Indian Journal of Chemistry

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1 CTETS 493 Website address: Indian Journal of Chemistry Sect. B: rganic Chemistry including Medicinal Chemistry VL. 49B UMBE ovember 00 CTETS Papers 499 Design, synthesis and in vivo hypoglycemic activity of tetrazole-bearing -glycosides as SGLT inhibitors ovel tetrazole-bearing -glycosides have been designed and synthesized, and in vivo hypoglycemic activity has also been evaluated. 4 a-f 4 g-l a, g, =, 4 = α- b, h, =, 4 = β- c, i, = Me, 4 = α- d, j, = Me, 4 = β- e, k, = Et, 4 = α- f, l, = Et, 4 = β- Y L Gao, G L Zhao, W Liu, Shao, Y L Wang, W Xu, L D Tang & J W Wang* School of Chemistry and Chemical Engineering, Shandong University, Jinan 5000, P.. China 509 Synthesis of -(3-chloro-4-flourophenyl)- 4 -substituted semicarbazones as novel anticonvulsant agents Several 3-chloro-4-flourophenyl substituted semicarbazones have been synthesized in three steps involving aryl urea and aryl semicarbazide formation. The structures have been confirmed by spectral and elemental analyses. Some selected compounds have been evaluated for anticonvulsant activity by using maximal electroshock seizure (MES) test. The compounds have also been screened for their neurotoxicity and CS depressant activity. F Cl 3a-p Mohd Amir*, Mohd J Ahsan & Israr Ali Department of Pharmaceutical Chemistry, Faculty of Pharmacy, amdard University, ew Delhi 0 06, India IDIA J CEM, 49B ()00

2 494 CTETS 55 Synthesis and antimicrobial activity of certain benzimidazole and fused benzimidazole derivatives ew series of benzimidazoles have been prepared and evaluated for their antimicrobial activity. Some of them show promising antimicrobial activity. assan M Eisa, Alaa-eldin M Barghash, Sahar M Badr* & Abdelbasset A Farahat Department of Pharmaceutical rganic Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura 3556, Egypt otes 56 Chemoselective hydrazine addition to diethyl - (,3-dioxo-,3-diarylpropyl)malonates and a tandem deesterification The structural features of the product of the chemoselective reaction of hydrazine on only one of the ketones in a gem diester system with two keto groups by hydrazinium sulfate and hydrazine hydrate are described. A tandem deesterification has also been noticed during the reaction with hydrazine hydrate. Sivaperuman Saravanan, Santhanagopalan Purushothaman & Shanmugam Muthusubramanian* Department of rganic Chemistry, Madurai Kamaraj University, Madurai 65 0, India 53 -Amino-5-sulphanyl-,3,4-thiadiazole derivatives as anticonvulsant agents: Synthesis and evaluation -Amino-5-sulphanyl-,3, 4-thiadiazole derivatives bearing different substituents have been synthesized and screened pharmacologically in order to evaluate their central nervous system activity. C 6 5 CCl S a - g SAr C 6 5 C S 3a - g SAr Priyabrata Pattanayak* & ajesh Sharma Jeypore College of Pharmacy, ondapalli, Jeypore, Koraput , India IDIA J CEM, 49B () 00

3 CTETS A novel versatile strategy for synthesis of new series of 4(3)-quinazolinone -nucleosides An integrated protocol for one-pot synthesis of 4(3)- quinazolinone -nucleoside analogues under microwave irradiation using montmorilloite K 0 as catalyst and solid support in solvent-free conditions has been reported C 3a-g µυ -5 min % 3 4 4, 5, 6, 7, 8a-g I Siddiqui*, Pravin K Singh, Vishal Srivastava, Sanjay Yadav & J Singh Laboratory of Green Technology, Department of Chemistry, University of Allahabad, Allahabad 00, India 54 Synthesis of Gossypin derivatives as potential anticancer and anti-inflammatory agents A new series of gossypin derivatives SGGS -9 have been synthesized from the combination of naturally occurring flavonol glycoside gossypin and substituted aromatic aldehydes, which exhibit significant anticancer and antiinflammatory activities. Ar SGGS -9 Vijay Kotra, S Ganapaty* & Srinivas Adapa University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam , India IDIA J CEM, 49B ()00

4 496 CTETS 547 Synthesis and antibacterial properties of some novel -substituted-6-(4-methyl-6-substitutedcinnoline-3-yl)imidazo[,-b][,3,4]thiadiazoles A series of -substituted-6-(4-methyl-6-substitutedcinnoline-3- yl)imidazo[,-b][,3,4] thiadiazoles 5a-k have been synthesized by reacting 3-(-bromoacetyl)-4-methyl-6-substitutedcinnolines 3 with various -amino-5-substituted-,3,4-thiadiazoles 4 taking absolute ethanol as solvent. The structures of the newly synthesized compounds have been characterized by elemental analysis, I, M spectral data. All the newly synthesized compounds have been tested for their antibacterial properties against gram-positive and gram-negative bacteria. Anshu Jakhar & J K Makrandi* Department of Chemistry, M. D. University, ohtak 4 00 India 55 Microwave-assisted zeolite catalyzed Claisen rearrangement of allyl aryl ethers under solventfree conditions Claisen rearrangement of allyl aryl ethers has been studied extensively over various zeolites under microwave activation and solvent free conditions at 80 C. β-zeolite is found to be an efficient catalyst for the rearrangement. The reaction gives o-rearranged product selectively instead of expected further cyclized dihydrobenzofuran derivative. Zeolite MW/80 o C Deepak K Deodhar, Amol S Tipnis & Shriniwas D Samant* Department of Chemistry, Institute of Chemical Technology, M Parekh Marg, Matunga, Mumbai , India IDIA J CEM, 49B () 00

5 CTETS Solid state synthesis of ring-substituted aminobenzenesulphonic acids under reduced thermal pressure 3 microwave S 3 =, = o- C 3 and = m- Cl Inder Pal Singh Kapoor, Manisha Kapoor, Gurdip Singh*, & oland Fröhlich Department of Chemistry, DDU Gorakhpur University, Gorakhpur , India 56 An excellent protocol for the synthesis of benzopyrans using basic resin under MWI + 3 a A K Tripathi*, S Koul & Subhash C Taneja Bio-rganic Chemistry Section, Indian Institute of Integrative Medicine (CSI), Canal oad, Jammu 80 00, India 565 ecombination of propargyl radicals to form benzene: A computational study Present study involves QCISD(T)/6-3G(d,p) level calculations to analyze reaction pathways during the recombination of propargyl radicals leading to the formation of benzene. Geometries of all the species are optimized at F/6-3G(d) level. Intrinsic eaction Coordinate (IC) calculation has been performed in order to ascertain the existence of the transition states... C C C C T C C ari Ji Singh* & and Kishor Gour Department of Chemistry, DDU Gorakhpur University, Gorakhpur , India C Authors for correspondence are indicated by (*) IDIA J CEM, 49B ()00