KATHRYN HAAS. P.O. Box 1802 Durham, NC Tel:

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1 KATHRYN HAAS P.O. Box 1802 Durham, NC Tel: EDUCATION AND TRAINING National Institutes of Health, National Institute of Environmental Health Sciences, RTP, NC 2011 Postdoctoral Intramural Research Training Award Fellow, Laboratory of Toxicology and Pharmacology Ph.D. Degree in Chemistry,, Durham, NC 2010 Dissertation: Metals at the Interface of Chemistry and Biology: New Insights into hctr1 Function and the Role of Histidine in Human Cellular Copper Acquisition. B.S. Degree in Chemistry, Gettysburg College, Gettysburg, PA 2004 Cumulative GPA 3.8, Chemistry GPA 4.0, Summa cum laude Thesis: Electronic tuning effects in titanium catalyzed transformations using 6,6 -substituted binol ligands. RESEARCH EXPERIENCE , National Institute of Environmental Health Sciences (RTP, NC) Laboratory of Dr. Jonathan Freedman Metabolic profiling of biological samples using TOF-LC-MS and GC-MS to determine nematode metabolic response to Cd exposure, specifically in the transsulfuration and fatty acid synthesis pathways Generated transgenic C. elegans by genetic crossing and by DNA microinjection in order to determine regulators of genetic response to heavy metal exposure Fluorescence Imaging using Confocal Fluorescence Microscopy on live transgenic nematodes , (Durham, NC) Laboratory of Dr. Katherine J. Franz Synthesized and characterized Cu(I) and Cu(II) binding properties of a series of human Ctr1 model peptides using UV-vis, NMR, ITC, CD, CV, HPLC, ESI-MS and LCMS Developed cloning, expression and protein purification protocol for isolation of a 65 amino acid fragment of N-terminal hctr1 from E. coli Prepared and characterized copper status of several mouse embryonic fibroblast (MEF) stable cell lines expressing wild type hctr1 and mutant hctr1 variants (in collaboration with Dr. Dennis Thiele, Duke University) Examined chemical and structural components of sepia melanin using electron microscopy (EM) and by synthesis and manipulation of melanin molecular components (which were air sensitive) Spectroscopically characterized pka s and Cu(II), Zn(II), Fe(II) and Fe(III)-binding properties of photoactive caged metal complexes using potentiometric (ph-dependant) spectrophotometric titrations and metal competition experiments Measured DNA binding of caged Pt(II) derivatives on DNA compared to cisplatin using DNA gel electrophoresis assays and analyzed ability of cage coumarin derivatives in sensing cellular copper status using confocal and fluorescence microscopy Developed skills in chemical synthesis, solid phase peptide synthesis, peptide purification, equilibrium analysis software, DNA cloning, gene expression, protein purification and analysis, tissue culture, immuno blot analysis, immunofluorescence imaging, and live cell fluorescence imaging

2 page , Gettysburg College (Gettysburg, PA) Laboratory of Dr. Darren MacFarland Synthesized series of 6, 6 -substituted 1,1'-binaphthalene-2,2'-diol (binol) ligands (which are air sensitive) and tested their efficiency as titanium ligands in titanium-catalyzed Diels-Alder reactions Gained experience in anaerobic organic synthesis and monitoring kinetics of metal-catalyzed reactions by quantitative GC-MS TEACHING EXPERIENCE Visiting Assistant Professor, Indiana University, South Bend Jan 2012-May2012 Responsible for teaching CHEM342 Organic Chemistry II Lectures and Discussion (38 sophomorelevel students, 3 credit hours), CHEM 430 Inorganic Chemistry (10 senior-level students, 3 credit hours), and CHEM 335 Inorganic Chemistry Laboratory (6 senior-level students). Served as course development consultant toward a general education laboratory course in forensic sciences. Graduate Student Teacher, The Science Behind Forensics, Designed an original course for undergraduates and successfully taught the course for two years with a team of five graduate students. This experience included the original design, team teaching, and grading of a class of 15 undergraduates, followed by revision and teaching of the course to a second class of undergraduates. This work is published in the Journal of Chemical Education. Teaching Assistant, Inorganic Chemistry, Created and administered weekly problem sets, led weekly problem sessions to guide students through difficult topics, and occasionally organized material and conducted lectures to a class of 50 students. Recitation Teaching Assistant, General Chemistry, 2008 Conducted 4 lectures per week to review basic material and held weekly office hours to guide students through challenging topics and problem sets. Tutor, General Chemistry and Organic Chemistry, Effectively coached students in learning both general and organic chemistry. Assessed student learning styles and gaps in knowledge or conceptual understanding, and then used organized presentation, as well as creative techniques and strategies customized each students learning style. Tutored approx. 2-5 students per semester. Laboratory Assistant, Organic Chemistry, Gettysburg College Assisted students in proper and safe laboratory procedures as well as preparation and setup for lab. Chemistry Department Teaching Associate, Gettysburg College Appointed as the chemistry department s first undergraduate teaching associate. As a sophomore undergraduate, successfully led weekly general chemistry problem sessions to coach under-classmates in approaching problem sets and learning chemistry. As a junior and senior, led both organic and general chemistry problem sessions to help students develop problem solving and learning skills.

3 page 3 OTHER TEACHER TRAINING Instructor at The Environment - A Human Health Perspective 2011 An Environmental Health Perspective s (EHP) outreach program. This teacher professional development workshop familiarizes high school chemistry and biology teachers with environmental health education resources to highlight the connection between the environment and human health. Instructional Uses of Technology, 2007 A teaching development course on using technology in the college classroom to enhance student learning. Leadership in Chemistry Workshop, 2007 A series of leadership development workshops. Teaching College Chemistry, A seminar in which five graduate students work under a faculty mentor to design, teach, and then redesign a freshman seminar course in chemistry. Introduction to College Teaching, 2005 A series of teaching development workshops about good methods in designing and teaching a collegelevel course. AWARDS AND FELLOWSHIPS Poster Award, The Second Bioinorganic Training Workshop at Penn State, 2012 Intramural Research Training Award, National Institutes of Health, 2011 Pelham Wilder, Jr. Fellowship for outstanding teaching assistants,, 2007 John Herbert Pearson Teaching Award,, 2007 NSF Fellowship, Integrated Graduate Education and Research Traineeship,, Award for Achievement in Organic Chemistry, Gettysburg College, 2004 Weiland Scholarship for undergraduate research, PUBLICATIONS Julie Hall, Kathryn L. Haas, and Jonathan Freedman. "Role of MTL-1, MTL-2 and CDR-1 in Mediating Cadmium Sensitivity in C. elegans. Toxicological Sciences, 2012, DOI /toxsci/kfs166. Kathryn L. Haas, Allison B. Putterman, Daniel R. White, Dennis J. Thiele and Katherine J. Franz. New Insights into hctr1 function and the role of Histidine in Human Cellular Copper Acquisition. J. Am. Chem. Soc.., 2011, 133 (12), Katie L. Ciesienski, Kathryn L. Haas, and Katherine Franz. Development of next-generation photolabile copper cages with improved copper binding properties". Dalton Trans., 2010, 39(40),

4 page 4 Katie L. Ciesienski, Lynne M. Hyman, Daniel T. Yang, Kathryn L. Haas, Marina G. Dickens, and Katherine Franz. A caged platinum(ii) complex that increases cytotoxicity upon light activation. European Journal of Inorganic Chemistry. 2010, 15, Kathryn L. Haas and Katherine J. Franz. Application of metal coordination chemistry to explore and manipulate cell biology. Chemical Reviews. 2009, 109 (10), Katie L. Ciesienski, Kathryn L. Haas, Marina G. Dickens, Yohannes T. Tesema, and Katherine J. Franz. A photolabile ligand for light-activated release of caged copper. Journal of the American Chemical Society. 2008, 130 (37), Louise K. Charkoudian, Jared J. Heymann, Marc J. Alder, Kathryn L. Haas, Kassy A. Mies, and James F. Bonk. Forensics as a gateway: Promoting undergraduate interest in science and graduate student professional development through a first-year seminar course. Journal of Chemical Education. 2008, 85 (6), 807. PRESENTATIONS Kathryn L. Haas, Allison B. Putterman, Daniel C. White, Dennis J. Thiele and Katherine J. Franz. Model Peptides Provide New Insights into the role of Histidine in Human Cellular Copper Acquisition via Ctr1. The Second Bioinorganic Training Workshop at Penn State Kathryn L. Haas, Julie Hall, and Jonathan Freedman. MTL-1, MTL-2, and CDR-1 are not essential in C. elegans resistance to cadmium. 18 th International C. elegans Meeting, UCLA, Los Angeles, CA, June Kathryn L. Haas, Allison B. Putterman, Daniel R. White, Katherine J. Franz, and Dennis J. Thiele. Characterization of Human Ctr1. Invited Speaker, Gordon Research Seminar in Bioinorganic Chemistry. Ventura, CA; February Kathryn L. Haas, Allison B. Putterman, Daniel R. White, and Katherine J. Franz. Spectroscopic studies of N-terminal and Cu(II)- and Cu(I)-binding hctr1 model peptides. American Chemical Society National Meeting, Washington, DC; August Jared J. Heymann, Louise K. Charkoudian, Kathryn L. Haas, Marc J. Adler, Kassy A. Mies and James F. Bonk. "Inside CSI: Teaching science in a non-majors freshman seminar using forensics". American Chemical Society, North Carolina Local Chapter Meeting. Durham, NC; June 2007 Kathryn L. Haas and Katherine J. Franz. "Spectroscopic studies of methionine- and histidine-rich hctr1 model peptides". Gordon Graduate Research Seminar in Bioinorganic Chemistry. Ventura, CA; February 2006.

5 page 5 PROFESSIONAL REFERENCES CONTACT INFORMATION Katherine J. Franz 2103 French Family Science Center katherine.franz@duke.edu James Bonk Teaching Mentor james.bonk.@duke.edu Alvin Crumbliss Ph.D. Committee Member 2104 French Family Science Center alvin.crumbliss@duke.edu Dennis J. Thiele Ph.D. Committee Member Professor of Pharmacology and Cancer Biology C134B Levine Science Research Center dennis.thiele@duke.edu RELATIONSHIP AND RANGE OF KNOWLEDGE Ph.D. research advisor and teaching mentor. I taught a total of 3 lectures and held weekly problem sessions for her inorganic chemistry course. I also mentored undergraduate students in her lab for several years. She can attest to my teaching ability in both the classroom as well as in the lab. Mentor in design and execution of an original undergraduate course, The Science behind Forensics. Dr. Bonk observed and provided feedback on individual lectures and guided creation and re-design of a course that was taught over two years. Ph.D. committee member in Inorganic Chemistry. Dr. Crumbliss knows me well, as our labs often had joint group meetings. He is an expert in kinetics and thermodynamics of metal-ligand interactions and can attest to my professionalism in the field of inorganic chemistry. Research mentor and Ph.D. committee member in Molecular Biology. I worked closely with Dr. Thiele and his lab for the last two years of my Ph.D. He is a reliable reference for my work ethic and versatility in science.