CHIN ESE JOURNAL OF B IOMEDICAL EN GIN EERIN G

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1 CHIN ESE JOURNAL OF B IOMEDICAL EN GIN EERIN G Vol. 23 No. 2 April 2004 : (2004) , 2, 2, 1 3 (1., ; 2., ) :,,, : ; ; ; ; : R318 ; Q65 : A,, (41 45 ),, [1,2 ],, [3 ],,,,,, 1,, [4 ],,,, Maxwell,,, [5 ], a, s, g, ef f, [5 ] : r = P 0 exp ( - ef f ( r - r 0 ) ) / (4 r 0 r) ( r > r 0 ) (1), P 0 ( W ), r, r 0 : ( ) :

2 158 23,,, (1) : Q ( r), a 2 = a P 0 exp ( - ef f ( r - r 0 ) ) / (4 r 0 r) (2),,,,,,, Pennes [6 ] C 5 T 5 t = K 1 r 5 5 r 2 r 2 5 T 5 r + Q b + Q m + Q r (4), Q b, Q b = W b C b ( T a - T v ) W b C b ( T a - T), Q m, Q r Beop2Min [7 ], W b = W 0 (1 + a T) exp ( - ) W 0, a, 0. 09, : r = r 0 : ; r : T = 37 : T ( r,0) = T 0 = 37,Henriques [8 ], : (1) ; (2) ; (3),, Arrhe2 nius, = - ln C ( t) C ( t 0 ) t = A E exp - R T ( t) 0 dt (5) C ( t 0 ) t 0, C ( t) t ; A ( s - 1 ) ; E ( J/ mol) ; R ( J/ mol K) = 1,,, ef f [5 ] : ef f = 3 a a + sd e - + sn (1 - e - ) (1 - g), a, sn, sd, ; g 3-1/ 2 (6) (3) (5) P 0 = 1 W, r 0 = 0. 8 m m 1, ( 600s),,, 5mm,,, 8mm,,

3 2 : 159 :, 1 P 0 = 1 W 2 P 0 = 1 W 3 P 0 = 1 W ( ) 4 P 0 = 1 W ( ) 5 P 0 = 1 W 6 P 0 = 1 W

4 ,, 10mm 40, 5 r < 10mm 1 ( ) t = 600s,,, 5,,,, 6, W b, 7,,,, 7 P 0 = 1 W , 1W 2W, 120,, 15mm, 15mm 8 P 0 = 2 W 9 P 0 = 2 W 3. 3,,,, r = 10mm,,,,,, 11, P 0 = 1 W, r 10mm,,

2 : 161 10 4 11 : (1),,,, (2),,, ;,,, (3), (4),,, 5 [1 ],,. [J ].,1988,9 (2) :1472152. [2 ],,,. [J ]., 1998,17 (2) :1352141. [3 ],,,. [J ].,2000,28 (4) :98299.

5 2 : : (1),,,, (2),,, ;,,, (3), (4),,, 5 [1 ],,. [J ].,1988,9 (2) : [2 ],,,. [J ]., 1998,17 (2) : [3 ],,,. [J ].,2000,28 (4) : [4 ] Markfol Niemz, Zhang Zhenxi, Trans. Laser2Tissue Interactions[ M ]. Xi an Jiaotong University Press,1999, [5 ]. [D ].,2002,80286.

6 [6 ],. [ M ].,1997, [7 ] Kim Beop2Min, Jacques, et al. Massoud nonlinear finite2element analysis of the role of dynamic changes in blood perfusion and optical properties in laser coagulation of tissue[j ]. IEEE Journal on Selected Topics in Quantum Electronics,1996,2 (4) : [8 ] Henriques FC, Moritz AR. Studies of thermal injury I, The conduction of heat to and through skin and the temperature at2 tained therein, a theoretical and an experimental investigation[j ]. Am J Pathol,1947,23 : STUDY ON THE OPTICAL2THERMAL RESPONSE AND DY NAMIC THERMAL DAMAGE OF BIO2TISSUE D URING LASER THERMOTHERAPY ZHU Guang2ming 1, ZHU Dan 2, L UO Qing2ming 2, L IU Wei 1 (1. School of Energy & Power Engineering, Huazhong University of Science & Technology, Wuhan ; 2. School of Life Science & Technology, Huazhong University of Science & Technology, Wuhan ) Abstract : Based on t he optical characteristic parameters and t hermal characteristic parameters of bio2tissue and the relation between blood perfusion and bio2tissue s thermal damage, the transmission of laser through the bio2 tissue, transient heat response and thermal damage zone of tissue are numerical simulated. By analyzing the ef2 fect of laser power input and the size of laser head on the curative effect of thermotherapy, some suggestions use2 ful for tumour clinical treatment were proposed and discussed. Key words : Laser ; Thermotherapy ; Temperature field ; Thermal damage ; Bio2tissue ( 186 ) [8 ],,. [J ].,1999,13 (1) : [9 ] Koizumi, et al. Cultivated corneal epithelial stem cell transplantion in ocular surface disorders[j ]. Ophthalmology,2001,108 (9) : [10 ] Germain, Lucie, et al. Can we produce a human corneal equivalent by tissue engineering? [J ]. Progress in Retinal and Eye Research,2000,19 (5) : THE PREPARATION AND PROPERTIES OF N2ACETYLATED CHITOSAN FILMS L IU Wei2zhi, L IU Wan2shun, HAN Bao2qin, HE J un (College of marine life sciences, Ocean University of Qingdao, Qingdao ) Abstract : In t his paper N2acetylated chitosan films were prepared by t he reaction of chitosan and acetic an2 hydride in the medium CH 3 OH and acetic acid. The hydrophlicity, hygroscopicity, crystallinity, transparency, permeability of t he films were measured respectively, and t he adsorption of serum proteins and t he biocompati2 bility between the films and the rabbit corneal epithelial cell were studied. The results showed that the N2acety2 lated chitosan films had hydrophlicity to some extent, hygroscopicity and crystallinity to some extent, and had good transparency and premeability, as well as the ability to absorb the serum proteins. The results of culturing rabbit corneal epit helial cell on t he films indicated t hat t he films were well compatible wit h rabbit corneal epit he2 lial cell. Key words : N2acetylated chitosan films ; Physical properties ; Corneal epithelial cell ; Biocompatibility

3D FEM temperature distribution analysis of the human eye exposed to laser radiation

Advanced Computational Methods and Experiments in Heat Transfer XI 303 3D FEM temperature distribution analysis of the human eye exposed to laser radiation M. Cvetković 1,D.Čavka 1,D.Poljak 1 & A. Peratta