System of Choice. Automated, Multiplexed Molecular Testing.

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1 Infectious Diseases Genetic Screening Pharmacogenetics (PGx) Carrier Predisposition Cancer Genetics Your System of Choice Automated, Multiplexed Molecular Testing

2 When the BEST becomes Better! Introducing our new fully automated NanoChip XL analyzer: FASTER. SIMPLER. SMARTER. 2 The NanoChip XL analyzer is a novel bench-top molecular microarray system enabling fully automated high throughput testing of DNA/RNA yielding results in the same working day with minimal hands-on time. Applications include Infectious Diseases, Genetic Screening, Pharmacogenetics, Cancer Genetics and Carrier Predisposition to diseases, enabling medium-high throughput labs to combine all their molecular testing on one simple screening platform. XL analyzer: Load & Go PCR On board allows for loading the PCR plate, reagents and cartridge, Pressing START and that s it you are all set! Friendly & Flexible Very simple operation, including touch screen option Up to 4 different assays in the same run and on the same cartridge Fast Improved robotics and optical mechanism- faster cartridge initialization allowing for shorter run time Robust Automated maintenance procedure and optical normalization

3 The New System The NanoChip XL System is an automated platform capable of detecting multiple targets for individual samples, and of analyzing multiple samples on the same electronic microarray with walk-away automation. When using the NanoChip XL System, molecular diagnostics labs are offered flexibility, cost savings and ease of use in a wide range of applications such as pathogen sequence detection, SNP genotyping and pharmacogenetics testing. CE-IVD approved kits are available for various applications. It s as simple as 1, Dispense the Master Mix to each well containing the extracted DNA sample. Seal the PCR plate with Microplate seals and load into the NanoChip XL thermo cycler (PCR block) Master Mix PCR plate 2. Load the NanoChip cartridge and reagents and start the run Reference Reagent Pack NanoChip Cartridge Position Sample Dataset pan-sal ipah cadf tpi tcda/b EH 18S ß-Gia COWP1 DF 16S Interpretation NC-GIP Salmonella NC-GIP Shigella NC-GIP Campylobacter NC-GIP Non toxinogenic C. difficile NC-GIP Toxinogenic C. difficile NC-GIP E. histolytica NC-GIP Giardia NC-GIP Cryptosporidium NC-GIP D. fragilis Example of Gastrointestinal Panel results demonstrated

4 NanoChip Electronic Microarray Technology The NanoChip cartridge is the heart of our technology. It houses a CMOS semiconductor microchip, or smart chip, called the NanoChip. SNP Application SNP There are 400 test sites available on the NanoChip, with each test site individually controlled by 12 electrical connections, which allow users to design and run molecular tests. Additionally, the smart chip technology allows for memory of which test sites have been previously used. Green Reporter (Wt Allele) T A Biotin C G Biotin Red Reporter (Mut Allele) Amplified DNA Sample Biotinylated Capture Probes Example of one Heterozygote sample on one pad 4 Each test site consists of the silicon CMOS circuitry, platinum electrode and permeable gel layer. Digital commands are sent to indicate which individual test sites are to be activated by applying a positive or negative charge. Pathogen Application Pathogen The permeable gel layer covering the chip contains streptavidin, which is utilitzed to non-covalently attach biotinylated DNA molecules (or capture oligos) to the test site. The strength of this streptavidin-biotin bond allows the amplicon to remain attached to the activated test site while excess amplicons are washed away, preventing cross contamination. Green Reporter (Pathogen 2) Amplified DNA Sample from Pathogen 2 Biotinylated Capture Probes for Pathogen 2 B Red Reporter (Pathogen 1) Example of Multiplexed Pathogen ID on a single pad B Amplified DNA Sample from Pathogen 1 Biotinylated Capture Probes for Pathogen 1

5 Molecular Diagnostics - Infectious Diseases HAI Cat. # Product name Targets Tests/kit Infection Control Panel Methicillin-resistant Staphylococcus aureus (MRSA) Vancomycin-resistant Enterococci (VRE) Carbapenemase - producing klebsiella pneumoniae (KPC) MRSA Panel spa & nuc meca SCCmec Clostridium difficile Panel gdh tcda/tcdb Gastrointestinal Panel Combi I Salmonella C. difficile (+Toxin) STEC Cryptosporidium spp. Entamoeba histolytica Giardia lamblia 78 GASTROENTRITIS * Gastrointestinal Panel Combi II Gastrointestinal Panel Combi III Salmonella Giardia lamblia Cryptosporidium spp. Salmonella STEC Yersinia enterocolitica Entamoeba histolytica Entamoeba dispar Dientamoeba fragilis Blastocystis spp. Giardia lamblia Cryptosporidium spp. Entamoeba histolytica Dientamoeba fragilis Blastocystis spp Gastrointestinal Parasites Panel I Giardia lamblia Entamoeba dispar Cryptosporidium spp. Dientamoeba fragilis Entamoeba histolytica Blastocystis spp * Gastrointestinal Bacteria Panel I Salmonella Yersinia enterocolitica STEC Sexually Transmitted Infections Panel STI Plex C. trachomatis N. gonorrhea T. vaginalis 192 STI Sexually Transmitted Infections Panel STI Plex + C. trachomatis N. gonorrhea T. vaginalis M. hominis M. genitalium U. urealyticum U. parvum 131 HPV HPV Screening Panel * HPV Genotyping Panel Genotyping of HPV High risk 16, 18 Identification of HPV High risk 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 73, 68, 82 Identification of HPV Low risk 6 and 11 Genotyping of HPV High risk 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 73, 68, 82 Genotyping of HPV Low risk 6, 11, 40, 42, 43, 44, 54, 55, 61, 62, 67, 69, 70, 71,72, 81, 84, Respiratory * Immunocompromised Respiratory panel Influenza A/B HSV Parainfluenza 1, 2, 3 Legionella spp. RSV A/B Aspergillus spp. Adenovirus Pneumocystis jirovecii CMV 96 * CE in-process

6 Cat. # Product name Disease Tests/kit CF14 Cystic Fibrosis (CFTR); 14 SNP's 64/ CF19 Cystic Fibrosis (CFTR); 19 SNP's 64/ CF70 Cystic Fibrosis (CFTR); 70 SNP's Genetic Carriers Screening AJP-12 (Ashkenazi Jewish Panel) Alpha 1 Antitripsin (PI) Bloom Syndrome (BLM) Fanconi Anemia C (FACC) Familial Dysautonomia (FD) Glycogen Storage Type 1a (GSD) Mucolipidosis IV (ML4) Maple Syrup Disease (MSUD) Niemann Pick Type A,B (NP) Usher Syndrome (US) Canavan (ASPA) Nemaline Joubert; 18 SNP s 64/ Connexin Hereditary Hearing Loss; 3 SNP s 96/ Tay Sachs Tay Sachs (HEXA); 6 SNP s 96/ Gaucher Gaucher Type 1 (GBA); 7 SNP s 96/ All-In-One 27 Diseases; 92 SNP s Beduins Panel 9 Diseases; 9 SNP s Carriers Predisposition to Disease Cat. # Product name Disease Tests/kit FMF-12 Familial Mediterranean Fever; 12 SNP s CVP5 Cardio Vascular Panel; 5 SNP s BRCA-19 Breast Cancer; BRCA1/2; 19 SNP s 64 6 Pharmacogenetics Cat. # Product name Disease Tests/kit * CYP2C9/VKORC1 Cytochrome * CYP2D6 Cytochrome * CYP2C19 Cytochrome * Under Development Please contact us for detailedsnp's/targets lists.

7 n f a c c u t e s t. n e t The Instrument Specifications: Instrument Dimensions: Height: 0.56 m Depth: 0.66 m Width: 0.90 m Instrument Weight: 105 kg Voltage Rating: or VAC, 50/60 Hz Power capacity: 650W Fuse: 250 VAC / 5A System Cartridge Specifications: Assay Cartridge: Length: 104 mm Width: 38 mm Height: 15 mm Laminar-Flow Fluidic Channels Sealed Fluidic Channels 400-Site Microarray with CMOS Logic Thermally Calibrated for Temperature Control Permeation Layer Coating for DNA/RNA Binding Cartridge-Tracking Barcode Label Environmental Restrictions: Operating Ambient Temp: 18 C to 30 C Operating Ambient Humidity: 40 to 80% Altitude: up to 2000 m Environmental Restrictions: Operating Temperature: Storage Temperature: C 2-8 C Optics: Illumination Information: Red LED: Green LED: Emission wavelength: Filters: Detection: Excitation Wavelength = 626 nm Excitation Wavelength = 525 nm 553 nm (green), 668 nm (red) Red, Green, Neutral Density CCD Camera and Board Computer Specifications: Portwell PPC, Core 2 Dou processor 17 inch flat touch screen display General purpose reagents needed in order to run the various assays Low Salt Buffer High Salt Buffer Target Prep Buffer NanoChip Microplate Seals (100/pack) NG-S NG-S NG-S NG-S The NanoChip XL system is an automated platform for the detection of multiple targets across multiple applications NanoChip XL System 400-site Cartridge Fluidics Cartridge (4/pack) NG-M800XL NG-S NG-S Distributed by: Jant Pharmacal Corporation Ventura Boulevard, Suite 512, Encino CA Fax i NanoChip is a registered trademarks of Gamida B.V, The Netherlands. The cartridge and NanoChip 400 system and their use may be covered by one or more of following U.S. Patents or Applications: 5,605,662; 5,929,208; 6,017,696; 6,238,624; 5,632,957; 6,582,660; 5,849,486; 6,245,508; 6,048,690; 6,051,380; 6,518,022; 2003/ ; 5,965,452; 6,258,606; 6,682,936; 6,687,048; 2002/ A1; 2004/ A1; 6,099,803; 6,726,880; 6,225,059; 6,068,818; 6,540,961; 6,254,827; 6,315,953; 6,821,729; 6,331,274; US A1; 6,306,348; 6,524,517; 6,303,082; 6,838,053; 2005/ A1; 6,960,298; 2005/ A1; 6,207,373; 6,395,493; 6,753,148; 6,468,742; 2003/ ; 6,379,897; 6,492,122. Please note: Purchase of this instrument conveys a limited non-transferable immunity from suit for the purchaser s own human in vitro diagnostics other than internal research and development and applied fields under non-real-time thermal cycler patents of Applied Biosystems LLC For Research Use Only