COMBI has been developed to be easily integrated in all types of laboratories and hospitals for routine, emergency as well as specific analysis.

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1 L A B O R A T O R Y

2

3 Clinical chemistry analyzers and reagents for laboratories needs. BIOCHEMICAL SYSTEMS INTERNATIONAL, as a diagnostic device manufacturer, has been researching for 25 years, with the aim of developing and producing innovative solutions for the diagnostic laboratory. The result is a unique analyzer, COMBI, that integrates new working concepts in a compact design. COMBI has been developed to be easily integrated in all types of laboratories and hospitals for routine, emergency as well as specific analysis.

4 COMBI is a multifunction random access bench top analyzer combining clinical chemistry, coagulation and immunochemistry.

5 Arezzo, Italy COMBI is dedicated to small & mid size laboratories, doctor office, hospitals, clinics.

6 COMPACT RANDOM ACCESS ANALYZER LOW REAGENT CONSUMPTION THROUGHPUT UP TO 200 TESTS/HOUR TRUSTED PERFORMANCE BSI LABORATORY 4 UP TO 4 REAGENTS HANDLING MINUTES OF REACTION TIME COMBINATION OF COAGULATION & CLINICAL CHEMISTRY TESTS COMPACTNESS, VERTICAL DESIGN USER FRIENDLY SOFTWARE LOW WATER CONSUMPTION TOUCH SCREEN

7 TEST LIST CLINICAL CHEMISTRY ALBUMIN CK-MB LIPASE ALKALINE PHOSPHATASE CK-NAC MAGNESIUM AMYLASE CREATININE PHOSPHORUS BILIRUBIN DIRECT GAMMA GT TOTAL PROTEINS BILIRUBIN TOTAL GLUCOSE TRIGLYCERIDES CALCIUM GOT UREA CHLORIDE GPT URIC ACID CHOLESTEROL HEMOGLOBIN A1c (HbA1c) ZINC CHOLESTEROL HDL DIRECT HOMOCYSTEINE (HCY) CHOLESTEROL LDL (calculated) IRON CHOLINESTERASE LDH IMMUNOCHEMISTRY ANTI- STREPTOLYSIN O (ASO) C-REACTIVE PROTEIN (CRP) IMMUNOGLOBULIN A (IGA) IMMUNOGLOBULIN G (IGG) IMMUNOGLOBULIN M (IGM) TRANSFERRIN RHEUMATOID FACTOR (RF) COAGULATION PROTHROMBIN TIME (PT) PARTIAL THROMBOPLASTIN TIME (PTT) FIBRINOGEN

8 Optical carousel with 45 reusable Bionex cuvettes. 03 Removable sample tray up to 48 sample positions. Removable reagent tray with 64 reagent positions. 02 Cuvette washing system integrated, 10 (5x2) steps. 04 Positive sample identification by barcode.

9 Needle capacitive liquid level detector with impact sensor. Touch screen user friendly software. SYSTEM SPECIFICATIONS THROUGHPUT UP TO 200 TESTS/HOUR CONTINUOUS SAMPLE LOADING SAMPLE TYPE PRIMARY TUBES OR PEDIATRIC CUPS COOLING REAGENT SYSTEM BY A DEDICATED SWITCH RUN TIME OPTICAL CUVETTE QUALITY CHECK SAMPLES AUTOMATIC DILUTION PRE, POST AND RE-RUN AVAILABLE BOTH AS OPEN AND CLOSED SYSTEM LESS THAN 1 LITER/HOUR WATER CONSUMPTION LEVEL SENSORS FOR WASH AND WASTE TANKS QUALITY CONTROL PROGRAM LOW MAINTENANCE

10 SOFTWARE FEATURES Graphical user interface for convenient operation. Continuous loading of samples and reagents refilling. Random access and stat, re-run sample worklists. Walk away capability with real time alarm. Unlimited patients, results and test database. Multi language software. Levey-Jennings plots and Westgard multi rules. Up to 3 qc levels per test, qc monitor and reports. Method statistics: including test counter, cv%, mean, graphical trend analysis. Active reagent monitoring (volumes, available tests, calibration, qc status). Automatic pre and post dilution. Up to 8 calibrators per method. Dynamic autodilution of standards. Bi-directional LIS/HIS. Positive identification of samples with internal barcode reader. Printing on any Windows compatible printer in most common formats. Customizable profiles to easy manage the workload. Touch screen software speeds up routine operations. SAMPLE ENTRY STATUS MONITOR ABSORBANCE CURVE RESULTS SOFTWARE Using the COMBI software, operators manage all the needs of today laboratories in flexible and efficient way. Unique software that combines the usability of Microsoft Windows with the advantage of touch screen interface, manages automatically the clinical chemistry, coagulation and immunochemistry test procedures giving the operator a new experience on routine work.

11 TECHNICAL FEATURES MODE - Random access, stat, continuous sample loading ANALYSIS - Throughput up to 200 tests/hour - End point, differential, fixed time, kinetic - Calibration up to 8 points for each analysis (linear, spline, logit-log, etc.) - Coagulation mode with seconds resolution - Reagent handling: automatic up to 4 reagents up to 24 minutes of cuvette reaction time SAMPLE - Removable tray - Up to 48 samples on board in primary tubes 75/100 mm, or pediatric cups 1.5 ml - Sample volume: μl - Barcode scan during sample processing - Automatic pre and post dilution - Test profiles and replicates REAGENT - Removable tray - Up to 64 reagents on board - Reagent bottles available in different volumes: 13 ml, 25 ml and 40 ml - Reagent tray cooling for all positions - Reagent volume: μl - Barcode scan for reagent identification REACTION - Reaction volume: μl - 6 mm optical path cuvette - 45 bionex reusable cuvettes - Reaction temperature 37 c PIPETTING SYSTEM - Ceramic piston diluter, maintenance free - Needle impact detection - Needle capacitive liquid level detection OPTICAL SYSTEM - Spectral range: nm - Interferential filters wavelengths: 340, 405, 505, 546, 578, 630, 660, 700 nm - Photometric linearity: od; resolution od - Optical source: tungsten halogen lamp (long life, auto-power off) - Optical range: 0-5 od (10 mm conversion) WASHING - 10 steps (5x2) cuvette wash station - Pipetting needle auto-washed internally and externally - Water consumption: less than 1 l/h - Level sensor on waste and wash tanks USER INTERFACE - External computer required, Windows based - Communication: usb port or serial rs232 - Various print-out format for patient results - Software usable for touch screen - Multi language software ENVIRONMENT CONDITIONS C; humidity 30-80% noncondensing POWER - AC 110/115/230 VOLT (50/60 HZ) DIMENSIONS - (WXDXH) 54X44X64 cm WEIGHT - 37 Kg OPTIONS ( ON REQUEST) - ISE MODULE - EXTERNAL PRINTER - TOUCH PANEL PC - UPS

12 BRO.COMBI.ING.ED2018OCT BIOCHEMICAL SYSTEMS INTERNATIONAL S.P.A. Headquarter Loc. Palazzo del Pero, Arezzo (AR) - Italia Tel Fax Instrument Division Via B. Buozzi, Campi Bisenzio (FI) - Italia Tel Fax biosys@biosys.it

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