Column - tested according to ISO including ready to use SPE glass column 200 mg Anhydrous Sodium Sulfate (top) / 200 mg Florisil Clean-up Column - tested according to ISO including ready to use SPE glass column 2000 mg Anhydrous Sodium Sulfate (top) / 2000 mg Florisil Clean-up Column - Suitable for the determination of Hydrocarbon Oil Index according ISO and NEN gr Activated Florisil *xx-different number for every pack size. For detailed product listings and technical information, please visit

33 J.T.Baker BAKERBOND spe Polymer-based Columns Functional Mode General Applications SDB-1 Adsorption Slightly polar to non-polar analytes SDB-2 Adsorption Polar to non-polar analytes *xx-different number for every pack size. For detailed product listings and technical information, please visit Number* 7519-xx 7523-xx J.T.Baker BAKERBOND Speedisk Columns Silica- based columns Functional Mode General Applications Number* J.T.Baker BAKERBOND Speedisk Special Application Columns Extraction columns for drugs of abuse Number* Octadecyl (C 18 ) Reverse Phase Non-ionic, non-polar to moderately polar analytes Octadecyl (C 18 ) Lightload Octadecyl (C 18 ) PolarPlus Reverse Phase Reverse Phase Non-ionic, non-polar to polar analytes Non-ionic, basic, non-polar to polar analytes Octyl (C 8 ) Reverse Phase Non-ionic, non-polar to moderately polar analytes 7606-xx 8151-xx 8153-xx 8154-xx Narc-1 - rapid, reproducible extraction of THC-carboxylic acid from urine using a unique, patented carboxy ester bonded phase. Narc-1 has a high selectivity for THC-carboxylic acid and provides highly consistent recoveries without co-extracting many other common drugs Narc-2 - for the extraction of basic compounds, such as opiates, LSD, phencyclidine, amine-based drugs, cocaine, and others. narc-2 columns can be used for basic drug screening, as well as acidic/neutral drugs 8174-xx 8175-xx Quanternary Amine (N + ) Strong Ion Exchange Ionic, acidic analytes 8168-xx Diol (COHCOH) Normal Phase Non-ionic, polar analytes 8167-xx Amino (N ) Aromatic Sulfonic Acid Ion Exchange/ Normal Phase Strong Ion Exchange Lipids (fatty acids, cholesterol) Ionic, basic analytes 8165-xx 8170-xx *xx-different number for every pack size. For detailed product listings and technical information, please visit Carboxylic Acid Weak Cation Exchange Ionic, basic analytes 8172-xx Silica Adsorption Adsorbs polar analytes from non-polar solvents like hydrocarbons and less polar esters and ethers 8163-xx Narc-1 ( 9-carboxy THC) - Carboxy-tetrahydrocannabinol (THC) 8174-xx Narc-2 (Cocaine, BEC) Mixed Hydrophobic/basic analytes (Cocaine, Benzoylecgonine) 8175-xx Polymer- based columns Hydrophilic DVB Hydrophilic SC-DVB (SO 3 ) Adsorption Polar to non-polar analytes 8108-xx Mixed Mode Ionic, basic analytes 8111-xx Hydrophobic DVB Adsorption Slightly polar to non-polar analytes 8109-xx Hydrophobic SC-DVB (SO 3 ) Mixed Mode Ionic, basic analytes 8196-xx *xx-different number for every pack size. For detailed product listings and technical information, please visit

34 J.T.Baker SPE Sorbent and Solvent Selection Guide The guide below can help you select appropriate sorbents and solvents for separations based on sample type and separation parameters. Organic Samples MW< 2000 (in solution) Sample Solubility Organic Solvent Soluble Water Soluble Sample Matrix Ionic Non-ionic/lon-paired Organic Organic Aqueous Aqueous Aqueous Aqueous Aqueous Polar Moderately Polar Non Polar Anionic Cationic Non Polar Moderately Polar Polar Mechanism 1 NPC LSC RPC IEC IEC RPC LSC NPC SPE Phase Recommended 2 O-Philic DVB Cyano Diol Amino 1,2 Amino O-Phobic DVB O-Philic DVB Silica gel Florisil Alumina O-Phobic DVB O-Philic DVB SDB-1/SDB-2 Octadecyl Octyl Cyclohexyl Phenyl Cyano Amino 1,2 Amino Quaternary Amine O-Phobic SC-DVB O-Philic SC-DVB Cyano Carboxylic Acid Sulfonic Acid O-Phobic DVB O-Philic DVB SDB-1/SDB-2 Octadecyl Octyl Cyclohexyl Phenyl Cyano O-Phobic DVB O-Philic DVB Silica gel Florisil Alumina O-Philic DVB Cyano Diol Amino 1,2 Amino Solvents 3,4 Hexane Chloroform Dichloromethane Acetone Hexane Chloroform Dichloromethane Ethyl acetate Hexane Dichloromethane Acetone Acetonitrile Acids, buffers Acids, bases, buffers Hexane Dichloromethane Acetone Acetonitrile Hexane Chloroform Dichloromethane Ethyl acetate Hexane Chloroform Dichloromethane Acetone Methanol Methanol Methanol Methanol Methanol Methanol Water Water 1 Separation Mechanisms LSC: Liquid Solid Chromatography (Adsorption) NPC: Normal Phase Chromatography (Bonded Phase Partition) RPC: Reversed Phase Chromatography (Bonded Phase Partition) IEC: Ion-Exchange Chromatography (Bonded Phase Ion-Exchange) SDB: styrene divinyl benzene DVB: divinyl benzene O-Phobic WA DVB: Weak anion exchanger O-Phobic SC DVB: Strong cation exchanger O-Philic SA DVB: Strong anion exchanger O-Philic SC DVB: Strong cation exchanger 2 Bonded phases listed in order of increasing polarity 3 Eluting solvents listed in order of increasing polarity Selective elution can be performed by combining two or more miscible solvents to achieve various degrees of polarity 3,4 Solvents: 9262 Hexane, ULTRA RESI-ANALYZED 9257 Chloroform, ULTRA RESI-ANALYZED 9264 Dichloromethane, ULTRA RESI-ANALYZED 9260 Ethyl acetate, ULTRA RESI-ANALYZED 9254 Acetone, ULTRA RESI-ANALYZED 9255 Acetonitrile, ULTRA RESI-ANALYZED 9077 Methanol, ULTRA RESI-ANALYZED 4219 Water, ULTRA RESI-ANALYZED

35 J.T.Baker BAKERBOND Speedisk Extraction Disks Versatile, silica- and polymer- based J.T.Baker BAKERBOND Speedisk extraction disks are the correct choice for samples from 200 ml to 2 L. Our patented disk is pre-assembled for use in preparing aqueous samples for analysis, and the laminar configuration provides filtration capacity and inlet characteristics that maximize access of analyte molecules to the microparticulate sorbent. The J.T.Baker BAKERBOND Speedisk design resists clogging and ensures high throughput rate, making it ideal to use for analysis of both clear and particle-rich samples. Capacity, recovery, and precision are high due to the unique disk configuration and performance of J.T.Baker BAKERBOND sorbents. The patented J.T.Baker BAKERBOND Speedisk extraction disk is neither cartridge nor membrane. A thin bed of microparticles of J.T.Baker BAKERBOND sorbent is supported in a laminar structure to maintain speed and capacity and enhance reproducibility of adsorption. With J.T.Baker BAKERBOND Speedisk extraction disk sample contamination is virtually eliminated. Hands never touch the wetted parts of the pre-assembled disk, the sorbent and disk housing are pre-cleaned, and polyester packaging provides a barrier that repels moisture and eliminates the risk of contamination by plastic additives (e.g., phthalates). Advantages Shortened extraction time less than one hour Rapid run completion, even with dirty samples Reduced solvent consumption and hazardous waste Improved precision with its optimized flow path design Provides additional technology options to meet EPA requirements Compatible with J.T.Baker standard vacuum processors and the J.T.Baker BAKERBOND Speedisk Extraction Station Typical Applications Multiresidue Analysis Method of Triazines Organochlorine Pesticides and Polyaromatic Hydrocarbons in Drinking Water Phenols in aqueous matrix such as SW 846 Method 8041 or EPA Method 528 analytes Extraction of Semivolatile Organic Compounds using a Single ph - EPA Method 8270 Analytes Extraction of Carbamates from Water using BAKERBOND spe SDB-1 or BAKERBOND Speedisk O-Phobic DVB Column Extraction of Chlorinated Acids from Water (EPA Method 515.2) Extraction of EPA Method Analytes from Water Extraction of EPA Method 528 and 8041 Analytes from Water Extraction of EPA Method 608/8080 Analytes Extraction of EPA Method 8081A or 8082 Analytes - Organochlorine Pesticides or Polychlorinated Biphenyls using BAKERBOND Speedisk O-Phobic DVB Extraction Disk Extraction of Pharmaceuticals from Water Extraction of Polycyclic Aromatic Hydrocarbons from Drinking Water Extraction of Phthalate and Adipate Esters from Drinking Water

36 J.T.Baker BAKERBOND Speedisk Extraction Disks General Applications Quantity per box Number C 18 (octadecyl) 50 mm disks for water samples For Use in EPA Methods 500 Series, 608, SW 846/3535 and with C 18 (octadecyl) 50 mm disks for water samples, High capacity slightly polar to non-polar industrial samples C 18 Polar Plus 50 mm disks for water samples containing slightly polar to non-polar analytes C 18 XF (Extra filter) 50 mm disks for crude and dirty samples For extraction of slightly polar to moderately polar compounds such as sulfonylureas, phenols, chlor-phenoxy acids and urones For dirty samples: EPA method 608, 846 and slightly polar to non-polar industrial samples C 8 (octyl) 50 mm disks for diquat/paraquat For diquat, paraquat, EPA method O Phobic DVB (DiVinylBenzene) 50 mm disks for chlorinated acids For chlorinated acids, EPA Method Slightly polar to O Phobic DVB (DiVinylBenzene) 50 mm disks, High capacity* non-polar analytes O Philic DVB (DiVinylBenzene) 50 mm disks for chlorinated acids For SW846 hydrophobic to slightly hydrophilic compounds O Philic DVB (DiVinylBenzene) 50 mm disks, High capacity* Oil & Grease 50 mm disks for hydrocarbons / Oil & Grease For extraction of slightly polar to non-polar hydrocarbons, EPA method 1664, Rev.A SAX (Strong Anion Exchanger) 50 mm disks for haloacetic acids / Dalapon For EPA Method 552.1, haloacetic acids and Dalapon * High capacity: higher sorbent mass General SPE Accessories Quantity per package Number Reservoirs for use with 1, 3 and 6 ml spe columns, 15 ml Reservoirs for use with 3 and 6 ml columns, 75 ml Adaptor (white-colored) PTFE for glass SPE columns Adaptor (blue-colored) for attaching reservoir or luer tip to PP spe columns

37 J.T.Baker Standard Vacuum Processors for Extraction Columns and Disks J.T.Baker standard vacuum processors offer the flexibility of processing SPE devices of different heights, diameters, or formats during the same experiment. The vacuum processor design is familiar throughout the industry, and it supports all devices and accessories with luer-type fittings such as J.T.Baker BAKERBOND spe, J.T.Baker BAKERBOND Speedisk columns as well as J.T.Baker BAKERBOND Speedisk extraction disks. The J.T.Baker BAKER spe-12g is a 12-port system, suitable for processing up to 12 SPE columns at the same time. The processor comes complete with a glass vacuum basin, a cover with luer fittings and gasket, individual flow control stopcocks, stainless steel needles, a sample collection rack, height-adjustable shelves, and a vacuum gauge/controller. A 24-port system with the same components is also available J.T.Baker BAKER spe-12g Column Processor (PTFE Design) ( ) J.T.Baker BAKER spe-12g Column Processor (PTFE Design) includes: 1 borosilicate glass vacuum chamber, 1 whitecolored polyamide lid inclusive 12 luer PTFE connectors, plugs (12x) for lid, 1 polyethylene gasket, 12 Luer PP Stopcocks, 1 PTFE sample collection rack set including height adjustable shelves, 1 vacuum gauge/ptfe controller assembly, 1 instruction sheet. The J.T.Baker BAKER spe-12g is also available in a glass design (PN ). Accessories for J.T.Baker BAKER spe-12g Column Processor (PTFE design) Quantity per box Number Autosampler Plate Drying Top, polyamide for drying (columns) or evaporation (eluates) purpose Luer Stainless Steel Stopcocks PTFE Lined Luer locks (taps), Stainless Steel Stop Cocks, polypropylene Extraction Column Processor Replacement Parts for J.T.Baker BAKER spe-12g Column Processor (PTFE design) Quantity per box Number Borosilicate Glass Vacuum Chamber Polyamide Lid (with 12 PTFE luer connectors) PTFE Sample Collection Rack Set Polyethylene Gasket Seals Neoprene Gasket Seals Plugs for lid that fits into luer PTFE connectors (4586) Luer PTFE Stopcocks Luer PTFE Connectors (one-piece) Polypropylene Stopcocks Vacuum Gauge/PTFE Controller Assembly 1 Assembly

38 J.T.Baker BAKER spe-24g Column Processor (PN ) J.T.Baker BAKER spe-24g Column Processor completeincludes: 1 glass vacuum chamber, 1 nylon cover with luer fitting connectors and 1 polyethylene gasket, 24 individual flow control polypropylene stopcocks, 24 stainless steel needles, 1 sample collection rack with 3 support posts, 3 height adjustable shelves, 9 shelf support clips, 1 vacuum gauge/polypropylene controller assembly, 1 instruction sheet. Extraction Column Processor Replacement Parts for J.T.Baker BAKER spe-24g Column Processor Quantity per box Number Glass Vacuum Chamber Nylon (blue-colored) Lid (with luer connectors) Polypropylene Rack Set Neoprene Gasket Seals Polypropylene Replacement Needles Vacuum Gauge / Controller Assembly 1 assembly Plugs for Lid Polypropylene Stopcocks Polypropylene Luer Connector Female Polypropylene Luer Connector Male Stainless steel needles Accessories for J.T.Baker BAKER spe-24g Column Processor Quantity per box Number Inert Flow Control Valves Luer PTFE Stopcocks Luer Stainless Steel Stopcocks

39 J.T.Baker BAKERBOND Speedisk Expanded Extraction Station (PN ) Whatever your space and sample loading requirements, we have a vacuum extraction disk processor to meet your needs - J.T.Baker BAKERBOND Speedisk Expanded Extraction Station used in reservoir, inverted, or remote sample feed modes. The J.T.Baker BAKERBOND Speedisk Expanded Extraction Station includes a six-port vacuum manifold and the accessories needed to support the extraction of analyte by J.T.Baker BAKERBOND Speedisk laminar extraction disks. The manifold has a rectangular footprint and inter-port spacing to accommodate six, side-by-side, 1 liter sample reservoirs. Each vacuum port has an individual open/close valve. Includes: extraction station, 2 remote sample adapters, 2 collection chamber and 2 vials, 6 reservoirs of 185ml. J.T.Baker BAKERBOND Speedisk Expanded Extraction Station Accessories Adapters Quantity per box Number Remote sample adapter For transfer of sample from remote container to Speedisk Disk Reservoirs 185 ml Reservoir Holds inverted 1L reservoir or 185 ml sample 1L Glass reservoir 1L sample reservoir, fits directly into a Speedisk extraction disk Collection chamber (includes sample vial) Collection vials (Sample vials) Sample tray Holds up to four 1L bottle at a tilt to ensure complete sample uptake by remote sample adapter suction tube 70mm/ Mason Jar Adapter Enables inverted feed directly to extraction disk from sample jar