Stefano Lazzari Ph.D.
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1 Stefano Lazzari Ph.D. 77, Massachusetts Avenue 02139, Cambridge, MA, USA Current Position Massachusetts Institute of Technology (MIT), Cambridge, MA, USA Postdoctoral Fellow in the Department of Chemical Engineering Advisor: Prof. Klavs Jensen Research Interests Colloid Assembly, Colloid Engineering, Modeling, Simulations Quantum Dots, Crystallization, Solid Formation Biodegradable Polymers, Polymer Reaction Engineering, Population Balances Education Ph.D. Chemical Engineering ETH Zurich, Zurich, Switzerland M.Sc. Chemical Engineering, cum laude Politecnico di Milano, Milan, Italy B.Sc. Chemical Engineering Politecnico di Milano, Milan, Italy Research Experience 2015-present Postdoctoral Fellow, Massachusetts Institute of Technology (MIT) Advisor: Prof. Jensen - Developed, in collaboration with a postdoc of the Jensen Lab, a temperaturedependent deterministic model for quantitatively predicting quantum dots concentrations, average sizes and polydispersity, proposing rate expressions for nucleation and growth - Developed a kinetic model based on population balance equations to account for the simultaneous deposition and aggregation of colloids - Quantified the interplay of growth and aggregation through Monte Carlo simulation (collaboration with Prof. Lattuada, University of Fribourg). Impact of growth on cluster fractality, aggregation and gelation rates was elucidated - Investigated the relevance of sintering in semiconductor nanocrystals with molecular dynamics, in collaboration with a postdoc from the University of Minnesota - Set up a collaboration between the Langer Lab (MIT) and the Moscatelli Lab (Politecnico di Milano) to investigate the internalization of nanoparticles in cells Page 1 of 7
2 Postdoctoral Associate, ETH Zurich Advisor: Prof. Morbidelli - Collaborated with a PhD and a Master Thesis student on deepening the understanding of amyloid fibril breakage - Studied the role of fractal clusters in colloid science. Proposed and led the writing of a review paper on the topic Research Assistant, ETH Zurich Advisor: Prof. Morbidelli, Prof. Storti - Developed models for describing crosslinking polymerization in the frame of a 3 years EU-sponsored project (Marie Curie Fellowship). Collaborated with PhD students from other institutions and published joint work. Led the organization and writing of a comparative modeling paper, together with the University of Porto and the University of the Basque country - Experimentally deepened the understanding of a complex, industrial colloid system in the frame of 3 years BASF-sponsored project Research Fellow, Mario Negri Institute for Pharmacological Research Advisor: Dr. Salmona - Reviewed the necessary equations for modeling nanoparticle pharmacokinetics Research Fellow, Politecnico di Milano M.Sc. in Chem. Engineering Advisor: Prof. Moscatelli - Performed experiments and developed a model quantifying drug release from degradable poly-lactic acid micro and nanoparticles Awards and Fellowships 2016 Langmuir Award for best oral presentation at the European Colloid and Interface Society (ECIS) Conference 2016, Rome, Italy 2016 Swiss National Science Foundation Postdoctoral Fellowship (75 kchf) 2014 Swiss National Science Foundation Postdoctoral Fellowship (70 kchf) 2013 Macro Award for best contribution at the 2nd Working Party for Polymer Reaction Engineering, sponsor: Wiley 2010 Marie Curie Fellowship in the frame of the European (FP7) project NANOPOLY Teaching and Mentoring Experience (i) Massachusetts Institute of Technology (MIT) - Student Supervision 2017 Co-supervision of 1 M.Sc. in his Thesis work (ii) Massachusetts Institute of Technology (MIT) 2016 Kaufman Teaching Certificate Program (iii) ETH Zurich - Teaching Assistant (TA) Polymer Reaction and Colloid Engineering (20-30 students per year) Responsibilities: grade exercises, answer students questions, assist oral examinations. Grade as TA: 4.8/ Lab Course on Emulsion Polymerization Page 2 of 7
3 Responsibilities: supervise students in performing emulsion polymerizations (6 groups of about 4 students each) (iv) ETH Zurich - Student Supervision Supervision of 4 M.Sc. and 1 B.Sc. students in their Thesis work (v) Politecnico di Milano - Student Supervision 2009 Supervision of 1 B.Sc. student in his Thesis work (vi) Redooc Scientific Editor of E-classes on calculus for high school Publications (i) Peer-reviewed papers S. Lazzari, M. Abolhasani, K.F. Jensen Modeling of the formation kinetics and size distribution evolution of II-VI Quantum Dots", Reaction Chemistry & Engineering, in press 23. S. Lazzari, M. Lattuada, Growth and aggregation regulate clusters structural properties and gel time", The Journal of Physical Chemistry B, 121 (11), B. Jaquet, S. Lazzari, L. Colonna, M. Soos, M. Morbidelli, "Effects of coalescence on shear-induced gelation of colloids", Langmuir, 33 (5), S. Lazzari, Modeling simultaneous deposition and aggregation of colloids, Chemical Engineering Science, 255, (2016) 20. S. Lazzari, L. Nicoud, B. Jaquet, M. Lattuada, M. Morbidelli, Fractal-like structures in colloid science, Advances in Colloid and Interface Science, 235, 1 13, (2016) 19. L. Nicoud, J. Jagielski, D. Pfister, S. Lazzari, J. Massant, M. Lattuada, M. Morbidelli, Kinetics of monoclonal antibody aggregation from dilute to concentrated conditions, The Journal of Physical Chemistry B, 120, 13, (2016) L. Nicoud, M. Lattuada, S. Lazzari, M. Morbidelli, Viscosity scaling in concentrated dispersions and its impact on colloidal aggregation, Physical Chemistry Chemical Physics, 17, 37, (2015) 17. S. Lazzari B. Jaquet, L. Colonna, G. Storti, M. Lattuada, M. Morbidelli, Interplay between aggregation and coalescence of polymeric particles: experimental and modeling insights, Langmuir, 31, 34, (2015) 16. L. Nicoud, S. Lazzari, D.B. Barragan, M. Morbidelli, Fragmentation of amyloid fibrils occurs in preferential positions depending on the environmental conditions, Journal of Physical Chemistry B, 13, 119 (2015) 15. S. Lazzari, B. Jaquet, H. Wu, M. Morbidelli, Shear stability of inverse latexes during their polymerization process, AIChE Journal, 4, 61 (2015) T. Casalini, F. Rossi, S. Lazzari, G. Perale, M. Masi, Mathematical modeling of PLGA microparticles: from polymer degradation to drug release, Molecular Pharmaceutics, 11, 11, (2014) Page 3 of 7
4 13. S. Lazzari, F. Codari, G. Storti, M. Morbidelli, D. Moscatelli, Modeling the ph-dependent PLA oligomer degradation kinetics, Polymer Degradation and Stability, 110 (2014) 12. S. Lazzari, S. Hamzehlou, Y. Reyes, J.R. Leiza, M.R.P.F.N. Costa, R.C.S Dias, G. Storti, Bulk crosslinking copolymerization: comparison of different modeling approaches, Macromolecular Reaction Engineering, 10, 8, (2014) 11. S. Lazzari, D. Pfister, V. Diederich, A. Kern, G. Storti, Modeling of acrylamide/n N -methylene-bisacrylamide solution copolymerization, Industrial and Engineering Chemical Research, 22, 53 (2014) 10. I. Kryven, S. Lazzari, G. Storti, Population balance modeling of aggregation and coalescence in colloidal systems, Macromolecular Theory and Simulations, 3, 23 (2014) 9. S. Lazzari, G. Storti, Modeling multiradicals in crosslinking MMA/EGDMA bulk copolymerization, Macromolecular Theory and Simulations, 1, 23, (2014) M. Lattuada, E. Del Gado, T. Abete, L. De Arcangelis, S. Lazzari, V. Diederich, G. Storti, M. Morbidelli, Kinetics of free-radical cross-linking polymerization: comparative experimental and numerical study, Macromolecules, 15, 46 (2013) 7. S. Lazzari, G.M. Maggioni, M. Soos, H. Wu, M. Morbidelli, Shear-stability and gelation of inverse latexes, Soft Matter, 45, 9 (2013) F. Codari, S. Lazzari, M. Soos, G. Storti, M. Morbidelli, D. Moscatelli, Kinetics of the hydrolytic degradation of poly(lactic acid), polymer degradation and stability, 11, 97 (2012) 5. S. Lazzari, D. Moscatelli, F. Codari, M. Salmona, M. Morbidelli, L. Diomede, Colloidal stability of polymeric nanoparticles in biological fluids, Journal of Nanoparticle Research, 6, 14 (2012) (ii) Papers in preparation 4. L.I. Costa, S. Lazzari, G. Storti, Population Balance Equations solved by Logarithmic Interpolation 3. S. Lazzari, P. Theiler, Y. Shen, C.W. Coley, A. Stemmer, K.F Jensen, Ligand-mediated growth of II-VI semiconductor nanocrystals 2. E. Goudeli, S. Lazzari, Sintering characteristic times of II-VI semiconductor nanocrystals 1. S. Lazzari, I.Kryven, Solving population balances with a Gaussian Basis Functions based open source software Oral Presentations (i) Invited Lectures S. Lazzari, Polymer and Colloid Assembly Engineering, Institute for Technical and Macromolecular Chemistry, University of Hamburg, January, S. Lazzari, Colloid Assembly Engineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, January, S. Lazzari, Polymer Reaction Engineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, January, 2016 Page 4 of 7
5 S. Lazzari, Polymeric Nanoparticles and Pharmacokinetics, Mario Negri Institute for Pharmacological Research, Milan, Italy, September, 2010 (ii) Conference Talks S. Lazzari, M. Abolhasani, K. Jensen, Temperature-dependent modeling of formation and growth of II-VI semiconductor nanocrystals, American Institute of Chemical Engineers (AIChE), San Francisco, USA, November, S. Lazzari, K. Jensen, M. Lattuada, Growth and Agglomeration Rates Regulate Colloid Fractal Dimension, American Institute of Chemical Engineers (AIChE), San Francisco, USA, November, S. Lazzari, M. Abolhasani, K. Jensen, Temperature-dependent modeling of formation and growth of II-VI semiconductor nanocrystals, European Colloid and Interface Society (ECIS), Rome, Italy, September, S. Lazzari, B. Jaquet, L. Colonna, G. Storti, M. Lattuada and M. Morbidelli, Interplay Between Aggregation and Coalescence of Polymeric Particles: Experimental and Modeling Insights, American Institute of Chemical Engineers (AIChE), Salt Lake City, USA, November, L. Nicoud, S. Lazzari, D. Barragan, M. Morbidelli, The Fragmentation of Amyloid Fibrils Occurs in Preferential Positions Depending on the Environmental Conditions, American Institute of Chemical Engineers (AIChE), Salt Lake City, USA, November, S. Lazzari, B. Jaquet, H. Wu, M. Morbidelli, Shear-Stability of Inverse Latexes during their Polymerization Process, American Institute of Chemical Engineers (AIChE), Atlanta, USA, November, S. Lazzari, F. Codari, D. Moscatelli, G. Storti, M. Morbidelli, ph-dependent Degradation Kinetics of Polylactic Acid, American Institute of Chemical Engineers (AIChE), Atlanta, USA, November, S. Lazzari, G. Storti, M. Morbidelli, Modeling Multiradicals in Bulk Crosslinking Copolymerization, Swiss Chemical Society (SCS), Zurich, Switzerland, September, S. Lazzari, G. M. Maggioni, M. Soos, H. Wu, M. Morbidelli, Shear-Stability and Gelation of Inverse Emulsions, American Institute of Chemical Engineers (AIChE), San Francisco, USA, November, S. Lazzari, G. M. Maggioni, M. Soos, H. Wu, M. Morbidelli, Shear-Stability and Gelation of Inverse Emulsions, European Colloid and Interface Society (ECIS), Sofia, Bulgaria, September, S. Lazzari, G. Storti, M. Morbidelli, Modeling Multiradicals in Bulk Crosslinking Copolymerization, Polymer Reaction Engineering (PRE), Hamburg, Germany, May, S. Lazzari, G. Storti, M. Morbidelli, Modeling Multiradicals in Bulk Crosslinking Copolymerization, Working Party for Polymer Reaction Engineering, Hamburg, Germany, May, S. Lazzari, D. Pfister, V. Diederich, G. Storti and M. Morbidelli, Modeling of Crosslinking in Free-Radical Polymerization, American Institute of Chemical Engineers (AIChE), Minneapolis, USA, October, 2011 Page 5 of 7
6 1. F. Codari, S. Lazzari, M. Soos, G. Storti, M. Morbidelli and D. Moscatelli, Polylactic Oligomers Degradation Kinetics, American Institute of Chemical Engineers (AIChE), Minneapolis, USA, October, 2011 Languages Italian German English Spanish French native speaker native speaker advanced fluent intermediate Courses 2016 European Colloid and Interface Society (ECIS) Colloids and Surfaces in Cultural Heritage: Physico-Chemical Methodologies and New Investigative Approaches 2016 Massachusetts Institute of Technology Kaufman Teaching Certificate Program 2014 ETH Zurich Entrepreneurship Course "Venture Challange" Membership in Professional Societies since 2016 since 2014 European Colloid and Interface Society (ECIS) American Institute of Chemical Engineers (AIChE) Interests Literature Sports Various writing short stories, reading swimming, basketball tango dancing, chess Page 6 of 7
7 References Prof. Klavs Jensen Department of Chemical Engineering Massachusetts Institute of Technology 77, Massachusetts Avenue Cambridge, MA, 02139, USA Relationship: Postdoctoral Advisor Tel: Prof. Massimo Morbidelli Inst. for Chemical and Bioengineering ETH Zurich Vladimir-Prelog-Weg Zurich, Switzerland Relationship: PhD Advisor massimo.morbidelli@chem.ethz.ch Tel: Prof. Marco Lattuada Adolphe Merkele Institute University of Fribourg Chemin des Verdiers Fribourg, Switzerland Relationship: Mentor, Collaborator marco.lattuada@unifr.ch Tel: Prof. Giuseppe Storti Inst. for Chemical and Bioengineering ETH Zurich Vladimir-Prelog-Weg Zurich, Switzerland Relationship: PhD Advisor giuseppe.storti@chem.ethz.ch Tel: Prof. Davide Moscatelli Dip. di Chimica, Materiali ed Ing. Chimica Politecnico di Milano Via Mancinelli Milan, Italy Relationship: Master Thesis Advisor davide.moscatelli@polimi.it Tel: Page 7 of 7
Stefano Lazzari Ph.D.
Stefano Lazzari Ph.D. 77, Massachusetts Avenue 02139, Cambridge, MA, USA slazzari@mit.edu Current Position Massachusetts Institute of Technology (MIT), Cambridge, MA, USA Postdoctoral Fellow in the Department
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