TANESHA C. OSBORNE. B.S., Chemistry, Georgia Southern University, Statesboro, GA, May TEACHING EXPERIENCE 08/2008 Present

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1 TANESHA C. OSBORNE EDUCATION Ph.D., Organic Chemistry, University of South Carolina, Columbia, SC, August 2008 Dissertation: Kinetic Characterization of Protein Arginine Methyltransferase 1 Aids the Development of PRMT-Selective Bisubstrate Inhibitors Advisor: Dr. Paul R. Thompson B.S., Chemistry, Georgia Southern University, Statesboro, GA, May 2003 TEACHING EXPERIENCE 08/2008 Present 01/ / / / / /2006 Lecturer (08/2011); Instructor (08/2008), Georgia Southern University Department of Chemistry, Statesboro, GA. Survey of Chemistry coordinator. Courses taught: Introduction to General, Organic, and Biological Chemistry; Principles of Chemistry I; Principles of Chemistry II; Organic Chemistry I; Survey of Chemistry I; Survey of Chemistry I online; and Survey of Chemistry II. Developed: Survey of Chemistry I; Survey of Chemistry II; Survey of Chemistry I online; and Survey of Chemistry II online (in progress). Adjunct Instructor, Augusta Technical College Department of Chemistry, Augusta, GA. Course taught: Chemistry I. NSF GK-12 Teaching Assistant, University of South Carolina Department of Mechanical Engineering, Columbia, SC. Course taught: 7 th grade science. Graduate Teaching Assistant, University of South Carolina Department of Chemistry & Biochemistry, Columbia, SC. Courses taught: organic chemistry laboratories and supplemental courses. RESEARCH EXPERIENCE 01/ / / /2008 Mentor Undergraduate Research, Georgia Southern University Department of Chemistry, Statesboro, GA. Collaborator: Dr. Karen Welch (Georgia South University). Explored the Synthesis of Azo Dyes for Comparison with Click Dyes. Graduate Research Assistant, University of South Carolina Department of Chemistry & Biochemistry, Columbia, SC. Advisor: Dr. Paul Thompson. Investigated the design, synthesis and evaluation of Protein Arginine Methyltransferase specific inhibitors that could be used as pharmacological probes to characterize the in vivo role of the enzyme. Tanesha C. Osborne, Ph.D. Page 1

2 05/ / / / / /2003 Undergraduate Research Assistant, University of South Carolina Department of Chemistry & Biochemistry, Columbia, SC. Advisor: Dr. John Lavigne. Studied the organic synthesis of thiophene monomers. Undergraduate Research Assistant, Georgia Southern University Department of Chemistry, Statesboro, GA. Advisor: Dr. Allison Amonette. Conducted a research study preparing crystals of various compounds which were used for crystallography purposes. Undergraduate Research Assistant, Georgia Southern University Department of Chemistry, Statesboro, GA. Advisor: Dr. Christine Whitlock. Explored an area of organic synthesis which involved the preparation of novel trisindolyl amines with potential iron chelating properties. PATENT Osborne, T. C.; Obianyo, O.; Causey, C. P.; and Thompson, P. R. (2010) Chloroacetamidine Based Inhibitors and Activity Based Probes for the Protein Arginine Methyltransferases. U.S. Patent application, Serial No. 12 / 637,223. PUBLICATIONS Laboratory Manuals Osborne, T.C. (2013) Chemistry 1151 Survey of Chemistry I Laboratory Manual 2 nd edition. Georgia Southern University Press, released August 2013, copyright Osborne, T.C. (2013) Chemistry 1152 Survey of Chemistry II Laboratory Manual 2 nd edition. Georgia Southern University Press, released August 2013, copyright Osborne, T.C. (2012) Chemistry 1151 Survey of Chemistry I Laboratory Manual 1 st edition. Georgia Southern University Press, released August 2012, copyright Osborne, T.C. (2012) Chemistry 1152 Survey of Chemistry II Laboratory Manual 1 st edition. Georgia Southern University Press, released August 2012, copyright Peer-Reviewed Journal Articles Knuckley, B., Causey, C.P., Jones, J.E., Bhatia, M., Dreyton, C.J., Osborne, T.C., Takahara, H., and Thompson, P.R. (2010) Substrate Specificity and Kinetic Studies of PADs 1, 3, and 4 Identify Potent and Selective Inhibitors of Protein Arginine Deiminase 3. Biochemistry 49 (23), Obianyo, O., Causey, C.P., Osborne, T.C., Jones, J.E., Lee, Y-H, Stallcup, M.R. and Thompson, P.R. (2010) A Chloroacetamidine-based Inactivator of Protein Arginine Methyltransferase 1: Design, Synthesis, and in Vitro and in Vivo Evaluation. Chembiochem 11 (9), Tanesha C. Osborne, Ph.D. Page 2

3 Obianyo, O., Osborne, T.C. and Thompson, P.R. (2008) Kinetic mechanism of Protein Arginine Methyltransferase 1. Biochemistry 47, Osborne, T., Weller-Roska, R.L., Rajski, S.R. and Thompson, P.R. (2008) In Situ Generation of a Bisubstrate Analog for Protein Arginine Methyltransferase 1. Journal of the American Chemical Society 130, Highlighted in Faculty of 1000 Biology Osborne, T.C., Obianyo, O., Zhang, X., Cheng, X. and Thompson, P.R. (2007) Protein Arginine Methyltransferase 1: Positively Charged Residues in Substrate Peptides Distal to the Site of Methylation Are Important for Substrate Binding and Catalysis. Biochemistry 46, ORAL PRESENTATIONS Osborne, T. and Thompson, P.R. 2007, In Situ Generation of a Bisubstrate Analog for Protein Arginine Methyltransferase 1, Abstract for poster presentation, Abcam Chromatin Structure & Function. Antigua. Obianyo, O., Osborne, T. and Thompson, P.R. 2007, Kinetic Characterization of Protein Arginine Methyltransferase 1, Abstract for poster presentation, Abcam Chromatin Structure & Function. Antigua. Osborne, T. and Thompson, P.R. 2006, Protein Arginine Methyltransferase1: Purification and Kinetic Analysis, Poster presentation, University of South Carolina Visitation Weekend. Columbia, South Carolina. Osborne, T. and Thompson, P.R. 2005, Protein Arginine Methyltransferase Specific Inhibitors, Poster presentation, University of South Carolina Graduate Student Forum. Columbia, South Carolina. UNDERGRADUATE STUDENT PRESENTATIONS Cowart, E.J., Osborne, T.C., Kibakaya, E.C. and Welch, K.T. 2010, Synthesis of Azo Dyes for Comparison with Click Dyes, Poster Presentation, Georgia Southern University 2010 COUR/ASPIRES/COST Undergraduate Research Symposium. Statesboro, Georgia. Cowart, E.J., Osborne, T.C., Kibakaya, E.C. and Welch, K.T. 2010, Synthesis of Azo Dyes for Comparison with Click Dyes, Poster Presentation, Georgia Southern University 2010 Phi Kappa Phi Research Symposium. Statesboro, Georgia. SKILLS Computer Skills. BlackBoard, ChemDraw, Chimera, Desire2Learn, Google Chrome, GraFit, Internet Explorer, Isis Draw, Kaleida Graph, Microsoft Excel, Microsoft PowerPoint, Microsoft Word, Mozilla FireFox, Quattro Pro, SciFinder Scholar, SlideRocket, Soft Max Pro, WordPerfect, 55 wpm Tanesha C. Osborne, Ph.D. Page 3

4 Laboratory Skills. Autoclave, Balances, Cell Cultures, Centrifuge, Column Chromatography, Distillation, DNA Cloning, DNA Gel Electrophoresis, DNA purification, Enzymatic Assays, Extraction, Ion-exchange Chromatography, Lyophilizer, ph Meters, Pipettes, Polymerase Chain Reaction, Protein Digestion, Protein Expression, Protein Ligation, Protein Purification, Radioactive Detection Techniques, Scintillation Counter, Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis, Thin-Layer Chromatography, Wet Chemistry Instrument Knowledge. Atomic Absorption Spectroscopy, Fast Protein Liquid Chromatography, Fourier Transform Infrared Spectrophotometer, Gas Chromatography, High- Performance Liquid Chromatography, Matrix Assisted Laser Desorption Ionization, Microplate Spectrophotometer, Nuclear Magnetic Resonance, Peptide Synthesizer, PhosphorImager, Ultraviolet Spectrophotometer SERVICE AND ACTIVITIES Departmental Awards Committee (2011 Present) Departmental Assessment Committee (2012 Present) Faculty Advisor for Chemistry Majors (2012 Present) Departmental Curriculum Committee (2013) Faculty Advisor for the GSU chapter of HairCrush (2013) Departmental Lecturer Search Committee (2011, 2012, 2013) Faculty Online Course Development Program (2012, 2013) Developed Survey Chemistry I Online Course (2012) Developed Survey of Chemistry II Course (2012) Developed Survey of Chemistry I Course (2011) Faculty Co-Advisor for the GSU Student Chapter of the National Organization for the Professional Advancement of Black Chemists and Chemical Engineers ( ) AWARDS 2011 Mentor to Teneshia Jordan, Omicron Delta Kappa Society, Inc. inductee (GSU) Outstanding Advocate for First-Year Students Nominee (GSU) 2006 National Science Foundation GK-12 Fellowship (USC) 2003 University of South Carolina Sloan Fellowship 2003 University of South Carolina Peyton C. Teague Fellowship 2003 University of South Carolina Copenhaver Scholar Tanesha C. Osborne, Ph.D. Page 4

5 PROFESSIONAL ORGANIZATIONS American Chemical Society National Organization for the Professional Advancement of Black Chemists and Chemical Engineers Tanesha C. Osborne, Ph.D. Page 5