Polycavernoside A: The Prins Macrocyclization Approach
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1 Polycavernoside A: The Prins Macrocyclization Approach Sang Kook Woo and Eun Lee Seoul National University, Seoul, Korea J. Am. Chem. Soc. 2010, 132, H Me H Me Me Me Marie-Céline Frantz Wipf Group - Current Literature April 24, 2010 Marie-Celine Wipf Group Page 1 of 11 4/26/2010
2 Polycavernoside A Isolated by Yasumoto from the edible red alga Polycavernosa tsudai in Guam in Responsible for sudden and fatal human intoxication in Guam in 1991 and in the Philippines in Symptoms: gastrointestinal (vomiting, diarrhea) and neurological (scratching, muscle spasms, paralysis) disorders. Cyanobacterial origin speculated. Group of macrolides with: structurally unique 13-membered central lactone ring disaccharide and trienyl side chains. Polycavernoside A analogs also isolated: Estimated LD 99 in mice (ip) of PA and PB: µg/kg. SAR: macrocyclic core and ipr-polyene side chain required for high toxicity. Hydrolysis of the disaccharide in the stomach would deliver the aglycone bioactive form. Postulated mechanism of action: triggers an initial extracellular calcium entry into the cytosol, resulting in membrane depolarization. R 2 R 3 Me Me Me H Me R 1 PC PC2 diene triene Polycavernosides C R 1 R 2 R 3 diene Ac Me triene Me Me Yotsu-Yamashita, M.; Haddock, R. L.; Yasumoto, T. J. Am. Chem. Soc. 1993, 115, Yotsu-Yamashita, M.; Yasumoto, T.; Yamada, S.; Bajarias, F. F. A.; Formeloza, M. A.; Romero, M. L.; Fukuyo, Y. Chem. Res. Toxicol. 2004, 17, Yotsu-Yamashita, M.; Seki, T.; Paul, V. J.; Naoki, H.; Yasumoto, T. Tetrahedron Lett. 1995, 36, Yotsu-Yamashita, M.; Abe, K.; Seki, T.; Fujiwara, K.; Yasumoto, T. Tetrahedron Lett. 2007, 48, Barriault, L.; Boulet, S. L.; Fujiwara, K.; Murai, A.; Paquette, L. A.; Yotsu-Yamashita, M. Bioorg. Med. Chem. Lett. 1999, 9, Cagide, E.; Louzao, M. C.; Ares, I. R.; Vieytes, M. R.; Yotsu-Yamashita, M.; Paquette, L. A.; Yasumoto, T. Cell. Phys. Biochem. 2007, 19, 185. Marie-Celine Wipf Group Page 2 of 11 4/26/2010
3 Polycavernoside A: Structure Determination & Synthesis Yasumoto (1993): determination (1D/2D NMR) of the partial relative structure of: each sugar component, bottom (C1-C8) and upper (C9-C15) halves of the macrolactone part. Murai (1995): determination (synthetically) of the relative configuration of the sequence of the fucose-xylose bottom half of the macrolactone. Murai (1998): 1st total synthesis & determination of the absolute configuration. Yotsu-Yamashita, M.; Haddock, R. L.; Yasumoto, T. J. Am. Chem. Soc. 1993, 115, Fujiwara, K.; Amano, S.; Murai, A. Chem. Lett. 1995, 855. Fujiwara, K.; Murai, A.; Yotsu-Yamashita, M.; Yasumoto, T. J. Am. Chem. Soc. 1998, 120, Paquette, L. A.; Barriault, L.; Pissarnitski, D. J. Am. Chem. Soc. 1999, 121, Paquette, L. A.; Barriault, L.; Pissarnitski, D.; Johnston, J. N. J. Am. Chem. Soc. 2000, 122, 619. White, J. D.; Blakemore, P. R.; Browder, C. C.; Hong, J.; Lincoln, C. M.; Nagornyy, P. A.; Robarge, L. A.; Wardrop, D. J. J. Am. Chem. Soc. 2001, 123, Blakemore, P. R.; Browder, C. C.; Hong, J.; Lincoln, C. M.; Nagornyy, P. A.; Robarge, L. A.; Wardrop, D. J.; White, J. D. J. rg. Chem. 2005, 70, Marie-Celine Wipf Group Page 3 of 11 4/26/2010
4 ( )-Polycavernoside A: Murai's synthesis (1998) H (R)-(+)-Glycidol Stereoselective intramol. H C 2 Me EtS 14 steps H Bn Michael cyclization 7 steps t-buk H C 2 Me H Bn 91% C 2 Me Bn SEt Sulfoxide anion addition Bn TBS LDA; then H PMB H 17 steps TBS PMB 1. Swern 2. PMB cleavage 3. Pinnick 4. Cl 3 PhCCl, Et 3 N; DMAP; >75% Me H H Bn Yamaguchi macrolactonization TsH, MeH/(Me) 3 CH 65-68% PMB - Thio/sulfinyl gps removal - TBS cleavage - Cyclic Me acetal formation H TBS SEt 33% TBS Bn + PMB H TBS EtS SEt 46% TBS Bn Me Bn MgBr + 1. Dihydroxylation 2. xidative cleavage 3. PG manipulation 4. Takai iodovinylation 5. TFA/H 2 /THF, >95% Acid-mediated acetal rearrangement H 1. TsCl 2. NaNH 2 Z/E sep. H H Hg Cp 2 ZrCl 2 LiEt 3 BH; I 2 I 1. Glycosidation 2. Bn cleavage 3. Cross-coupling I t-buli; HgCl steps (longest linear sequence) Me H Me Me Me ( )-Polycavernoside A Fujiwara, K.; Murai, A.; Yotsu-Yamashita, M.; Yasumoto, T. J. Am. Chem. Soc. 1998, 120, H Marie-Celine Wipf Group Page 4 of 11 4/26/2010
5 ( )-Polycavernoside A: Paquette's synthesis (1999) 32 steps (longest linear sequence) Paquette, L. A.; Barriault, L.; Pissarnitski, D. J. Am. Chem. Soc. 1999, 121, Paquette, L. A.; Barriault, L.; Pissarnitski, D.; Johnston, J. N. J. Am. Chem. Soc. 2000, 122, 619. Marie-Celine Wipf Group Page 5 of 11 4/26/2010
6 ( )-Polycavernoside A: White's synthesis (2001) 25 steps (longest linear sequence) White, J. D.; Blakemore, P. R.; Browder, C. C.; Hong, J.; Lincoln, C. M.; Nagornyy, P. A.; Robarge, L. A.; Wardrop, D. J. J. Am. Chem. Soc. 2001, 123, Blakemore, P. R.; Browder, C. C.; Hong, J.; Lincoln, C. M.; Nagornyy, P. A.; Robarge, L. A.; Wardrop, D. J.; White, J. D. J. rg. Chem. 2005, 70, Marie-Celine Wipf Group Page 6 of 11 4/26/2010
7 The Prins Reaction Prins cyclization vs competing oxonia-cope rearrangement Cyclization of (E)- and (Z)-Homoallylic Alcohols H EtCH, EtAlCl 2 TBS DCM Cl TBS 38% (40% r.s.m.) H TBS 9:1 Z/E EtCH, EtAlCl 2 DCM Cl + TBS Cl 1 : 3 (36%) TBS Stereochemical outcome for Prins cyclizations Excellent stereocontrol. All the substituents in the equatorial position. Selectivity of nucleophilic capture at C4 dependent on reactivity: - Highly reactive nucleophile (e.g.: Br - ) and electrophile: axial attack - Less reactive nucleophile (e.g.: Ac -, TFA - ) and electrophile: equatorial attack Crosby, S. R.; Harding, J. R.; King, C. D.; Parker, G. D.;Willis, C. L. rg. Lett. 2002, 4, 577. Barry, C. S. J.; Crosby, S. R.; Harding, J. R.; Hughes, R. A.; King, C. D.; Parker, G. D.; Willis, C. L. rg. Lett. 2003, 5, Jasti, R.; Anderson, C. D.; Rychnovsky, S. D. J. Am. Chem. Soc. 2005, 127, Jasti, R.; Rychnovsky, S. D. J. Am. Chem. Soc. 2006, 128, Marie-Celine Wipf Group Page 7 of 11 4/26/2010
8 The Prins Reaction: Application in Total Synthesis Application in the total synthesis of ( )-Blepharocalyxin D (Lee, 2007) ptimization of the conditions of Willis & coworkers Me (1.2 equiv.) H H H H Me H CH TESTf (4.0 equiv.) TMSAc (1.0 equiv.) Me Me H Ac Ac AcH (40 equiv.) rt, 1 h, 60% single diastereomer Ac Ac Ac ( )-Blepharocalyxin D H Application of the intramolecular Prins macrocyclization in the total synthesis of (+)-Neopeltolide (Lee, 2008) Ko, H. M.; Lee, D. G.; Kim, M. A.; Kim, H. J.; Park, J.; Lah, M. S.; Lee, E. rg. Lett. 2007, 9, 141. Ko, H. M.; Lee, D. G.; Kim, M. A.; Kim, H. J.; Park, J.; Lah, M. S.; Lee, E. Tetrahedron 2007, 63, Woo, S. K.; Kwon, M. S.; Lee, E. Angew. Chem., Int. Ed. 2008, 47, Marie-Celine Wipf Group Page 8 of 11 4/26/2010
9 ( )-Polycavernoside A Total Synthesis: Title Paper (enantiomer) Woo, S. K.; Lee, E. J. Am. Chem. Soc. 2010, 132, Marie-Celine Wipf Group Page 9 of 11 4/26/2010
10 ( )-Polycavernoside A Total Synthesis: Title Paper H TBS HF py 81% Et Et 1. Ac 2 DMAP 2. HF py 90% Ac H Et Et TESTf TMSAc AcH 85% Prins 6:1 d.r. Ac * Ac 3 ; PPh 3 79% Ac Ac CrCl 2 CHI 3 Complex product mixture H H Et Et Fortuitous rearrangement upon prolonged exposure to Takai conditions 1. 3 ; PPh 3 2. CrCl 2, CHI 3 3. K 2 C 3 54% H TESTf (10 equiv) TMSAc (15 equiv) AcH H 69% Prins I 5.5:1 d.r. H * Ac 1. NBS, 4 A MS Me SPh Me Me Bn Me 2. DDQ 3. PdCl 2 Bu 3 Sn 23% Pt 2, C K 2 C 3 ; 2. TPAP, NM 4 A MS 4 A MS Me 72% (3 steps) 6-endo intramol. alkyne hydration Ac H 1. DMD; PPTS, MeH Me H Me Me Me ( )-Polycavernoside A Ac Woo, S. K.; Lee, E. J. Am. Chem. Soc. 2010, 132, Marie-Celine Wipf Group Page 10 of 11 4/26/2010
11 Conclusion and Perspectives Novel approach for the total synthesis of ( )-Polycavernoside A. Use of a Prins macrocyclization strategy to build chemical complexity in a single step: 2 new rings 3 new stereocenters Comparison of synthetic routes to the macrocycle: Murai Paquette White Lee Longest linear sequence (steps) verall yield (%) Perspectives: further applications of the Prins macrocyclization strategy in the synthesis of complex natural products. Marie-Celine Wipf Group Page 11 of 11 4/26/2010
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