Curriculum Vitae Prof. Dr. Karl Gademann
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1 Curriculum Vitae Prof. Dr. Karl Gademann Address Prof. Dr. Karl Gademann from August 2015: Department of Chemistry, University of Basel University of Zurich St. Johanns-Ring 19 Department of Chemistry CH-4056 Basel, Switzerland Winterthurerstrasse CH-8057 Zürich Personal Date of Birth: June 27, 1972 Nationality: Swiss Marital Status: Married Languages: German, English and French Research Mission Total synthesis of natural products and derivatives for the discovery of novel molecular function in biology, medicine and materials science. Education : Habilitation ETH Zürich, venia legendi, awarded 10/ : Dissertation ETH Zürich, Dr. sc. nat., awarded 2/ : Diploma ETH Zürich, Dipl. Chem. ETH, awarded 10/1996. Research from Aug. 2015: Full professor for organic chemistry and chemical biology, University of Zürich : Ordinarius für Chemie (full professor/chair), University of Basel : Extraordinarius (associate professor), University of Basel : Assistant professor (Tenure Track), EPF Lausanne : Oberassistent/Habilitand (ETH Zürich, mentor Prof. Dr. Erick M. Carreira) : Postdoctoral fellow (Chemistry and Chemical Biology, Harvard University). Research advisor: Prof. Dr. Eric N. Jacobsen. 2000: Postdoctoral fellow (Givaudan Fragrance Research, Dübendorf) : Dr. sc. nat. ETH (ETH Zürich, Advisor: Prof. Dr. Dieter Seebach. 1996: Dipl. Chem. ETH (ETH Zürich). Advisor: Prof. Dr. Dieter Seebach. 1995: Undergraduate research (ETH Zürich). Advisor: Prof. Dr. Steven A. Benner : Internship (CILAG AG, Schaffhausen). Awards 2014: The Boehringer-Ingelheim Lectureship at MIT, Cambridge, MA, USA 2012: National Latsis Prize 2010: Novartis Early Career Award in Organic Chemistry, Novartis, Cambridge MA, USA 2009: Ruzicka Prize and Medal, ETH Zürich 2009: Liebig Lectureship of the German Chemical Society 2008: ERC Starting Grant (declined in favor of EURYI award) 2007: European Young Investigator Award (EURYI) 2006: Prix A. F. Schläfli, Swiss Academy of Sciences. 2006: Thieme Journal Award, Germany. 2005: Lilly Lecture Award, Lilly GmbH, Hamburg, Germany. 2004: Latsis-Prize of the ETH. 1
2 2003: European Science Foundation Sponsored Participant, Bürgenstock Meeting. 2003: Award for the Best Lecture in Organic Chemistry, Swiss Chemical Society. Highlights of own scientific work by others (selected): Article # 92 picked up by several media outlets in Europe Article # 79 selected as 'hot paper' by the editors of Angewandte Chemie (January 2012) Article # 60 highlighted in ACS Chem. Biol., CHIMIA, Nat. Prod. Rep. Hot off the press (March 2010) Article # 55 presented in Noteworthy Chemistry of the American Chemical Society (Sept. 21, 2009) Research highlighted in MedChemWatch of the European Society for Medicinal Chemistry (July 2009) Article # 46 highlighted by the Faculty of 1000 in biology (Sept. 1, 2008) Article # 46 presented in Noteworthy Chemistry of the American Chemical Society (Sept. 15, 2008) Article # 46 highlighted by Medical News Today (Aug. 4, 2008) Article # 40 highlighted in Synfacts 2008, 4, 342, totallysynthetic.com (October 10, 2007) and CHIMIA (issue 12/2007). Visiting Professorship 2014: UNICAMP, Universidade Estadual de Campinas, Brasil (host: Prof. Dr. R. Pilli) Intramural service (selected) at the University of Basel 2011-to date: Elected member of the Regenz (senate) : Dean of Research, Faculty of Sciences, University of Basel : Member of the directing board of the department of chemistry : Elected dean of research, faculty of natural sciences : Director of undergraduate studies in chemistry to 2013: Departmental representative for outreach activities to high school teachers. Extramural service to date: Member of the board (Vorstand) of the Swiss Academy of Science to date: DECHEMA (Germany), Wissenschaftlicher Beirat Fachgruppe Biotechnologie/Naturstoffe 2014: DAAD (Germany), Scientific expert in the panel (Referat 521) for outgoing postdoctoral applications 2012-to date: Energy commission of the Swiss Academies, member President, Swiss Academy of Sciences, Platform chemistry AERES evaluation committee member, France : Member of the editorial board of CHIMIA, international journal for chemistry Reviewer for ca. 20 premier journals and for national and international funding agencies (SNF, ERC, ESF, FWF, ANR). Conference organization (selected) Co-organized the Flagship Workshop on Graphene, Bern, Switzerland, 2012 Co-organized the Rigi Workshop in Chemical Biology, Switzerland 2009 Co-organized the 15th symposium for young faculty in bioorganic chemistry, Berlin/Germany As of March 25th 2015, 146 lectures (plenary, invited, departmental or named) were held in Switzerland, Germany, France, UK, Belgium, Norway, United States, China and Japan. Departmental lectures were given at departments of chemistry (many), pharmacy (ETH Zürich, Univ. Basel), plant biology (Univ. of Zürich), material science (ETH Zurich and EMPA St. Gallen) and oceanography (Southampton, UK). 2
3 List of publications of the last 5 years Full list of publications, see Research publications (peer reviewed): 100. Hideki Miyatake Ondozabal, Elias Kaufmann and Karl Gademann Total Synthesis of the Protected Aglycon of Fidaxomicin (Tiacumicin B, Lipiarmycin A3) Angew. Chem. Int. Ed. 2015, 54, Samuel Bader, Michael Lüscher, and Karl Gademann Synthesis of Maculalactone A and Derivatives for Environmental Fate Tracking Studies Org. Biomol. Chem. 2015, 13, Verena Grundler, Karl Gademann Direct Arginine Modification in Native Peptides and Application to Chemical Probe Development ACS Med. Chem. Lett. 2014, 5, Patrick Burch, Fabian Schmid, Karl Gademann Neuritogenic Surfaces Using Natural Product Analogs Advanced Healthcare Materials 2014, 3, doi: /adhm Esther Kohler, Verena Grundler, Daniel Häussinger, Rainer Kurmayer, Karl Gademann, Jakob Pernthaler, Judith F. Blom The toxicity and enzyme activity of a chlorine and sulfate containing aeruginosin isolated from a non-microcystin-producing Planktothrix strain Harmful Algae 2014, 39, Doi: /j.hal Fabian Schmid, Maurizio Bernasconi, Henning J. Jessen, Andreas Pfaltz, Karl Gademann Catalytic Enantioselective Total Synthesis of ( )-Pyridovericin Synthesis 2014, Cyril Portmann, Simon Sieber, Silvan Wirthensohn, Judith F. Blom, Laeticia Da Silva, Emilie Baudat, Marcel Kaiser, Reto Brun, and Karl Gademann Balgacyclamides, Antiplasmodial Heterocyclic Peptides from Microcystis aeruguinosa EAWAG 251 J. Nat. Prod. 2014, 77, doi: /np400814w 93. Patrick Burch, Andrea Chicca, Jürg Gertsch, and Karl Gademann Functionally Optimized Neuritogenic Farinosone C Analogs: SAR-Study and Investigations on Their Mode of Action ACS Med. Chem. Lett. 2014, 5, doi: /ml400435h 92. José Gomes, Natalie Huber, Alexander Grunau, Leo Eberl and Karl Gademann Fluorescent Labeling Agents for Quorum Sensing Receptors (FLAQS) in Live Cells Chem. Eur. J. 2013, 19,
4 91. Raphael Liffert, Johannes Hoecker, Chandan Kumar Jana, Tom M. Woods, Patrick Burch, Henning Jessen, Markus Neuburger and Karl Gademann Withanolide A: Synthesis and Structural Requirements for Neurite Outgrowth Chem. Sci. 2013, 4, doi: /C3SC50653C 90. Christophe Thommen, Chandan Kumar Jana, Markus Neuburger, and Karl Gademann Syntheses of Taiwaniaquinone F and Taiwaniaquinol A via an Unusual Remote C H Functionalization Org. Lett. 2013, 15, Johannes Hoecker, Raphael Liffert, Patrick Burch, Robin Wehlauch and Karl Gademann Caged retinoids as photoinducible activators: implications for cell differentiation and neurite outgrowth Org. Biomol. Chem. 2013, DOI: /C3OB40106E 87. Malika Makhlouf Brahmi, Cyril Portmann, Danilo D'Ambrosio, Tom M. Woods, Damiano Banfi, Patrick Reichenbach, Laeticia Da Silva, Emilie Baudat, Gerardo Turcatti, Joachim Lingner and Karl Gademann Telomerase Inhibitors from Cyanobacteria: Isolation and Synthesis of Sulfoquinovosyl Diacylglycerols from Microcystis aeruguinosa PCC 7806 Chem. Eur. J. 2013, 19, Hideki Miyatake Ondozabal, Linda Bannwart and Karl Gademann Enantioselective Total Synthesis of Virosaine A and Bubbialidine Chemical Communications 2013, 49, doi: /C3CC38783F 85. Johannes Hoecker and Karl Gademann Enantioselective Total Syntheses and Absolute Configuration of JBIR-02 and Mer-A2026B Org. Lett. 2013, 5, , doi: /ol303502a 84. Patrick Burch, Massimo Binaghi, Manuel Scherer, Corinna Wentzel, David Bossert, Luc Eberhardt, Markus Neuburger, Peter Scheiffele and Karl Gademann Total Synthesis of Gelsemiol Chem. Eur. J. 2013, 19, doi: /chem José Gomes, Alexander Grunau, Adrien K. Lawrence, Leo Eberl and Karl Gademann Bioinspired, Releasable Quorum Sensing Modulators Chemical Communications 2013, 49, DOI: /C2CC37287H 82. Fabian Schmid, Henning J. Jessen, Patrick Burch and Karl Gademann Truncated Militarinone Fragments Identified by Total Chemical Synthesis Induce Neurite Outgrowth MedChemComm 2013, 4, DOI: /C2MD20181J 81. Robin Wehlauch, Johannes Hoecker and Karl Gademann Nitrocatechols as Tractable Surface Release Systems ChemPlusChem 2012, 77, DOI: /cplu
5 80. Carles Cantó, Riekelt H. Houtkooper, Eija Pirinen, Dou Y. Youn, Maaike H. Oosterveer, Yana Cen, Pablo J. Fernandez-Marcos, Hiroyasu Yamamoto, Pénélope A. Andreux, Philippe Cettour-Rose, Karl Gademann, Chris Rinsch, Kristina Schoonjans, Anthony A. Sauve, Johan Auwerx The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity Cell Metabolism 2012, 15, Elamparuthi Elangovan, Cindy Fellay, Markus Neuburger, Karl Gademann Total Synthesis of Cyrneine A Angew. Chem. Int. Ed. 2012, 51, DOI: /anie Henning J. Jessen, Andreas Schumacher, Fabian Schmid, Andreas Pfaltz and Karl Gademann Catalytic Enantioselective Total Synthesis of (+)-Torrubiellone C Org. Lett. 2011, 13, Chandan K. Jana, Johannes Hoecker, Tom M. Woods, Henning J. Jessen, Markus Neuburger, Karl Gademann Synthesis of Withanolide A, Biological Evaluation of its Neuritogenic Properties and Studies on Secretase Inhibition Angew. Chem. Int. Ed. 2011, 50, doi: /anie Henning J. Jessen, Andreas Schuhmacher, Travis Shaw, Andreas Pfaltz, Karl Gademann A Unified Approach for the Stereoselective Total Synthesis of Pyridone Alkaloids and Their Neuritogenic Activity Angew. Chem. Int. Ed. 2011, 50, doi: /anie Patents 31. Judith Blom, Karl Gademann Antifouling agents EP A1 30. Karl Gademann, Samuele Tosatti, Marcus Textor, Stefan Zürcher Catechol functionalized polymers and method for preparing them PCT/CH2005/ Review articles Karl Gademann Copy, Edit, and Paste: Natural Product Approaches to Biomaterials and Neuroengineering Acc. Chem. Res. 2015, 48, Jean-Yves Wach and Karl Gademann Reduce to the Maximum: Truncated Natural Products as Powerful Modulators of Biological Processes Synlett 2012, 23,
6 77. Karl Gademann and Simon Sieber Chemical Interference of Biological Systems with Natural Products CHIMIA 2011, 65, Karl Gademann Out in the Green: Biologically Active Metabolites Produced by Cyanobacteria CHIMIA 2011, 65, Karl Gademann Controlling Protein Transport by Small Molecules Current Drug Targets 2011, 12,
Total Synthesis of the Protected Aglycon of Fidaxomicin (Tiacumicin B, Lipiarmycin A3)
Total Synthesis of the Protected Aglycon of Fidaxomicin (Tiacumicin B, Lipiarmycin A3) H. Miyatake-Ondozabal, E. Kaufmann, K.Gademann* Angew. Chem. Int. Ed. 2015, 54, 1933 1936 06.08.2015 Literature Presentation
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