Medical Applications at the University of Huddersfield

Transcription

1 Medical Applications at the University of Huddersfield Who we are Rob Edgecock on behalf of the IIAA, University of Huddersfield Accelerator applications network Radioisotope production studies Therapy Conclusions

2 IIAA Physics Department has existed for 3-4 years: - International Institute of Accelerator Applications - Advanced materials group IIAA: staff - 2 postdocs - 13 PhD students Work on: - Medical applications - Thorium and waste transmutation - Meta materials, particularly for RF - MEIS - FETS - Target studies for neutrons and neutrinos - Collimators in HI-LUMI - Neutrons for security screening - Cyclotron studies at PSI - etc

3 IIAA

4 IIAA Physics Department has existed for 3-4 years: - International Institute of Accelerator Applications - Advanced materials group IIAA: staff - 2 postdocs - 13 PhD students Work on: - Medical applications - Thorium and waste transmutation - Meta materials, particularly for RF - MEIS - FETS - Target studies for neutrons and neutrinos - Collimators in HI-LUMI - Neutrons for security screening - Cyclotron studies at PSI - etc

5 EuCARD2 Accelerator Applications Network EuCARD2: 3 rd in series of Accelerator R&D FP6/7 projects Coordinate the Accelerator Applications Network Task leaders: - Rob Edgecock (Huddersfield) - Marco Cavenago (LNL) - Marco Schippers & David Meer (PSI) - Giulia Bellodi (CERN) - Hywel Owen (Manchester) Website at: >53 partners 5 workshops so far, another 5 in preparation

6 EuCARD2 Accelerator Applications Network Modern hadron therapy gantry developments UMAN & PSI - 16 th -17 th January Cockcroft, UK - Accelerator based neutron production (ABNP2014) - INFN - 14 th -15 th April Legnaro - BNCT, radioisotope production, security, etc - Compact accelerators for radioisotope production - UMAN - 26 th -27 th March Daresbury, UK - Compact gantries for charged particle therapy - September PSI

7 EuCARD2 Accelerator Applications Network Plan to do an EU version: Updated European focus For policy makers Applications where we can make a difference Organising committee: Roy Aleksan Oliver Boine-Frankenheim Phil Burrows Angeles Faus-Golfe (Chair) Steve Myers Andrea Pisent Kick-off meeting: 18 th -19 th June RAEng

8 Radioisotope Production Well-known 99m Tc problems due to (old) reactor production Moly crisis in 2008/9 Potential shortage in 2016 due NRU closure & LEU Various alternative production methods proposed, including accelerators BNMS & STFC Report, December 2014

9 Therapeutic Radioisotopes All reactor produced None in the UK, some in the US Supply has been a problem Some isotopes need α beams, difficult with cyclotrons: 211 At, 67 Cu, 47 Sc

10 FFAG for Radioisotopes FFAG/strong focussing cyclotron Injection energy: Extraction: Isochronous to 0.3% 75 kev Very flexible: protons, alphas, variable energy Huge beam acceptance Unique features: 10 MeV 102cm 14 MeV 120cm 28 MeV 170cm 20mA internal target Hud: Roger Barlow, David Bruton, RE STFC: Jim Clarke, Rob Clarke Glasgow: Sally Pimlott PAC: Carol Johnstone

11 FFAG for Radioisotopes FFAG/strong focussing cyclotron Injection energy: Extraction: Isochronous to 0.3% 75 kev Very flexible: protons, alphas, variable energy Huge beam acceptance Unique features: 10 MeV 102cm 14 MeV 120cm 28 MeV 170cm 20mA internal target Basil Gonsalves working at CERN with Thierry Stora on the MEDICIS target Hud: Roger Barlow, David Bruton, RE STFC: Jim Clarke, Rob Clarke Glasgow: Sally Pimlott PAC: Carol Johnstone Target cooling studies: radioisotopes & BNCT

12 Naomi Ratcliffe G4 Simulations

13 Therapy Becky Seviour: Working with Alceli Accelerator Technology Designing a proton & carbon linac for therapy: - 800MHz RF Hz operation - 1mm to 10mm FWHM - 0.1mm beam accuracy voxel scan in ~1 min - 4% dose homogeneity - <2% dose at 2mm outside target Aim is a significant cost reduction cf CNAO Huddersfield developing solid state RF Also work with Best Medical

14 OpenMed Modify LEIR for biomedical applications Accelerate protons up to neon Beam transport lines to two end stations: Vertical beamline for up to 75 MeV/u Horizontal beamline for up to 430 MeV/u Two contributions: Neutron production & shielding calculations - Roxana Rata Horizontal beam line Transport line re-design Tanjilul Amin Vertical beam line

15 Neutron dose from proton beam Roxana Rata Clatterbridge

16 CNAO 5 Pancreas AP - PRONE 2 ph3-phi [mm] abdominal compressor AP mask AP free breathing AP 5 Pancreas CC - PRONE 2 Cezarina Chirvase: Studied the motion of the pancreas Using 4D MRI Aim to optimise CNAO treatment using respiratory gating Moving onto pct studies in Nice ph3-phi [mm] abdominal compressor CC mask CC free breathing CC

17 Conclusions IIAA has only existed for a few years Small number of staff but many students! Main funding source: grants Making important contributions to accelerator applications Many in the medical area: - Networking - Radioisotope production - Therapy