Progress in using prompt gammas for ion range monitoring during hadrontherapy
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1 Progress in using prompt gammas for ion range monitoring during hadrontherapy J. Krimmer 1, M. Chevallier 1, J. Constanzo 1, M. Dahoumane 1, D. Dauvergne 1, M. De Rydt 1,2, G. Dedes 1, N. Freud 3, J.M. Létang 3, M. Pinto 1, C. Ray 1, V. Reithinger 1, M.H. Richard 1,3, F. Roellinghof 1,3,4, E. Testa 1, A.H. Walenta 1 1 PNL, 2 K.U. Leuven, 3 CREATS, 4 BA CTR-PHE 2012 Geneva, Switzerland
2 Dose Monitoring during Hadrontherapy measurement of β + activity (200 MeV/u 12 C on a PMMA phantom) counts/ion/mm 12 95MeV/u C, PMMA target, GEANT γ n p α nuclear reactions goal 3D reconstruction of applied dose (online) techniques Target depth [cm] β + activity PET emitted radiation (p,γ) for ion range monitoring proton V talk E. Testa Wed. 15:45 (Nr. 241) prompt γ this talk
3 Prompt Gamma Measurements collimated camera single and multislit slit camera see poster by J. Smeets (Nr. 89) Compton camera "electronic collimation"
4 Common Device: Hodoscope hardware array of scintillating fibres (1 mm x 1 mm) 2 prototypes: 2x32 and 2x128 fibres multianode PM or MCP-PMT time resolution 1 ns goal: count rates up to 108 1/s electronics development of ASC S. Deng DO /CECS first version tested at CAL Nice new version with DLL timing see poster M. De Rydt (Nr.136) J. Krimmer (PNL) Progress in using prompt gammas for ion range monitoring during hadrontherapy CTR-PHE 2012
5 Collimated Camera 95MeV 12 C, PMMA target counts / ion 1.4e e-06 1e-06 8e-07 6e-07 4e-07 data QMD improved QMD default 2e depth in target [mm] measurements at carbon beams (homogeneous targets): E. Testa et al. Appl. Phys. Lett. 93 (2008) E. Testa et al. NM B 297 (2009) 993 M. Testa et al. Radiat. Environ. Biophys. 49 (2010) 337 improvements in simulations (GEANT4): G. Dedes poster (Nr.148)
6 Target Dependence (GANL) PMMA (1.2 g/cm 3 ) 12 C
7 Target Dependence (GANL) PMMA (1.2 g/cm 3 ) PMMA+teflon(2.3 g/cm 3 ) 12 C 12 C
8 Target Dependence (GANL) PMMA (1.2 g/cm 3 ) PMMA+teflon(2.3 g/cm 3 ) PMMA+lung(0.2 g/cm 3 ) 12 C 12 C 12 C
9 First Measurement at the Proton Beam setup results of a scan proton beam PMMA target tungsten collimator LaBr 3 LYSO proton beam 160 MeV at WPE (Essen) 2 LYSO detectors 3 x 40 x 50 mm 3 1 LaBr 3 detector ø25.4 mm x 50.1 mm W collimator (100 mm) TOF selection: background reduction see talk of F. Roellinghoff Wed. 15:00, (Nr. 235)
10 Multi-Slit Collimators GANL, 13 C 73 MeV/u on PMMA Count per incident ion parallel collimator With TOF selection 1.5 Without TOF selection Longitudinal position (mm) convergent collimator J. Krimmer (PNL) Progress in using prompt gammas for ion range monitoring during hadrontherapy CTR-PHE 2012
11 Compton Camera intersection: line/cone
12 Compton Camera: Simulations scatterer: 10 silicon strip detectors (SSD) 80 x 80 x 2 mm 3 absorber: LYSO detector 300 x 300 x 25 mm 3 photons: point source simulation: hit in SSD + hit in absorber resolution: 8 mm FWHM efficiency: F. Roellinghoff et al. NM A 648 (2011) S20-S23 M.H. Richard et al. proceedings EEE NSS-MC (2011), Valencia
13 cts/s Compton Camera: Hardware 152Eu Eγ = 40keV and Eγ = kev E [kev] Double-sided Silicon Strip Detectors test detectors (12 x 12 x 2mm3 ) 8 strips on each side energy resolution E=10 kev goal: E< 2 kev cooling needed delivery of final DSSD detectors (90 x 90 x 2mm3 ), 2x64 strips, expected 2012 J. Krimmer (PNL) Progress in using prompt gammas for ion range monitoring during hadrontherapy CTR-PHE 2012
14 Test Measurements: HT (Heidelberg) carbon LaBr3 scint. beam beam.c. target cts/s beam C 310 MeV/u background difference cut on scint. beam 1 scint. CC silicon det. LaBr 3det E [kev] single rates silicon detector: cts/ion (scaler, thres. 350 kev) absorber: cts/ion (scaler, thresh 180 kev) coincidence rates all events: cts/ion (scaler) uncharged: cts/ion (software cuts) extrapolation to prototype dimensions silicon det.: cts/ion single absorber: cts/ion single 10-2
15 Test Measurements: HT (Heidelberg) protons LaBr3 scint. beam beam.c. target cts/s 1 beam p 160 MeV background difference scint. CC silicon det. LaBr 3det E [kev] single rates silicon detector: cts/ion (scaler, thres. 350 kev) absorber: cts/ion (scaler, thresh 180 kev) coincidence rates all events: cts/ion (scaler) uncharged: cts/ion (software cuts) extrapolation to prototype dimensions silicon det.: cts/ion single absorber: cts/ion single for protontherapy conditions (10 10 p/s) absorber needs to be segmented 10-2
16 Summary and Outlook Collimated Camera prompt γ profiles for p and carbon beams TOF selection necessary improvements in simulations convergent multi-slit collimator Compton Camera simulation and test measurements count rates cooling for SSD absorber
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