Hypervalent Iodine(III): Property and Reactivity. Penghao Chen g Dong Group Seminar October, 21 st, 2015
|
|
|
- Octavia Gilmore
- 6 years ago
- Views:
Transcription
1 Hypervalent Iodine(III): Property and Reactivity Penghao Chen g Dong Group Seminar October, 21 st, 2015
2 Structure and Nomenclature Aryl λ 3 iodanes: L I L L : hypervalent bond with a pure 5p orbital Ar I : typical bond with sp 2 hybridized orbital Aryl λ 5 iodanes L I L : hypervalent bond with two pure 5 p orbitals Ar I : typicalbond withsp hybridized orbital Iodanes with oxidation state of IV or higher generally undergoes oxidative processes Ochiai, Top. Curr. Chem. 2002, 224, 1.
3 Structure and Nomenclature [N X L] N: valence electron. X: central atom. L: ligand λ N : nonstandard bonding number Ochiai, Top. Curr. Chem. 2002, 224, 1.
4 General Reactivity Property Ligand Exchange Ochiai, Top. Curr. Chem. 2002, 224, 1.
5 General Reactivity Property Ligand Exchange Ochiai, Top. Curr. Chem. 2002, 224, 1.
6 General Reactivity Property Hypernucleofuge: Reductive Elimination Okuyama and Ochiai, J. Am. Chem. Soc. 1995, 117, Ochiai and Nagao, J. Chem. Soc., Chem. Commun. 1986, 1382.
7 General Reactivity Property Hypernucleofuge: Reductive Elimination Okuyama and Ochiai, J. Am. Chem. Soc. 1995, 117, Ochiai and Nagao, J. Chem. Soc., Chem. Commun. 1986, 1382.
8 General Reactivity Property Hypernucleofuge: Reductive Elimination Okuyama and Ochiai, J. Am. Chem. Soc. 1995, 117, Ochiai and Nagao, J. Chem. Soc., Chem. Commun. 1986, Wiberg, J. Org. Chem. 1982, 47, 2720.
9 General Reactivity Property Pseudorotation of λ 3 Iodane Berry, J. Chem. Phys. 1960, 32, 933. Ochiai, J. Am. Chem. Soc. 1990, 112, 5677.
10 General Reactivity Property Ligand Coupling on Iodine (III) Weigand, J. Org. Chem. 1976, 41, Okawara, Bull. Chem. Soc. Jpn. 1974, 47, Okawara, Bull. Chem. Soc. Jpn. 1972, 45, 1860.
11 General Reactivity Property Ligand Coupling on Iodine (III) Ochiai, J. Org. Chem. 1997, 62, 2130.
12 General Reactivity Property Electronic Nature Ochiai and Nagao, J. Chem. Soc., Chem. Commun. 1988, 1076.
13 General Reactivity Property Homolytic Cleavage Togo, Synlett. 2001, 565. Zhdankin, Rev. Heteroatom Chem. 1997, 17, 213.
14 General Reactivity Property Homolytic Cleavage Plesnicar, J. Am. Chem. Soc. 1968, 90, Ochiai, J. Am. Chem. Soc. 1992, 114, Zhdankin, J. Am. Chem. Soc. 1996, 118, 5192.
15 General Reactivity Property Single Electron Transfer Kita, J. Am. Chem. Soc. 1994, 116, Kita, Tetrahedron 2001, 57, 345.
16 General Reactivity Property Transformation RIL 2 Oxidation to form Multiple Bonds Reductive Elimination with Substitution Reductive Elimination with Rearrangement Activation of Multiple Bonds Oxidative Dearomatization Radical Transformation R2 IL Alkyl(aryl) IL Alkenyl(aryl) IL Alkynyl(aryl) IL
17 Preparation RIL 2 I PhI(OAc) 2 NaClO, HCl H 2 O, 20 o C, 5 min NaOH, H 2 O RT, 3h PhIO Cl I Cl R AcOOH, Ac 2 O ArI ArI(OAc) 2 Me I OMe 1) NaBO 3,HOAc 2) TsOH H 2 O R Me OMe I(OH)OT s OH HC(OMe) 3 PhI(OH)OTs PhI(OMe)OTs O I(Ph)OTs Zhang, Synthesis, 2009, 14, Dauban and Fleurat Lessard, J. Org. Chem., 2015, 80, Saltzman, Org. Synth. Coll., 1973, 5, 660. Wirth, Eur. J. Org. Chem. 2001, Koser, J. Am. Chem. Soc. 1990, 112, 5672.
18 Transformation RIL 2 Oxidation to form Multiple Bonds Kitamura, Heterocyclic Commun. 1998, 4, 205. Nagao, Tetrahedron Lett. 1988, 29, 6913.
19 Transformation RIL 2 Oxidation to form Multiple Bonds Kita, J. Chem. Soc., Chem. Commun. 1998, 173. Magnus, Synthesis. 1998, 547.
20 Transformation RIL 2 Oxidation to form Multiple Bonds Magnus, J. Am. Chem. Soc. 1992, 114, 767. Kiyokawa and Minakata, Angew. Chem. Int. Ed. 2015, 54, ASAP.
21 Transformation RIL 2 Reductive Elimination with Substitution Imamura, Bull. Chem. Soc. Jpn. 1978, 51, 335. Koser, J. Org. Chem. 1982, 47, 2487.
22 Transformation RIL 2 Reductive Elimination with Substitution Moriarty, Tetrahedron Lett. 1990, 31, 201. Hanaoka, Tetrahedron Lett. 1986, 27, 2023.
23 Transformation RIL 2 Reductive Elimination with Substitution Taschner and Koser, Tetrahedron Lett. 1986, 27, 4557.
24 Transformation RIL 2 Reductive Elimination with Substitution Wang, Synlett, 2009, Dong, Org. Lett. 2007, 9, 5345.
25 Transformation RIL 2 Reductive Elimination with Rearrangement Loudon, J. Org. Chem. 1984, 49, Tomasini, Org. Biomol. Chem. 2008, 6, 1849.
26 Transformation RIL 2 Reductive Elimination with Rearrangement 77-91% Ochiai and Fujita, J. Org. Chem. 1989, 54, 4832.
27 Transformation RIL 2 Reductive Elimination with Rearrangement Du and Zhao, Org. Lett. 2013, 15, 2906.
28 Transformation RIL 2 Reductive Elimination with Rearrangement Du and Zhao, Org. Lett. 2014, 16, 5772.
29 Transformation RIL 2 Reductive Elimination with Rearrangement Zhu, Chem. Commun. 2013, 49, Zhu, Org. Lett. 2013, 15, 3476.
30 Transformation RIL 2 Reductive Elimination with Rearrangement Antonchick, Angew. Chem. Int. Ed. 2014, 53, 8163.
31 Transformation RIL 2 Activation of Multiple Bonds Wirth, ChemistryOpen, 2012, 1, 245.
32 Transformation RIL 2 Activation of Multiple Bonds Moon, Tetrahedron Lett. 2013, 54, Wirth, Synthesis, 2012, 44, 1171.
33 Transformation RIL 2 Activation of Multiple Bonds Stuart, Angew. Chem. Int. Ed. 2015, 54, ASAP.
34 Transformation RIL 2 Oxidative Dearomatization Quideau, Tetrahedron 2010, 66, 2235.
35 Transformation RIL 2 Oxidative Dearomatization Fujioka and Kita, Chem. Commun. 2010, 46, 4133.
36 Transformation RIL 2 Oxidative Dearomatization Canesi, Org. Lett. 2009, 11, 4756.
37 Transformation RIL 2 Oxidative Dearomatization Canesi, Org. Lett. 2014, 16, 4928.
38 Transformation RIL 2 Oxidative Dearomatization ArSO 2 HN O N H O N CO 2 Me 1.1 eq PhI(OAc) eq LiOAc CF 3 CH 2 OH -20 o C, 10 min ArSO 2 HN 20-25% HN O O N CO 2 Me HO N H O NH Br Br Harran, Angew. Chem. Int. Ed. 2003, 42, 4961.
39 Transformation RIL 2 Oxidative Dearomatization Canesi, Chem. Eur. J. 2015, 21, ASAP.
40 Transformation RIL 2 Radical Suarez, Tetrahedron Lett. 1985, 26, Paquette, Tetrahedron Lett. 1997, 38, 195.
41 Transformation RIL 2 Radical Breslow, J. Am. Chem. Soc. 1991, 113, 8977.
42 Transformation RIL 2 Radical Pattenden, Tetrahedron Lett. 1993, 34, 127. Zhao and Du, J. Org. Chem. 2014, 79, 7451.
43 Transformation RIL 2 Radical Antonchick, Angew. Chem. Int. Ed. 2013, 52, 3267.
44 Transformation RIL 2 Radical Antonchick, Angew. Chem. Int. Ed. 2013, 52, 7985.
45 Preparation R 2 IL Fujita, Tetrahedron Lett. 1985, Stang, J. Am. Chem. Soc. 1994, 116, 93.
46 Transformation R 2 IL Alkyl(aryl) IL Reich, J. Am. Chem. Soc. 1978, 100, Magnus, J. Am. Chem. Soc. 1992, 114, 767.
47 Transformation R 2 IL Alkyl(aryl) IL DMSO/THF (94%) Kitamura, J. Am. Chem. Soc. 1999, 121, Rawal, J. Am. Chem. Soc. 1998, 120,
48 Transformation R 2 IL Alkenyl(aryl) IL Ochiai, J. Am. Chem. Soc. 1988, 110, 6565.
49 Transformation R 2 IL Alkenyl(aryl) IL Ochiai, J. Am. Chem. Soc. 1991, 113, Ochiai, J. Am. Chem. Soc. 1993, 115, 2528.
50 Transformation R 2 IL Alkenyl(aryl) IL Ochiai, J. Am. Chem. Soc. 1996, 118,
51 Transformation R 2 IL Alkenyl(aryl) IL Ochiai, J. Org. Chem. 1999, 64, Ochiai, J. Am. Chem. Soc. 1996, 118, Ochiai, J. Am. Chem. Soc. 1988, 110, 6565.
52 Transformation R 2 IL Alkynyl(aryl) IL Ochiai and Fujita, J. Am. Chem. Soc. 1986, 108, 8281.
53 Transformation R 2 IL Alkynyl(aryl) IL Ochiai and Fujita, J. Am. Chem. Soc. 1986, 108, 8281.
54 Transformation R 2 IL Alkynyl(aryl) IL Ochiai, J. Am. Chem. Soc. 1991, 113, Ochiai, J. Am. Chem. Soc. 1986, 108, Feldman, J. Org. Chem. 1995, 60, 7722.
55 Transformation R 2 IL Alkynyl(aryl) IL Stang, J. Am. Chem. Soc. 1994, 116, 93. Feldman, Org. Lett. 2000, 2, 2603.
56 Acknowledgement Welcome Marshall!!
57 Q1
58 Q2
59 Q3
60 A1
61 A2
62 A3
Recent Developments in the Chemistry of Polyvalent Iodine Compounds
Recent Developments in the Chemistry of Polyvalent Iodine Compounds Jiang Zhongping 2005-9-23 Content I. Introduction II. Iodine(III) Compounds III. Iodine(V) Compounds IV. Conclusions Introduction Why
Hypervalent (III) iodine chemistry
Hypervalent (III) iodine chemistry Alcohol and phenol oxydation by 1 Diacetyliodobenzene (DIB) H NH PhI(2.2 eq.) H 2,12h,rt 74% NH chiai, M. et al., Chem. Pharm. Bull. 2004, 1143-1144 2 Summary Generalities
Metalloporphyrin. ~as efficient Lewis acid catalysts with a unique reaction-field~ and. ~Synthetic study toward complex metalloporphyrins~
Metalloporphyrin ~as efficient Lewis acid catalysts with a unique reaction-field~ and ~Synthetic study toward complex metalloporphyrins~ Literature Seminar Kenta Saito (D1) 1 Topics Chapter 1 ~as efficient
Recent Advances in C-B Bond Formation through a Free Radical Pathway
Recent Advances in C-B Bond Formation through a Free Radical Pathway G. Yan. D. Huang, X. Wu, Adv. Synth. Catal. 2017, 359, 188. Daniel Meyer University of Bern 18.01.2018, Topic Review Classical Methodes
Recent Developments in Alkynylation
--New approaches to introduce an alkynyl group Reporter: Zhao-feng Wang Supervisor: Yong Huang 2013-03-27 Contents 1. Introduction of Acetylene Chemistry 2. Nucleophilic alkynylation : Classic text book
Catellani Reaction (Pd-Catalyzed Sequential Reaction) Todd Luo
Catellani Reaction (Pd-Catalyzed Sequential Reaction) Todd Luo 2014.1.6 1 Content Introduction Progress of Catellani Reaction o-alkylation and Applications o-arylation and Applications Conclusion and Outlook
Rising Novel Organic Synthesis
Literature report Rising Novel Organic Synthesis Methods Based on the Cleavage of N-N and N-O Bonds Reporter: Zhang-Pei Chen Checker : Mu-Wang Chen Date: 04/03/2014 Kürti, L. et al. Kürti, L. et al. Science
molecules ISSN
Molecules 2006, 11, 43-48 molecules ISS 1420-3049 http://www.mdpi.org Synthesis of Some ew 2-(3-Aryl-1-phenyl-4-pyrazolyl)- benzoxazoles Using Hypervalent Iodine Mediated Oxidative Cyclization of Schiff
General Papers ARKIVOC 2007 (xiii) 28-33
Hypervalent iodine oxidation of 1-phenyl-3-arylpyrazole-4- carboxaldehyde oximes: a facile and efficient synthesis of new 3,4-bis(1-phenyl-3-arylpyrazolyl)-1,2,5-oxadiazole--oxides m Prakash* and Kamaljeet
A convenient one-pot synthesis of aryl amines from aryl aldoximes mediated by Koser s reagent
A convenient one-pot synthesis of aryl amines from aryl aldoximes mediated by Koser s reagent Harisadhan Ghosh, Arghya Baneerjee, Saroj Kumar Rout, and Bhisma K. Patel* Department of Chemistry, Indian
N-Heterocyclic Carbene Catalysis via Azolium Dienolates: An Efficient Strategy for Enantioselective Remote Functionalizations
Angew. Chem. Int. Ed. 2017, 10.1002. 1 N-Heterocyclic Carbene Catalysis via Azolium Dienolates: An Efficient Strategy for Enantioselective Remote Functionalizations Reporter: En Li Supervisor: Prof. Yong
Study of Chemical Reactions
Study of Chemical Reactions Introduction to Mechanisms There are four different types of organic reactions: Additions Eliminations Substitutions Rearrangements 149 Addition Reactions Occur when 2 reactants
sp 3 C-H insertion by α-oxo Gold Carbene B4 Kei Ito
1 sp 3 C-H insertion by α-oxo Gold Carbene B4 Kei Ito 2016. 1. 30 1. Introduction 2 About Carbene 3 Brief history of carbene (~2000) Carbene Neutral compounds featuring a divalent carbon atom with only
Aza-Wacker-Type Cyclization. Group Meeting Tuesday, April 19, 2011 William Kuester
Aza-Wacker-Type Cyclization Group Meeting Tuesday, April 19, 2011 William Kuester N-heterocylization Reductive Amination Hydroamination Oxidative Cyclization Chemler, S.R. Org. Biomol. Chem. 2009, 7, 3009-3019.
Palladium-catalyzed sp 3 C H activation. Yan Xu Dong Group Meeting Apr. 2, 2014
Palladium-catalyzed sp 3 C H activation, Yan Xu Dong Group Meeting Apr. 2, 2014 Content 1 Allylic C H activation 2 Benzylic C H activation Palladiumcatalyzed sp 3 C H activation 3 4 Common sp 3 C H activation:
CHEMISTRY 332 FALL 08 EXAM II October 22-23, 2008
First Three Letters of Last Name NAME Network ID CHEMISTRY 332 FALL 08 EXAM II October 22-23, 2008 The following materials are permissible during the exam: molecular model kits, course notes (printed,
Halogen Bond Applications in Organic Synthesis. Literature Seminar 2018/7/14 M1 Katsuya Maruyama
Halogen Bond Applications in Organic Synthesis Literature Seminar 2018/7/14 M1 Katsuya Maruyama 1 Contents 1. Introduction 2. Property of Halogen Bond 3. Application to Organic Synthesis 2 1. Introduction
C H activation of aliphatic amines without unnecessary mask M2 Takaya Togo
C H activation of aliphatic amines without unnecessary mask 2017.11.25 M2 Takaya Togo 1 Outline 1.Introduction 2.Free amines as DG Discovery of new activation mode Mechanistic studies Application of the
Hypervalent Iodine. Diaryl-λ 3 -iodanes vs. diaryliodonium salts (Ar 2 IL) [10-I-3] Dess-Martin periodinane (DMP) General reactivity
![Hypervalent Iodine. Diaryl-λ 3 -iodanes vs. diaryliodonium salts (Ar 2 IL) [10-I-3] Dess-Martin periodinane (DMP) General reactivity](/thumbs/76/73300326.jpg "Hypervalent Iodine. Diaryl-λ 3 -iodanes vs. diaryliodonium salts (Ar 2 IL) [10-I-3] Dess-Martin periodinane (DMP) General reactivity")
ypervalent odine Baran Group eting 1. ntroduction ypervalent refers to a main group element that breaks the octet rule and formally has more than 8 electrons in its valence shell iodobenzene dichloride
Asymmetric Palladium Catalyzed Cross-Coupling Reactions. Topic Talk September 4 th, 2014 Morken Lab Emma Edelstein 1
Asymmetric Palladium Catalyzed Cross-Coupling Reactions Topic Talk September 4 th, 2014 Morken Lab Emma Edelstein 1 Palladium Catalyzed Cross-Coupling Reactions 2 Kumada/Negishi Cross-Coupling Kumada:
Organic Reactions catalyzed by rhenium carbonyl complexes
Organic Reactions catalyzed by rhenium carbonyl complexes Fanyang Mo Dong group seminar Feb. 26, 2014 Ref: Kuninobu, Y.; Takai, K. Chem Rev. 2011, 111, 1938. 1 Accidentally found by Ogawa in 1908, and
Synthesis, Mechanism, and Properties of Cyclopenta-fused Polycyclic Aromatic Hydrocarbons. Chaolumen. Introduction
March 22, 2018 Synthesis, Mechanism, and Properties of Cyclopenta-fused Polycyclic Aromatic Hydrocarbons Reaxys Prize Club Symposium in Japan 2018 Chaolumen Institute for Chemical Research, Kyoto University
Benzene and Aromatic Compounds. Chapter 15 Organic Chemistry, 8 th Edition John McMurry
Benzene and Aromatic Compounds Chapter 15 Organic Chemistry, 8 th Edition John McMurry 1 Background Benzene (C 6 H 6 ) is the simplest aromatic hydrocarbon (or arene). Four degrees of unsaturation. It
Facile and efficient oxidation of sulfides to sulfoxides in water using hypervalent iodine reagents
Facile and efficient oxidation of sulfides to sulfoxides in water using hypervalent iodine reagents Hirofumi Tohma, Tomohiro Maegawa, and Yasuyuki Kita* Graduate School of Pharmaceutical Sciences, Osaka
sp 3 C-H Alkylation with Olefins Yan Xu Dec. 3, 2014
sp 3 C-H Alkylation with Olefins, Yan Xu Dec. 3, 2014 1) sp 3 C-H Alkylation via Directed C-H activation 2) Hydroaminoalkylation (still via C-H activation) 3) Hydrohydroxyalkylation (via radical chemistry)
Discussion Addendum for: (Phenyl)[2-(trimethylsilyl)phenyl]iodonium Triflate. An Efficient and Mild Benzyne Precursor
![Discussion Addendum for: (Phenyl)[2-(trimethylsilyl)phenyl]iodonium Triflate. An Efficient and Mild Benzyne Precursor](/thumbs/82/85700948.jpg "Discussion Addendum for: (Phenyl)[2-(trimethylsilyl)phenyl]iodonium Triflate. An Efficient and Mild Benzyne Precursor")
DI:10.157/orgsyn.089.0098 Discussion Addendum for: (enyl)[-(trimethylsilyl)phenyl]iodonium Triflate. An Efficient and Mild Benzyne Precursor A. Cl Cl + Me 3 Cl Mg, I (cat.) HMPA 1 B. I(Ac) 1. TfH, CH Cl.
Modern Synthetic Methods
Modern Synthetic Methods Dr. Dorian Didier dodich@cup.uni-muenchen.de Functionnalized Organometallic Reagents C-N, C-O and C-S Bond Formation Introduction to Organoboron Chemistry Introduction to Organosilicon
Cambrian Explosion, Complex Eukaryotic Organism, Ozonosphere 3
Reporter: Wang Yuefan Reporter: Wang Yuefan Supervisor: Prof. Yang Zhen Supervisor: Prof. Yang Zhen Prof. Chen Jiahua Prof. Chen Jiahua 1 2011-12-2727 2011-02 2012-03 02-25 03-23 25 Content Preface Nature
Iron Catalysed Coupling Reactions
LONG LITERATURE REPORT Iron Catalysed Coupling Reactions Mingyu Liu 2017. 8. 31 1 Fe [Ar]3d 6 4s 2 The fourth most common element in the Earth s crust Relatively less understanding and manipulation of
C H Activated Trifluoromethylation
Literature report C H Activated Trifluoromethylation Reporter:Yan Fang Superior:Prof. Yong Huang Jun. 17 th 2013 Contents Background Trifluoromethylation of sp-hybridized C-H Bonds Trifluoromethylation
Rh(III)-catalyzed C-H Activation and Annulation via Oxidizing Directing Group. Lei Zhang 03/23/2016 Dong Group
Rh(III)-catalyzed C-H Activation and Annulation via Oxidizing Directing Group Lei Zhang 03/23/2016 Dong Group Content 1 Alkyne involved Annulation in Hua group 2 3 4 Brief Introduction of Internal Oxidants
Supplementary Materials: Metathetical Redox Reaction of (Diacetoxyiodo)arenes and Iodoarenes
Supplementary Materials: Metathetical Redox Reaction of (Diacetoxyiodo)arenes and Iodoarenes Antoine Jobin-Des Lauriers and Claude Y. Legault 1. Determination of Free Energies of Reaction (Equation (1)
Regioselective Reductive Cross-Coupling Reaction
Lit. Seminar. 2010. 6.16 Shinsuke Mouri (D3) Regioselective Reductive Cross-Coupling Reaction Glenn C. Micalizio obtained a Ph.D. at the University of Michigan in 2001 under the supervision of Professor
Palladium-Catalyzed Oxygenation of Unactivated sp 3 C-H Bonds
Palladium-Catalyzed xygenation of Unactivated sp 3 C- Bonds Pd(Ac) 2 5 mol% PhI(Ac) 2 1.1 eq. Pd 2 Ac Desai, L. P.; ull, K. L.; Sanford *, M. S. University of Michigan J. Am. Chem. Soc. 2004, 126, ASAP
Topic Review Group meeting
Topic Review Group meeting Memory of chirality Christian Gloor Based on: Zhao, H.; Hsu, D. C.; Carlier, P.R. Synthesis 2005,1, 1. Table of content > Definitions of memory of chirality > Types of chirality
Construction of C-C or C-N Bond via C-H Activation ~Chemistry of Yong-Qiang Tu~
Literature Seminar 2010.5.26 Yao u(2) Construction of C-C or C-N Bond via C-H Activation ~Chemistry of Yong-Qiang Tu~ Contents: 1. Yong-Qiang Tu's Profile 2.LatestWorkofProfessorTu 2-1. C-H Activation
Copper-Catalyzed Diastereoselective Arylation of Tryptophan Derivatives: Total Synthesis of (+)-
Literature Report Copper-Catalyzed Diastereoselective Arylation of Tryptophan Derivatives: Total Synthesis of (+)- aseseazines A and B Reporter: Mu-Wang Chen Checker: Zhang-Pei Chen Date: 2013-05-28 Reisman,
Mechanistic Implications in the Morita Baylis Hillman Alkylation: Isolation and Characterization of an Intermediate
Mechanistic Implications in the Morita Baylis Hillman Alkylation: Isolation and Characterization of an Intermediate M. E. Krafft,* T. F. N. Haxell, K. A. Seibert, and K. A. Abboud Department of Chemistry
Xuefeng Jiang Professor Education Academic Career Awards International Invited Lecture USA Germany Shanghai Taiwan Singapore)
Xuefeng Jiang( 姜雪峰 ) Professor East China Normal University, 200062, Shanghai, China Tel: +86-21-52133654 E-mail: xfjiang@chem.ecnu.edu.cn Web: http://faculty.ecnu.edu.cn/s/641/main.jspy Education 1999-2003
A project report on SYNTHESIS AND CHARACTERISATION OF COPPER NANOPARTICLE-GRAPHENE COMPOSITE. Submitted by Arun Kumar Yelshetty Roll no 410 CY 5066
A project report on SYNTHESIS AND CHARACTERISATION OF COPPER NANOPARTICLE-GRAPHENE COMPOSITE Submitted by Arun Kumar Yelshetty Roll no 410 CY 5066 Under the guidance of Prof. (Ms). Sasmita Mohapatra Department
Review. Frank Glorius & His Rh(III) C-H Activation. Li Yuanhe. Supervisors: Prof. Yang Prof. Chen Prof. Tang Prof. Luo 1 /21
Review Frank Glorius & His Rh(III) C-H Activation Li Yuanhe Supervisors: Prof. Yang Prof. Chen Prof. Tang Prof. Luo 1 /21 Author Introduction Prof. Dr. Frank Glorius 1972 Born 1991-1992 Military service
Learning Guide for Chapter 11 - Alkenes I
Learning Guide for Chapter 11 - Alkenes I I. Introduction to alkenes - p 1 bond structure, classifying alkenes, reactivity, physical properties, occurrences and uses, spectroscopy, stabilty II. Unsaturation
Synthesis of Enamides via CuI-Catalyzed Reductive Acylation of. Ketoximes with NaHSO 3
Supporting Information For Synthesis of Enamides via CuI-Catalyzed Reductive Acylation of Ketoximes with NaHSO 3 Zheng-Hui Guan*, Zhi-Yuan Zhang, Zhi-Hui Ren, Yao-Yu Wang, and Xumu Zhang Key Laboratory
C H Bond Functionalization: New Strategies for the Synthesis of Complex Natural Products and Pharmaceuticals. Phil Knutson Ferreira Group 12/3/2015
C H Bond Functionalization: New Strategies for the Synthesis of Complex Natural Products and Pharmaceuticals Phil Knutson Ferreira Group 12/3/2015 New strategies in organic synthesis nsf-cchf.com What
Metal Hydrides, Alkyls, Aryls, and their Reactions
Metal Hydrides, Alkyls, Aryls, and their Reactions A Primer on MO Theory σ-bonding in Organotransition Metal Complexes M-C Bond Energies in Organotransition Metal Complexes Thermodynamic Predictions
Chapter 19: Alkenes and Alkynes
Chapter 19: Alkenes and Alkynes The vast majority of chemical compounds that we know anything about and that we synthesize in the lab or the industrial plant are organic compounds. The simplest organic
Microreactors in Chemistry! Christina Moberg!
Microreactors in Chemistry! Christina Moberg! 19th century equipment for synthesis 20th centrury equipment for synthesis Today: high throughput and downsizing Microreactors! Threedimensional structures
A Tandem Semipinacol Rearrangement/Alkylation of a-epoxy Alcohols: An Efficient and Stereoselective Approach to Multifunctional 1,3-Diols
A Tandem Semipinacol Rearrangement/Alkylation of a-epoxy Alcohols: An Efficient and Stereoselective Approach to Multifunctional 1,3-Diols B() 2 H H B() 2 H H Hu, X.-D.; Fan, C.-A.; Zhang, F.-M.; Tu, Y.
CHEMISTRY Topic #3: Using Spectroscopy to Identify Molecules: Radicals and Mass Spectrometry (MS) Spring 2018 Dr.
CHEMISTRY 2600 Topic #3: Using Spectroscopy to Identify Molecules: Radicals and Mass Spectrometry (MS) Spring 2018 Dr. Susan Findlay Mass Spectrometry: How Does It Work? In CHEM 1000, you saw that mass
Self-stable Electrophilic Reagents for Trifluoromethylthiolation. Reporter: Linrui Zhang Supervisor: Prof. Yong Huang Date:
Self-stable Electrophilic Reagents for Trifluoromethylthiolation Reporter: Linrui Zhang Supervisor: Prof. Yong Huang Date: 2017-12-25 Content Introduction Trifluoromethanesulfenates: Preparation and reactivity
Preparation, structure, and oxidative reactivity of (dichloroiodo)pyridines: recyclable hypervalent iodine reagents
The Free Internet J ournal for Organic Chemistry Paper Archive for Organic Chemistry Arkivoc 2018, part ii, 40-49 Preparation, structure, and oxidative reactivity of (dichloroiodo)pyridines: recyclable
Stereoselective Allylation of Imines. Joshua Pierce Research Topic Seminar
Stereoselective Allylation of Imines Joshua Pierce esearch Topic Seminar 10-30-04 Josh Pierce @ Wipf Group 1 11/3/2004 Topic Overview: Introduction Imines: Why is C=N different? Synthesis of Allylating
Oxidative couplings of two nucleophiles
Oxidative Couplings of Hydrocarbons Oxidative couplings of two nucleophiles Oxidants involved: O 2 H 2 O 2 high h valent metals(copper salts) halides(iodine(Ⅲ) oxidants) Lei, A. W. Chem. Rev., 2011, 111,
LECTURE #14 Thurs., Oct.20, Midterm exam: Tues.Oct.25 during class Ch.1, , 7.10, 2, Sections
CHEM 221 section 01 LECTURE #14 Thurs., Oct.20, 2005 Midterm exam: Tues.Oct.25 during class Ch.1, 7.2-7.5, 7.10, 2, 3.1-3.5 ASSIGNED READINGS: TODAY S CLASS: NEXT LECTURE: Sections 4.7-4.10 finish Ch.4,
Mechanisms of Ion Fragmentation (McLafferty Chapter 4) Business Items
Mechanisms of Ion Fragmentation (McLafferty Chapter 4) CU- Boulder CHEM 5181 Mass Spectrometry & Chromatography Prof. Jose-Luis Jimenez 1 Business Items Last real lecture is today Material from today,
Beyond Directing Groups
Beyond Directing Groups Transition-Metal-Catalyzed C-H Activation of Simple Arenes Reporter: Huan Sun Supervisor: Yong Huang 2013-01-07 N. Kuhl, M. N. Hopkinson, J. W. Delord, F. Glorius, Angew. Chem.
Review Revisiting the Baldwin s Rules Guidelines for Ring Closure Li Yuanhe Anion- 3/4 4/5 5/6 6/7 endo- -dig exo- endo- -trig exo- endo- -tet exo-
Review Revisiting the Baldwin s Rules Guidelines for Ring Closure Li Yuanhe Anion - 3/4 4/5 5/6 6/7 -trig Supervisors: Prof. Yang Prof. Chen -tet Prof. Tang Introduction (Sir) Jack Baldwin 1938, Born,
Converting Cycloalkanones into N- Heterocycles: Formal Synthesis of ( )-Gephyrotoxin 287C. Claude Spino et al., J. Org. Chem. 2013, 78,
Converting Cycloalkanones into N- Heterocycles: Formal Synthesis of ( )-Gephyrotoxin 287C Claude Spino et al., J. Org. Chem. 2013, 78, 12532 12544. Poison frog alkaloids Isolated from poison frog skin.
Bio-inspired C-H functionalization by metal-oxo complexes
1 Literature Seminar Bio-inspired C-H functionalization by metal-oxo complexes 2016. 7. 23. Nagashima Nozomu 2 C-H functionalization by enzymes Enzymes enable aliphatic C-H functionalization 3 P450 oxidation
A Simple Introduction of the Mizoroki-Heck Reaction
A Simple Introduction of the Mizoroki-Heck Reaction Reporter: Supervisor: Zhe Niu Prof. Yang Prof. Chen Prof. Tang 2016/2/3 Content Introduction Intermolecular Mizoroki-Heck Reaction Intramolecular Mizoroki-Heck
Denmark Group Meeting. & Electrophilic rearrangement of amides
Denmark Group Meeting Palladium catalyzed Dearomatizationeaction & Electrophilic rearrangement of amides 11 th Bo Peng th Feb. 2014 1 https://maps.google.com 2 Palladium catalyzed Dearomatization eaction
Organic Chemistry(I) Chapter 3
Organic Chemistry(I) Chapter 3 1. Carbon-carbon bonds are not easily broken. Which bond in the following compound would be the least difficult to break homolytically? 2. Which of the following molecules
Copper-catalyzed cleavage of benzyl ethers with diacetoxyiodobenzene and p-toluenesulfonamide
General Papers ARKIVC 2008 (xii) 103-108 Copper-catalyzed cleavage of benzyl ethers with diacetoxyiodobenzene and p-toluenesulfonamide Ling He a,b, Qin Wang a, Guo-Chuan Zhou b, Lei Guo b, and Xiao-Qi
16. Chemistry of Benzene: Electrophilic Aromatic Substitution. Based on McMurry s Organic Chemistry, 7 th edition
16. Chemistry of Benzene: Electrophilic Aromatic Substitution Based on McMurry s Organic Chemistry, 7 th edition Substitution Reactions of Benzene and Its Derivatives Benzene is aromatic: a cyclic conjugated
Silenes in organic synthesis: a concise synthesis of (±)-epi-picropodophyllin
lenes in organic synthesis: a concise synthesis of (±)-epi-picropodophyllin obert D. C. Pullin, Jonathan D. Sellars, and Patrick G. Steel* rg. Biomol. Chem., 2007, 5, 3201-3206 H H C Adam Hoye Current
Planar-Chiral Phosphine-Olefin Ligands Exploiting a (Cyclopentadienyl)manganese(I) Scaffold to Achieve High Robustness and High Enantioselectivity
Planar-Chiral Phosphine-Olefin Ligands Exploiting a (Cyclopentadienyl)manganese(I) Scaffold to Achieve High Robustness and High Enantioselectivity Reporter: Cong Liu Checker: Hong-Qiang Shen Date: 2017/02/27
The aza-baylis-hillman Reaction: Mechanism, Asymmetric Catalysis, & Abnormal Adducts. Larry Wolf SED Group Meeting
The aza-baylis-hillman Reaction: Mechanism, Asymmetric Catalysis, & Abnormal Adducts Larry Wolf SED Group Meeting 04-10-07 Outline Brief historical account and Utility Mechanism Different methods for asymmetric
Chapter 21 Coordination chemistry: reactions of complexes
CHEM 511 chapter 21 page 1 of 7 Chapter 21 Coordination chemistry: reactions of complexes Reactions of Complexes Typically measure ligand substitution reactions in solution (usually water) Lability and
AP CHEMISTRY CHAPTERS 5 & 6 Problem Set #4. (Questions 1-13) Choose the letter that best answers the question or completes the statement.
NAME: AP CHEMISTRY CHAPTERS 5 & 6 Problem Set #4 (Questions 1-13) Choose the letter that best answers the question or completes the statement. (Questions 1-2) Consider atoms of the following elements.
Nucleophilic Substitutions. Ionic liquids
ucleophilic Substitutions & Ionic liquids S 2 Reaction S 2 Substitution Reaction ucleophilic (electron rich) Bimolecular The rate depends on the concentration of both of the reactants S 2 Reaction Mechanism
Complex Interactions of Pillar[5]arene with Paraquats and. Bis(pyridinium) Derivatives
![Complex Interactions of Pillar[5]arene with Paraquats and. Bis(pyridinium) Derivatives](/thumbs/94/119880372.jpg "Complex Interactions of Pillar[5]arene with Paraquats and. Bis(pyridinium) Derivatives")
Electronic supplementary information Complex Interactions of Pillar[5]arene with Paraquats and Bis(pyridinium) Derivatives Chunju Li,* Qianqian Xu, Jian Li, Feina Yao and Xueshun Jia* Department of Chemistry,
Chem 251 Fall Learning Objectives
Learning Objectives Chapter 8 (last semester) 1. Write an electron-pushing mechanism for an SN2 reaction between an alkyl halide and a nucleophile. 2. Describe the rate law and relative rate of reaction
Chapter 16 Chemistry of Benzene: Electrophilic Aromatic Substitution
John E. McMurry www.cengage.com/chemistry/mcmurry Chapter 16 Chemistry of Benzene: Electrophilic Aromatic Substitution Paul D. Adams University of Arkansas Substitution Reactions of Benzene and Its Derivatives
Literature Report IX. Cho, S. H. et al. Org. Lett. 2016, 18, Cho, S. H. et al. Angew. Chem. Int. Ed. 2017, 56,
Literature Report IX ynthesis of β-aminoboronates by Copper(I)- Catalyzed Addition of Diborylalkanes to Imines Reporter Checker Date : hubo Hu : Xiaoyong Zhai : 2017-9-1818 Cho,. H. et al. rg. Lett. 2016,
Química Orgânica I. Organic Reactions
Química Orgânica I 2008/09 w3.ualg.pt\~abrigas QOI 0809 A6 1 Organic Reactions Addition two molecules combine Elimination one molecule splits Substitution parts from two molecules exchange Rearrangement
16. Chemistry of Benzene: Electrophilic Aromatic Substitution جانشینی الکتروندوستی آروماتیک شیمی آلی 2
16. Chemistry of Benzene: Electrophilic Aromatic Substitution جانشینی الکتروندوستی آروماتیک شیمی آلی 2 Dr M. Mehrdad University of Guilan, Department of Chemistry, Rasht, Iran m-mehrdad@guilan.ac.ir Based
16. Chemistry of Benzene: Electrophilic Aromatic Substitution جانشینی الکتروندوستی آروماتیک شیمی آلی 2
16. Chemistry of Benzene: Electrophilic Aromatic Substitution جانشینی الکتروندوستی آروماتیک شیمی آلی 2 Dr M. Mehrdad University of Guilan, Department of Chemistry, Rasht, Iran m-mehrdad@guilan.ac.ir Based
Alcohols, Ethers and Epoxides. Chapter Organic Chemistry, 8th Edition John McMurry
Alcohols, Ethers and Epoxides Chapter 17-18 Organic Chemistry, 8th Edition John McMurry 1 Introduction Structure and Bonding Alcohols contain a hydroxy group (OH) bonded to an sp 3 hybridized carbon. 2
Ligand Effects in Nickel Catalysis. Anthony S. Grillo Chem 535 Seminar October 22, 2012
Ligand in Nickel Catalysis Anthony S. Grillo Chem 535 Seminar October 22, 2012 Transition Metals in Chemistry Organotransition Metal Chemistry, Hartwig, J. F. University Science Books: Mill Valley, CA,
Highly Efficient, Convergent, and Enantioselective Synthesis of Phthioceranic Acid
Highly Efficient, Convergent, and Enantioselective Synthesis of Phthioceranic Acid Shiqing Xu, Akimichi Oda, Thomas Bobinski, Haijun Li, Yohei Matsueda, and Ei-ichi Negishi Angew. Chem. Int. Ed. 2015,
Synthesis and Reactivity of Vinyl Iodonium Salts
Chemistry Honors Final Report Mackenzie Liebl Synthesis and Reactivity of Vinyl odonium Salts Background n Dr. Zhdankin s research lab, one of our main focuses is on the chemistry of iodine. odine is the
Direct, Catalytic Hydroaminoalkylation of Unactivated Olefins with N-Alkyl Arylamines
Current Literature - May 12, 2007 Direct, Catalytic ydroaminoalkylation of Unactivated lefins with -Alkyl ylamines ' '' Ta[ 2 ] 5 (4-8 mol%), 160-165 o C 24-67h 66-95% ' '' S. B. erzon and J. F. artwig,
L.7. Mass Spectrum Interpretation
L.7. Mass Spectrum Interpretation Fragmentation reactions Spectrum interpretation Confirmation of ion structural assignment Biomolecule dissociation Fragmentation reactions 1. Fragmentation reactions of
CHAPTER TEN MOLECULAR GEOMETRY MOLECULAR GEOMETRY V S E P R CHEMICAL BONDING II: MOLECULAR GEOMETRY AND HYBRIDIZATION OF ATOMIC ORBITALS
CHAPTER TEN CHEMICAL BONDING II: AND HYBRIDIZATION O ATOMIC ORBITALS V S E P R VSEPR Theory In VSEPR theory, multiple bonds behave like a single electron pair Valence shell electron pair repulsion (VSEPR)
Organohypervalent Iodine: Application as a Hypernucleofuge
rganohypervalent odine: Application as a Hypernucleofuge Application to the α-functionalization of Carbonyl Compounds L. Cullen SED Group Meeting 5.22.12 Aryl-λ 3 -odanes (ArL 2 ): ntroduction to odane
Supporting Information
Supporting Information Ruthenium-Catalyzed Oxidative Annulation and Hydroarylation of Chromene-3- carboxamides with Alkynes via Double C-H Functionalization R. N. Prasad Tulichala, Mallepalli Shankar and
STEREOELECTRONIC EFFECTS (S.E.) IN ORGANIC CHEMISTRY
STEREOELECTRONIC EFFECTS (S.E.) IN ORGANIC CHEMISTRY Pierre Deslongchamps (version du 16 février 2010) Cf. pour le livre: http://pages.usherbrooke.ca/pdeslongchamps/cv.htm 1 SECTION 8 Stereoelectronic
a. Why do the amides coordinate to Zr and the phosphines to Co?
Reactivity and Bonding of mplexes with Metal-Metal Bonds Goals: Determine electron counts and oxidation states of complexes with M-M bonds using CBC method of electron counting Draw molecular orbital diagrams
The Study of Chemical Reactions. Mechanism: The complete, step by step description of exactly which bonds are broken, formed, and in which order.
The Study of Chemical Reactions Mechanism: The complete, step by step description of exactly which bonds are broken, formed, and in which order. Thermodynamics: The study of the energy changes that accompany
Functionalized Organometallic Reagents
Availability Availability Preparation via Insertion Grignard s Synthesis Generally Considered as a Radical Process Schlenk Equilibrium Parasite Reactions Reversible Reaction in THF Substitution Reactions
Dr. P. Wipf Chem /26/2007
I. Basic Principles I-L. Radicals & Carbenes Features of Radical Reactions Review: Curran, D. P. In Comprehensive Organic Synthesis; B. M. Trost and I. Fleming, Ed.; Pergamon Press: Oxford, 1991; Vol.
Grob Fr agmentations. Dan Tao Overman Group Meeting 9/24/12
: Grob Fr agmentations Dan Tao Overman Group Meeting 9/24/12 What is a Grob Fragmentation? Heterolytic fragmentation is certain combinations of carbon and hetero atoms which undergo a regulated cleavage
Copyright 2017 Dan Dill 1
TP In pure water at 25, there is only a tiny, tiny amount of self ionization, ~ 7 mol/l. In pure water, how many water molecules are there for every OH ion? 1. 1 2. 3. 0 4.,000 5. 1,000,000 6.,000,000
51. Pi bonding occurs in each of the following species EXCEPT (A) CO 2 (B) C 2 H 4 (C) CN (D) C 6 H 6 (E) CH 4
Name AP Chemistry: Bonding Multiple Choice 41. Which of the following molecules has the shortest bond length? (A) N 2 (B) O 2 (C) Cl 2 (D) Br 2 (E) I 2 51. Pi bonding occurs in each of the following species
Alkynyl(phenyl) iodonium triflates as precursors to iridium(iii) σ acetylide complexes
Alkynyl(phenyl) iodonium triflates as precursors to iridium(iii) σ acetylide complexes Darren Bykowski, Robert McDonald, and Rik R. Tykwinski* Department of Chemistry, University of Alberta, Edmonton,
Amines and Heterocycles. McMurry: Chapter 24
Amines and Heterocycles McMurry: Chapter 24 Introduction to Amines and Heterocycles Amines and heterocycles (cyclic amines) are ammonia derivatives, many of whichare found widely in livingorganisms: 2
Organocatalytic Umpolung via N- Heterocyclic Carbenes. Qinghe Liu Hu Group Meeting August 20 th 2015
rganocatalytic Umpolung via N- Heterocyclic Carbenes Qinghe Liu Hu Group Meeting August 20 th 2015 Contents Part 1: Introduction Part 2: N-Heterocyclic carbene-catalyzed umpolung: classical umpolung, conjugated
Construction of Chiral Tetrahydro-β-Carbolines: Asymmetric Pictet Spengler Reaction of Indolyl Dihydropyridines
Literature Report V Construction of Chiral Tetrahydro-β-Carbolines: Asymmetric Pictet Spengler Reaction of Indolyl Dihydropyridines Reporter Checker Date : Xiao-Yong Zhai : Xin-Wei Wang : 2018-04-02 You,
Synthesis of 1,3-Diols via Controlled, Radical-Mediated C-H Functionalization
Synthesis of 1,3-Diols via Controlled, Radical-Mediated C- Functionalization Chen, K.; Richter, J. M.; Baran, P. S. J. Amer. Chem. Soc. 2008, 130, 7247-7249. Literature Group Presentation Wynter Gilson
An Overview of Organic Reactions. Reaction types: Classification by outcome Most reactions produce changes in the functional group of the reactants:
An Overview of Organic Reactions Reaction types: Classification by outcome Most reactions produce changes in the functional group of the reactants: 1. Addition (forward) Gain of atoms across a bond Example: