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1 Conference and for Organic Process Chemists and Chemical Engineers in Industry Scientific Update Ltd Maycroft Place, Stone Cross, Mayfield, East Sussex, TN20 6EW, UK Telephone: Fax:

2 Organic Process Research & Development October 2016, Prague, Czech Republic 6-8 March 2017, Pasadena, USA 2-4 October 2017, Stockholm, Sweden - Planning The efficient conversion of a chemical process into a process for manufacture on tonnage scale has always been of key importance in the chemical and pharmaceutical industries. In the current economic and regulatory climate, it has become increasingly vital and challenging to do so efficiently. At this conference, you will hear detailed presentations and case studies from top international chemists. Our hand-picked programme of speakers - put together specifically for an industrial audience will discuss the latest issues relating to synthetic route design, development and optimisation in the pharmaceutical, fine chemical and allied fields. Delegate Fee Europe USA $2245 Academic Rate $700 Exhibitor Package Europe from USA from $3300 Conferences 4 th Winter Process Chemistry Conference December 2016, University of Strathclyde, Glasgow The Winter Process Conference will consist of presentations from International Chemists and Chemical Engineers covering all aspects of Process Development. The speakers will discuss the latest issues in synthetic route design, development and optimisation, reactor design, work up and purification, crystallisation, process engineering, hazards studies, and quality and regulatory issues. The presentations will be either from speakers within the chemical industry or academics with a strong link to industrial process development so the material presented will be of particular relevance to all chemists and engineers in industry as well as graduate students considering a career in industry. Delegate Fee Academic Rate Exhibitor Package inc inc from inc The Scale-Up of Chemical Processes June 2017, Rochester, USA Whether you are a chemist, chemical engineer, QA or safety specialist, your aims when scaling up your process are often the same: Designing and developing safe processes; Achieving greater process efficiency, yield and throughput; Eliminating unsafe and non-green processes and materials; Decreasing the costs and number of steps involved. Since the first conference in 1994, The Scale-Up of Chemical Processes Conference has become the major international forum for the discussion of all these aspects of scale-up and more, in the pharmaceutical, fine chemical and allied fields. Key speakers will present case studies and examples of some of the pitfalls and problems they encountered and how they overcame them. With unparalleled networking opportunities, this broad-based conference is the best place to learn about and discuss the latest novel ideas and techniques with the key people in the industry. Delegate Fee Europe 1,495 USA $2,245 Academic Rate Europe 550 USA $700 Exhibitior Package Europe 2,200 USA $3,300

3 Chemical Development & Scale-Up in the Fine Chemical and Pharmaceutical Industries October 2016, Clearwater, Florida 1-3 March 2017, Pasadena, USA March 2017, Nice, France 6-8 June 2017, Edinburgh, UK October 2017, Lisbon, Portugal October 2017, Savannah, USA This ever-popular 3-day training course for chemists and engineers in industry aims to discuss the most efficient methods for developing cheap, robust processes. It covers the principles of scale-up and development and provides examples and case studies from industry. Not to be missed if you are just starting work in chemical development and a useful refresher for more experienced development chemists! Course Fee: USA $2,250 Europe 1,445 John Knight, Consultant Practical Approaches to Quality by Design (QbD) for Pharmaceutical Process Research, Development and Manufacturing 1-3 November 2016, Boston, USA 4-6 April 2017, Verona, Italy June 2017, Chicago, USA September 2017, Prague, Czech Republic 31 Oct-2 Nov 2017, Boston, USA This course focuses on practical approaches to accelerated QbD implementation, and it makes practical recommendations for realistic implementation of QbD elements. Participants will learn how to prioritize process parameters for screening designs, how to design robust processes using statistical design of experiments (DoE), how to bridge the bench and the commercial design spaces using mixing and scale-up calculations, how to quantify process risk, how to select suitable process analytical technology tools (PAT) and more. For the benefit of process scientists, engineers, formulators, analytical chemists and manufacturing personnel, this course includes highly interactive, hands-on workshops, based on several case studies. Effective technology transfer to pilot and manufacturing plants is also discussed, including process validation in the QbD paradigm. Course Fee: Andrei Zlota The Zlota Company LLC $2,400 USA, 1,635 Europe Scaling from Milligrams to 1-2kg: Making the First GMP Batch September 2016, Basel 6 7 October 2016, Clearwater, Florida 9-10 October 2017, Lisbon, Portugal The aim of the course is to provide attendees with a good basis to work from when involved in taking development candidates to the first in human trials with a view also on some longer-term requirements. The course content will therefore focus on the necessary early phases of chemical development as would typically be required to support production of up to about 2kg using laboratory-based 20L glassware. Course Tutor: John Knight, Consultant Course Fee: Europe 1,175 Secrets of Batch Process Scale-Up April 2017, San Francisco, USA May 2017, Amsterdam, The Netherlands September 2017, Madrid, Spain This course presents an overview of scale-up issues and examines their impact on process operation in the pilot plant and beyond, including scale-up considerations for route selection, raw material charging, reaction steps, workup, crystallization, product isolation, drying, etc. Common bench techniques for each of these steps are contrasted to the safety and operability criteria for successful pilot plant operation. Numerous examples and case histories are presented, along with tips and techniques for operators and experimenters. Heavy emphasis is placed on process safety. Course Fee: Francis X. McConville, Impact Technology 1,395 Europe, $2095 USA Practical Approaches to Statistical Design of Experiments (DoE) for Chemical Process Research & Development and Manufacturing May 2017 Boston, USA The synergy between fundamental science and statistical design of experiments (DoE) has been demonstrated to create more significant process understanding than that achieved by the same number of one-variable-at-a-time (OVAT) experiments. This course takes a balanced approach presenting basic DoE theory as well as numerous examples of DoE use in the pharmaceutical industry. The course will discuss statistical and practical significance, assumptions and limitations of DoE methodology, together with practical approaches for the process scientist to be in control of the DoE investigation (and not the computer). Precedent and experience compel many chemists to use OVAT experimentation in spite of its incomplete nature, and in spite of its inability to detect factor interactions, e.g., cases when the impact of one factor depends on the level of another factor. When such interactions occur between scale dependent and scale independent factors, ignoring such factor interactions can lead to high risk process scale-up and technology transfer. Andrei Zlota The Zlota Company Course Fee: $

4 Safety and Selectivity in the Scale-Up of Chemical Reactions September 2016, Basel, Belgium 6 7 October 2016, Clearwater, Florida, USA 9-10 October 2017, Lisbon, Portugal The aim of the course is to give lab chemists an understanding of the issues that need to be considered during the early stages of scale up to large laboratory scale equipment (10-20 litre vessels) / kilo lab. The course will concentrate on chemical safety and selectivity issues and include information on what safety testing equipment is available and the uses and limitations of this equipment. Attendees will learn how to identify potential problems whether they be thermal hazards or selectivity issues. Methods used by other companies for handling hazardous reagents and reactions will be described as well as alternative chemistry to circumvent these reactions and/or reagents. Course Tutor: Course Fee: USA $1,825 Europe 1,175 Organic Synthesis: A Toolkit for the Industrial Chemist 9-11 May 2017, Split, Croatia This 3-day course, written and presented by highly experienced chemists from the pharmaceutical and fine chemical industry, provides a modular overview of the most important tools available for the organic chemist working in industry. The concepts are illustrated with an abundance of industrial and academic case studies from literature, conferences and private communications. The lectures are interspersed with interactive problem sessions, enabling participants to share in the problem solving and troubleshooting typically experienced when practising organic chemistry in an industrial environment. Course Fee: 1,395 John Knight Consultant & Will Watson, Scientific Update Ltd Biocatalysis as a Tool for the Synthetic Chemist 8-9 November 2016, Dublin, Ireland The aim of the course is to give organic chemists an understanding and an overview of the subject of biotransformations. Attendees will learn about the main classes of enzymes and the transformations these enzymes carry out. Each transformation type will be illustrated with examples and case studies and the course will also include problem sessions where attendees will work on real examples applying biotransformations to organic synthesis. Recent developments in the field will be covered as well as an overview of the sort of equipment and resources required. Course Tutors: Course Fee: 1,195 Andrew Carnell, University of Liverpool Heterogeneous Catalytic Hydrogenation June 2017, Lisbon, Portugal Participants on this comprehensive course will be familiarized with all the important aspects of heterogeneous catalytic hydrogenation. Attendees will learn how to successfully design, develop and realize economic, safe, fool proof and ecological hydrogenation processes. The main focus will particularly be on a deeper understanding of the underlying disciplines such as catalysis on surfaces and transport processes. Guidelines on how to approach specific hydrogenation problems and concepts and tools for the design, development and scale up of catalytic hydrogenation processes will be presented, rather than summing up transformations of functional groups by catalytic hydrogenation, as this information can nowadays easily be searched and found in literature and patents. Course Fee: 1,195 Felix Roessler, Consultant Flow Chemistry 8-9 June 2017, Barcelona Flow chemistry has been used in petrochemical and bulk chemical production for over 100 years but has only really been taken up in the pharmaceutical and fine chemical industries over the last 10 years or so. This course aims to give an introduction to the subject and an overview of the current state of the art. A variety of chemical reactions in flow and how to translate a conventional reaction in to a flow process will be described. This also entails choosing the right type of flow reactor for the chemistry, and a number of different flow reactor systems will be discussed and compared. Handling solids in flow systems, inline and online monitoring of flow reactions will also be covered along with the hazards and pitfalls associated with scaling up flow reactions. Interfacing Chemistry with Patents November 2016, Cardiff, UK This course is a lively introduction to how the patent system works and the nature and scope of the rights a patent gives with an emphasis on chemical inventions. It will cover patentability, patent procedures, infringement, the commercial exploitation of patents, the interpretation of patent literature and the role of the inventor. There will also be chemically orientated workshops aimed at exploring and reinforcing the basic course teachings. Andrea Brewster, Greave Brewster Carol Greaves, CP Greaves & Co Course Fee: 1,175 + VAT at 20% Course Fee: Oliver Kappe University of Graz Will Watson Scientific Update Ltd 1,250 Europe $1700 USA

5 NEW COURSE Organometallic Chemistry From Magnesium to Palladium October 2016, Spain This course will cover stoichiometric organometallics such as Grignard reagents and catalytic organometallics based mainly on palladium and other platinum group metals. The first day will concentrate on Grignard reagents and organolithiums and organozincs including preparation and uses and safety aspects of these reagents. Catalytic C-C and C-X bond forming reactions will be covered on day 2, concentrating on palladium catalysis, but with discussion of systems using other metals such as copper, nickel, ruthenium, rhodium and iridium. Throughout the course the emphasis will be on practical methods of carrying out synthetically useful reactions. Many case studies and industrial examples will be included to illustrate the utility of both catalytic and stoichiometric organometallic reactions. Course Fee: 1,175 A Chemist s Guide to Chemical Engineering October 2016, Madrid, Spain This 3½ -day course will include some basic problems and case studies on an individual and group basis. These will include elevation of mass and energy balances, estimating pumping requirements and fluid flow, some basic process design concepts and calculation of heating and cooling requirements. Some of these will be done manually and some by using PCs. It is hoped to show how PCs are used by engineers and use will be made of multimedia interactive techniques where possible. Course Fee: 1,425 Keith Turner, Kappa Tau Consulting Understanding Polymorphism & Crystallisation October 2016, Verona, Italy This course teaches chemists and engineers some fundamental aspects of crystal chemistry, nucleation and crystal growth, the operation of batch crystallisers and methodologies of characterisation. Salt selection and polymorph control and selection are emphasised. Case studies are used to illustrate important issues. Course Fee: 1,395 Terry Threlfall, University of Southampton Dr John Knight, Consultant Discounts are available if you send two or more attendees on our courses Call or us for more details:

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