Vplyv testosterónu na prežívanie lásky v romantických vzťahoch u mladých mužov

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1 Vplyv testosterónu na prežívanie lásky v romantických vzťahoch u mladých mužov RNDr. Jaroslava Durdiaková Školiteľka: prof. MUDr. Daniela Ostatníková, PhD. Fyziologický ústav, Lekárska fakulta, Univerzita Komenského v Bratislave

2 Láska je jediné bohatstvo, ktoré rastie tým, že sa s ním človek delí. (Cesare Cantú)

3 Endokrinné faktory v láske kortizol: zvýšené hladiny stresových hormónov u čerstvo zamilovaných ľudí v dôsledku obavy a neistoty, či vo vzťahu uspejú a či naplnia očakávania toho druhého serotonín: v skorých fázach zamilovanosti nám klesajú hladiny serotonínu, čo zodpovedá za to, že čerstvá láska pripomína miernu formu obsesie dopamín: v ďalšej fáze prichádza typická romantická láska z filmov, sprevádzaná vyplavovaním endorfínov a dopamínu, ktoré spôsobujú dobré pocity z blízkosti druhého až závislosť na partnerovi oxytocín, vazopresín: vyplavovanie oxytocínu a vazopresínu vytvára trvalé puto, vernosť a naviazanosť jedného na druhého, čo je predpokladom pre vznik zrelej a zodpovednej lásky testosterón

4 Testosterón a láska vplyv partnerských vzťahov na testosterón: zmeny v rodinných stavoch menia aj hladiny T vplyv testosterónu na formovanie vzťahov: T ovplyvňuje správanie sa vo vzťahoch nízke hladiny testosterónu nízke hladiny testosterónu

5 Ciele práce analyzovať vplyv testosterónu, kortizolu a oxytocínu na prežívanie lásky u mladých mužov

6 Metodika mladí zdraví muži (N=6) vzorky venóznej krvi a sliny koncentrácie hormónov stanovené metódou ELISA (DRG Diagnostics) DNA izolovaná z venóznej krvi (Qiagen Blood Mini Kit) počet CAG opakovaní v géne pre androgénový receptor indikátor citlivosti AR kapilárna elektroforéza pomer dĺžky prstov na ruke (2D:4D) indikátor prenatálnych hladín T meraný z elektronických skenov dlane Love Attitude Scale dotazník na posúdenie štýlu prežívania lásky štatistická analýza: Spearmanov korelačný test

7 Výsledky Korelácie medzi hladinami testosterónu v plazme a romantickou láskou neboli štatisticky významné Vyšší pomer 2D:4D indikujúci slabší prenatálny účinok testosterónu pozitívne ovplyvňuje romantické vnímanie lásky v partnerských vzťahoch R 2 = -.12, p =.1 R 2 =.2, p = romantic love [score] romantic love [score] plasma testosterone [nmol/l] right 2D/4D ratio

8 Výsledky R 2 =.28, p =.3 altruistic love [score] Vyšší počet CAG opakovaní v prvom exóne génu pre androgénový receptor spojený s nižšou mierou androgénovej signalizácie vedie k altruistickým prejavom lásky (CAG)n in AR

9 passionate love [score] 1 1 r =.6, p = ns oxytocin - plasma [pg/ml] 2 r =.186, p = ns playful love [score] r = -.2, p = ns oxytocin - plasma [pg/ml] 2 r =.112, p = ns Výsledky Koncentrácie oxytocínu v plazme nemajú signifikantný vplyv na prežívanie lásky u mladých mužov friendly love [score] 1 1 practical love [score] oxytocin - plasma [pg/ml] oxytocin - plasma [pg/ml] possessive love [score] r = -.84, p = ns oxytocin - plasma [pg/ml] altruistic love [score] 1 1 r =.23, p = ns oxytocin - plasma [pg/ml]

10 passionate love [score] 1 1 r =.11, p = ns salivary cortisol [ng/ml] playful love [score] r =.17, p = ns salivary cortisol [ng/ml] Výsledky Koncentrácie kortizolu v sline nemajú signifikantný vplyv na spôsob prežívania lásky u mladých mužov r =.18, p = ns r =.18, p = ns 2 2 friendly love [score] 1 1 practical love [score] salivary cortisol [ng/ml] salivary cortisol [ng/ml] possessive love [score] r =.16, p = ns salivary cortisol [ng/ml] altruistic love [score] 1 1 r =.1, p = ns salivary cortisol [ng/ml]

11 Zhrnutie testosterón ovplyvňuje spôsob prežívania ľúbostných vzťahov nižšia miera androgenicity má za následok romantické a nesebecké prežívanie lásky presný mechanizmus účinku testosterónu na romantické správanie ostáva neobjasnený

12 Ďakujem... Prof. MUDr. Daniela Ostatníková, PhD. doc. MUDr. Ing. RNDr. Peter Celec, PhD., MPH. Mgr. Ivana Koborová Lucia Kukulová Študenti 3. ročníka Lekárskej fakulty UK v Bratislave (Všeobecné lekárstvo)

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