Thirupathi Barla, Ph.D. C/o Prof. E. J. Corey Email: thirupathibarla@fas.harvard.edu 12 Oxford Street bthirupathi56@gmail.com Department of Chemistry and Chemical Biology phone: +1-6172308362 Harvard University Cambridge, MA-02138 EXECUTIVE SUMMARY I am looking for the challenging academic position where I can utilize my research experience and knowledge greatly influence the chemistry students, I want to learn from the organization and growth with organization. ACADEMIC QUALIFICATIONS 2015 - present Postdoctoral Studies with Prof. E. J. Corey, Harvard University, Cambridge, USA [04/2009 03/2014] Ph.D. in Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, India. Research supervisor: Dr. D. K. Mohapatra Title of Thesis Stereoselective Total Synthesis of Herboxidiene, Pyrenolide-D, (3R,5R)-Sonnerlactone, (3R,5S)-Sonnerlactone, Cryptosporiopsin A, Streptopyrrolidins, Clavaminols A, C and H [06/2006 05/2008] M.Sc. in Organic Chemistry, Osmania University. First class (70%) [07/2002 05/2005] B.Sc. (MPC), Kakatiya University. First class (72%) RESEARCH INTEREST Alkylation of chiral enolates, Asymmetric catalysis, Lewis acid catalysis, Development of new fluorinated N-Heterocyclic Carbenes (NHC s) and their applications to organocatalysis. Total synthesis of biologically active natural products or model compounds having important biological activity. AWARDS & HONORS April 2011-April 2014 Awarded Senior Research Fellowship (SRF) from the Council for Scientific and Industrial Research (CSIR), New Delhi, India
April 2009-April 2011 February 2008 Awarded Junior Research Fellowship (JRF) from the Council for Scientific and Industrial Research (CSIR), New Delhi, India Qualified Graduate Aptitude Test in Engineering (GATE) with 96 percentile INDUSTRIAL EXPERIENCE 03/2014-02/2015 Associate Research Scientist, Process Research & Development division, Sai Life Sciences, Hyderabad, India Involved in the process optimization and synthesis of Trichostatin A, a antifungal antibiotic activitie along with selective inhibition of the class I and II mammalian histone deacetylase (HDAC) families of enzymes As an Associate Research Scientist, I involved in the late stage process optimization and scalability of Beraprost 314d (chiral purity, >99.5%), a synthetic analogue of prostacyclin, successfully completed phase-iii clinical trials for the treatment of pulmonary hypertension As a team lead, optimized process for the synthesis of (S)-3- propionamidopyrrolidin-1-ium 4-methylbenzenesulfonate (Chiral purity, >99.0%), project was successfully completed within the stipulated time and multi gram quantities of the target compound was dispatched with excellent chiral purity [05/2008-03/2009] Research Chemist, GVK BIO sciences, Hyderabad, India Involved in the synthesis various anti-cancer agents Received best performance award. POSTERS AND PRESENTATIONS 1. Presented poster entitled Total Synthesis of Pyrenolide D in 12 th CRSI International Symposium in Chemistry & 4 th CRSI-RSC Symposium in Chemistry, on February 2010 2. Participated International Symposium in Organic Synthesis and Human Well Being: Emerging Opportunities and Challenges on August 2010. 3. Participated International Symposium in Chemistry and Chemical Biology of Natural Products on August 2012
4. Participated International Symposium in 100 th The Indian Science Congress Association on January 2013. 5. Participated International Symposium in Nature Inspired Initiatives in Chemical Trends on March 2014. 6. Organized and conducted 2017 Northeastern Student Chemistry Research Conference at Harvard University, April 8, 2017 EDITORIAL BOARD MEMBERSHIP 1. Editor-in-chief for International Journal of Chemistry 2. Editorial Board Member for American Research Journals 3. Editorial Board Member for International Journal of Modern Chemistry and Applied Science SERVING AS POTENTIAL REVIEWER FOR: Tetrahedron, Bioorganic and Medicinal Chemistry, Bioorganic and Medicinal Chemistry Letters, Applied Organometallics, Tetrahedron Letters, Synlett, Synthetic Communications, Chemistry and Biodiversity, Molecules, Chem Texts, International Journal of Chemistry, Beilstein Journal of Organic Chemistry, Letters in Organic Chemistry and Polymers. PUBLICATIONS: 1. Useful Applications of Enantioselective (4+2)-Cycloadditions Reactions to the Synthesis of Chiral 1,2-Amino Alcohols, 1,2-Diamines, β-amino Acids; K. M.; Reddy.; Thirupathi, B *.; Corey, E. J. Org. Lett. 2017, 19, 4956-4957 (*equal first author contribution) 2. Acceleration of Enantioselective Cycloadditions Catalyzed by Second-Generation Chiral Oxazaborolidinium Triflimidates by Bis-Coordinating Lewis Acids, Thirupathi, B.; Breitler, S.; Reddy, K. M.; Corey, E. J. J. Am. Chem. Soc. 2016, 138, 10842-10845
3. Cationic Chiral Fluorinated Oxazaborolidines. More Potent, Second-Generation Catalysts for Highly Enantioselective Cycloaddition Reactions, Reddy, K. M.; Bhimireddy, E.; Thirupathi, B.; Breitler, S.; Yu, S.; Corey, E. J. J. Am. Chem. Soc. 2016, 138, 2443-2453 4. A Carbohydrate-Based Total Syntheses of (+)-Pyrenolide D and ( )-4-epi-Pyrenolide D, Thirupathi. B, P. Purushotam Reddy, Mohapatra. D. K. J. Org. Chem. 2011, 76, 9835 9840. 5. Gold-Catalyzed Hosomi-Sakurai Type Reaction for the Total Synthesis of Herboxidiene Thirupathi. B, Mohapatra. D. K. Org. Biomol. Chem., 2016, 14, 6112-6224 6. First Total Syntheses of (3R,5R)-Sonnerlactone and (3R,5S)-Sonnerlactone. Thirupathi. B, Gundapaneni. R. R, Mohapatra. D. K. Synlett. 2011, 18, 2667-2670. 7. First total synthesis of cryptosporiopsin A, Thirupathi. B; Mohapatra. D. K. RSC Adv. 2014, 4, 8027 8030.
8. Chemoenzymatic total synthesis of four stereoisomers of centrolobine. B. Nagarjuna, Thirupathi, B; Mohapatra D. K. Tetrahedron Lett. 2015, 56, 4916 4918. 9. An Efficient Synthesis of Dibenzo[b,f]oxepins by Ring-Closing Metathesis, Bharath. Y, Thirupathi. B, Gurram Ranjit and Mohapatra. D. K. Asian J. Org. Chem. 2013, 2, 848-851 10. Stereoselective synthesis of four possible isomers of streptopyrrolidine. Mohapatra. D. K., Thirupathi. B, Das. P. P. and. Yadav. J. S. Beilstein J. Org. Chem. 2011, 7, 34 39 11. General synthetic strategy for clavaminols A, C and H, Thirupathi, B.; Bharath, Y.; Mohapatra, D. K. ARKIVOC 2016, 162 171. 12. Inside Cover: Gold-Catalyzed Hosomi-Sakurai Type Reaction for the Total Synthesis of Herboxidiene Thirupathi. B, Mohapatra. D. K. Org. Biomol. Chem., 2016, 14, 6112-6224, DOI: 10.1039/C6OB90097F 13. Inside Cover: An Efficient Synthesis of Dibenzo[b,f]oxepins by Ring-Closing Metathesis. Bharath. Y, Thirupathi. B, Ranjit. G, and Mohapatra. D. K. Asian J. Org. Chem. 2013, 2, 848-851, DOI: 10.1002/ajoc.201390028
REFERENCES: 1. Prof. Elias J. Corey, Nobel Laureate (1990) (Sheldon Emory Professor Emeritus) Department of Chemistry & Chemical Biology Harvard University 12 Oxford Street Cambridge, MA 02138, USA Email: corey@chemistry.harvard.edu Phone: +1-617 4954033 2. Dr. J. S. Yadav, FNA, FTWAS, J C Bose Fellow (Former Director, CSIR-IICT and CSIR-Bhatnagar Fellow) Director and Trustee Indrashil University At/PO: Rajpur, Taluka: Kadi Dist: Mehsana-382740 Gujarat, India Email: yadavfna@gmail.com Mobile: +91-7069076528 3. Dr. Debendra K. Mohapatra (Principal Scientist) Genetic Chemistry Laboratory CSIR-Indian Institute of Chemical Technology Hyderabad-500007 Telangana, India Email: mohapatra@iict.res.in : dkm0077@gmail.com Phone: +91-9177221611